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Cucurbits Plants: A Key Emphasis to Its Pharmacological Potential

Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran
Faculty of Chemical & Metallurgical Engineering, Food Engineering Department, Istanbul Technical University, 34469 Maslak, Turkey
Laboratoire de Biotechnologie Végétale et d’Ethnobotanique, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia 06000, Algérie
Department of Plant Sciences, LCWU, Lahore 54000, Pakistan
G.B. Pant National Institute of Himalayan Environment & Sustainable Development Kosi-Katarmal, Almora 263 643, India
G.B. Pant National Institute of Himalayan Environment & Sustainable Development Garhwal Regional Centre, Srinagar 246174, India
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Mevsim Gida Sanayi ve Soguk Depo Ticaret A.S. (MVSM Foods), Turankoy, Kestel, 16540 Bursa, Turkey
Institute of Fermentation Technology and Microbiology, Lodz University of Technology, Wolczanska 171/173, 90-924 Lodz, Poland
Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata 700019, India
Department of Botany, Fakir Chand College, Diamond Harbour, West Bengal 743331, India
Department of Medical Biology, Faculty of Medicine, Nigde Ömer Halisdemir University, Campus, 51240 Nigde, Turkey
Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol 61615-585, Iran
Department of Pharmacy, Faculty of Pharmacy, University of Concepcion, Concepcion 4070386, Chile
LEPABE, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal
Department of Pharmaceutical Technology, Avicenna Tajik State Medical University, Rudaki 139, Dushanbe 734003, Tajikistan
Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal
Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy
Authors to whom correspondence should be addressed.
Molecules 2019, 24(10), 1854;
Received: 2 April 2019 / Revised: 9 May 2019 / Accepted: 13 May 2019 / Published: 14 May 2019
(This article belongs to the Special Issue Plant Extracts: Biological and Pharmacological Activity)
Cucurbita genus has received a renowned interest in the last years. This plant species, native to the Americas, has served worldwide folk medicine for treating gastrointestinal diseases and intestinal parasites, among other clinical conditions. These pharmacological effects have been increasingly correlated with their nutritional and phytochemical composition. Among those chemical constituents, carotenoids, tocopherols, phenols, terpenoids, saponins, sterols, fatty acids, and functional carbohydrates and polysaccharides are those occurring in higher abundance. However, more recently, a huge interest in a class of triterpenoids, cucurbitacins, has been stated, given its renowned biological attributes. In this sense, the present review aims to provide a detailed overview to the folk medicinal uses of Cucurbita plants, and even an in-depth insight on the latest advances with regards to its antimicrobial, antioxidant and anticancer effects. A special emphasis was also given to its clinical effectiveness in humans, specifically in blood glucose levels control in diabetic patients and pharmacotherapeutic effects in low urinary tract diseases. View Full-Text
Keywords: cucurbits; pumpkin; squash; antimicrobial; antioxidant; anticancer; traditional medicine cucurbits; pumpkin; squash; antimicrobial; antioxidant; anticancer; traditional medicine
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MDPI and ACS Style

Salehi, B.; Capanoglu, E.; Adrar, N.; Catalkaya, G.; Shaheen, S.; Jaffer, M.; Giri, L.; Suyal, R.; Jugran, A.K.; Calina, D.; Docea, A.O.; Kamiloglu, S.; Kregiel, D.; Antolak, H.; Pawlikowska, E.; Sen, S.; Acharya, K.; Selamoglu, Z.; Sharifi-Rad, J.; Martorell, M.; Rodrigues, C.F.; Sharopov, F.; Martins, N.; Capasso, R. Cucurbits Plants: A Key Emphasis to Its Pharmacological Potential. Molecules 2019, 24, 1854.

AMA Style

Salehi B, Capanoglu E, Adrar N, Catalkaya G, Shaheen S, Jaffer M, Giri L, Suyal R, Jugran AK, Calina D, Docea AO, Kamiloglu S, Kregiel D, Antolak H, Pawlikowska E, Sen S, Acharya K, Selamoglu Z, Sharifi-Rad J, Martorell M, Rodrigues CF, Sharopov F, Martins N, Capasso R. Cucurbits Plants: A Key Emphasis to Its Pharmacological Potential. Molecules. 2019; 24(10):1854.

Chicago/Turabian Style

Salehi, Bahare, Esra Capanoglu, Nabil Adrar, Gizem Catalkaya, Shabnum Shaheen, Mehwish Jaffer, Lalit Giri, Renu Suyal, Arun K. Jugran, Daniela Calina, Anca O. Docea, Senem Kamiloglu, Dorota Kregiel, Hubert Antolak, Ewelina Pawlikowska, Surjit Sen, Krishnendu Acharya, Zeliha Selamoglu, Javad Sharifi-Rad, Miquel Martorell, Célia F. Rodrigues, Farukh Sharopov, Natália Martins, and Raffaele Capasso. 2019. "Cucurbits Plants: A Key Emphasis to Its Pharmacological Potential" Molecules 24, no. 10: 1854.

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