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Molecules 2014, 19(9), 13225-13234;

Cytotoxic Compounds Isolated from Murraya tetramera Huang

State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Haidian District, Beijing 100875, China
State Key Laboratory Breeding Base of Dao-di Herbs, China Academy of Chinese Medical Sciences, Dongcheng District, Beijing 100700, China
China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Xicheng District, Beijing 100088, China
Analytical and Testing Center, Beijing Normal University, Haidian District, Beijing 100875, China
Authors to whom correspondence should be addressed.
Received: 21 July 2014 / Revised: 21 August 2014 / Accepted: 21 August 2014 / Published: 27 August 2014
(This article belongs to the Collection Bioactive Compounds)
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A new compound and seven known compounds were isolated from Murraya tetramera Huang for the first time, and they were identified with NMR and MS spectral analysis. It was confirmed that the new compound was 10-methoxy-7-methyl-2H-benzo[g]chromen-2-one (3) and the others were β-eudesmol (1), trans-3β-(1-hydroxy-1-methylethyl)-8-methyl-5-methylenedecalin-2-one (2), 5,7-dimethoxy-8-[(Z)-3'-methyl-butan-1',3'-dienyl]coumarin (4), 7-geranyloxy-6-methoxycoumarin (5), 5,7-dimethoxy-8-(3-methyl-2-oxo-butyl)coumarin (6), murrangatin acetate (7) and toddalenone (8). Furthermore, the cytotoxic activity against human lung adenocarcinoma (A549), human hepatocellular carcinoma cells (SMMC-7721), human bladder tumor cells (EJ), human cervical carcinoma cells (HeLa), and human B-lineage acute lymphoblastic leukemia 1 cells (BALL-1) was evaluated for all compounds. It was found that five of them displayed various degrees of cytotoxicity against different testing targets. Compound 1 showed significant cytotoxic activity against the five cell lines (A549, SMMC-7721, EJ, Hela and BALL-1). Compounds 2 and 5 showed significant cytotoxicity against three cell lines (A549, SMMC-7721 and BALL-1). Compound 4 showed significant cytotoxicity against three cell lines (A549, EJ and BALL-1). However, compound 3 only showed fair cytotoxicity against the BALL-1 cell line. The structure-active relationships were investigated as well. These active compounds might be potential lead compounds for the treatment of cancer. View Full-Text
Keywords: M. tetramera; cytotoxicity; coumarin; sesquiterpene M. tetramera; cytotoxicity; coumarin; sesquiterpene

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You, C.-X.; Yang, K.; Wang, C.-F.; Zhang, W.-J.; Wang, Y.; Han, J.; Fan, L.; Du, S.-S.; Geng, Z.-F.; Deng, Z.-W. Cytotoxic Compounds Isolated from Murraya tetramera Huang. Molecules 2014, 19, 13225-13234.

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