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Open AccessArticle

Chemical Characterization and Hypoglycaemic Activities In Vitro of Two Polysaccharides from Inonotus obliquus by Submerged Culture

1
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
2
Bio-Pharmaceutical College, Beijing City University, Beijing 100094, China
3
School of Life Sciences, Inner Mongolia University, Inner Mongolia 010021, China
*
Author to whom correspondence should be addressed.
Academic Editors: Isabel C.F.R. Ferreira and Derek J. McPhee
Molecules 2018, 23(12), 3261; https://doi.org/10.3390/molecules23123261
Received: 2 November 2018 / Revised: 30 November 2018 / Accepted: 3 December 2018 / Published: 10 December 2018
(This article belongs to the Collection Bioactive Compounds)
Polysaccharides from the fungus Inonotus obliquus have been found to be biologically active. In this study, we carried out a preliminary characterisation and assessment of the hypoglycaemic activities of the polysaccharides (IOEP) from Inonotus obliquus obtained by liquid fermentation. Two polysaccharides, IOEP1 and IOEP2, were isolated from IOEP. IOEP1, with a molecular weight of 20 KDa, was mainly composed of galatose and mannose, while IOEP2, with a molecular weight of 200 KDa, was mainly composed of arabinose. Fourier-transform infrared analysis showed that both IOEP1 and IOEP2 were pyran-type polysaccharides. 1H-NMR spectra showed that the glycosidic bonds of IOEP1 and IOEP2 were both α-type and β-type. In addition, IOEP1 and IOEP2 strongly increased the glucose consumption of HepG2 cells and insulin-resistant HepG2 cells in vitro. These findings provide a theoretical basis that IOEP1 and IOEP2 might be suitable as anti-diabetes agents in functional foods and natural drugs. View Full-Text
Keywords: Inonotus obliquus; submerged culture; polysaccharides; diabetes; HepG2 cells Inonotus obliquus; submerged culture; polysaccharides; diabetes; HepG2 cells
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MDPI and ACS Style

Xue, J.; Tong, S.; Wang, Z.; Liu, P. Chemical Characterization and Hypoglycaemic Activities In Vitro of Two Polysaccharides from Inonotus obliquus by Submerged Culture. Molecules 2018, 23, 3261.

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