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Keywords = belamcanosides A and B

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Article
Phenolic Compounds from Belamcanda chinensis Seeds
by Ying-Ying Song, Ying Liu, Yong-Ming Yan, Xi-Feng Lu and Yong-Xian Cheng
Molecules 2018, 23(3), 580; https://doi.org/10.3390/molecules23030580 - 5 Mar 2018
Cited by 12 | Viewed by 4606
Abstract
Two new sucrose derivatives, namely, belamcanosides A (1) and B (2), together with five other known compounds (37), were isolated from the seeds of Belamcanda chinensis (L.) DC. Their structures were identified based on spectroscopic [...] Read more.
Two new sucrose derivatives, namely, belamcanosides A (1) and B (2), together with five other known compounds (37), were isolated from the seeds of Belamcanda chinensis (L.) DC. Their structures were identified based on spectroscopic data. Especially, the absolute configurations of fructose and glucose residues in 1 and 2 were assigned by acid hydrolysis, followed by derivatization and gas chromatography (GC) analysis. Among the known compounds, (−)-hopeaphenol (3), (+)-syringaresinol (4), and quercetin (5), were isolated from B. chinensis for the first time. In addition, biological evaluation of 1 and 2 against cholesterol synthesis and metabolism at the gene level was carried out. The results showed that compounds 1 and 2 could regulate the expression of cholesterol synthesis and metabolism-associated genes, including 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), squalene epoxidase (SQLE), low density lipoprotein receptor (LDLR), and sortilin (SORT1) genes in HepG2 cells. Full article
(This article belongs to the Section Natural Products Chemistry)
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