Fiber-Optic-Based Biosensors

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: closed (30 July 2023) | Viewed by 2692

Special Issue Editors


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Guest Editor
Research Center of Analytical Instrumentation, School of Mechanical Engineering, Sichuan University, Chengdu, China
Interests: optic biosensor; fiber optic sensing technology; laser spectroscopy

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Guest Editor
Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, Guangzhou, China
Interests: optical fiber Bragg grating; fiber optic biosensors; fiber lasers; optical-fiber-based theranositics
Research Center of Analytical Instrumentation, School of Mechanical Engineering, Sichuan University, Chengdu 610041, China
Interests: fiber optic-based biosensor; isothermal nucleic acid amplification; nanomaterials; aptamer; public health; environmental monitoring; clinic diagnosis; food safety
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Special Issue Information

Dear Colleagues,

Fiber-optic-based biosensors have been considered as promising techniques for point-of-caring testing and implant analyses due to their unique merits of miniaturized devices, remote monitoring, low costs, and strong anti-interference. Recently, advanced processing techniques have fabricated many fiber optic probes, including long-period fiber gratings, titled fiber Bragg gratings, microfibers, bent fiber optics, and tapered fiber optics. The emerging fiber optic probes significantly enhance the sensitivity of biosensors. Moreover, selected recognition elements, including aptamers, bacteriophages, antibodies, and polypeptides, also improve the specificity of fiber-optic-based biosensors. Due to the flexible operation of light in cells, tissues, and even organs, fiber-optic-based biosensors were also employed as implanted biosensors for in vivo diagnoses, imaging, and novel treatment technologies. Based on these efforts, fiber-optic-based biosensors have been a hot topic in the field of optical engineering, showing an increasing interest in sensitive and specific analyses in vitro and in vivo. 

Therefore, this Special Issue, “Fiber-Optic-Based Biosensors”, focuses on advances in the novel theory and structure of fiber optic probes, the different types of fiber-optic-based fluorescent biosensors (SPR, LSPR, SERS, and interferometric biosensors), and their application to wide targets, ranging from nucleic acids, small molecules, metal ions, proteins, bacteria, exosomes, and cancer cells. We invite the submission of research that promotes the development and application of fiber-optic-based biosensors.

Prof. Dr. Yixiang Duan
Prof. Dr. Yang Ran
Dr. Zewei Luo
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • fiber optic
  • SPR
  • LSPR
  • fluorescent biosensors
  • SERS
  • interferometric biosensor
  • sensitivity
  • specificity

Published Papers (1 paper)

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Research

17 pages, 3925 KiB  
Article
Fiber Laser-Based Lasso-Shaped Biosensor for High Precision Detection of Cancer Biomarker-CEACAM5 in Serum
by Jie Hu, Enlai Song, Yuhui Liu, Qiaochu Yang, Junhui Sun, Jinna Chen, Yue Meng, Yanwei Jia, Zhiguang Yu, Yang Ran, Liyang Shao and Perry Ping Shum
Biosensors 2023, 13(7), 674; https://doi.org/10.3390/bios13070674 - 24 Jun 2023
Cited by 6 | Viewed by 1933
Abstract
Detection of trace tumor markers in blood/serum is essential for the early screening and prognosis of cancer diseases, which requires high sensitivity and specificity of the assays and biosensors. A variety of label-free optical fiber-based biosensors has been developed and yielded great opportunities [...] Read more.
Detection of trace tumor markers in blood/serum is essential for the early screening and prognosis of cancer diseases, which requires high sensitivity and specificity of the assays and biosensors. A variety of label-free optical fiber-based biosensors has been developed and yielded great opportunities for Point-of-Care Testing (POCT) of cancer biomarkers. The fiber biosensor, however, suffers from a compromise between the responsivity and stability of the sensing signal, which would deteriorate the sensing performance. In addition, the sophistication of sensor preparation hinders the reproduction and scale-up fabrication. To address these issues, in this study, a straightforward lasso-shaped fiber laser biosensor was proposed for the specific determination of carcinoembryonic antigen (CEA)-related cell adhesion molecules 5 (CEACAM5) protein in serum. Due to the ultra-narrow linewidth of the laser, a very small variation of lasing signal caused by biomolecular bonding can be clearly distinguished via high-resolution spectral analysis. The limit of detection (LOD) of the proposed biosensor could reach 9.6 ng/mL according to the buffer test. The sensing capability was further validated by a human serum-based cancer diagnosis trial, enabling great potential for clinical use. The high reproduction of fabrication allowed the mass production of the sensor and extended its utility to a broader biosensing field. Full article
(This article belongs to the Special Issue Fiber-Optic-Based Biosensors)
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