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Short Note

N-(3,4-Dichlorophenyl)methyl Oxamic Acid

by
Shu-Kun Lin
1
1
Ciba-Geigy Limited, Pharmaceuticals Division, CH-4002 Basel, Switzerland
2
Present Address: Molecular Diversity Preservation International (MDPI), Saengergasse 25, CH-4054 Basel, Switzerland
Molecules 1997, 2(4), M4; https://doi.org/10.3390/M4
Submission received: 15 January 1997 / Published: 15 April 1997
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Browse Figure
Versions Notes
Molecules 02 m4 sch001
A mixture of N-(3,4-dichlorophenyl)methyl oxamic acid ethyl ester [1] (7.609 g, 27.56 mmol), ethanol (400 ml), NaOH (1N, 32 ml) and water (200ml) was stirred at r.t. overnight under N2. HCl (2N) was added to give pH 3 followed by extraction with CH2Cl2 (6x100 ml). The organic phases were combined, washed with water (100ml), dried (Na2SO4) and evaporated in vacuo to afford 6.163 g (90%) of N-(3,4-dichlorophenyl)methyl oxamic acid, a white solid.
M.p. 163deg.C (dec.).
IR (KBr): 3224, 2250, 1725 (COOH); 1690 (C=O), 1528, 1472, 1400, 1348.
1H-NMR ((D6)DMSO): 9.40 (bt, 1H, NH); 7.60 (d, 1H, HC(6)); 7.51 (d, 1H, HC(2)); 7.26 (q, 1H, HC(5)); 4.30 (d, 2H, CH2).
(+)-FAB-MS: 247 (M+).

Supplementary materials

Supplementary File 1Supplementary File 2

Acknowledgment 

The author would like to thank Dr. Vittorio Rasetti for his support.

References

  1. Lin, S. -K. N-(3,4-Dichlorophenyl)methyl oxamic acid ethyl ester. Molecules 1997, 2, M2. [Google Scholar] [CrossRef]
  • Sample Availability: Not available.

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MDPI and ACS Style

Lin, S.-K. N-(3,4-Dichlorophenyl)methyl Oxamic Acid. Molecules 1997, 2, M4. https://doi.org/10.3390/M4

AMA Style

Lin S-K. N-(3,4-Dichlorophenyl)methyl Oxamic Acid. Molecules. 1997; 2(4):M4. https://doi.org/10.3390/M4

Chicago/Turabian Style

Lin, Shu-Kun. 1997. "N-(3,4-Dichlorophenyl)methyl Oxamic Acid" Molecules 2, no. 4: M4. https://doi.org/10.3390/M4

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