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The C5 Variant of the Butyrylcholinesterase Tetramer Includes a Noncovalently Bound 60 kDa Lamellipodin Fragment
Article

Therapeutic Delivery of Butyrylcholinesterase by Brain-Wide Viral Gene Transfer to Mice

Department of Molecular Pharmacology and Experimental Therapeutics, Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA
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Author to whom correspondence should be addressed.
Molecules 2017, 22(7), 1145; https://doi.org/10.3390/molecules22071145
Received: 29 June 2017 / Revised: 5 July 2017 / Accepted: 6 July 2017 / Published: 8 July 2017
Recent research shows that butyrylcholinesterase (BChE) is not simply a liver enzyme that detoxifies bioactive esters in food and medications. In fact, in pursuing other goals, we recently found that it has an equally important role in regulating the peptide hormone ghrelin and its impact on hunger, obesity, and emotions. Here, we present and examine means of manipulating brain BChE levels by viral gene transfer, either regionally or globally, to modulate ghrelin signaling for long-term therapeutic purposes and to set the stage for exploring the neurophysiological impact of such an intervention. View Full-Text
Keywords: butyrylcholinesterase; adeno-associated virus (AAV)-8; AAV-9; AAV-PHP.B; enzyme expression; ghrelin butyrylcholinesterase; adeno-associated virus (AAV)-8; AAV-9; AAV-PHP.B; enzyme expression; ghrelin
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MDPI and ACS Style

Gao, Y.; Geng, L.; Chen, V.P.; Brimijoin, S. Therapeutic Delivery of Butyrylcholinesterase by Brain-Wide Viral Gene Transfer to Mice. Molecules 2017, 22, 1145. https://doi.org/10.3390/molecules22071145

AMA Style

Gao Y, Geng L, Chen VP, Brimijoin S. Therapeutic Delivery of Butyrylcholinesterase by Brain-Wide Viral Gene Transfer to Mice. Molecules. 2017; 22(7):1145. https://doi.org/10.3390/molecules22071145

Chicago/Turabian Style

Gao, Yang, Liyi Geng, Vicky P. Chen, and Stephen Brimijoin. 2017. "Therapeutic Delivery of Butyrylcholinesterase by Brain-Wide Viral Gene Transfer to Mice" Molecules 22, no. 7: 1145. https://doi.org/10.3390/molecules22071145

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