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Volume 21
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10.3390/molecules21080967
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Article

Synthesis and Spectral Characterization of Benzo-[6,7][1,5]diazocino[2,1-a]isoindol-12-(14H)-one Derivatives

by
Jatinder P. Bassin
*,
Bhavani Anagani
,
Christopher Benham
,
Madhu Goyal
,
Maryam Hashemian
and
Ute Gerhard
*
School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK
*
Authors to whom correspondence should be addressed.
Molecules 2016, 21(8), 967; https://doi.org/10.3390/molecules21080967
Submission received: 28 June 2016 / Revised: 19 July 2016 / Accepted: 20 July 2016 / Published: 23 July 2016
(This article belongs to the Collection Heterocyclic Compounds)
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Abstract

A simple synthetic route affording 27%–85% yields of benzo[6,7][1,5]diazocino[2,1-a]isoindol-12(14H)-one ring systems from readily available 3-(2-oxo-2-phenylethyl) isobenzofuran-1(3H)-ones and 2-(aminomethyl)aniline starting materials in toluene and catalysed by p-toluene-sulfonic acid is developed. The 1H- and 13C-NMR spectra of the final products were assigned using a variety of one and two-dimensional NMR experiments. The distinction between the two potential isomers of the final products was made on the basis of heteronuclear multiple bond connectivity (HMBC) NMR spectra.
Keywords: diazocine; isoindole; isobenzofuran-1(3H)-ones; 2D-NMR diazocine; isoindole; isobenzofuran-1(3H)-ones; 2D-NMR
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MDPI and ACS Style

Bassin, J.P.; Anagani, B.; Benham, C.; Goyal, M.; Hashemian, M.; Gerhard, U. Synthesis and Spectral Characterization of Benzo-[6,7][1,5]diazocino[2,1-a]isoindol-12-(14H)-one Derivatives. Molecules 2016, 21, 967. https://doi.org/10.3390/molecules21080967

AMA Style

Bassin JP, Anagani B, Benham C, Goyal M, Hashemian M, Gerhard U. Synthesis and Spectral Characterization of Benzo-[6,7][1,5]diazocino[2,1-a]isoindol-12-(14H)-one Derivatives. Molecules. 2016; 21(8):967. https://doi.org/10.3390/molecules21080967

Chicago/Turabian Style

Bassin, Jatinder P., Bhavani Anagani, Christopher Benham, Madhu Goyal, Maryam Hashemian, and Ute Gerhard. 2016. "Synthesis and Spectral Characterization of Benzo-[6,7][1,5]diazocino[2,1-a]isoindol-12-(14H)-one Derivatives" Molecules 21, no. 8: 967. https://doi.org/10.3390/molecules21080967

APA Style

Bassin, J. P., Anagani, B., Benham, C., Goyal, M., Hashemian, M., & Gerhard, U. (2016). Synthesis and Spectral Characterization of Benzo-[6,7][1,5]diazocino[2,1-a]isoindol-12-(14H)-one Derivatives. Molecules, 21(8), 967. https://doi.org/10.3390/molecules21080967

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