Interactive Association of Drugs Binding to Human Serum Albumin
AbstractHuman serum albumin (HSA) is an abundant plasma protein, which attracts great interest in the pharmaceutical industry since it can bind a remarkable variety of drugs impacting their delivery and efficacy and ultimately altering the drug’s pharmacokinetic and pharmacodynamic properties. Additionally, HSA is widely used in clinical settings as a drug delivery system due to its potential for improving targeting while decreasing the side effects of drugs. It is thus of great importance from the viewpoint of pharmaceutical sciences to clarify the structure, function, and properties of HSA–drug complexes. This review will succinctly outline the properties of binding site of drugs in IIA subdomain within the structure of HSA. We will also give an overview on the binding characterization of interactive association of drugs to human serum albumin that may potentially lead to significant clinical applications.
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Yang, F.; Zhang, Y.; Liang, H. Interactive Association of Drugs Binding to Human Serum Albumin. Int. J. Mol. Sci. 2014, 15, 3580-3595.
Yang F, Zhang Y, Liang H. Interactive Association of Drugs Binding to Human Serum Albumin. International Journal of Molecular Sciences. 2014; 15(3):3580-3595.Chicago/Turabian Style
Yang, Feng; Zhang, Yao; Liang, Hong. 2014. "Interactive Association of Drugs Binding to Human Serum Albumin." Int. J. Mol. Sci. 15, no. 3: 3580-3595.