Special Issue "Proteins and Protein-Ligand Interactions"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry, Molecular Biology and Biophysics".

Deadline for manuscript submissions: closed (30 March 2014)

Special Issue Editors

Guest Editor
Dr. Tatyana Karabencheva-Christova
Faculty of Health and Life Sciences, Department of Applied Sciences, Northumbria University, UK
Website: http://www.northumbria.ac.uk/sd/academic/lifesciences/ad/biomed/staff/tatyana_kc/
E-Mail: tatyana.karabencheva-christova@northumbria.ac.uk
Interests: computational chemical biology; enzyme mechanisms; catalytic activity and inhibition; computer-aided drug design; conformational dynamics of proteins and nucleic acids; biomolecular spectroscopy; bioinorganic enzymology

Guest Editor
Dr. Christo Z. Christov
Senior Lecturer in Computational Biochemistry Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University Ellison Building, Newcastle-upon-Tyne, NE1 8ST, UK
Website: http://www.northumbria.ac.uk/sd/academic/lifesciences/ad/biomed/staff/cchristov/
E-Mail: christo.christov@northumbria.ac.uk
Phone: +44 191 243 7964
Fax: +44 191 227 3519
Interests: computational biomolecular science; enzyme mechanisms; protein conformational dynamics; biomolecular spectroscopy; combined quantum mechanical and molecular mechanical methods (QM/MM); quantum chemistry; molecular dynamics; protein-ligands interactions; bioinorganic electronic structure and mechanisms

Special Issue Information

Dear Colleagues,

Proteins are biopolymers present in all living cells/organisms that take part in basically all processes in life by exerting extremely broad functional versatility such us structural, catalytic, signaling, transportational and regulatory.

All protein functions are realized by highly specific and highly effective protein-ligand interactions, where ligands can be either other protein molecules, nucleic acids, lipids, small molecules, substrates, allosteric modulators, inhibitors or some drugs. Indeed the specificity of protein-ligand interactions and their regulatory mechanisms are responsible for normal cell functionality and alterations might lead to pathological processes. Knowledge about the nature of those interactions at the atomistic level and the impact of the conformational flexibility and mutational effects on them is crucially important for understanding the molecular nature of cell processes and will contribute to the fields of drug design and biotechnology.

This special issue of IJMS aims to present a tribune to broad range state-of-the-art experimental or computational studies or their synergetic combination for understanding protein-ligand interactions in their very broad context. We are also looking for contributions underlining the impact of the investigated processes in biomedicine and molecular pathology as well as applications of protein-ligands interactions in biotechnology and food industry.

Dr. Tatyana Karabencheva-Christova
Dr. Christo Z. Christov
Guest Editors

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF.

Keywords

  • protein
  • protein-protein interactions
  • protein-ligand interactions
  • protein-lipid complexes
  • protein-nucleic acids interactions
  • enzyme inhibition
  • drug design
  • computational modelling
  • docking, binding studies
  • QSAR

Published Papers (20 papers)

Int. J. Mol. Sci. 2014, 15(4), 5221-5232; doi:10.3390/ijms15045221
Received: 25 January 2014; in revised form: 15 March 2014 / Accepted: 17 March 2014 / Published: 25 March 2014
Show/Hide Abstract | Download PDF Full-text (527 KB)

Int. J. Mol. Sci. 2014, 15(3), 3580-3595; doi:10.3390/ijms15033580
Received: 27 January 2014; in revised form: 17 February 2014 / Accepted: 18 February 2014 / Published: 27 February 2014
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Int. J. Mol. Sci. 2014, 15(2), 2622-2645; doi:10.3390/ijms15022622
Received: 18 December 2013; in revised form: 17 January 2014 / Accepted: 21 January 2014 / Published: 14 February 2014
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Int. J. Mol. Sci. 2014, 15(2), 2431-2453; doi:10.3390/ijms15022431
Received: 4 December 2013; in revised form: 10 January 2014 / Accepted: 22 January 2014 / Published: 11 February 2014
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Int. J. Mol. Sci. 2014, 15(2), 2359-2367; doi:10.3390/ijms15022359
Received: 13 December 2013; in revised form: 18 January 2014 / Accepted: 28 January 2014 / Published: 7 February 2014
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Int. J. Mol. Sci. 2014, 15(1), 438-455; doi:10.3390/ijms15010438
Received: 28 November 2013; in revised form: 19 December 2013 / Accepted: 27 December 2013 / Published: 2 January 2014
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Int. J. Mol. Sci. 2014, 15(1), 141-158; doi:10.3390/ijms15010141
Received: 6 November 2013; in revised form: 12 December 2013 / Accepted: 17 December 2013 / Published: 23 December 2013
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Int. J. Mol. Sci. 2014, 15(1), 75-99; doi:10.3390/ijms15010075
Received: 1 November 2013; in revised form: 5 December 2013 / Accepted: 12 December 2013 / Published: 20 December 2013
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Int. J. Mol. Sci. 2014, 15(1), 29-43; doi:10.3390/ijms15010029
Received: 28 October 2013; in revised form: 28 November 2013 / Accepted: 6 December 2013 / Published: 20 December 2013
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Int. J. Mol. Sci. 2013, 14(12), 23955-23979; doi:10.3390/ijms141223955
Received: 13 September 2013; in revised form: 13 November 2013 / Accepted: 19 November 2013 / Published: 9 December 2013
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Int. J. Mol. Sci. 2013, 14(12), 23244-23256; doi:10.3390/ijms141223244
Received: 31 July 2013; in revised form: 31 October 2013 / Accepted: 11 November 2013 / Published: 25 November 2013
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Int. J. Mol. Sci. 2013, 14(11), 22845-22856; doi:10.3390/ijms141122845
Received: 12 September 2013; in revised form: 6 November 2013 / Accepted: 7 November 2013 / Published: 20 November 2013
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Int. J. Mol. Sci. 2013, 14(11), 22331-22345; doi:10.3390/ijms141122331
Received: 9 October 2013; in revised form: 1 November 2013 / Accepted: 5 November 2013 / Published: 13 November 2013
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Int. J. Mol. Sci. 2013, 14(11), 21551-21560; doi:10.3390/ijms141121551
Received: 26 September 2013; in revised form: 16 October 2013 / Accepted: 22 October 2013 / Published: 31 October 2013
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Int. J. Mol. Sci. 2013, 14(10), 19556-19586; doi:10.3390/ijms141019556
Received: 11 July 2013; in revised form: 14 August 2013 / Accepted: 10 September 2013 / Published: 26 September 2013
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Int. J. Mol. Sci. 2013, 14(9), 19067-19085; doi:10.3390/ijms140919067
Received: 15 August 2013; in revised form: 6 September 2013 / Accepted: 11 September 2013 / Published: 16 September 2013
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Int. J. Mol. Sci. 2013, 14(8), 16836-16850; doi:10.3390/ijms140816836
Received: 15 July 2013; in revised form: 31 July 2013 / Accepted: 6 August 2013 / Published: 15 August 2013
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Int. J. Mol. Sci. 2013, 14(7), 15121-15140; doi:10.3390/ijms140715121
Received: 14 May 2013; in revised form: 2 July 2013 / Accepted: 4 July 2013 / Published: 22 July 2013
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Int. J. Mol. Sci. 2013, 14(7), 14408-14425; doi:10.3390/ijms140714408
Received: 24 May 2013; in revised form: 27 June 2013 / Accepted: 2 July 2013 / Published: 11 July 2013
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Int. J. Mol. Sci. 2013, 14(7), 12914-12930; doi:10.3390/ijms140712914
Received: 2 May 2013; in revised form: 7 June 2013 / Accepted: 7 June 2013 / Published: 24 June 2013
Show/Hide Abstract | Download PDF Full-text (1717 KB) | View HTML Full-text | Download XML Full-text |  Supplementary Files

Last update: 30 December 2013

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert