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Molecules 2018, 23(12), 3283; https://doi.org/10.3390/molecules23123283

The Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention/Treatment of Neurodegenerative Diseases: In Vitro, In Vivo and Clinical Trials

School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen AB10 7GJ, UK
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Academic Editor: Isabel C.F.R. Ferreira
Received: 8 November 2018 / Revised: 29 November 2018 / Accepted: 30 November 2018 / Published: 11 December 2018
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease and Huntington’s disease, present a major health issue and financial burden for health care systems around the world. The impact of these diseases will further increase over the next decades due to increasing life expectancies. No cure is currently available for the treatment of these conditions; only drugs, which merely alleviate the symptoms. Oxidative stress has long been associated with neurodegeneration, whether as a cause or as part of the downstream results caused by other factors. Thus, the use of antioxidants to counter cellular oxidative stress within the nervous system has been suggested as a potential treatment option for neurological disorders. Over the last decade, significant research has focused on the potential use of natural antioxidants to target oxidative stress. However, clinical trial results have lacked success for the treatment of patients with neurological disorders. The knowledge that natural extracts show other positive molecular activities in addition to antioxidant activity, however, has led to further research of natural extracts for their potential use as prevention or treatment/management of neurodegenerative diseases. This review will cover several in vitro and in vivo research studies, as well as clinical trials, and highlight the potential of natural antioxidants. View Full-Text
Keywords: antioxidants; natural products; in vitro; in vivo; clinical trials; plant extracts; phytochemicals; phenolics; Ginkgo biloba; secondary metabolites antioxidants; natural products; in vitro; in vivo; clinical trials; plant extracts; phytochemicals; phenolics; Ginkgo biloba; secondary metabolites
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Pohl, F.; Kong Thoo Lin, P. The Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention/Treatment of Neurodegenerative Diseases: In Vitro, In Vivo and Clinical Trials. Molecules 2018, 23, 3283.

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