Search Results (22,824)

Cancer is still one of the world’s major causes of morbidity and mortality; thus, safer and more efficient treatment approaches are required. The structural variety, multitargeted mechanisms, and generally good safety profiles of plant-derived polyphenols have made them attractive anticancer medicines. Flavonoids (like quercetin), stilbenes (like resveratrol), phenolic acids and curcuminoids (like curcumin) are major classes that have shown strong anticancer action against a variety of cancers, including prostate, colorectal and breast cancers. Through targets including PI3K/Akt, MAPK, NF-κB, and p53 signaling networks, these substances influence important molecular pathways involved in tumor initiation and development, including oxidative stress, inflammation, apoptosis, cell cycle control, angiogenesis and metastasis. The clinical translation of polyphenols is still constrained by poor bioavailability, fast metabolism, low aqueous solubility and inefficient pharmacokinetic characteristics, which lead to insufficient systemic exposure and therapeutic efficacy despite strong preclinical data. Their therapeutic applicability is further complicated by variations in absorption and possible dose-related restrictions. To overcome these limitations, the anticancer efficacy of polyphenols has been enhanced via delivery technologies like polymeric nanoparticles, lipid-based carriers, nanoemulsions and phytosome complexes, which have shown improved stability, increased bioavailability and targeted delivery to tumor tissues. This review provides a comprehensive and integrative analysis of plant-derived polyphenols by linking molecular mechanisms, pharmacokinetic limitations and emerging delivery strategies within a translational framework. By bridging these interconnected domains, this review highlights the potential of polyphenols as viable candidates in next-generation cancer therapeutics and underscores the need for well-designed clinical studies to facilitate their successful integration into oncology practice. Full article

This paper presents a comprehensive evaluation of control strategies for a highly energy-efficient plus-energy terraced housing complex equipped with photovoltaic generation, modulating ground-source heat pumps, electrical and thermal energy storage systems, and activation of building thermal mass. The study combines long-term monitoring data, annual simulations, and hardware-in-the-loop (HiL) experiments to assess modulating heat-controlled operation (HC), PV-controlled (PVC), and predictive control strategies, including simple predictive control (SPC) and model predictive control (MPC). The simulation results show that the baseline HC operation already achieves a high load cover factor (LCF), defined as the fraction of total electrical demand covered by local PV generation (direct use + battery discharge) of 65.6% and a seasonal performance factor (SPF) of the central heat pumps of 5.8. PVC increases LCF (71.0%) by shifting heat pump operation toward PV-rich periods but leads to elevated storage temperatures up to 5 K and a reduced SPF of 4.8. MPC further enhances LCF by 4–7 percentage points in simulated and HiL environments. However, its real-world performance is strongly influenced by forecast quality and the limited controllability of the heat pump system. In addition, building thermal mass activation is investigated as a complementary flexibility option. Simulation and monitoring results demonstrate that moderate room temperature set-point (2 K) increases during PV availability significantly improve LCF from 20% to 55% while maintaining thermal comfort. Overall, the findings indicate that in highly efficient plus-energy buildings, robust rule-based strategies combined with thermal mass activation can achieve a large share of the attainable benefits, while the added complexity of MPC must be carefully weighed against practical limitations. Full article

Digital twins have become a central paradigm for cultural heritage documentation, monitoring, and preventive preservation. Yet, when cultural heritage systems promise prediction, simulation, intervention planning, and decision support, a more explicit account is needed of the computational commitments behind such claims. This position paper proposes the notion of the heritage world model as a conceptual and architectural abstraction that uses the semantic digital twin as its representational layer and extends it toward prediction, memory, uncertainty-aware reasoning, and intervention evaluation. We define a heritage world model as a structured, temporally updated, semantically grounded, and action-aware model of a heritage asset and its preservation environment, capable of integrating observations, estimating latent risk states, predicting plausible future trajectories, and evaluating interventions under uncertainty. The paper does not present a validated deployed system. Rather, it clarifies the architectural conditions under which a decision-support digital twin infrastructure could support the kind of world-model-like preservation system proposed here. It further argues that such a model becomes operationally meaningful only when it includes a human-supervised controller layer that maps semantic state, predicted risk trajectories, uncertainty, memory, and institutional constraints into preservation-relevant actions, alerts, monitoring adaptations, or requests for expert review. Sensor data, remote sensing, computational models, risk assessments, policies, and conservation actions are interpreted as possible observational, dynamic, and intervention layers of a heritage world model. The paper reviews adjacent work in heritage digital twins, semantic and reactive ontologies, risk-aware preservation, agentic AI, and modern AI world models, and proposes a research agenda for moving toward predictive, memory-bearing, and intervention-aware preservation intelligence. Full article

Lubricating oil monitoring provides continuous health information for early fault warning and maintenance decision-making in industrial gas turbines. However, real-world multi-sensor monitoring streams exhibit pronounced nonstationary thermodynamic drifts that often obscure subtle high-frequency residuals containing critical incipient degradation signatures. Prevailing data-driven monitoring models typically struggle to separate these macroscopic trends from stochastic wear-related fluctuations, and their restrictive distributional assumptions are often inadequate for the heteroscedastic and heavy-tailed nature of industrial residuals. To address these challenges, this study proposes ResAD-Net, a framework for early fault warning in nonstationary multi-sensor oil monitoring that combines trend–residual decoupling, trend-conditioned residual modeling, and residual-domain dependency learning. Specifically, a signal trend–residual decoupling strategy is adopted to separate slowly varying operational trends from stochastic residual fluctuations captured by the sensors, thereby exposing residual information that is more sensitive to incipient degradation. On this basis, a trend-conditioned diffusion model is introduced to characterize state-dependent, skewed residual distributions and generate residual sample ensembles for nonstationary monitoring. Meanwhile, a graph-based variational autoencoder is employed to learn latent intersensor dependency structures from the residual domain, providing diagnostic cues for temporal risk evolution analysis and sensor-level inspection. Experiments on a real-world industrial oil-monitoring record show that the proposed framework achieves an average F1-score of 0.985 with no observed false positives in the predefined pre-alarm reference interval of the finite test set. In addition to accurate anomaly detection, ResAD-Net captures early residual distributional shifts before clear macroscopic deviations emerge and provides diagnostic association cues for interpreting oil-monitoring changes around the system-level alarm. Full article

Post-Traumatic Stress Disorder (PTSD) is a prevalent and costly mental health condition characterized by symptoms such as hyperarousal, avoidance, and re-experiencing. While machine learning (ML) approaches have shown promise in detecting PTSD-related physiological patterns, most validation efforts rely on computational metrics rather than real-world user perceptions. This study evaluates the perceived precision of a smartwatch-based ML tool designed to detect PTSD hyperarousal events using heart rate and activity data. The tool, previously developed using XGBoost 1.0.0, was deployed in a 21-day naturalistic study with 12 participants diagnosed with PTSD. Quantitative results showed a median perceived precision of 65.27%, with substantial variability across participants. A Mann–Kendall trend analysis revealed a significant increase in perceived precision over time for most participants, suggesting calibration of trust. Qualitative findings indicated high usability, general trust in the system, and acceptance of false positives, though concerns about notification design and battery life were noted. The results highlight the importance of incorporating user-centered, real-world validation into the evaluation of ML-based mental health monitoring tools. This work provides preliminary evidence supporting the feasibility of wearable-based PTSD monitoring and underscores the role of perceived precision in technology adoption and sustained use. Full article

Tomato is one of Thailand’s most significant economic crops, generating substantial export value and serving as a primary source of income for local farmers. However, the traditional manual grading process often fails to comply with the Thai Agricultural Standard TACFS 1503–2007, as grading decisions rely heavily on individual experience and subjective perception, resulting in inconsistent quality. Existing automated systems face the challenges of low accuracy, high costs, and complex hardware, while many are incompatible with Thailand’s grading standards. This study presents a multi-view tomato grading system (MVT-Grader), utilizing a dataset acquired from Doi Kham Food Products Co., Ltd. (Third Royal Factory, Tao Ngoi) under controlled lighting conditions. Subsequently, MVT-Grader is built on a custom-designed lightweight CNN architecture with an adjusted spatially aware loss function to enhance the model’s sensitivity in detecting subtle surface defects and color variations. The proposed model was trained using tomato images captured from two and three different viewpoints via a low-cost webcam setup and processed by a GPU-embedded system. Experiments conducted using stratified 5-fold cross-validation on a real-world industrial dataset demonstrate average grading accuracies of 99.43% (two-view) and 99.64% (three-view). Furthermore, the proposed Real-Time Lightweight CNN with Spatially Aware Loss Optimization achieves processing speeds of 87 ms and 114 ms per tomato for two- and three-view cases, respectively. Compared with MVCNN-Siamese, SDF-ConvNets, and Multi-View Spatial Network, the proposed system outperforms the others in both accuracy and speed, improving accuracy by 1.6–6.11% and reducing processing time by 39–49 ms. Full article

Complex networks have become a fundamental paradigm for modeling real-world systems. Synchronization of such networks, particularly under hyperchaotic dynamics, presents a significant control challenge due to the high-dimensional state space and multiple positive Lyapunov exponents. This paper addresses the driver node selection problem in a 4D Hyperchaotic Lorenz complex network, formulating it as a constrained binary optimization task. We evaluate a pool of advanced metaheuristics, including the quantum genetic algorithm (QGA), seahorse optimizer (SHO), and artificial bee colony (ABC), across multiple network experiments conducted over 30 independent runs to guarantee statistical validity. The performance of these solvers is rigorously benchmarked against traditional topological heuristics, a random selection baseline comprising 600 feasible configurations, and verified through Wilcoxon statistical testing. Furthermore, addressing computational sustainability, we introduce a “Green-Artificial Intelligence” architecture based on dual-tier structured query language memoization (SQL-memoization) and provide a detailed runtime comparison evaluating its efficiency. The empirical results indicate that swarm-intelligence methods such as ABC and SHO exhibit robust competitive performance in minimizing synchronization errors while the Green-AI framework consistently and drastically reduces the computation of the repetitive simulations. Full article

Sarcoidosis is a multisystem granulomatous disorder of uncertain origin which still presents major therapeutic dilemmas. Longstanding dependence on corticosteroids, while effective for acute inflammation, carries considerable adverse effects over time. Advances in deciphering sarcoidosis pathobiology—including aberrant Janus kinase (JAK)- signal transducer and activator of transcription (STAT) signaling, mechanistic target of rapamycin (mTOR)-driven metabolic shifts, Th1/Th17.1 immune skewing, effector T-cell exhaustion, and granuloma-centered cytokine circuits—have revealed several targets for intervention. The treatment options are rapidly changing: the SARCORT trial showed that low-dose prednisolone is non-inferior to higher prednisolone doses; the pivotal PREDMETH trial validated methotrexate as a feasible first-line steroid-sparing option; efzofitimod, a novel immunomodulator targeting neuropilin-2, produced steroid-reducing effects in Phase IIbut not in Phase III trials; and JAK inhibitors are accumulating evidence across cutaneous and systemic presentations. The 2025 World Association for Sarcoidosis and Other Granulomatoses (WASOG) statement supports a move toward earlier steroid-sparing approaches. This review methodically connects sarcoidosis molecular and pathophysiological mechanisms to new targeted treatments, examines clinical trial evidence, and proposes future directions toward biomarker-driven individualized care. Full article

Multimodal biometric systems have become essential components of modern electronic identity and authentication platforms where robustness under real-world degradation is critical. However, opaque face masks impose severe facial occlusion and attenuate high-frequency spectral components. Conversely, transparent face shields introduce complex specular reflections and act as an acoustic channel distortion source. Addressing these asymmetric degradation challenges, this paper proposes a reliability-aware Dynamic Score Fusion (DSF) for multimodal biometric identification. The proposed method performs sample-level reliability estimation for both face and voice modalities at the input stage. This enables sample-wise adaptive weighting of modality scores based on their estimated reliability. The framework integrates an ElasticFace-Arc backbone for face recognition with an Emphasized Channel Attention, Propagation and Aggregation—Time Delay Neural Network (ECAPA-TDNN) for speaker identification. The proposed approach is evaluated on the FaciaVox dataset, comprising face images and voice recordings acquired under multiple face-covering conditions. Experiments under the Standard to Cross-Condition Protocol (SCCP) and Multi-Condition Protocol (MCP) demonstrate that the proposed DSF consistently outperforms conventional score-level fusion methods, including Weighted Sum Fusion (WSF) and Logistic Regression Fusion (LRF). It achieves average Rank-1 accuracies of 89.6% (SCCP) and 93.7% (MCP), with gains of up to 9.3 percentage points over these baselines. The reliability estimators further demonstrate strong predictive capability, yielding Area Under the Curve (AUC) values above 0.95 for both modalities in distinguishing correctly and incorrectly identified samples under the closed-set identification setting. These findings confirm that sample-wise reliability modeling provides an effective mechanism for enhancing multimodal biometric performance under challenging mask and shield conditions, supporting the deployment of robust AI-driven electronic identification systems. Full article

In complex low-altitude environments, unmanned aerial vehicles (UAVs) require reliable positioning, yet Global Navigation Satellite System (GNSS) signals are vulnerable to occlusion and interference. Pseudolite-augmented cooperative localization, which combines ground base-station signals with inter-UAV relative observations, can complement GNSS in such environments. However, two practical issues remain in real-world deployment: UAV-to-base-station (U-B) and UAV-to-UAV (U-U) observations have markedly different error statistics that a unified noise adjustment cannot handle, and the conservative covariance estimates produced by Covariance Intersection (CI) fusion bias the innovation-based adaptive noise estimation in distributed architectures. To address these issues, this paper proposes a Distributed Group Covariance Compensation Adaptive Kalman Filter (DGCC-AKF) for collaborative enhancement of UAV regional localization. DGCC-AKF establishes a group adaptive mechanism that independently adjusts the noise covariance matrices of U-B and U-U observations, enabling observation-type-level adaptive weighting that suppresses anomalous U-B or U-U measurements at the group level. In addition, a bounded covariance compensation factor is incorporated to alleviate the CI-induced conservatism in the adaptive noise estimation. The proposed method is evaluated on a 2800 km² semi-physical testbed based on the Ground-based High-precision Local Positioning System (GH-LPS) pseudolite network using measured U-B observations and high-dynamic (>300 km/h) flight trajectories collected from a fixed-wing platform across three independent flight sessions. Results demonstrate that under observation fault periods, the proposed method improves 3D positioning accuracy by up to about 75% over single-UAV extended Kalman filter (EKF). Compared with two advanced algorithms in this field, variational Bayesian adaptive Kalman filter (VBAKF) and maximum correntropy criterion Kalman filter (MCC-EKF), it is the only scheme that remains accurate and stable across all UAVs and fault types. The framework provides a practical step toward field deployment for resilient multi-UAV cooperative navigation in pseudolite-augmented GNSS-denied regions. Full article

This research investigates atmospheric neutron-induced single event effects (SEEs) on advanced artificial intelligence (AI) chips during natural environment operation. The RK3588 neural processing unit (NPU) is the evaluated target chip, and its SEE is assessed through a combination of irradiation testing and software fault injection. During the irradiation test, the chip was exposed to a spectrum neutron at the China Spallation Neutron Source. Upon reaching a cumulative fluence of 8.25 × 10⁹ n·cm², a total of 14,018 soft errors were detected, of which 99.97% manifested as variations in target recognition accuracy and network inference latency. Among these variations, both detrimental effects (reduced target recognition accuracy or prolonged network inference time) and beneficial effects (enhanced target recognition accuracy or shortened network inference time) caused by single event effects were observed. In addition, atmospheric neutron single event effects were found to cause NPU operation suspension and system crashes. Based on the irradiation test results, failure predictions for neural processing units in real-world environments were estimated, and mitigation recommendations were proposed. Furthermore, software fault injections were employed to conduct in-depth analysis of detected soft errors during irradiation testing. This research provides support and references for the reliable application of artificial intelligence chips in natural environments. Full article

Accurate fault detection is essential for the safe and reliable operation of grid-connected photovoltaic (PV) systems under complex and dynamically varying conditions. However, existing data-driven approaches are often hindered by the scarcity of labeled fault data and by their limited ability to model complex multivariate temporal dependencies. To address these challenges, this paper first develops a realistic simulation of a grid-connected PV system to generate a large volume of labeled multivariate time-series fault data spanning diverse fault scenarios under varying operating conditions. The simulated data augment the limited real-world measurements, improving fault coverage and model generalization. On this basis, a dual-channel enhanced Mamba model is proposed for PV fault detection. The model decouples temporal modeling and variable-wise modeling into two dedicated channels, enabling complementary extraction of global temporal dependencies and intra-variable dynamics. Extensive experiments show that the proposed approach consistently outperforms several mainstream time-series classification methods in accuracy, precision, recall, and F1-score, demonstrating that it provides an effective and scalable solution for data-driven fault detection in grid-connected PV systems. Full article

In complex urban environments, Global Navigation Satellite System (GNSS) signals are easily affected by building blockage and multipath effects, which may degrade positioning quality or even cause GNSS denial. As a result, conventional integrated navigation systems suffer from accumulated errors due to insufficient global constraints. To address this problem, a multi-source integrated positioning method incorporating semantic information is proposed. Fixed traffic lights are selected as semantic landmarks, and an object detection network is used to extract the center pixel coordinates and detection confidence of the landmarks. Then, by combining depth information, camera pose, and the prior global coordinates of fixed semantic landmarks, a semantic target inversion model is established to transform two-dimensional image information into three-dimensional position estimates in the world coordinate system. Semantic factors are further constructed and incorporated into backend factor graph optimization. To determine the weighting of semantic factors, the influences of pixel localization error, depth estimation error, camera pose error, and prior coordinate error of fixed semantic landmarks on semantic observations are analyzed, and a noise covariance model for semantic factors is established. Finally, an unmanned ground vehicle experimental platform is built to validate and analyze the proposed factor graph algorithm. The experimental results show that, under GNSS-degraded conditions, the algorithm with semantic factors can provide supplementary global constraints for the system and effectively suppress accumulated positioning errors. In Experiment 1, compared with the algorithm without semantic factors, the maximum absolute trajectory error is reduced by 46.26%. To further verify the applicability of the proposed method in more complex scenarios, Experiment 2 is conducted on a longer route with multiple semantic landmarks and a more severe GNSS-degraded interval. The results show that the proposed method reduces the maximum APE from 6.5432 m to 3.4778 m, corresponding to a reduction of approximately 46.85%. These results demonstrate that the proposed semantic factor can improve the robustness of multi-source fusion localization in GNSS-degraded environments. Full article

This paper aims to investigate the effect of global uncertainty as measured by the World Uncertainty Index (WUI) on bank stability in the MENA region. It uses a sample of 69 MENA banks over the period 2005–2022 and performs the System Generalized Method of Moments (SGMM). Due to several economic, financial, and regulatory differences, the whole sample was divided into two sub-samples. The first covers 51 banks located in the Middle Eastern region, while the second is relative to 18 banks located in North Africa. Overall, the empirical findings support the negative effect of WUI on bank stability. However, the results of the disaggregate analysis show that this effect differs across regions. We found that WUI significantly decreases bank stability in the Middle Eastern region. However, no significant effect for banks located in North Africa was found. The results of this study are robust when using two other metrics of bank stability. We found that uncertainty increases both portfolio risk and leverage risk for the whole sample and banks in the Middle East. Full article

The rapid development of Internet of Things technologies has accelerated the deployment of smart home systems. However, perception solutions based on visual sensors remain constrained by illumination sensitivity, occlusion, and privacy concerns. Frequency-modulated continuous-wave (FMCW) millimeter-wave radar provides a promising alternative because it operates independently of lighting conditions, is robust to environmental changes, and preserves user privacy. To address multiple-extended-target tracking in cluttered indoor environments, this paper proposes a high-accuracy tracking algorithm that combines an improved Density-Based Spatial Clustering of Applications with Noise (DBSCAN) algorithm, an optimized Nearest-Neighbor Data Association (NNDA) scheme, and an Extended Kalman Filter (EKF). The improved DBSCAN algorithm introduces spatial-extent constraints, velocity-consistency checks, and candidate-cluster validation to cluster raw radar point clouds and convert extended targets into representative point targets with little additional computational cost. The optimized NNDA scheme then integrates clustering information into the association process, improving the matching accuracy between existing tracks and current measurements. Finally, the EKF estimates the state of each target from the associated measurements. Real-world experiments show that the proposed algorithm achieves tracking errors below 0.4 m in typical motion scenarios, maintains continuous tracking in two-person crossing scenarios, and reaches 93.3% counting accuracy in five-person scenarios. These results outperform the tracking system based on the commercial Texas Instruments (TI) IWR6843ISK millimeter-wave radar evaluation board. The proposed method offers a reliable and privacy-preserving sensing solution for smart homes, elderly care, and intelligent building applications. Full article