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Open AccessArticle

Phenolic Compounds from Belamcanda chinensis Seeds

1
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
2
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China
3
University of Chinese Academy of Sciences, Beijing 100049, China
4
College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450008, China
*
Authors to whom correspondence should be addressed.
Molecules 2018, 23(3), 580; https://doi.org/10.3390/molecules23030580
Received: 4 February 2018 / Revised: 20 February 2018 / Accepted: 21 February 2018 / Published: 5 March 2018
(This article belongs to the Section Natural Products Chemistry)
Two new sucrose derivatives, namely, belamcanosides A (1) and B (2), together with five other known compounds (37), were isolated from the seeds of Belamcanda chinensis (L.) DC. Their structures were identified based on spectroscopic data. Especially, the absolute configurations of fructose and glucose residues in 1 and 2 were assigned by acid hydrolysis, followed by derivatization and gas chromatography (GC) analysis. Among the known compounds, (−)-hopeaphenol (3), (+)-syringaresinol (4), and quercetin (5), were isolated from B. chinensis for the first time. In addition, biological evaluation of 1 and 2 against cholesterol synthesis and metabolism at the gene level was carried out. The results showed that compounds 1 and 2 could regulate the expression of cholesterol synthesis and metabolism-associated genes, including 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), squalene epoxidase (SQLE), low density lipoprotein receptor (LDLR), and sortilin (SORT1) genes in HepG2 cells. View Full-Text
Keywords: Belamcanda chinensis; belamcanosides A and B; GC analysis; HMGCR; SQLE; LDLR; SORT1 Belamcanda chinensis; belamcanosides A and B; GC analysis; HMGCR; SQLE; LDLR; SORT1
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MDPI and ACS Style

Song, Y.-Y.; Liu, Y.; Yan, Y.-M.; Lu, X.-F.; Cheng, Y.-X. Phenolic Compounds from Belamcanda chinensis Seeds. Molecules 2018, 23, 580.

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