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Molecules 2017, 22(4), 661;

Reactions of 5-Indolizyl Lithium Compounds with Some Bielectrophiles

Life Sciences Center, Moscow Institute of Physics and Technology, Institutskii per. 9/7, Dolgoprudniy, Moscow Region 141701, Russia
Chemistry Department, Moscow State University, Moscow 119991, Russia
Peoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya str. 6, Moscow 117198, Russia
Author to whom correspondence should be addressed.
Academic Editor: Roman Dembinski
Received: 3 March 2017 / Revised: 9 April 2017 / Accepted: 17 April 2017 / Published: 20 April 2017
(This article belongs to the Collection Heterocyclic Compounds)
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Abstract: Indolizyl-5-lithium anions react with succinic and phtalic anhidrides giving 1,4-keto acids, with oxallyl chloride giving 1,2-diketone, and with ethyl pyruvate giving 1,2-hydroxyacid. However, with α-halocarbonyl compounds, they react in different ways, forming the products of selective bromination at C-5 (with α-bromo ketones and esters of α-bromo acids) and 5-chloroacetyl indolizines. View Full-Text
Keywords: indolizine; 5-indolizyl lithium; reactivity; bielectrophilic reagents indolizine; 5-indolizyl lithium; reactivity; bielectrophilic reagents

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Rzhevskii, S.A.; Rybakov, V.B.; Khrustalev, V.N.; Babaev, E.V. Reactions of 5-Indolizyl Lithium Compounds with Some Bielectrophiles. Molecules 2017, 22, 661.

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