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Molecules 2018, 23(7), 1807; https://doi.org/10.3390/molecules23071807

Identification and Growth Inhibitory Activity of the Chemical Constituents from Imperata Cylindrica Aerial Part Ethyl Acetate Extract

School of Life Sciences, Chinese University of Hong Kong, Shatin, Hong Kong, China
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Received: 27 June 2018 / Revised: 16 July 2018 / Accepted: 16 July 2018 / Published: 21 July 2018
(This article belongs to the Special Issue Natural Products and Drug Discovery)
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Abstract

Imperata cylindrica (L.) Raeusch. (IMP) aerial part ethyl acetate extract has anti-proliferative, pro-apoptotic, and pro-oxidative effects towards colorectal cancer in vitro. The chemical constituents of IMP aerial part ethyl acetate extract were isolated using high-performance liquid chromatography (HPLC) and identified with tandem mass spectrometry (ESI-MS/MS) in combination with ultraviolet-visible spectrophotometry and 400 MHz NMR. The growth inhibitory effects of each identified component on BT-549 (breast) and HT-29 (colon) cancer cell lines were evaluated after 48/72 h treatment by MTT assay. Four isolated compounds were identified as trans-p-Coumaric acid (1); 2-Methoxyestrone (2); 11, 16-Dihydroxypregn-4-ene-3, 20-dione (3); and Tricin (4). Compounds (2), (3), and (4) exhibited considerable growth inhibitory activities against BT-549 and HT-29 cancer cell lines. Compounds (2), (3), and (4) are potential candidates for novel anti-cancer agents against breast and colorectal cancers. View Full-Text
Keywords: Imperata cylindrica; HPLC; ESI-MS/MS; growth inhibitory activity; cancer Imperata cylindrica; HPLC; ESI-MS/MS; growth inhibitory activity; cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Wang, Y.; Shen, J.Z.; Chan, Y.W.; Ho, W.S. Identification and Growth Inhibitory Activity of the Chemical Constituents from Imperata Cylindrica Aerial Part Ethyl Acetate Extract. Molecules 2018, 23, 1807.

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