Next Article in Journal
Spectroscopic Methods in the Evaluation of Modified Vegetable Base Oils from Crambe abyssinica
Previous Article in Journal
Structural Moieties Required for Cinnamaldehyde-Related Compounds to Inhibit Canonical IL-1β Secretion
Previous Article in Special Issue
FAK and S6K1 Inhibitor, Neferine, Dually Induces Autophagy and Apoptosis in Human Neuroblastoma Cells
Article Menu

Export Article

Open AccessArticle
Molecules 2018, 23(12), 3242; https://doi.org/10.3390/molecules23123242

Evaluating Antitumor and Antioxidant Activities of Yellow Monascus Pigments from Monascus ruber Fermentation

1
School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China
2
Pan Asia (Jiangmen) Institute of Biological Engineering and Health, Jiangmen 529080, China
3
The Key Laboratory of Pathobiology, Ministry of Education, The College of Basic Medical Sciences, Jilin University, Changchun 130021, China
4
School of Environmental Ecology and Biological Engineering, Wuhan Institute of Technology, Wuhan 430205, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Roberto Fabiani
Received: 23 November 2018 / Revised: 4 December 2018 / Accepted: 4 December 2018 / Published: 7 December 2018
(This article belongs to the Special Issue Antitumoral Properties of Natural Products)
Full-Text   |   PDF [3217 KB, uploaded 7 December 2018]   |  
  |   Review Reports

Abstract

Yellow Monascus pigments can be of two kinds: Natural and reduced, in which natural yellow Monascus pigments (NYMPs) attract widespread attention for their bioactivities. In this study, the antioxidative and antibreast cancer effects of the water-soluble NYMPs fermented by Monascus ruber CGMCC 10910 were evaluated. Results showed that water-soluble NYMPs had a significantly improved antioxidative activities compared to the reduced yellow Monascus pigments (RYMPs) that were chemically derived from orange or red Monascus pigments. Furthermore, NYMPs exhibited a concentration-dependent inhibition activity on MCF-7 cell growth (p < 0.001). After a 48-h incubation, a 26.52% inhibition yield was determined with 32 μg/mL of NYMPs. NYMPs also significantly inhibited the migration and invasion of MCF-7 cells. Mechanisms of the activities were associated with a down-regulation of the expression of matrix metalloproteinases and vascular endothelial growth factor. Rather than being alternatively used as natural colorants or antioxidants, this work suggested that NYMPs could be selected as potential functional additives in further test of breast cancer prevention and adjuvant therapy. View Full-Text
Keywords: natural yellow Monascus pigments; water-soluble; antioxidation; migration; invasion; MCF-7 cells natural yellow Monascus pigments; water-soluble; antioxidation; migration; invasion; MCF-7 cells
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Tan, H.; Xing, Z.; Chen, G.; Tian, X.; Wu, Z. Evaluating Antitumor and Antioxidant Activities of Yellow Monascus Pigments from Monascus ruber Fermentation. Molecules 2018, 23, 3242.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top