Phenolic Compounds from Belamcanda chinensis Seeds
AbstractTwo new sucrose derivatives, namely, belamcanosides A (1) and B (2), together with five other known compounds (3−7), were isolated from the seeds of Belamcanda chinensis (L.) DC. Their structures were identified based on spectroscopic data. Especially, the absolute configurations of fructose and glucose residues in 1 and 2 were assigned by acid hydrolysis, followed by derivatization and gas chromatography (GC) analysis. Among the known compounds, (−)-hopeaphenol (3), (+)-syringaresinol (4), and quercetin (5), were isolated from B. chinensis for the first time. In addition, biological evaluation of 1 and 2 against cholesterol synthesis and metabolism at the gene level was carried out. The results showed that compounds 1 and 2 could regulate the expression of cholesterol synthesis and metabolism-associated genes, including 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), squalene epoxidase (SQLE), low density lipoprotein receptor (LDLR), and sortilin (SORT1) genes in HepG2 cells. View Full-Text
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Song, Y.-Y.; Liu, Y.; Yan, Y.-M.; Lu, X.-F.; Cheng, Y.-X. Phenolic Compounds from Belamcanda chinensis Seeds. Molecules 2018, 23, 580.
Song Y-Y, Liu Y, Yan Y-M, Lu X-F, Cheng Y-X. Phenolic Compounds from Belamcanda chinensis Seeds. Molecules. 2018; 23(3):580.Chicago/Turabian Style
Song, Ying-Ying; Liu, Ying; Yan, Yong-Ming; Lu, Xi-Feng; Cheng, Yong-Xian. 2018. "Phenolic Compounds from Belamcanda chinensis Seeds." Molecules 23, no. 3: 580.
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