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Soft Tissue Sarcomas: From Laboratory to Clinical Practice
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Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa-shi, Ishikawa-ken 920-8641, Japan
Dr. Po-Kuei Wu
Orthopaedic Department School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan
Dr. Hiroyuki Tsuchiya
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University 13-1 Takara-machi, Kanazawa 920-8641, Japan
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Soft Tissue Sarcomas: From Laboratory to Clinical Practice

Abstract submission deadline
closed (31 October 2024)
Manuscript submission deadline
closed (31 December 2024)
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Topic Information

Dear Colleagues,

This collection is the second edition of the previous Topics entitled "Soft Tissue Sarcomas: Treatment and Management", which is available at https://www.mdpi.com/topics/STS. Due to the rarity and heterogeneity of soft tissue sarcoma, the investigation of novel treatments and methods of management has been challenging. Although intensive chemotherapy and the establishment of surgical procedures have improved the outcome of patients with soft tissue sarcomas, there remain limited options regarding anticancer agents, a high incidence of postoperative complications, and an unsatisfactory curative rate for recurrent and metastatic soft tissue sarcomas. The Special Issue aims to compile the highest quality original/review articles on basic and clinical research into soft tissue sarcomas. Papers that address molecular biology, the microenvironment, anticancer agents, and the management of soft tissue sarcomas are welcome.

Dr. Shinji Miwa
Dr. Po-Kuei Wu
Dr. Hiroyuki Tsuchiya
Topic Editors

Keywords

  • soft tissue sarcoma
  • molecular biology
  • microenvironment
  • anticancer agents
  • management of soft tissue sarcomas

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Cancers
cancers 		4.5 8.0 2009 17.4 Days CHF 2900
Current Oncology
curroncol 		2.8 3.3 1994 19.8 Days CHF 2200
Diseases
diseases 		2.9 0.8 2013 21.4 Days CHF 1800
Journal of Clinical Medicine
jcm 		3.0 5.7 2012 16 Days CHF 2600
Onco
onco 		- - 2021 27.8 Days CHF 1000

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Published Papers (1 paper)

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Article
Paradoxical Response to Neoadjuvant Therapy in Undifferentiated Pleomorphic Sarcoma: Increased Tumor Size on MRI Associated with Favorable Pathology
by Mariam H. Goreish, Nicolò Gennaro, Laetitia Perronne, Gorkem Durak, Amir A. Borhani, Hatice Savas, Linda Kelahan, Ryan Avery, Kamal Subedi, Tugce Agirlar Trabzonlu, Ulas Bagci, Baris Turkbey, Spyridon Bakas, Sean Sachdev, Ronen Sumagin, Borislav A. Alexiev, Pedro Hermida de Viveiros, Seth M. Pollack and Yuri S. Velichko
Cancers 2025, 17(5), 830; https://doi.org/10.3390/cancers17050830 - 27 Feb 2025
Viewed by 607
Abstract
Background/Objectives: To correlate size changes in undifferentiated pleomorphic sarcoma (UPS) on magnetic resonance imaging (MRI) after neoadjuvant chemoradiation therapy (nCRT) with pathological response, risk of local recurrence, and therapeutic regimens. Methods: This retrospective study analyzed clinical, pathological, and imaging data from [...] Read more.
Background/Objectives: To correlate size changes in undifferentiated pleomorphic sarcoma (UPS) on magnetic resonance imaging (MRI) after neoadjuvant chemoradiation therapy (nCRT) with pathological response, risk of local recurrence, and therapeutic regimens. Methods: This retrospective study analyzed clinical, pathological, and imaging data from 39 biopsy-proven UPS subjects. Four readers measured the tumor dimensions before and after nCRT, including two perpendicular axial diameters and the longest coronal/sagittal diameter. Three cross-sectional areas and bounding volume were also calculated. Responders (pR) were defined as having ≤10% viable cells and non-responders (pNR) as having more. Inter-reader agreement was evaluated using Kendall’s concordance coefficient. Changes in tumor size were compared between pR and pNR using one-way ANOVA and Tukey’s HSD test for multiple comparisons of means. Results: pR showed a greater increase in size across all measurements compared to pNR. For the longest axial diameter, the mean increase was 30% ± 35% for pR and 14% ± 31% for pNR, with a mean difference (pR-pNR) of 16% (95% CI: 6–27%, p = 0.003). In tumors treated with radiotherapy alone, pR exhibited larger size increases in all dimensions compared to pNR. In contrast, in the chemoradiation group, pR showed a slight increase, while pNR generally shrank, although these differences did not reach statistical significance. Notably, pNR with local recurrence exhibited a reduction in all tumor dimensions compared to pNR without local recurrence. Conclusions: This exploratory study suggests that tumor size changes may predict pathological response and local recurrence after nCRT in UPS; however, the small sample size limits the generalizability of these findings. Full article
(This article belongs to the Topic Soft Tissue Sarcomas: From Laboratory to Clinical Practice)
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