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Int. J. Mol. Sci. 2014, 15(4), 6717-6724; doi:10.3390/ijms15046717

Towards Personalized Medicine Mediated by in Vitro Virus-Based Interactome Approaches

Division of Interactome Medical Sciences, the Institute of Medical Science, the University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
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Received: 2 February 2014 / Revised: 24 March 2014 / Accepted: 9 April 2014 / Published: 21 April 2014
(This article belongs to the Collection Proteins and Protein-Ligand Interactions)
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Abstract

We have developed a simple in vitro virus (IVV) selection system based on cell-free co-translation, using a highly stable and efficient mRNA display method. The IVV system is applicable to the high-throughput and comprehensive analysis of proteins and protein–ligand interactions. Huge amounts of genomic sequence data have been generated over the last decade. The accumulated genetic alterations and the interactome networks identified within cells represent a universal feature of a disease, and knowledge of these aspects can help to determine the optimal therapy for the disease. The concept of the “integrome” has been developed as a means of integrating large amounts of data. We have developed an interactome analysis method aimed at providing individually-targeted health care. We also consider future prospects for this system. View Full-Text
Keywords: cell-free protein synthesis system; in vitro selection; in vitro virus; protein-protein interaction cell-free protein synthesis system; in vitro selection; in vitro virus; protein-protein interaction
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Ohashi, H.; Miyamoto-Sato, E. Towards Personalized Medicine Mediated by in Vitro Virus-Based Interactome Approaches. Int. J. Mol. Sci. 2014, 15, 6717-6724.

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