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Open AccessCommunication

Production of Anti-Cancer Agent Using Microbial Biotransformation

by Changhyun Roh 1,* and ChanKyu Kang 2,*
1
Division of Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), 1266, Sinjeong-dong, Jeongeup, Jeonbuk 580-185, Korea
2
Ministry of Environment, Daegu Regional Environmental Office, Government Complex, Hwaam-ro, Dalseo-Gu, Daegu 704-841, Korea
*
Authors to whom correspondence should be addressed.
Molecules 2014, 19(10), 16684-16692; https://doi.org/10.3390/molecules191016684
Received: 4 September 2014 / Revised: 10 October 2014 / Accepted: 11 October 2014 / Published: 16 October 2014
(This article belongs to the Section Molecular Diversity)
Microbial biotransformation is a great model system to produce drugs and biologically active compounds. In this study, we elucidated the fermentation and production of an anti-cancer agent from a microbial process for regiospecific hydroxylation of resveratrol. Among the strains examined, a potent strain showed high regiospecific hydroxylation activity to produce piceatannol. In a 5 L (w/v 3 L) jar fermentation, this wild type Streptomyces sp. in the batch system produced 205 mg of piceatannol (i.e., 60% yields) from 342 mg of resveratrol in 20 h. Using the product, an in vitro anti-cancer study was performed against a human cancer cell line (HeLa). It showed that the biotransformed piceatannol possessed a significant anticancer activity. This result demonstrates that a biotransformation screening method might be of therapeutic interest with respect to the identification of anti-cancer drugs. View Full-Text
Keywords: biotransformation; screening; production; fermentation biotransformation; screening; production; fermentation
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Roh, C.; Kang, C. Production of Anti-Cancer Agent Using Microbial Biotransformation. Molecules 2014, 19, 16684-16692.

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