Int. J. Mol. Sci. 2013, 14(11), 21551-21560; doi:10.3390/ijms141121551
Review

Maternal Embryonic Leucine Zipper Kinase (MELK): A Novel Regulator in Cell Cycle Control, Embryonic Development, and Cancer

1,2,3email and 1,2,3,* email
Received: 26 September 2013; in revised form: 16 October 2013 / Accepted: 22 October 2013 / Published: 31 October 2013
(This article belongs to the collection Proteins and Protein-Ligand Interactions)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Maternal embryonic leucine zipper kinase (MELK) functions as a modulator of intracellular signaling and affects various cellular and biological processes, including cell cycle, cell proliferation, apoptosis, spliceosome assembly, gene expression, embryonic development, hematopoiesis, and oncogenesis. In these cellular processes, MELK functions by binding to numerous proteins. In general, the effects of multiple protein interactions with MELK are oncogenic in nature, and the overexpression of MELK in kinds of cancer provides some evidence that it may be involved in tumorigenic process. In this review, our current knowledge of MELK function and recent discoveries in MELK signaling pathway were discussed. The regulation of MELK in cancers and its potential as a therapeutic target were also described.
Keywords: maternal embryonic leucine zipper kinase; protein interaction; cell cycle; embryonic development; tumorigenic process; therapeutic target
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MDPI and ACS Style

Jiang, P.; Zhang, D. Maternal Embryonic Leucine Zipper Kinase (MELK): A Novel Regulator in Cell Cycle Control, Embryonic Development, and Cancer. Int. J. Mol. Sci. 2013, 14, 21551-21560.

AMA Style

Jiang P, Zhang D. Maternal Embryonic Leucine Zipper Kinase (MELK): A Novel Regulator in Cell Cycle Control, Embryonic Development, and Cancer. International Journal of Molecular Sciences. 2013; 14(11):21551-21560.

Chicago/Turabian Style

Jiang, Pengfei; Zhang, Deli. 2013. "Maternal Embryonic Leucine Zipper Kinase (MELK): A Novel Regulator in Cell Cycle Control, Embryonic Development, and Cancer." Int. J. Mol. Sci. 14, no. 11: 21551-21560.


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