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Article

Phenolic Glycosides from Capsella bursa-pastoris (L.) Medik and Their Anti-Inflammatory Activity

1
Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea
2
Gachon Institute of Pharmaceutical Science, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 21936, Korea
3
College of Pharmacy, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 21936, Korea
*
Author to whom correspondence should be addressed.
Molecules 2017, 22(6), 1023; https://doi.org/10.3390/molecules22061023
Received: 16 May 2017 / Revised: 12 June 2017 / Accepted: 18 June 2017 / Published: 20 June 2017
(This article belongs to the Collection Bioactive Compounds)
A new sesquilignan glycoside 1, together with seven known phenolic glycosides 28 were isolated from the aerial parts of Capsella bursa-pastoris. The chemical structure of the new compound 1 was elucidated by extensive nuclear magnetic resonance (NMR) data (1H- and 13C-NMR, 1H-1H correlation spectroscopy (1H-1H COSY), heteronuclear single-quantum correlation (HSQC), heteronuclear multiple bond correlation (HMBC), and nuclear overhauser effect spectroscopy (NOESY)) and HR-FABMS analysis. The anti-inflammatory effects of 18 were evaluated in lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cells. Compounds 4 and 7 exhibited moderate inhibitory effects on nitric oxide production in LPS-activated BV-2 cells, with IC50 values of 17.80 and 27.91 µM, respectively. View Full-Text
Keywords: Capsella bursa-pastoris; Cruciferae; sesquilignan glycoside; anti-inflammatory Capsella bursa-pastoris; Cruciferae; sesquilignan glycoside; anti-inflammatory
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    Link: http://supplementary data.docx
    Description: Fig. S1 1H NMR spectrum of 1 (700 MHz, CD3OD) Fig. S2 13C NMR spectrum of 1 (175 MHz, CD3OD) Fig. S3 HSQC spectrum of 1 Fig. S4 HMBC spectrum of 1 Fig. S5 1H-1H COSY spectrum of 1 Fig. S6 NOESY spectrum of 1 Fig. S7 HR-FAB-MS spectrum of 1 Fig. S8 CD spectra of compound 1
MDPI and ACS Style

Cha, J.M.; Suh, W.S.; Lee, T.H.; Subedi, L.; Kim, S.Y.; Lee, K.R. Phenolic Glycosides from Capsella bursa-pastoris (L.) Medik and Their Anti-Inflammatory Activity. Molecules 2017, 22, 1023. https://doi.org/10.3390/molecules22061023

AMA Style

Cha JM, Suh WS, Lee TH, Subedi L, Kim SY, Lee KR. Phenolic Glycosides from Capsella bursa-pastoris (L.) Medik and Their Anti-Inflammatory Activity. Molecules. 2017; 22(6):1023. https://doi.org/10.3390/molecules22061023

Chicago/Turabian Style

Cha, Joon M., Won S. Suh, Tae H. Lee, Lalita Subedi, Sun Y. Kim, and Kang R. Lee 2017. "Phenolic Glycosides from Capsella bursa-pastoris (L.) Medik and Their Anti-Inflammatory Activity" Molecules 22, no. 6: 1023. https://doi.org/10.3390/molecules22061023

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