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Open AccessArticle

HFIP-Promoted Bischler Indole Synthesis under Microwave Irradiation

Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou 510642, China
State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou 510642, China
Department of Applied Chemistry, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China
Authors to whom correspondence should be addressed.
Academic Editors: Philippe Belmont, Richard A. Bunce, Wim Dehaen and Eugene Babaev
Molecules 2018, 23(12), 3317;
Received: 27 November 2018 / Revised: 10 December 2018 / Accepted: 11 December 2018 / Published: 14 December 2018
(This article belongs to the Collection Heterocyclic Compounds)
1,1,1,3,3,3-Hexafluoropropan-2-ol (HFIP) was found to be effective for the Bischler indole synthesis under microwave irradiation in the absence of a metal catalyst. Under the catalysis of HFIP, a wide range of α-amino arylacetones were successfully transformed into indole derivatives with moderate to good yields. View Full-Text
Keywords: indole; cyclization; microwave synthesis indole; cyclization; microwave synthesis
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MDPI and ACS Style

Yao, G.; Zhang, Z.-X.; Zhang, C.-B.; Xu, H.-H.; Tang, R.-Y. HFIP-Promoted Bischler Indole Synthesis under Microwave Irradiation. Molecules 2018, 23, 3317.

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