Molecules 2017, 22(8), 1331; https://doi.org/10.3390/molecules22081331
Anti-Anxiety Effect of (−)-Syringaresnol-4-O-β-d-apiofuranosyl-(1→2)-β-d-glucopyranoside from Albizzia julibrissin Durazz (Leguminosae)
1
School of Chinese Materia Medica, Beijing University of Chinese Medicine, 11ANorth Third Ring East Road, Chaoyang District, Beijing 100029, China
2
Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 4ADatun Road, Chaoyang District, Beijing 100101, China
*
Authors to whom correspondence should be addressed.
Received: 4 July 2017 / Revised: 4 August 2017 / Accepted: 10 August 2017 / Published: 11 August 2017
(This article belongs to the Collection Herbal Medicine Research)
Abstract
Albizzia julibrissin Durazz, a Chinese Medicine, is commonly used for its anti-anxiety effects. (−)-syringaresnol-4-O-β-d-apiofuranosyl-(1→2)-β-d-glucopyranoside (SAG) is the main ingredient of Albizzia julibrissin Durazz. The present study investigated the anxiolytic effect and potential mechanisms on the HPA axis and monoaminergic systems of SAG on acute restraint-stressed rats. The anxiolytic effect of SAG was examined through an open field test and an elevated plus maze test. The concentration of CRF, ACTH, and CORT in plasma was examined by an enzyme-linked immune sorbent assay (ELISA) kit while neurotransmitters in the cerebral cortex and hippocampus of the brain were examined by High Performance Liquid Chromatography (HPLC). We show that repeated treatment with SAG (3.6 mg/kg, p.o.) significantly increased the number and time spent on the central entries in the open-field test when compared to the vehicle/stressed group. In the elevated plus maze test, 3.6 mg/kg SAG could increase the percentage of entries into and time spent on the open arms of the elevated plus maze. In addition, the concentration of CRF, ACTH, and CORT in plasma and neurotransmitters (NE, 5-HT, DA and their metabolites 5-HIAA, DOPAC, and HVA) in the cerebral cortex and hippocampus of the brain were decreased after SAG treatment, as compared to the repeated acute restraint-stressed rats. These results suggest that SAG is a potential anti-anxiety drug candidate. View Full-TextKeywords:
(−)-syringaresnol-4-O-β-d-apiofuranosyl-(1→2)-β-d-glucopyranoside; open field test; elevated maze plus; HPA axis; monoaminergic systems
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Liu, J.; Lv, Y.-W.; Shi, J.-L.; Ma, X.-J.; Chen, Y.; Zheng, Z.-Q.; Wang, S.-N.; Guo, J.-Y. Anti-Anxiety Effect of (−)-Syringaresnol-4-O-β-d-apiofuranosyl-(1→2)-β-d-glucopyranoside from Albizzia julibrissin Durazz (Leguminosae). Molecules 2017, 22, 1331.
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