Int. J. Mol. Sci. 2013, 14(11), 21551-21560; doi:10.3390/ijms141121551
Review

Maternal Embryonic Leucine Zipper Kinase (MELK): A Novel Regulator in Cell Cycle Control, Embryonic Development, and Cancer

1,2,3email and 1,2,3,* email
1 Research Laboratory of Virology, Immunology & Bioinformatics, Division of Veterinary Microbiology & Virology, Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling 712100, Shaanxi, China 2 MOA Key Laboratory of Animal Biotechnology of National Ministry of Agriculture, Institute of Veterinary Immunology, Northwest A&F University, Yangling 712100, Shaanxi, China 3 Investigation Group of Molecular Virology, Immunology, Oncology & Systems Biology, Center for Bioinformatics, Northwest A&F University, Yangling 712100, Shaanxi, China
* Author to whom correspondence should be addressed.
Received: 26 September 2013; in revised form: 16 October 2013 / Accepted: 22 October 2013 / Published: 31 October 2013
(This article belongs to the Special Issue Proteins and Protein-Ligand Interactions)
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Abstract: Maternal embryonic leucine zipper kinase (MELK) functions as a modulator of intracellular signaling and affects various cellular and biological processes, including cell cycle, cell proliferation, apoptosis, spliceosome assembly, gene expression, embryonic development, hematopoiesis, and oncogenesis. In these cellular processes, MELK functions by binding to numerous proteins. In general, the effects of multiple protein interactions with MELK are oncogenic in nature, and the overexpression of MELK in kinds of cancer provides some evidence that it may be involved in tumorigenic process. In this review, our current knowledge of MELK function and recent discoveries in MELK signaling pathway were discussed. The regulation of MELK in cancers and its potential as a therapeutic target were also described.
Keywords: maternal embryonic leucine zipper kinase; protein interaction; cell cycle; embryonic development; tumorigenic process; therapeutic target

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MDPI and ACS Style

Jiang, P.; Zhang, D. Maternal Embryonic Leucine Zipper Kinase (MELK): A Novel Regulator in Cell Cycle Control, Embryonic Development, and Cancer. Int. J. Mol. Sci. 2013, 14, 21551-21560.

AMA Style

Jiang P, Zhang D. Maternal Embryonic Leucine Zipper Kinase (MELK): A Novel Regulator in Cell Cycle Control, Embryonic Development, and Cancer. International Journal of Molecular Sciences. 2013; 14(11):21551-21560.

Chicago/Turabian Style

Jiang, Pengfei; Zhang, Deli. 2013. "Maternal Embryonic Leucine Zipper Kinase (MELK): A Novel Regulator in Cell Cycle Control, Embryonic Development, and Cancer." Int. J. Mol. Sci. 14, no. 11: 21551-21560.

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