Synthesis and Antimicrobial Evaluation of Some New Oxadiazoles Derived from Phenylpropionohydrazides
Abstract
:1. Introduction
2. Results and Discussion
2.1. Chemistry
2.2. Biological activity
3. Experimental Section
3.1. General
3.2. General procedure for the synthesis of 1-(2-aryl-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanones (2a-e)
4. Conclusions
Acknowledgements
References
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Sample Availability: Samples of the compounds 2a-e are available from the authors. |
Compound No. | Zone of inhibition in mm | |||
---|---|---|---|---|
Antibacterial Activity | Antifungal Activity | |||
SA | PA | CA | AF | |
2a | 24 | 24 | 16 | 15 |
2b | 25 | 24 | 15 | 13 |
2c | 23 | 20 | 13 | 12 |
2d | 22 | 23 | 16 | 13 |
2e | 19 | 20 | 16 | 15 |
Ampicillin | 25 | 24 | - | - |
Fluconazole | - | - | 17 | 16 |
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Fuloria, N.K.; Singh, V.; Shaharyar, M.; Ali, M. Synthesis and Antimicrobial Evaluation of Some New Oxadiazoles Derived from Phenylpropionohydrazides. Molecules 2009, 14, 1898-1903. https://doi.org/10.3390/molecules14051898
Fuloria NK, Singh V, Shaharyar M, Ali M. Synthesis and Antimicrobial Evaluation of Some New Oxadiazoles Derived from Phenylpropionohydrazides. Molecules. 2009; 14(5):1898-1903. https://doi.org/10.3390/molecules14051898
Chicago/Turabian StyleFuloria, Neeraj Kumar, Vijender Singh, Mohammad Shaharyar, and Mohammad Ali. 2009. "Synthesis and Antimicrobial Evaluation of Some New Oxadiazoles Derived from Phenylpropionohydrazides" Molecules 14, no. 5: 1898-1903. https://doi.org/10.3390/molecules14051898