Search Results (2,224)

This study introduces a novel photocatalyst derived from pumpkin peel bio-waste, calcined at 200 °C and incorporated with magnetite nanoparticles to form a hybrid PK-P/Fe₃O₄ catalyst. The material was characterized using X-ray diffraction (XRD), diffuse reflectance spectra (DRS), and scanning electron microscopy (SEM) with energy-dispersive X-ray spectroscopy (EDX) mapping to confirm its structure and elemental distribution. The catalyst was applied for the photo-Fenton degradation of Synozol Red KHL dye under natural solution conditions (pH 5.7). Optimal parameters were achieved with a 20 mg/L catalyst and 200 mg/L H₂O₂, resulting in complete dye removal within 25 min of irradiation. The PK-P/Fe₃O₄ catalyst exhibited excellent reusability, retaining 72% removal efficiency after 10 successive cycles. Kinetic analysis confirmed a first-order model, while thermodynamic evaluation revealed a non-spontaneous, endothermic process with a low activation energy barrier, indicating energy-efficient dye degradation. These findings highlight the potential of bio-waste-derived PK-P/Fe₃O₄ as a sustainable, low-cost, and highly effective catalyst for treating dye-polluted wastewater under photo-Fenton conditions. Full article

Critical metals associated with aluminum-bearing strata have garnered increasing attention due to their considerable economic potential. Recent investigations have identified notable enrichment of Li, Ga, Zr, Nb, REEs (rare earth elements), etc., within the Upper Carboniferous Benxi Formation in the Yangquan mining area, the Northeastern Qinshui Basin, Northern China. However, their mineralogical characteristics and micro-scale modes of occurrence remain insufficiently constrained. In this study, we employed the TESCAN Integrated Mineral Analyzer (TIMA) in combination with X-ray diffraction (XRD) and clay-separation experiments to provide direct mineralogical evidence for the occurrence of Ti, Li, Ga, Zr, and REEs in claystone and aluminous claystone from the Benxi Formation, Yangquan mining area, Northeastern Qinshui Basin. Our results indicate that both lithologies are primarily composed of kaolinite and diaspore, with minor amounts of anatase and cookeite; illite is additionally present in the claystone. Titanium predominantly occurs as anatase in both lithologies, though a portion in aluminous claystone may be incorporated into kaolinite and other Ti-bearing minerals such as rutile and leucoxene. Lithium is primarily hosted by cookeite in both rock types. Mineral assemblage variations further suggest that kaolinite may have partially transformed into Li-rich chlorite (i.e., cookeite) during the transformation from aluminous claystone to claystone. Gallium is chiefly associated with diaspore and kaolinite, with a stronger correlation with diaspore in the aluminous claystone. Zircon is the sole carrier of Zr in both lithologies. Importantly, La and Ce show a consistent spatial association with O–Al–Si–Ti–P mixed aggregates in TIMA maps, particularly in aluminous claystone. Based on these spatial patterns, textural relationships, and comparisons with previous studies, phosphate minerals are inferred to be the dominant REE hosts, although minor contributions from other phases cannot be completely excluded. These findings highlight a previously underexplored mode of critical-metal enrichment in Northern Chinese bauxite-bearing strata and provide a mineralogical basis for future extraction and utilization. Full article

The filarioid nematode Dirofilaria immitis is the causative agent of heartworm disease, a major parasitic infection of canids, felids and occasionally humans. Current prevention relies on macrocyclic lactone-based chemoprophylaxis, but the emergence of drug resistance highlights the need for new intervention strategies. Here, we applied a machine learning (ML)-based framework to predict and prioritise essential genes in D. immitis in silico, using genomic, transcriptomic and functional datasets from the model organisms Caenorhabditis elegans and Drosophila melanogaster. With a curated set of 26 predictive features, we trained and evaluated multiple ML models and, using a defined threshold, we predicted 406 ‘high-priority’ essential genes. These genes showed strong transcriptional activity across developmental stages and were inferred to be enriched in pathways related to ribosome biogenesis, translation, RNA processing and signalling, underscoring their potential as anthelmintic targets. Transcriptomic analyses suggested that these genes are associated with key reproductive and neural tissues, while chromosomal mapping revealed a relatively even genomic distribution, in contrast to patterns observed in C. elegans and Dr. melanogaster. In addition, initial evidence suggested structural variation in the X chromosome compared with a recently published D. immitis assembly, indicating the importance of integrating long-read sequencing with high-throughput chromosome conformation capture (Hi-C) mapping. Overall, this study reinforces the potential of ML-guided approaches for essential gene discovery in parasitic nematodes and provides a foundation for downstream validation and therapeutic target development. Full article

Background: Tumor-associated macrophages (TAMs) are essential regulators of the glioblastoma (GBM) microenvironment; their functional heterogeneity and interaction networks are not fully elucidated. We identify RNF135 as a novel TAM-enriched gene associated with immune activation and adverse prognosis in GBM. Methods: To evaluate RNF135’s expression profile, prognostic significance, and functional pathways, extensive transcriptome analyses from TCGA and CGGA cohorts were conducted. The immunological landscape and cellular origin of RNF135 were outlined using single-cell RNA-seq analyses and bulk RNA-seq immune deconvolution (MCP-counter, xCell and ssGSEA). Cell–cell communication networks between tumor cells and RNF135-positive and -negative tumor-associated macrophage subsets were mapped using CellChat. Results: RNF135 predicted a poor overall survival and was markedly upregulated in GBM tissues. Functional enrichment analyses showed that increased cytokine signaling, interferon response, and innate immune activation were characteristics of RNF135-high samples. Immune infiltration profiling showed a strong correlation between the abundance of T cells and macrophages and RNF135 expression. According to the single-cell analyses, RNF135 was primarily expressed in TAMs, specifically in proliferation, phagocytic, and transitional subtypes. RNF135-positive TAMs demonstrated significantly improved intercellular communication with aggressive tumor subtypes in comparison to RNF135-negative TAMs. This was facilitated by upregulated signaling pathways such as MHC-II, CD39, ApoE, and most notably, the CCL signaling axis. The CCL3/CCL3L3–CCR1 ligand–receptor pair was identified as a major mechanistic driver of TAM–TAM crosstalk. High RNF135 expression was also linked to greater sensitivity to Selumetinib, a selective MEK1/2 inhibitor that targets the MAPK/ERK pathway, according to drug sensitivity analysis. Conclusions: RNF135 defines a TAM phenotype in GBM that is both immunologically active and immunosuppressive. This phenotype promotes inflammatory signaling and communication between cells in the tumor microenvironment. Targeting the CCL–CCR1 axis or combining RNF135-guided immunomodulation with certain inhibitors could be a promising therapeutic strategies for GBM. Full article

Chitosan-based hydrogels are used in the adsorption of pharmaceutical compounds from water. The adsorption process of diclofenac and naproxen on chitosan hydrogels cross-linked with glutaraldehyde has been studied theoretically and experimentally. According to the thermodynamic properties, the adsorption processes were spontaneous and endothermic, due to the negative values of Gibbs free energy, and the enthalpies of formation were positive. Furthermore, the different systems were studied by electrostatic potential maps, where the functional groups (amino and hydroxyl) represented the active sites of the hydrogel. The maximum adsorption capacity obtained for diclofenac and naproxen was 108.85 and 97.22 mg/g, respectively, at a temperature of 308.15 K. On the other hand, the adsorbent was characterized by FTIR (Fourier Transform Infrared Spectroscopy) and XRD (X-ray Diffraction) before and after the adsorption of the drugs to confirm the binding of the adsorbates on the surface of the material. Full article

Visual inspection remains a cornerstone of quality control in welded structures, yet manual evaluations are inherently constrained by subjectivity, inconsistency, and limited scalability. This study presents WeldVGG, a deep learning-based visual inspection model designed to automate weld defect classification using radiographic imagery. The proposed model is trained on the RIAWELC dataset, a publicly available collection of X-ray weld images acquired in real manufacturing environments and annotated across four defect conditions: cracking, porosity, lack of penetration, and no defect. RIAWELC offers high-resolution imagery and standardized class labels, making it a valuable benchmark for defect classification under realistic conditions. To improve trust and explainability, Grad-CAM++ is employed to generate class-discriminative saliency maps, enabling visual validation of predictions. The model is rigorously evaluated through stratified cross-validation and benchmarked against traditional machine learning baselines, including SVC, Random Forest, and a state-of-the-art architecture, MobileNetV3. The proposed model achieves high classification accuracy and interpretability, offering a practical and scalable solution for intelligent weld inspection. Furthermore, to prove the model’s ability to generalize, a test on the GDXray was performed, yielding positive results. Additionally, a Wilcoxon signed-rank test was conducted separately to assess statistical significance between model performances. Full article

We investigate the Hyers–Ulam–Rassias stability of a generalized quadratic functional equation of the asymmetric four-function form $F(x+y)+G(x-y)=L\left(x\right)+M\left(y\right)$, where F, G, L, and M are unknown mappings. This study is conducted within the framework of non-Archimedean normed spaces over the p-adic numbers. Our approach employs a separation technique, analyzing the even and odd parts of the functions to establish stability results. We show that all four functions are approximated by a combination of a quadratic function and two additive functions. Full article

Identifying concealed explosives in X-ray backscatter (XRBS) imagery remains a critical challenge, primarily due to low image contrasts, cluttered backgrounds, small object sizes, and limited structural details. To address these limitations, we propose YOLOv11-XRBS, an enhanced detection framework tailored to the characteristics of XRBS images. A dedicated dataset (SBCXray) comprising over 10,000 annotated images of simulated explosive scenarios under varied concealment conditions was constructed to support training and evaluation. The proposed framework introduces three targeted improvements: (1) adaptive architectural refinement to enhance multi-scale feature representation and suppress background interference, (2) a Size-Aware Focal Loss (SaFL) strategy to improve the detection of small and weak-feature objects, and (3) a recomposed loss function with scale-adaptive weighting to achieve more accurate bounding box localization. The experiments demonstrated that YOLOv11-XRBS achieves better performance compared to both existing YOLO variants and classical detection models such as Faster R-CNN, SSD512, RetinaNet, DETR, and VGGNet, achieving a mean average precision (mAP) of 94.8%. These results confirm the robustness and practicality of the proposed framework, highlighting its potential deployment in XRBS-based security inspection systems. Full article

Addressing the challenge of acquiring high-precision leader Unmanned Ground Vehicle (UGV) pose information in real time for communication-denied leader–follower formations, this study proposed Pillar-Bin, a 3D object detection algorithm based on the PointPillars framework. Pillar-Bin introduced an Interval Discretization Strategy (Bin) within the detection head, mapping critical target parameters (dimensions, center, heading angle) to predefined intervals for joint classification-residual regression optimization. This effectively suppresses environmental noise and enhances localization accuracy. Simulation results on the KITTI dataset demonstrate that the Pillar-Bin algorithm significantly outperforms PointPillars in detection accuracy. In the 3D detection mode, the mean Average Precision (mAP) increased by 2.95%, while in the bird’s eye view (BEV) detection mode, mAP was improved by 0.94%. With a processing rate of 48 frames per second (FPS), the proposed algorithm effectively enhanced detection accuracy while maintaining the high real-time performance of the baseline method. To evaluate Pillar-Bin’s real-vehicle performance, a leader UGV pose extraction scheme was designed. Real-vehicle experiments show absolute X/Y positioning errors below 5 cm and heading angle errors under 5° in Cartesian coordinates, with the pose extraction processing speed reaching 46 FPS. The proposed Pillar-Bin algorithm and its pose extraction scheme provide efficient and accurate leader pose information for formation control, demonstrating practical engineering utility. Full article

Background/Objectives: The recent development of four-dimensional X-ray velocimetry (4DXV) technology (three-dimensional space and time) provides a unique opportunity to obtain preclinical quantitative functional lung images. Only single-scan measurements in non-survival studies have been obtained to date; thus, methodologies enabling animal survival for repeated imaging to be accomplished over weeks or months from the same animal would establish new opportunities for the assessment of pathophysiology drivers and treatment response in advanced preclinical drug-screening efforts. Methods: An anesthesia protocol developed for animal recovery to allow for repetitive, longitudinal scanning of individual animals over time. Test–retest imaging scans from the lungs of healthy mice were performed over 8 weeks to assess the repeatability of scanner-derived quantitative imaging metrics and variability. Results: Using a murine model of fibroproliferative lung disease, this longitudinal scanning approach captured heterogeneous progressive changes in pulmonary function, enabling the visualization and quantitative measurement of averaged whole lung metrics and spatial/regional change. Radiation dosimetry studies evaluated the effects of imaging acquisition protocols on X-ray dosage to further adapt protocols for the minimization of radiation exposure during repeat imaging sessions using these newly developed image acquisition protocols. Conclusions: Overall, we have demonstrated that the 4DXV advanced imaging scanner allows for repeat measurements from the same animal over time to enable the high-resolution, noninvasive mapping of quantitative lung airflow dysfunction in mouse models with heterogeneous pulmonary disease. The animal anesthesia and image acquisition protocols described will serve as the foundation on which further applications of the 4DXV technology can be used to study a diverse array of murine pulmonary disease models. Together, 4DXV provides a novel and significant advancement for the longitudinal, noninvasive interrogation of pulmonary disease to assess spatial/regional disease initiation, progression, and response to therapeutic interventions. Full article

Humidity sensing elements based on sodium-doped titanium dioxide (Na-doped TiO₂) were prepared using a sol–gel method in the presence of cerium ions and sintered at 400 °C and 800 °C. Titanium (IV) n-butoxide and a saturated solution of diammonium hexanitratocerate in isobutanol served as starting materials. Sodium hydroxide and sodium tert-butoxide were used as inorganic and organometallic sodium sources, respectively. The influence of sodium additives on the properties of the humidity sensing elements was systematically investigated. The surface morphologies of the obtained layers were examined by scanning electron microscopy (SEM). Elemental mapping was conducted by energy-dispersive X-ray (EDX) spectroscopy, and structural characterization was performed using X-ray diffractometry (XRD). Electrical properties were studied for samples sintered at different temperatures over a relative humidity range of 15% to 95% at 20 Hz and 25 °C. Experimental results indicate that sodium doping enhances humidity sensitivity compared to undoped reference samples. Incorporation of sodium additives increases the resistance variation range of the sensing elements, reaching over five orders of magnitude for samples sintered at 400 °C and four orders of magnitude for those sintered at 800 °C. Full article

Lung-protective ventilation and other experimental conditions raise arterial carbon dioxide tension (PaCO₂) and alter pH. Short-term benefits are reported in non-infectious settings, whereas infection and/or prolonged exposure are typically harmful. This scoping review systematically maps immune-mediated effects of hypercapnia on innate immunity and alveolar epithelial repair. Scoping review per Levac et al. and PRISMA Extension for Scoping Reviews (Open Science Framework protocol: 10.17605/OSF.IO/WV85T; post hoc). We searched original preclinical studies (in vivo/in vitro) in PubMed, Web of Science, ScienceDirect, Cochrane Reviews, and SciELO (2008–2023). PaCO₂ (mmHg) was prioritized; %Fraction of inspired Carbon Dioxide (%FiCO₂) was recorded when PaCO₂ was unavailable; pH was classified as buffered/unbuffered. Data were organized by context, PaCO₂, and exposure duration; synthesis used heat maps (0–120 h) and a narrative description for >120 h. Mechanistic axes extracted the following: NF-κB (canonical/non-canonical), Bcl-2/Bcl-xL–Beclin-1/autophagy, AMPK/PKA/CaMKKβ/ERK1/2 and ENaC/Na,K-ATPase trafficking, Wnt/β-catenin in AT2 cells, and miR-183/IDH2/ATP. Thirty-five studies met the inclusion criteria. In non-infectious models, a “protective window” emerged, with moderate PaCO₂ and brief exposure (65–95 mmHg; ≤4–6 h), featuring NF-κB attenuation and preserved epithelial ion transport. In infectious models and/or with prolonged exposure or higher PaCO₂, harmful signals predominated: reduced phagocytosis/autophagy (Bcl-2/Bcl-xL–Beclin-1 axis), AMPK/PKA/ERK1/2-mediated internalization of ENaC/Na,K-ATPase, depressed β-catenin signaling in AT2 cells, impaired alveolar fluid clearance, and increased bacterial burden. Chronic exposures (>120 h) reinforced injury. Hypercapnia is a context-, dose-, time-, and pH-dependent double-edged modulator. The safe window is narrow; standardized, parallel reporting of PaCO₂ and pH—with explicit comparisons of buffered vs. unbuffered hypercapnia—is essential to guide clinical translation. Full article

Accurate preoperative staging of bladder cancer on MRI remains challenging because visual reads vary across observers. We investigated a multiparametric MRI (mpMRI) radiomics approach to predict muscle invasion (≥T2) and prospectively tested it on a validation cohort. Eighty-four patients with urothelial carcinoma underwent 1.5-T mpMRI per VI-RADS (T2-weighted imaging and DWI-derived ADC maps). Two blinded radiologists performed 3D tumor segmentation; 37 features per sequence were extracted (LifeX) using absolute resampling. In the training cohort (n = 40), features that differed between non-muscle-invasive and muscle-invasive tumors (Mann–Whitney p < 0.05) underwent ROC analysis with cut-offs defined by the Youden index. A compact descriptor combining GLRLM-LRLGE from T2 and GLRLM-SRLGE from ADC was then fixed and applied without re-selection to a prospective validation cohort (n = 44). Histopathology within 6 weeks—TURBT or cystectomy—served as the reference. Eleven T2-based and fifteen ADC-based features pointed to invasion; DWI texture features were not informative. The descriptor yielded AUCs of 0.934 (training) and 0.871 (validation) with 85.7% sensitivity and 96.2% specificity in validation. Collectively, these findings indicate that combined T2/ADC radiomics can provide high diagnostic accuracy and may serve as a useful decision support tool, after multicenter, multi-vendor validation. Full article

Detecting small split pins on transmission lines poses significant challenges, including low accuracy in complex backgrounds and slow inference speeds. To address these limitations, this study proposes a novel two-stage collaborative detection framework. The first stage utilizes a Yolo11x-based model to localize and crop components containing split pins from high-resolution images. This procedure transforms the difficult small-object detection problem into a more manageable, conventional detection task on a simplified background. For the second stage, a new high-performance detector, Mamba-YOLO-SPDC, is introduced. This model enhances the Yolo11 backbone by incorporating a Vision State Space (VSS) block, which leverages Mamba—a State Space Model (SSM) with linear computational complexity—to efficiently capture global context. Furthermore, a Space-to-Depth Convolution (SPD-Conv) module is integrated into the neck to mitigate the loss of fine-grained feature information during downsampling. Experimental results confirm the efficacy of the two-stage strategy. On the cropped dataset, the Mamba-YOLO-SPDC model achieves a mean Average Precision (mAP) of 61.9%, a 238% improvement over the 18.3% mAP obtained by the baseline Yolo11s on the original images. Compared to the conventional SAHI framework, the proposed method provides superior accuracy with a substantial increase in inference speed. This work demonstrates that the ‘localize first, then detect’ strategy, powered by the Mamba-YOLO-SPDC model, offers an effective balance between accuracy and efficiency for small object detection. Full article

As Virtual Try-On (VTON) technology matures, 2D VTON methods based on diffusion models can now rapidly generate diverse and high-quality try-on results. However, with rising user demands for realism and immersion, many applications are shifting towards 3D VTON, which offers superior geometric and spatial consistency. Existing 3D VTON approaches commonly face challenges such as barriers to practical deployment, substantial memory requirements, and cross-view inconsistencies. To address these issues, we propose an efficient 3D VTON framework with robust multi-view consistency, whose core design is to decouple the monolithic 3D editing task into a four-stage cascade as follows: (1) We first reconstruct an initial 3D scene using 3D Gaussian Splatting, integrating the SMPL-X model at this stage as a strong geometric prior. By computing a normal-map loss and a geometric consistency loss, we ensure the structural stability of the initial human model across different views. (2) We employ the lightweight CatVTON to generate 2D try-on images, that provide visual guidance for the subsequent personalized fine-tuning tasks. (3) To accurately represent garment details from all angles, we partition the 2D dataset into three subsets—front, side, and back—and train a dedicated LoRA module for each subset on a pre-trained diffusion model. This strategy effectively mitigates the issue of blurred details that can occur when a single model attempts to learn global features. (4) An iterative optimization process then uses the generated 2D VTON images and specialized LoRA modules to edit the 3DGS scene, achieving 360-degree free-viewpoint VTON results. All our experiments were conducted on a single consumer-grade GPU with 24 GB of memory, a significant reduction from the 32 GB or more typically required by previous studies under similar data and parameter settings. Our method balances quality and memory requirement, significantly lowering the adoption barrier for 3D VTON technology. Full article