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Molecules 2018, 23(9), 2334; https://doi.org/10.3390/molecules23092334

Suppressive Effects of EGCG on Cervical Cancer

Tea Research Institute, Zhejiang University, # 866 Yuhangtang Road, Hangzhou 310058, China
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Academic Editor: Helieh S. Oz
Received: 9 August 2018 / Revised: 5 September 2018 / Accepted: 11 September 2018 / Published: 12 September 2018
(This article belongs to the Special Issue EGCG, Green Tea and Polyphenols)
Full-Text   |   PDF [880 KB, uploaded 12 September 2018]   |  

Abstract

Cervical cancer is the fourth most common gynecological cancer worldwide. Although prophylactic vaccination presents the most effective method for cervical cancer prevention, chemotherapy is still the primary invasive intervention. It is urgent to exploit low-toxic natural anticancer drugs on account of high cytotoxicity and side-effects of conventional agents. As a natural product, (-)-epigallocatechingallate (EGCG) has abilities in anti-proliferation, anti-metastasis and pro-apoptosis of cervical cancer cells. Moreover, EGCG also has pharmaceutical synergistic effects with conventional agents such as cisplatin (CDDP) and bleomycin (BLM). The underlying mechanisms of EGCG suppressive effects on cervical cancer are reviewed in this article. Further research directions and ambiguous results are also discussed. View Full-Text
Keywords: Camellia sinensis; EGCG; cervical cancer; human papillomavirus (HPV); anticancer Camellia sinensis; EGCG; cervical cancer; human papillomavirus (HPV); anticancer
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Wang, Y.-Q.; Lu, J.-L.; Liang, Y.-R.; Li, Q.-S. Suppressive Effects of EGCG on Cervical Cancer. Molecules 2018, 23, 2334.

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