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Open AccessArticle

HFIP-Promoted Bischler Indole Synthesis under Microwave Irradiation

1
Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou 510642, China
2
State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou 510642, China
3
Department of Applied Chemistry, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Philippe Belmont, Richard A. Bunce, Wim Dehaen and Eugene Babaev
Molecules 2018, 23(12), 3317; https://doi.org/10.3390/molecules23123317
Received: 27 November 2018 / Revised: 10 December 2018 / Accepted: 11 December 2018 / Published: 14 December 2018
(This article belongs to the Collection Heterocyclic Compounds)
1,1,1,3,3,3-Hexafluoropropan-2-ol (HFIP) was found to be effective for the Bischler indole synthesis under microwave irradiation in the absence of a metal catalyst. Under the catalysis of HFIP, a wide range of α-amino arylacetones were successfully transformed into indole derivatives with moderate to good yields. View Full-Text
Keywords: indole; cyclization; microwave synthesis indole; cyclization; microwave synthesis
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MDPI and ACS Style

Yao, G.; Zhang, Z.-X.; Zhang, C.-B.; Xu, H.-H.; Tang, R.-Y. HFIP-Promoted Bischler Indole Synthesis under Microwave Irradiation. Molecules 2018, 23, 3317.

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