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Molecules 2018, 23(5), 1168; https://doi.org/10.3390/molecules23051168

Effectiveness and Safety of Dietetic Supplementation of a New Nutraceutical on Lipid Profile and Serum Inflammation Biomarkers in Hypercholesterolemic Patients

1
Cardiology Unit, San Camillo de Lellis Hospital, Manfredonia, Foggia 71100, Italy
2
Human Nutrition, “G. D’Annunzio” University, Chieti-Pescara 66013, Italy
3
Department of Biomedical and Biotechnological Science, School of Medicine, University of Catania, Catania 95100, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Fabio Galvano
Received: 18 January 2018 / Revised: 25 April 2018 / Accepted: 25 April 2018 / Published: 14 May 2018
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Abstract

Background: To assess the effectiveness and safety of a new nutraceutical (NC) on lipid profile, inflammation biomarkers and creatine phosphokinase (CPK) serum levels in hypercholesterolemic patients. Methods: 40 patients underwent hypolipemic treatment with NC. Initial and final (after 12 weeks) screening included medical history, physical examination, and measurement of serum lipid profile (total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglycerides), hepatic (GOT, GPT, γGT), and renal (serum creatinine and urea) functions, CPK level and many inflammation biomarkers (hs-CRP and fibrinogen). At the screening visit, all patients were instructed to follow a normocaloric and hypolipidic diet during the study period. Results: The treatment with supplementation of NC demonstrated a significant reduction of serum total cholesterol (224 ± 11.2 mg/dL vs. 178 ± 10.7; p < 0.001), LDL-cholesterol (141 ± 10.6 vs. 116 + 10.1; p < 0.001), triglycerides (183 ± 13 vs. 159 ± 11.5; p < 0.01), serum inflammatory biomarkers as hs-CRP (2.24 ± 0.83 vs. 1.76 ± 0.61 mg/dL; p < 0.01), fibrinogen (315 ± 43 vs. 199 ± 41 mg/dL; p < 0.01) and a significantly increase of HDL-cholesterol (44 ± 7 vs. 53 ± 7 mg/dL; p < 0.01). Hepatic and renal function and serum CPK were normal. No adverse events was reported. Conclusions: The treatment with NC has demonstrated a significant reduction of LDL-cholesterol (−17.73%), total cholesterol (−20.53%) and triglycerides (−13.1%), with a significant increase of HDL-cholesterol values (+20.45%). The improvement of lipid profile was associated with a significant reduction of serum inflammation biomarkers as hs-PCR (−27%) and fibrinogen (−36.8%) with good tolerability profile. View Full-Text
Keywords: berberine; red yeast rice; monacolin K; resveratrol; lycopene; cholesterol; triglycerides; hypercholesterolemia; hydroxytyrosol; zinc berberine; red yeast rice; monacolin K; resveratrol; lycopene; cholesterol; triglycerides; hypercholesterolemia; hydroxytyrosol; zinc
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Riccioni, G.; Gammone, M.A.; Currenti, W.; D’Orazio, N. Effectiveness and Safety of Dietetic Supplementation of a New Nutraceutical on Lipid Profile and Serum Inflammation Biomarkers in Hypercholesterolemic Patients. Molecules 2018, 23, 1168.

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