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Open AccessArticle

Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV1, Glutamate, and Opioid Receptors

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia Selangor, Serdang 43400, Malaysia
Laboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Serdang 43400, Malaysia
Faculty of Industrial Sciences & Technology, University Malaysia Pahang, Pahang, Gambang 26300, Malaysia
Author to whom correspondence should be addressed.
Molecules 2018, 23(9), 2237;
Received: 3 July 2018 / Revised: 29 July 2018 / Accepted: 30 July 2018 / Published: 3 September 2018
(This article belongs to the Special Issue Natural Products and Drug Discovery)
Pain is one of the most common cause for hospital visits. It plays an important role in inflammation and serves as a warning sign to avoid further injury. Analgesics are used to manage pain and provide comfort to patients. However, prolonged usage of pain treatments like opioids and NSAIDs are accompanied with undesirable side effects. Therefore, research to identify novel compounds that produce analgesia with lesser side effects are necessary. The present study investigated the antinociceptive potentials of a natural compound, cardamonin, isolated from Boesenbergia rotunda (L) Mansf. using chemical and thermal models of nociception. Our findings showed that intraperitoneal and oral administration of cardamonin (0.3, 1, 3, and 10 mg/kg) produced significant and dose-dependent inhibition of pain in abdominal writhing responses induced by acetic acid. The present study also demonstrated that cardamonin produced significant analgesia in formalin-, capsaicin-, and glutamate-induced paw licking tests. In the thermal-induced nociception model, cardamonin exhibited significant increase in response latency time of animals subjected to hot-plate thermal stimuli. The rota-rod assessment confirmed that the antinociceptive activities elicited by cardamonin was not related to muscle relaxant or sedative effects of the compound. In conclusion, the present findings showed that cardamonin exerted significant peripheral and central antinociception through chemical- and thermal-induced nociception in mice through the involvement of TRPV1, glutamate, and opioid receptors. View Full-Text
Keywords: cardamonin; antinociceptive; TRPV1; glutamate; opioid cardamonin; antinociceptive; TRPV1; glutamate; opioid
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Ping, C.P.; Tengku Mohamad, T.A.S.; Akhtar, M.N.; Perimal, E.K.; Akira, A.; Israf Ali, D.A.; Sulaiman, M.R. Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV1, Glutamate, and Opioid Receptors. Molecules 2018, 23, 2237.

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