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Keywords = sesquilignan glycoside

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Article
Phenolic Glycosides from Capsella bursa-pastoris (L.) Medik and Their Anti-Inflammatory Activity
by Joon Min Cha, Won Se Suh, Tae Hyun Lee, Lalita Subedi, Sun Yeou Kim and Kang Ro Lee
Molecules 2017, 22(6), 1023; https://doi.org/10.3390/molecules22061023 - 20 Jun 2017
Cited by 33 | Viewed by 10191
Abstract
A new sesquilignan glycoside 1, together with seven known phenolic glycosides 28 were isolated from the aerial parts of Capsella bursa-pastoris. The chemical structure of the new compound 1 was elucidated by extensive nuclear magnetic resonance (NMR) data (1 [...] Read more.
A new sesquilignan glycoside 1, together with seven known phenolic glycosides 28 were isolated from the aerial parts of Capsella bursa-pastoris. The chemical structure of the new compound 1 was elucidated by extensive nuclear magnetic resonance (NMR) data (1H- and 13C-NMR, 1H-1H correlation spectroscopy (1H-1H COSY), heteronuclear single-quantum correlation (HSQC), heteronuclear multiple bond correlation (HMBC), and nuclear overhauser effect spectroscopy (NOESY)) and HR-FABMS analysis. The anti-inflammatory effects of 18 were evaluated in lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cells. Compounds 4 and 7 exhibited moderate inhibitory effects on nitric oxide production in LPS-activated BV-2 cells, with IC50 values of 17.80 and 27.91 µM, respectively. Full article
(This article belongs to the Collection Bioactive Compounds)
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