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Nutritional Regulators of Bcl-xL in the Brain

1
Department of Human Nutrition and Hospitality Management, College of Human Environmental Science, The University of Alabama, Tuscaloosa, AL 35487, USA
2
Department of Biological Sciences, College of Arts and Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA
3
Department of Internal Medicine, Section of Endocrinology, Yale University, New Haven, CT 06520, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Peter Koulen
Molecules 2018, 23(11), 3019; https://doi.org/10.3390/molecules23113019
Received: 10 August 2018 / Revised: 15 November 2018 / Accepted: 18 November 2018 / Published: 19 November 2018
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PDF [538 KB, uploaded 19 November 2018]
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Abstract

B-cell lymphoma-extra large (Bcl-xL) is an anti-apoptotic Bcl-2 protein found in the mitochondrial membrane. Bcl-xL is reported to support normal brain development and protects neurons against toxic stimulation during pathological process via its roles in regulation of mitochondrial functions. Despite promising evidence showing neuroprotective properties of Bcl-xL, commonly applied molecular approaches such as genetic manipulation may not be readily applicable for human subjects. Therefore, findings at the bench may be slow to be translated into treatments for disease. Currently, there is no FDA approved application that specifically targets Bcl-xL and treats brain-associated pathology in humans. In this review, we will discuss naturally occurring nutrients that may exhibit regulatory effects on Bcl-xL expression or activity, thus potentially providing affordable, readily-applicable, easy, and safe strategies to protect the brain. View Full-Text
Keywords: Bcl-xL; mitochondria; neuroprotection; nutrients Bcl-xL; mitochondria; neuroprotection; nutrients
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Park, H.-A.; Broman, K.; Stumpf, A.; Kazyak, S.; Jonas, E.A. Nutritional Regulators of Bcl-xL in the Brain. Molecules 2018, 23, 3019.

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