Search Results (723)

The secularization of religion in late-nineteenth and early-twentieth-century Britain profoundly altered the ethical foundations of the modernist novel, challenging writers to reimagine the role of literature in the absence of religious authority. Against this backdrop, the present study investigates how modernist authors—exemplified by Virginia Woolf—both inherited and transformed the ethical ideals of religious communities. Through a comparative approach, this article traces the secularization of the Clapham Sect’s “moral covenant” and the Quaker notion of the “inner light”, revealing how these religious legacies, as mediated through the intellectual frameworks of Leslie Stephen and George Moore, contributed to Woolf’s construction of an author–reader intellectual community. The study demonstrates how this religious inheritance is reconfigured in Woolf’s theory of the ‘common reader,’ highlighting her contribution to modernist aesthetics and ethics. Through the figure of the ‘common reader,’ religion emerges not as a set of fixed doctrines, but as a foundation for constructing ethical communities in a secular age. Full article

Purpose: This study investigated the attributes of confession pages on Facebook, their role within social networks, and their impact on society. It also explored their defining traits, the need for confession pages and the effects of anonymity. Methodology: The research methodology involved coding 1280 posts extracted from select pages, and semi-structured in-depth interviews with 15 prominent followers. Findings: Anonymity was found to be important because it helps individuals avoid social repercussions. Prominent recurring themes included formal behavior, relationships, and sexuality, topics that frequently involve social sanctions and penalties. The study also underscored the sense of community fostered by interaction between writers posting on confession pages and readers of these posts. The current study suggests that confession pages reflect society-level value preferences that shape interaction on social media according to Hofstede’s framework. Moreover, different confession groups serve to satisfy different needs, aligning with the theory of uses and gratifications in communication media. Practical implications: Engagement was shown by readers who extended offers to help and provided suggestions to support authors facing different challenges. Social implications: The motivations of anonymity for contributors to communities fostered through writer–reader interactions on the platform. Value: An in-depth examination of confession within contemporary society, redefining the contemporary landscape of confession, shedding light on its various perspectives within the public internet sphere, and thus contributing to comprehension of the different needs for anonymous expression. Full article

In this paper, we apply an information-theoretic method proposed by Ryabko and Savina (therefore called the RS-method), based on the use of data compression, to recognize the individual author’s style of a writer across four languages from different language groups and families. In this paper, the presented method was used to study fiction texts in Russian (East Slavic group of languages of the Indo-European language family), Amharic (South Ethiosemitic group of the Semitic language family), Chinese (Sinitic group of the Sino-Tibetan language family) and English (West Germanic language group of the Indo-European language family). It was found that the amount of data necessary for recognizing an author’s style is almost the same for all four languages, i.e., the amount of data is invariant across different language groups. The results obtained are of interest to computer science, literary studies, linguistics and, in particular, computational linguistics. Full article

This article explores Truman Capote’s parodic/reconstructive exploitation of decadent aesthetics in his “Southern Gothic” novel, Other Voices, Other Rooms (1948), as dissident self-distancing from postwar conservatism. Modernist Southern Gothic writers owe European decadent culture for their thematization of the sociocultural decay of the antebellum South and characterization of dandiacal dissidents, while often reiterating the claustrophobic mood of the patriarchal and racist society and excluding/villainizing those dandies. Critically analogizing the nationalist heteronormativity of the early-Cold War American society with the oppressive patriarchy of the South, OVOR playfully deconstructs the tragic narrative of Modernist Southern Gothic by foregrounding the reparative aspect of decadent aesthetics mainly through the pedagogic relationship between a Wildean dilettante, Randolph, and a young protagonist, Joel. Simultaneously, with the ironical self-satire against the potential authoritarianism of white bourgeois decadence, Capote democratizes decadent aesthetics as a non-normative survival method through the exposure of Randolph’s vulnerability and the parodic adaptation of his dilettantism by the non-white characters. I argue that OVOR marks the vacillating but inevitable transition from decadence to camp as a seemingly non-political but necessary survivalist strategy in the Cold War/Pre-Stonewall American society that conducts surveillance of, persecutes, and stigmatizes as “decadence” non-normative genders and sexualities. Full article

The global expansion of Korean language education has created an urgent need for scalable, objective, and consistent methods for assessing the writing skills of non-native (L2) learners. Traditional manual grading is resource-intensive and prone to subjectivity, while existing Automated Essay Scoring (AES) systems often struggle with the linguistic nuances of Korean and the specific error patterns of L2 writers. This paper introduces a novel hybrid AES system designed specifically for Korean L2 writing. The system integrates two complementary feature sets: (1) a comprehensive suite of conventional linguistic features capturing lexical diversity, syntactic complexity, and readability to assess writing form and (2) a novel semantic relevance feature that evaluates writing content. This semantic feature is derived by calculating the cosine similarity between a student’s essay and an ideal, high-proficiency reference answer generated by a Large Language Model (LLM). Various machine learning models are trained on the Korean Language Learner Corpus from the National Institute of the Korean Language to predict a holistic score on the 6-level Test of Proficiency in Korean (TOPIK) scale. The proposed hybrid system demonstrates superior performance compared to baseline models that rely on either linguistic or semantic features alone. The integration of the LLM-based semantic feature provides a significant improvement in scoring accuracy, more closely aligning the automated assessment with human expert judgments. By systematically combining measures of linguistic form and semantic content, this hybrid approach provides a more holistic and accurate assessment of Korean L2 writing proficiency. The system represents a practical and effective tool for supporting large-scale language education and assessment, aligning with the need for advanced AI-driven educational technology systems. Full article

This article traces the trajectory of China’s dominant literary field as it shifted from proletarian to intellectual literature in the early reform era. It examines the conditions and cultural logic underlying the striking phenomenon whereby former industrial workers, once incorporated into the literary field, rapidly distanced themselves from the very genre historically rooted in their own industrial experiences, namely, worker literature. Focusing on writers emerging from factories and on Shanghai Literature—a journal once known for publishing worker literature. The article analyzes the reconfiguration of class and identity that accompanied China’s transition from its high socialist past. I argue that socialist worker literature never fully reconciled the structural antagonism between manual and mental labor. In the early reform era, factory-based writers appropriated literature as a mode of symbolic escape and ideological critique. Hence, literature itself became a site where the contradictions of socialist and capitalist modernity were negotiated and contested. Full article

The first film signed by Paolo Taviani without his brother Vittorio (who died in 2018) in more than 60 years, Leonora addio (2022) recapitulates and condenses an entire career by recounting the grotesque (real-life) journey of the burial, cremation, exhumation, transfer (from Rome to Sicily) and re-burial of Luigi Pirandello’s corpse over more than ten years, as well as by showing in the last thirty minutes an adaptation for the screen of “The Nail” (“Il chiodo”, the last novella by the renowned Sicilian writer). A quintessential testament film refracting the writer’s death in Vittorio’s (one of the film’s many Pirandello-esque mirror games) and alluding to the intellectual legacies of either, Leonora addio daringly thematizes the exploitation of cultural value as well as its political implications—particularly in the specific Italian context and, implicitly yet unmistakably, in the present day too. My paper will analyse Leonora addio paying particular attention to how this subtext intersects the film’s “testamentary” surface, to Deleuze’s “crystal images” (pervasively informing the structure of Leonora addio), to the film’s many nods to Kaos (a 1984 Pirandello adaptation for the screen by the Taviani, analysed mainly through the lens of Lacanian gaze theory) and to the role of death in both films. Full article

Luo Weizhang’s novel Under the Sun centers on a fictionalized writer who reconstructs the life of protagonist Huang Xiaoyang through encounters with his literary remains and the memories of those who knew him personally. Set against the backdrop of the WWII Japanese bombings of Chongqing, the novel challenges dominant historical narratives by using the genre of historiographic metafiction and employing narrative strategies of counter-memory and postmemory. This paper reads Under the Sun as a literary performance of ethical remembrance: one that interrogates conventional notions of subjectivity, the fragile responsibility of narrating trauma, and the psychological toll of bearing witness across generations. Drawing on the framework of critical humanism, with its emphasis on relationality and ethical openness to the other, I argue that Luo’s novel reveals both the moral necessity and the psychic cost of engaging with histories of violence. In reframing the Chongqing bombings—long marginalized in global WWII memory—Under the Sun demonstrates how Chinese literature can expand the geography of remembrance and contribute to transnational debates on trauma, justice, and historical responsibility. Full article

N⁶-methyladenosine (m⁶A) is the most abundant modification of mRNA and plays a crucial role in mediating cellular functions, and it is associated with cancer and neurodegenerative diseases. Studies have shown that m⁶A is predominantly deposited on its consensus motif by the m⁶A writer proteins RNA methyltransferase METLL3/METLL14. However, it was found that nonconventional m⁶A deposition by other alternative pathways may also exist and can modulate epitranscriptomic regulation in cells. Thus, understanding the molecular mechanisms underlying nonconventional m⁶A deposition outside the canonical motifs will provide novel insights into the full scope of the functional impact of m⁶A. In this study, we discovered that m⁶ATP was efficiently incorporated by the repairing DNA polymerases pol β and pol η through RNA gap-filling synthesis on an RNA-DNA hybrid. Steady-state kinetics results showed that m⁶ATP was incorporated into RNA by the DNA polymerases with a comparable efficiency to ATP. AlphaFold3-assisted molecular dynamics simulations further elucidated the structural basis for the DNA polymerases to incorporate m⁶ATP into the RNA substrates by showing that the enzymes employed the unique base-stacking mechanism to govern the distance between the 3′-OH group of the 3′-terminus nucleotide of the primer and the 5′-α-phosphate of m⁶ATP to perform their catalysis. Furthermore, we detected a significant amount of m⁶ATP in human cells. We showed that the m⁶ATP level was associated with that of the oxidative stress biomarker 8-oxoGTP in cells, suggesting that unscheduled m⁶A deposition on RNA can be mediated by m⁶ATP incorporation that is associated with cellular oxidative stress. Our study sheds light on the unscheduled m⁶A deposition as a potential alternative mechanism for altering epitranscriptomic modifications. Full article

This essay is an analysis of poetry written by Latinx Undocupoets in the United States. It focuses on three contemporary poets—Javier O. Huerta, Yosimar Reyes, and Javier Zamora. The author examines the way these poets navigate borderland identities by cultivating cultural mestizaje to advance a political project, where consciousness-raising and advocating for those who cross or are crossed by borders are the priorities. The author argues that three common themes related to transformation appear in the work of Undocupoets: rebirth, shapeshifting, and activism. These poets transform themselves and their communities by engaging in differential movement and relocating marginalized individuals and communities to positive social locations while portraying them in their full complexity—a postnationalist perspective that manifests itself in a borderlands framework. The author demonstrates how these writers formulate decolonial imaginaries and differential consciousness to relocate migrants and undocumented people to social locations that transcend the negative stereotypes that have historically shaped their identities and lived experiences. Through rebirth, shapeshifting, and activism, Undocupoets enact a form of agency and present new ways of seeing and understanding the migrant experience. Full article

American Indians and Alaska Natives experience disproportionately high cancer diagnoses and death rates. This study aims to elucidate American Indian and Alaska Native understandings of cancer as voiced through poetry. Ten writers submitted poems in response to a call for American Indians and Alaskan Natives to share their perspectives, experiences, and knowledge about cancer through poetry. Poetry submissions were analyzed for emergent themes through an inductive-deductive approach using framework analyses grounded in the Native Wellness Model and Cancer Control Continuum. Four overarching themes, one within each of the four Native Wellness Model constructs (mind, body, spirit, and context) and 17 sub-themes, reveal that cancer is a holistic experience for American Indian and Alaska Native Peoples. Participant knowledge and experiences varied across the Cancer Control Continuum, with survivorship and palliative care most reflected in the poetry. Fewer poems addressed detection, etiology, and prevention. Poetry can serve as a culturally relevant data source to better understand cancer from American Indian and Alaskan Native perspectives, experiences, and knowledge. More holistic approaches to cancer education, prevention, treatment, and research with American Indians and Alaskan Natives could improve efforts to address cancer within this population. Full article

The intracellular topography of RNA molecules, encompassing ribonucleotides with biochemical modifications, such as N6-methyladenosine (m6A), 5-methylcytosine (m5C), adenosine to inosine (A → I) editing, and isomerization of uridine to pseudouridine (Ψ), as well as of non-coding RNA molecules, is currently studied within the frame of the epigenome. Circulating RNA molecules in the intracellular space that have incorporated information by carrying specific modifications depend on the balanced activity and correct subcellular installation of their modifying enzymes, the “writers”, “readers” and “erasers”. Modifications are critical for RNA translocation from the nucleus to the cytoplasm, for stability and translation efficiency, and for other, still-uncovered functions. Moreover, trafficking of non-coding RNA molecules depends on membrane transporters capable of recognizing signal sequences and RNA recognition-binding proteins that can facilitate their transport to different intracellular locations, guiding the establishment of interconnection possibilities with different macromolecular networks. The potential of long non-coding RNAs to form multilayer molecular connections, as well as the differential topology of micro-RNAs in cell nuclei, compared to cytoplasm, has been recognized by several studies. The study of the intercellular compartmentalization of these molecules has recently become feasible thanks to technological progress; however, a wealth of information has not yet been produced that would lead to safe conclusions regarding non-coding RNA’s contributions to the early steps of pathogenesis and disease progression in hematological malignancies. Both, the bone marrow, as the main hematopoietic tissue, and the lymphoid tissues are composed of cells with highly reactive potential to signals affecting the epigenome and initiating cascade pathways in response. Independently or in combination with coexistent driver genetic mutations, especially mutations of enzymes involved in epigenomic surveillance, intracellular microenvironmental alterations within the cell nuclear, cytoplasmic, and mitochondrial compartments can lead to disorganization of hematopoietic stem cells’ epigenomes, promoting the generation of hematological malignancies. In this review, we discuss the various intracellular processes that, when disrupted, may result in the ectopic placement of RNA molecules, either inducing specific modifications or non-coding molecules or promoting hematological malignant phenotypes. The crosstalk between mitochondrial and nuclear genomes and the complex regulatory effects of mis-localized RNA molecules are highlighted. This research approach may constitute a field for new, more specifically targeted therapies in hematology based on RNA technology. Full article

This article provides a comprehensive review and explores the gaps in current knowledge of lysine metabolism in humans and its potential nutritional and therapeutic indications. The first part of this study examines lysine sources, requirements, transport through the plasma membrane, lysine catabolism, and its disorders. The central part is focused on post-translational modifications of lysine in proteins, primarily desmosine formation in elastin, hydroxylation in collagen, covalent bonds with glutamine, methylation, ubiquitination, sumoylation, neddylation, acylation, lactylation, carbamylation, and glycation. Special sections are devoted to using lysine as a substrate for homoarginine and carnitine synthesis and in nutrition and medicine. It is concluded that the identification and detailed knowledge of writers, readers, and erasers of specific post-translational modifications of lysine residues in proteins is needed for a better understanding of the role of lysine in epigenetic regulation. Further research is required to explore the influence of lysine availability on homoarginine formation and how the phenomenon of lysine–arginine antagonism can be used to influence immune and cardiovascular functions and cancer development. Of unique importance is the investigation of the use of lysine in osteoporosis therapy and in reducing the resorption of harmful substances in the kidneys, as well as the therapeutic potential of polylysine and lysine analogs. Full article

Over recent years, epitranscriptomic research has provided a new layer of gene regulation during hematopoietic development and aberrant hematopoiesis. Among the 170 identified RNA chemical marks, N⁶-methyladenosine (m⁶A) is the most abundant in eukaryotic cells and plays a critical role in various biological processes. This dynamic modification is regulated by a series of methyltransferases, demethylases, and m⁶A binding proteins, known as writers, erasers, and readers, respectively. Emerging evidence suggests that m⁶A modification and its regulators are involved in every aspect of normal hematopoietic development, from the emergence of hematopoietic stem cells to the generation of mature blood cells. Also, it has been established that abnormal expression of m⁶A regulators is implicated in the initiation of blood diseases. In this review, we summarize the latest findings regarding the role of m⁶A in erythropoiesis and highlight its implications in the pathophysiology of hemoglobin disorders. Full article

Obesity has emerged as a global health challenge, closely associated with multiple metabolic diseases, such as cardiovascular diseases, type 2 diabetes, and non-alcoholic fatty liver disease. The traditional “calories-in minus calories-out” paradigm is no longer sufficient to explain the heterogeneity of obesity; consequently, a growing body of research has turned its focus to epigenetic regulation—particularly chemical modifications at the RNA level. N⁶-methyladenosine (m⁶A) modification is one of the most abundant epigenetic modifications on RNA, which dynamically regulates the methylation reaction in specific sequences on mRNA through methyltransferases (writers), demethylases (erasers), and binding proteins (readers). Accumulating evidence in recent years has revealed that m⁶A modification plays a pivotal role in the pathogenesis and progression of obesity, particularly through its regulation of key biological processes, such as adipocyte differentiation, lipid metabolism, and energy homeostasis. Given its critical involvement in metabolic dysregulation, targeting m⁶A-related mechanisms may offer novel therapeutic avenues for obesity management. This review systematically summarizes the current understanding of m⁶A modification in obesity, elucidates its underlying molecular mechanisms, and evaluates its potential as a therapeutic target. By integrating recent advances in the field, we aim to provide new perspectives for the development of innovative strategies in obesity treatment. Full article