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Lamium Plants—A Comprehensive Review on Health Benefits and Biological Activities

Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran
Department of Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa, Paraná 84030900, Brasil
Department of Biomedical Sciences, University of Cagliari, s.s. 554 bivio Sestu, I-09042 Monserrato, CA, Italy
Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 480012, Kazakhstan
Department of Medicinal and Aromatic Plants, University of Health Sciences, 34668 Istanbul, Turkey
Department of Health Sciences; Faculty of Science, University of Mauritius, Réduit 80837, Mauritius
Department of Pharmaceutical Technology, Avicenna Tajik State Medical University, Rudaki 139, Dushanbe 734003, Tajikistan
CREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy
Department of Pharmacy, University of Napoli Federico II, Via D. Montesano, 49-80131 Napoli, Italy
Department of Health Sciences, University Magna Graecia, viale Europa-Germaneto, 88100 Catanzaro, Italy
Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy
Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol 61615-585, Iran
Authors to whom correspondence should be addressed.
Academic Editor: Raphaël E. Duval
Molecules 2019, 24(10), 1913;
Received: 16 April 2019 / Revised: 8 May 2019 / Accepted: 14 May 2019 / Published: 17 May 2019
(This article belongs to the Special Issue Plant Extracts: Biological and Pharmacological Activity)
PDF [905 KB, uploaded 17 May 2019]


This work is an updated snapshot of Lamium plants and their biological activities. The main features of the plant are described and the components of its essential oils are summarized. The traditional medicinal uses of Lamium plants has been reported. The presence of these chemicals i.e., hydroxycinnamic acids, iridoids, secoiridoids, flavonoids, anthocyanins, phenylpropanoids, phytoecdysteroids, benzoxazinoids, betaine can provide biological activities. After the discussion of antioxidant properties documented for Lamium plants, the biological activities, studied using in vitro models, antimicrobial, antiviral, anti-inflammatory, anti-nociceptive activity, and pain therapy and cytotoxicity and cytoprotective activity are here described and discussed. Finally, targeted examples of in vivo studies are reported. View Full-Text
Keywords: Lamium plants; antiviral; antioxidant; anti-inflammatory; cytotoxicity Lamium plants; antiviral; antioxidant; anti-inflammatory; cytotoxicity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Salehi, B.; Armstrong, L.; Rescigno, A.; Yeskaliyeva, B.; Seitimova, G.; Beyatli, A.; Sharmeen, J.; Mahomoodally, M.F.; Sharopov, F.; Durazzo, A.; Lucarini, M.; Santini, A.; Abenavoli, L.; Capasso, R.; Sharifi-Rad, J. Lamium Plants—A Comprehensive Review on Health Benefits and Biological Activities. Molecules 2019, 24, 1913.

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