Search Results (880)

Sports footwear is widely used across a range of physical activities. A key factor distinguishing running shoes from other types of footwear is the “drop,” the millimeter difference between the heel and the forefoot. This study aimed to analyze the influence of different drops (0, 5, and 10 mm) on ground reaction forces during walking and to examine the effects of sex and body mass index (BMI) under these conditions. An observational, descriptive, and cross-sectional study was conducted with 117 participants (56 men and 61 women). The Dinascan/IBV^® dynamometric platform (Instituto de Biomecánica de Valencia, Valencia, Spain) was used to measure ground reaction forces during walking (braking, take-off, propulsion, and swing forces), walking speed, and stance time. The descriptive analysis revealed comparable values for the left and right limbs, with slightly higher values observed in the right limb. Statistically significant differences were found in stance time, braking force, and swing force between the 0 mm and 10 mm drop conditions. Take-off force showed highly significant differences when comparing the 0–5 mm and 0–10 mm drop conditions. Sex-based differences were observed in all variables at the initial proposed drop condition of 0 mm, except for walking speed, possibly due to anatomical and physiological differences. Significant differences were found in stance time at 0 mm drop, braking force, and propulsion force. Highly significant values were obtained for take-off force and during the swing phase. A strong correlation was found between ground reaction forces and BMI with the different proposed drops in all forces studied, except for the support force, where a moderate correlation was obtained. Although shoe drop was found to influence ground reaction forces in this study, it is one of several factors that affect gait biomechanics. Other footwear characteristics, such as sole stiffness, material composition, weight, and elasticity, also play important roles in walking performance. Therefore, shoe drop should be considered an important but not exclusive parameter when selecting footwear. However, these results are limited to healthy young adults and may not be generalizable to other age groups or populations. Full article

Background: The progression of cognitive decline is accelerated in older adults with sarcopenia, but the protective dietary factors have remained uncertain. Objective: This study aims to investigate the association between dietary factors and cognitive decline in older adults, and to explore the potential mediating effects of sarcopenic components. Methods: Data from the Mr. OS and Ms. OS cohort study in Hong Kong (N = 3146, aged ≥65 years) were used. Cognitive function was assessed based on the Mini-Mental State Examination (MMSE). Sarcopenic status was assessed according to the Asian Working Group for Sarcopenia 2019 updated consensus. Dietary protein intake and adherence to dietary patterns were assessed using a food frequency questionnaire. Linear regression was used to examine the associations between dietary factors and MMSE scores. Mediation analysis was conducted to identify the possible mediators in the diet–cognition associations. Results: Sarcopenia and its components were associated with baseline MMSE and MMSE changes. Positive associations were observed for plant protein intake (β = 0.79, 95% CI 0.24–1.35) and dietary patterns such as the Dietary Approaches to Stop Hypertension (DASH) diet (β = 0.14, 95% CI 0.02–0.26) and diets with lower Dietary Inflammatory Index (DII) scores (β = −0.18, 95% CI −0.26–−0.09) with better MMSE outcomes. Protective effects were more profound in participants with sarcopenia/severe sarcopenia. The effects of the DASH diet and DII were more profound in female participants, while higher adherence to the Mediterranean–DASH Intervention for Neurodegenerative Delay (MIND) diet was associated with an increment in MMSE score in male participants with sarcopenia. Handgrip strength and physical performance are significant mediators in the diet–cognition associations. Conclusions: The protective effects of healthy dietary patterns were beneficial, especially for participants with sarcopenia, while handgrip strength and walking speed potentially mediated the associations. Full article

Metabolic syndrome (MetS) is a global public health challenge, characterized by the coexistence of cardiometabolic risk factors such as abdominal obesity, dyslipidaemia, hypertension, and insulin resistance. Non-pharmacological strategies, including the Mediterranean diet (MD) and physical activity (PA), have been widely studied for their potential to prevent and manage MetS. This systematic review aimed to synthesize the evidence on the combined effect of MD and PA on MetS components in adults, based on randomized controlled trials (RCTs). Twenty-two RCTs published between 2018 and 2024 were included, involving 11,478 participants. The interventions ranged from 8 weeks to 3 years and combined adapted or hypocaloric MDs with moderate-to-high-intensity PA, typically including walking, aerobic exercise, or high-intensity interval training (HIIT), performed 3 to 7 times per week. The combined interventions resulted in reductions in body weight (−2.5 to −7.2 kg), body mass index (−0.7 to −2.2 kg/m²), waist circumference (−5.1 to −7.8 cm), and blood pressure (up to −9.0 mmHg systolic and −6.7 mmHg diastolic). Improvements in HDL cholesterol, triglyceride levels, and insulin sensitivity were also observed. These findings suggest that integrated interventions based on the Mediterranean lifestyle are effective in reducing MetS components and may support future public health strategies. Full article

Total knee arthroplasty (TKA) is a commonly conducted surgery to relieve pain and enhance mobility in patients with end-stage knee osteoarthritis. Patient-reported outcome measures are often used whereas biomechanical variables are too complicated for clinicians and patients to assess functional improvement. There is a need for a simplified integrated knee biomechanics index (KBI) to compare improvements in TKA patients across various daily activities and examine the relationships between clinical functional tests and daily activities. Age-, gender-, and BMI-matched three groups (20 each in posterior stabilized TKA, bi-cruciate stabilized TKA, and healthy controls) were recruited and tested pre-op and 6-month post-op to perform walking on level, slope, and stairs, and two clinical tests (timed-up-go, 10-time sit-to-stand). Knee joint kinematics and kinetics variables were calculated from motion data and ground reactions captured at 120 Hz and 1200 Hz, respectively. KBI was developed based on these variables relative to healthy controls. The longitude comparison of KBI and the differences of KBI across various daily activities were identified using repeated-measure ANOVA. Pearson correlation analysis was used to compare clinical tests and KBI of daily activities. KBIs of five daily activities were significantly increased following TKA follow-up. KBI improvement during level walking was significantly higher than those during stair ascending and descending. Significant correlations were found between timed-up-go test time and KBIs for stair ascending and descending. Full article

Motor skills in students can be developed or improved through regular physical activity such as walking in nature, Nordic walking, hiking, cycling and swimming. This study aimed to examine the relationship between motor skills and various anthropometric and health-related factors, and to appraise any differences in motor performance and body mass index (BMI) on a sample of university students from Croatia. A total of 122 students (73 of them in health programs and 49 in non-health programs) aged 18 to 44 years participated in the study. Motor abilities were evaluated using standardized motor tests, while body composition was assessed via bioelectrical impedance analysis, which measured fat tissue, muscle and bone mass, metabolic age, degree of obesity, total body water, and BMI. While the groups were similar in terms of BMI and weight, students in non-health-related study programs had significantly higher values across a wide array of detailed body composition measures, particularly related to fat and muscle mass. Significant negative correlations were observed between body fat percentage and trunk lift performance (r = −0.55, p < 0.01), as well as between metabolic age and trunk lift performance (r = −0.44, p < 0.01) in health students. In non-health students, the strongest negative correlation was found between body fat percentage and flexibility (r = −0.47, p < 0.01). Higher muscle mass was a positive predictor of motor performance while higher fat mass and metabolic age were significant negative predictors. These findings underscore the impact of body composition on motor performance, particularly strength and flexibility, and highlight the need for targeted preventive strategies among university students. The study supports the implementation of early interventions promoting physical activity and healthy body composition to preserve motor abilities and long-term functional health in this critical age group—especially since lifestyle habits formed during university years tend to persist into adulthood. Full article

Background: Childhood overweight and obesity are increasing public health concerns globally, with a high prevalence in Chile, particularly in rural areas. Excess weight may impair physical fitness, affecting children’s overall health and development. Objectives: This study aimed to compare the physical fitness of schoolchildren with normal weight (NW) and overweight/obesity (OW/OB) from a rural school in Maule, Chile. Methods: A total of 87 students (boys and girls, aged 9–14 years) were evaluated and classified into NW and OW/OB groups based on their body mass index. Physical fitness was assessed using the 6 min walk test (6MWT) for cardiovascular endurance, handgrip strength (HGS) and squat jump (SJ) for muscular strength, 20 m sprint for speed, and 4 × 10 m shuttle run for agility. Results: Significant differences were found between groups in most physical fitness components. The NW group covered 11.13% more distance in the 6MWT than the OW/OB group (p < 0.001; d = 1.28). NW children also performed better in the 20 m sprint (p = 0.023; d = 1.02) and the 4 × 10 m shuttle run (p < 0.001; d = 0.72). SJ was higher in the NW group (p = 0.004; d = 0.45). No significant differences were found in HGS (p = 0.893; d = 0.01). Conclusions: Children with normal weight demonstrated better physical fitness compared to their overweight or obese peers. These findings support the need for targeted strategies to prevent overweight and obesity in rural schoolchildren to improve physical health and functional capacities. Full article

Eggshell membrane (ESM) is composed of approximately 90% protein. Our previous studies in healthy adults demonstrated that two months of daily ESM intake improved respiratory function, zigzag walking speed, and skin elasticity. The present study aims to address the knowledge gap regarding the in vivo effects of ESM in the context of inflammatory bowel disease (IBD). Proteomic analysis was performed on powdered ESM used as a dietary supplement. To investigate its pharmacokinetics in mice, tritium (³H)-labeled ESM was prepared using the ⁶Li(n,α)³H nuclear reaction. The therapeutic potential of ESM was further examined in a 2.0% dextran sulfate sodium (DSS)-induced murine model of IBD. In addition, fecal samples from both mice and healthy human subjects were analyzed using a modified terminal restriction fragment length polymorphism (T-RFLP) method. Lysozyme C (LYZ) was the most abundant protein (47%), followed by lysyl oxidase (12%) in ESM used in this study. ³H-ESM was mixed with MediGel, and orally administered to mice. Radioactivity levels were measured in blood, organs (duodenum, small intestine, large intestine, liver, kidney, lung, skin), and rectal feces at 0.5, 2, 5, 24, 48, and 72 h post-administration. Radioactivity in feces indicated excretion of undigested components, while systemic distribution suggested potential whole-body effects of ESM. Oral ESM and LYZ significantly alleviated body weight loss, diarrhea, and hematochezia in a DSS-induced murine model of IBD, leading to a significantly lower disease activity index on day 3 and showing a similar trend on day 5. Gut microbiota analysis showed increased Bacteroidales in the DSS group, while the ESM + DSS group maintained levels similar to the control. In humans, a double-blind, randomized controlled trial was conducted to evaluate the effects of ESM on gut microbiota in healthy adults. Participants received either ESM or placebo for 8 weeks. revealed a significant increase in alpha diversity at weeks 1 and 8 in the ESM group (p < 0.05), with between-group differences evident from week 1 (p < 0.01). ESM intake reduced Bacteroides and significantly increased Bifidobacterium and Lactobacillales at weeks 4 and 8. These findings suggest ESM supplementation promotes beneficial modulation of gut microbiota. These findings suggest that ESM, through its major protein components such as LYZ, may serve as a promising dietary intervention for maintaining intestinal health and mitigating inflammation in the context of IBD. Full article

Background and Objectives: This systematic review and meta-analysis aimed to analyze the available body of published peer-reviewed randomized controlled trials (RCTs) on the effects of concurrent training (CT) on biomarkers, morphological variables, and physical performance in people with sarcopenic obesity. Materials and Methods: Using six databases—PubMed, Medline, CINAHL Complete, Scopus, Cochrane Library, and Web of Science—a comprehensive literature search was conducted through July 2025. The GRADE, TESTEX, Rob 2, and PRISMA tools were used to assess the methodological quality and certainty. The protocol was registered in PROSPERO (CRD420251052935). Results: Out of 669 records, 8 RCTs with a total of 453 participants (68.9 ± 11.1 years) were included. Fifteen overall and three subgroup meta-analyses revealed significant improvements (p < 0.05) in insulin-like growth factor-1 (ES = 1.01, 95% CI = 0.26 to 1.75, p = 0.008) and leptin (ES = 2.54, 95% CI = 0.07 to 5.01, p = 0.04) levels; significant decreases (p < 0.05) in body mass index (ES = 0.54, 95% CI = 0.12 to 0.97, p = 0.01), waist circumference (ES = 1.80, 95% CI = 0.32 to 2.12, p = 0.008), and body fat (BF, ES = 1.31, 95% CI = 0.53 to 2.09, p = 0.001); and significantly increased (p < 0.05) appendicular skeletal muscle mass/weight (ES = 0.42, 95% CI = 0.14 to 0.71, p = 0.004), walking speed (ES = 1.80, 95% CI = 1.05 to 2.55, p = 0.000), and knee extension (ES = 0.76, 95% CI = 0.09 to 1.42, p = 0.02). However, no significant improvements (p > 0.05) were observed in IL-6, CRP, total cholesterol, triglycerides, trunk fat, BF mass, and MIHS. On the other hand, an important result in the meta-regression revealed that weeks of training can predict decreases in BF (R² = 0.32; p = 0.02). Conclusions: CT has been associated with significant clinical improvements in biomarkers related to increased muscle mass and decreased BF percentage. Full article

Background/Objectives: Juvenile localized scleroderma (jLoS) is a chronic inflammatory disorder with skin and subcutaneous tissue involvement. Microvascular alterations are thought to contribute to its pathogenesis. This study aimed to investigate microvascular alterations in children with jLoS using nailfold capillaroscopy (NFC) and to compare the capillaroscopic findings between patients and healthy controls. Methods: A total of 13 children diagnosed with jLoS and 16 age- and sex-matched healthy controls were enrolled. Capillaroscopic assessment included capillary density, tortuosity, dilatation, disorganization, branching, and neoangiogenesis. Dilated and giant capillaries, hemorrhages, avascular areas, and capillary loss were evaluated. The Microangiopathy Evaluation Score (MES) was used to semi-quantitatively assess capillary loss, disorganization, and ramifications. Disease activity and damage were evaluated using the modified Localized Scleroderma Skin Severity Index (mLoSSI) and the Localized Scleroderma Damage Index (LoSDI), respectively. Functional status was measured via the 6 min walk test (6MWT). Results: Plaque morphea was the most common subtype (61.5%), and antinuclear antibody (ANA) positivity was present in 53.8% of patients. Compared to controls, jLoS patients exhibited significantly more frequent capillaroscopic abnormalities, including increased tortuosity, crossing, dilatation, and neoangiogenesis (p < 0.05). Capillary density, length, arterial limb width, apical loop width, and disorganization scores were significantly higher, while intercapillary distance was lower in jLoS patients (p < 0.05). No avascular areas or giant capillaries were observed. MESs were similar between groups. Conclusions: NFC revealed significant microvascular alterations in jLoS patients, supporting its utility as a non-invasive tool for early vascular assessment in localized scleroderma. Full article

Background/Objectives: Overcoming resistance to diuretics is extremely important in decompensated chronic heart failure (HF). The objective of this study was to assess the efficacy and safety of oral acetazolamide, in addition to standard therapy, in HF patients admitted to the hospital with decompensation requiring intravenous loop diuretic therapy. Methods: In this open-label, prospective, multicenter, randomized trial, we included 416 patients hospitalized with decompensated HF. The patients were randomized into two groups: (1) standard therapy, and (2) standard therapy + acetazolamide orally 250 mg 3 times a day in the first 3 days of hospitalization. At randomization, oral thiazide/thiazide-like and loop diuretics were stopped, and intravenous furosemide was initiated. Results: Successful decongestion within 72 h of randomization was observed in 82 patients (39.6%) in the acetazolamide group and in 83 patients (39.7%) in the standard therapy group (p = 0.983). There was a significant difference in the increase in diuresis in the first 72 h (p = 0.028) and in natriuresis on the 2nd day (p = 0.04). There were no differences between the groups in duration of stay in the intensive care unit, duration of index hospitalization, 6 min walk test distance, and clinical assessment scale scores. Death from any cause occurred in three (1.4%) patients in the acetazolamide group, and in the same number of patients in the standard therapy group (p = 0.996). Death from cardiovascular cause and due to decompensated HF also did not differ between the groups during follow-up. Conclusions: The addition of acetazolamide to standard therapy in decompensated chronic HF resulted in a higher cumulative urine output during the first 72 h and natriuresis on the 2nd day after randomization. Full article

Autonomic dysfunction is a key non-motor feature of Parkinson’s disease (PD) and may influence motor performance, particularly gait. While heart rate variability (HRV) has been associated with freezing of gait, its relationship with broader gait parameters remains unclear. The objective was to investigate correlations between resting-state HRV time-domain measures and spatiotemporal gait parameters during comfortable and fast walking in patients with idiopathic PD. Twenty-eight PD patients (mean age 68 ± 9 years) were evaluated at Campus Bio-Medico University Hospital. HRV was recorded at rest using the e-Sense pule™ portable sensor, including the Baevsky’s Stress Index a measure increasing with sympathetic burden. Gait parameters were assessed via the 10 m Timed Up and Go (TUG) test using the Mon4t™ smartphone app at comfortable and fast pace. Clinical data included UPDRS III, MoCA, and disease characteristics. Gait metrics significantly changed between walking conditions. HRV parameters clustered separately from gait metrics but intersected with significant correlations. Higher Stress Index values, reflecting sympathetic dominance, were associated with poorer gait performance, including prolonged transition times, shorter steps, and increased variability (p < 0.001, r = 0.57–0.61). MoCA scores inversely correlated with the Stress Index (r = −0.52, p = 0.004), linking cognitive and autonomic status. UPDRS III and MoCA were related to TUG metrics but not HRV. Time-domain HRV measures, particularly the Stress Index, are significantly associated with spatiotemporal gait features in PD, independent of gait speed. These findings suggest that impaired autonomic regulation contributes to functional mobility deficits in PD and supports the role of HRV as a biomarker in motor assessment. Full article

Enhancing the vitality of historic districts is a key challenge in China’s urban regeneration. This study takes Shanghai’s Zhangyuan Historic District as a case, constructing a framework with six spatial indicators—width-to-height ratio (W/H), interface transparency, connectivity, integration, Universal Thermal Climate Index (UTCI), and mean radiant temperature (MRT)—across spatial morphology, path accessibility, and thermal comfort. Using Grey Relational Analysis, the study quantitatively examines how these factors affect spatial vitality and pedestrian behavior. Findings indicate that, overall, W/H and connectivity are the primary drivers of vitality in plazas and alleys, while thermal comfort (MRT, UTCI) strongly affects stationary behaviors. By typology, plazas exhibit the strongest association with interface transparency (grey relational grade = 0.870), demonstrating that open sightlines and permeable interfaces promote pedestrian flow and staying. North–south alleys show pronounced associations with thermal comfort (MRT = 0.918; UTCI = 0.874), suggesting microclimate-friendly environments can substantially enhance vitality in linear walking spaces. East–west alleys are dominated by connectivity (0.831) and W/H (0.849), whereas integration shows a low grade (0.512), revealing weaker configurational coherence for this spatial type. At the micro-scale, connectivity outperforms integration in predicting pedestrian route choices, reflecting actual movement preferences. The study highlights the combined effects of multidimensional built environment factors and provides a scientific basis for targeted spatial optimization, sustainable renewal, and vitality-oriented design in historic urban areas. Full article

Postural stability is influenced by several anthropometric factors as well as age. The aim of this study was to investigate the relationship between body height, body mass, BMI, and arch index with stabilometric parameters in physically active young adults. A total of 169 sport science university students participated in the study. Their arch index and their stabilometric parameters were measured using the P-Walk BTS platform. Spearman’s rank correlations showed a significant positive correlation between body mass and arch index (r = 0.25, p = 0.001), and BMI and arch index (r = 0.30, p < 0.001). Also, negative correlations were observed between body height and CoP speed (r = −0.22, p = 0.004) and CoP distance (r = −0.23, p = 0.003), as well as body weight and CoP speed (r = −0.17, p = 0.028) and CoP distance (r = −0.19, p = 0.015). Age was negatively correlated to postural sway variables (i.e., CoP distance, CoP area, and CoP speed). The findings suggest that, in physically active people, larger anthropometric values may confer stabilizing advantages, potentially due to increased body volume. Also, the significant correlation of age to stability metrics may highlight enhanced proprioceptive integration or adaptive neural mechanisms. The results highlight the importance of individualised proprioceptive training programmes, particularly for athletes of lower body mass or stature. Future research should extend on the results’ potential training and rehabilitative implications. Full article

Gyrification, the folding of the cerebral cortex, plays a crucial role in brain development and function. Perinatal hypoxia–ischemia (HI) is a leading cause of neonatal brain injury, affecting cortical folding that can be measured by the gyrification index (GI). Using a late-preterm ferret model, our objective was to explore the relationships between HI injury, GI changes, and behavior, as well as the potential moderating effects of sex and treatment. Animals received 3 mg/kg E. coli lipopolysaccharide and underwent bilateral carotid artery ligation followed by alternating hypoxia and hyperoxia (HIH) and were randomized to saline vehicle (n = 25), erythropoietin (n = 20), therapeutic hypothermia (6 h at 33.5 °C, n = 20), and uridine monophosphate (n = 6), with n = 20 unexposed littermates serving as controls. Early reflex testing, CatWalk gait analysis, open-field behavior, and an open-water swim test were performed. Average, peak, motor, and somatosensory strip GIs were then assessed using ex vivo MRI. In control animals, males had lower GI than females; however, HIH exposure resulted in male GI being more similar to females, where HIH animals had significantly higher average GI than controls (p = 0.02). Adjusting for brain volume and injury, GIs in motor and somatosensory areas were associated with faster reflex outcomes in males but not females. In female controls, motor and somatosensory GIs were associated with increased anxiety-like behaviors, such as spending less time in open water during the swim test. By comparison, in male controls, higher GI was associated with decreased anxiety-like behaviors, including higher exploration index in the swim test. These sex-specific relationships between GI and behavior were lost with HIH injury. Treatment did not meaningfully restore the relationship between GI and behavior after HIH, but targeting this outcome may be an important measure for use in future neuroprotection studies in the ferret. Full article

Background: Exercise is known to help with the effects of the menopause, but women from low socioeconomic status (SES) tend to exercise less at this stage of life. Therefore, this study aimed to investigate the physical and psychological effects of a Zumba Gold^® community-based intervention in postmenopausal women from low SES. Methods: Forty-three women were divided into a Zumba Gold^® (ZG) and control (C) group, and participated in pre- and post-testing sessions, separated by a 12-week intervention period. The outcomes measured were: body composition, sit-to-stand (STS), six-minute walk test (6MWT), balance, Short Form Health Survey (SF-12), Multidimensional Fatigue Index (MFI-20), Self-Efficacy for Exercise (SEE), Behavioral Regulations in Exercise (BREQ-2), Hospital Anxiety and Depression Scale (HADS), and Social Connectedness questionnaires. Semi-structured interviews were also performed on 15 ZG participants. Results: The results showed significant improvements in the ZG group only for STS, 6MWT, mental health, fatigue (general, physical, and mental), social connectedness score, and a significantly lower level of amotivation. Zumba Gold^® had positive effects on four main themes: belonging, non-judgmental place, psychological motivational factors, and mind–body connection. Conclusions:This is the first study to show that ZG is beneficial for this population and encourages similar studies on other aspects of the menopause. Full article