Nuclear Receptors: Honorary Special Issue Commemorating the Work of Prof. Jan-Åke Gustafsson

Dear Colleagues,

Recently, we passed 25-year mark since the discovery of the two important nuclear receptors LXRβ and Erβ. The publication of Professor Gustafsson’s paper (PNAS 14;92 (6) 2096-2100, 1995) where he described the cloning of the nuclear receptor OR-1, later renamed to LXRβ, was fundamental to understanding cholesterol homeostasis and its regulation, and has resulted in many publications from Professor Gustafsson and others. One year later, another nuclear receptor was cloned (PNAS 93 (12) 5925-5930, 1996). This was a second estrogen receptor and was named Erβ; it was a fundamental paradigm shift since all effects until then had been attributed to the only known estrogen receptor which was then renamed to ERα. The cloning of ERβ initiated much activity from individual researchers as well as from companies because of the potential new drug target for the treatment of diseases. Evaluation of ERβ as a drug target is still ongoing. In addition, Gustafsson has been involved in revealing the 3D structure of nuclear receptors, the binding of nuclear receptors to DNA, and the discovery of the steroid response element.

This Special Issue is focused on the role of nuclear receptors in health and disease. The Special Issue begins with a short review of Professor Gustafsson’s contribution to the field of nuclear receptors followed by original research articles and reviews on all aspects of nuclear receptors in health and disease.

Dr. Anders Strom
Guest Editor

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