Topic Editors
2. School of Human Sciences, The University of Western Australia, Nedlands, Perth, WA 6009, Australia
3. Trichy SRM Medical College Hospital and Research Centre, SRM Nagar, Trichy—Chennai Highways, Trichy 621 105, India
2. Cuor Stem Cellutions Pvt Ltd., Manipal Institute of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore 560065, India
The Integration of New Technologies and Interdisciplinary Approaches in Cancer Stem Cells (CSCs)
Topic Information
Dear Colleagues,
Cancer stem cells (CSCs) are a small population of tumor cells with the ability to self-renew, differentiate, initiate tumors, and resist conventional therapies. They are considered major contributors to tumor recurrence, metastasis, and treatment failure. Recent advances in technology and interdisciplinary research have significantly improved the understanding, detection, and targeting of CSCs. Some of the new technologies include the following:
- Single-cell RNA sequencing (scRNA-seq) enables researchers to study individual cancer cells rather than bulk tumor tissue. This technology helps identify CSC heterogeneity, molecular signatures, and treatment-resistant subpopulations.
- AI and machine learning analyze large genomic, epigenomic and proteomic datasets to predict CSC behavior, treatment response, and patient prognosis.
- CRISPR technology allows precise editing of genes involved in CSC survival and stemness pathways such as Wnt, Notch, and Hedgehog.
- Circulating tumor cells (CTCs), exosomes, and circulating tumor DNA (ctDNA) provide minimally invasive methods for monitoring CSC activity and tumor progression.
The integration of advanced technologies and interdisciplinary approaches has transformed cancer stem cell research. Techniques such as single-cell sequencing, AI/ML, CRISPR, organoids, metabolic landscape, targeted immunotherapy and nanotechnology are providing deeper insights into CSC biology and opening new avenues for precision cancer therapy. Continued collaboration among molecular biologists, clinicians, engineers, data scientists, synthetic chemists, system biologists and immunologists is essential. This Topic will cover all aspects of modern technologies related to CSC isolation and identification.
Prof. Dr. Arun Dharmarajan
Prof. Dr. Sudha Warrier
Topic Editors
Keywords
- cancer stem cells (CSCs)
- precision oncology
- single-cell sequencing
- tumor microenvironment
- artificial intelligence (AI)
- circulating tumor cells
- wnt signaling
- SFRP4
Participating Journals
| Journal Name | Impact Factor | CiteScore | Launched Year | First Decision (median) | APC | |
|---|---|---|---|---|---|---|
Cancers
|
4.8 | 9.0 | 2009 | 19.1 Days | CHF 2900 | Submit |
Cells
|
6.0 | 11.4 | 2012 | 15.5 Days | CHF 2700 | Submit |
International Journal of Molecular Sciences
|
5.6 | 10.0 | 2000 | 17.8 Days | CHF 2900 | Submit |
Onco
|
- | 2.0 | 2021 | 23.7 Days | CHF 1000 | Submit |
Sci
|
4.1 | 5.4 | 2019 | 26.7 Days | CHF 1400 | Submit |
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