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Molecules 2018, 23(1), 100; https://doi.org/10.3390/molecules23010100

Increasing the Strength and Production of Artemisinin and Its Derivatives

1
Department of Chemistry, Islamia College University Peshawar, Peshawar 25120, Pakistan
2
Department of Chemistry, College of Sciences, King Saud University, Riyadh 11451, Saudi Arabia
*
Authors to whom correspondence should be addressed.
Received: 14 November 2017 / Revised: 19 December 2017 / Accepted: 28 December 2017 / Published: 3 January 2018
(This article belongs to the Special Issue Artemisinin: Against Malaria, Cancer and Viruses)
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Abstract

Artemisinin is a natural sesquiterpene lactone obtained from the Artemisia annua herb. It is widely used for the treatment of malaria. In this article, we have reviewed the role of artemisinin in controlling malaria, spread of resistance to artemisinin and the different methods used for its large scale production. The highest amount of artemisinin gene expression in tobacco leaf chloroplast leads to the production of 0.8 mg/g of the dry weight of the plant. This will revolutionize the treatment and control of malaria in third world countries. Furthermore, the generations of novel derivatives of artemisinin- and trioxane ring structure-inspired compounds are important for the treatment of malaria caused by resistant plasmodial species. Synthetic endoperoxide-like artefenomel and its derivatives are crucial for the control of malaria and such synthetic compounds should be further explored. View Full-Text
Keywords: artemisinin; novel analogues; malaria; Plasmodium; mass scale production artemisinin; novel analogues; malaria; Plasmodium; mass scale production
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Badshah, S.L.; Ullah, A.; Ahmad, N.; Almarhoon, Z.M.; Mabkhot, Y. Increasing the Strength and Production of Artemisinin and Its Derivatives. Molecules 2018, 23, 100.

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