Search Results (10,386)

This work is designed to assist researchers and interested learners in comprehending and putting deep machine learning classification approaches into practice. It aimed to simplify, facilitate, and advance classification methodology skills. To make it easier for the users to understand, it employed a methodical approach. The categorization assessment measures seek to give the fundamentals of these measures and demonstrate how they operate to function as a comprehensive resource for academics interested in this area. Intrusion detection and threat analysis (IDAT) is a particularly unpleasant cybersecurity issue. In this study, IDAT is identified as a case study, and a real-sample dataset that was used for institutional and community awareness was generated by the researchers. This review shows that, to solve a classification problem, it is crucial to use the output of classification in terms of performance measurements, encompassing both conventional criteria and contemporary metrics. This study focused on addressing the dynamic of classification assessment capabilities for using both scalars and visual metrics, and to fix imbalanced dataset difficulties. In conclusion, this review is a useful tool for researchers, especially when they are working on big data preprocessing, handling imbalanced data for multiclass assessment, and ML classification. Full article

In safety-critical systems like nuclear power plants, the rapid and accurate perception of visual interface information is vital. This study investigates the relationship between visual attention dispersion measured via heatmap entropy (as a specific measure of gaze entropy) and response time during information search tasks. Sixteen participants viewed a prototype of an accident response support system and answered questions at three difficulty levels while their eye movements were tracked using Tobii Pro Glasses 2. Results showed a significant positive correlation (r = 0.595, p < 0.01) between heatmap entropy and response time, indicating that more dispersed attention leads to longer task completion times. This pattern held consistently across all difficulty levels. These findings suggest that heatmap entropy is a useful metric for evaluating user attention strategies and can inform interface usability assessments in high-stakes environments. Full article

Background: Fractures of the first and second cervical vertebrae are common in both young and elderly patients. Surgical management of C1–C2 fractures in elderly patients is controversial. The aim of this study is to report the rate of fusion in elderly patients who underwent surgery for C1 or C2 fractures. Methods: A retrospective review of all patients over the age of 65 years old who underwent surgical treatment for C1 or C2 fracture was reported. Visual analog scale (VAS) and neck disability index (NDI) were used to assess patients’ clinical outcome at 1 year follow-up. Cervical spine computer tomography (CT) scans were performed in all cases before surgery and at 1 year follow-up to evaluate the long-term postoperative rate of fusion, according to Lenke fusion grade. Results: From 2019 to 2023, 105 patients with cervical craniocervical junction (CCJ) fracture underwent surgical treatment in our Pisana University Hospital. Among all these, 74 patients (70.5%) were over 65 years old. The mean age of the study population was 76.9 years old (12.2% aged 65–70, 51.4% aged 70–79, and 36.5% over 80). According to the AO Spine Upper Cervical Injury Classification System, 6 (8.1%) patients presented a type II fracture and 68 (91.9%) patients presented a type III fracture. At admission, neurological examination resulted in American Spinal Injury Association (ASIA) E in 97.3% of cases. Over 60% of all patients underwent C1–C2 posterior fixation. Postoperative complications occurred in 12.25% of patients. According to the criteria described by Lenke, a good rate of fusion (A-B grade) was obtained in 71.6% of patients. Conclusions: In elderly patients with CCJ fractures, precision medicine can help identify those at higher risk for complications and guide personalized treatment strategies. Surgical treatment of CCJ fractures in elderly patients, although not always associated with bone fusion, can be performed with an acceptable incidence of mortality and morbidity, allowing rapid mobilization and return to pre-trauma levels of independence. Full article

Background/Objectives: The aim of this study was to evaluate the correlation between the visual curve (ViC) and Area of the Curve (AoC) indices and the subjective perception of vision-related quality of life in patients who had undergone pseudophakic presbyopia correction. The central hypothesis was that AoC indices would show stronger correlations with vision-specific quality-of-life measures than single-point visual acuity (VA) assessments. Methods: A total of 100 patients who underwent bilateral pseudophakic presbyopia correction at the University Hospital of Alexandroupolis, Greece, were included in the study. Six months following surgery, visual acuity was assessed at nine distances using the DDART tool. The AoC was calculated using VA data from four, five, six, and nine distances, and further categorized into Near Vision AoC (AoCN) and Distance Vision AoC (AoCD). Participants also completed the NEI-VFQ-25 questionnaire to evaluate their subjective vision-related quality of life. Results: Statistically significant correlations were observed between AoC values and NEI-VFQ-25 total scores (r = 0.668–0.682, p < 0.001), near activity subscale scores (r = 0.656–0.686, p < 0.001), and distance activity subscale scores (r = 0.733–0.758, p < 0.001). In all analyses, the AoC indices derived from ViC demonstrated stronger correlations with quality-of-life scores than those observed with AoC-derived DCT and single VA measurements, even when the AoC was computed using only four measurement points. Conclusions: The AoC metric is a superior indicator of vision-specific quality of life compared to isolated VA measurements. AoC effectively captures the multifaceted nature of functional vision following presbyopia correction. Full article

In South Korea, sunlight rights and daylight rights are legally distinguished, yet no standardized methodology exists for their quantitative assessment. Current evaluations of sunlight rights are narrowly defined, relying on the duration of direct solar penetration at the window center during the winter solstice, while excluding reflected and diffuse light. This restrictive approach has led to confusion among both researchers and legal practitioners, as it diverges from daylighting evaluations that account for indoor brightness and energy performance. The recent enactment of regulations to secure solar access in schools has further intensified disputes between educational institutions striving to protect students’ visual comfort and developers seeking to maximize building potential. To address this gap, this study proposes an evaluation framework tailored to the Korean context. A reference classroom model representative of standard Korean schools was developed, and simulations were conducted by introducing obstructing building masses to block direct sunlight. The methodology evaluated key variables, including time of day and solar altitude, and analyzed daylighting performance and lighting-related energy consumption under obstructed conditions. The results show that blocking sunlight through south-facing windows reduces daylighting performance by 89% to 98%, leading to additional reliance on artificial lighting, with energy use increasing between 128 Wh and 768 Wh. These findings underscore the limitations of current legal interpretations based solely on sunlight duration and highlight the necessity of adopting performance-based evaluation methods. Protecting school sunlight rights through such approaches is essential to enhancing classroom visual environments and reducing energy demand. Full article

The construction and maintenance of ecological corridors not only facilitate species migration and gene flow but also enhance ecosystem stability and resilience, providing critical support for achieving global carbon neutrality goals. Despite their importance, research on urban ecological corridors—specifically their role in carbon sequestration and emission reduction within urban environments—remains insufficiently explored. To address this gap, we employed bibliometric and network analysis methods, utilizing the CiteSpace6.3.1 visualization tool to systematically review existing literature from the Web of Science Core Collection database. This study examines the research progress and trends in urban ecological corridors from 2000 to 2023, focusing on their role and significance in the context of global carbon neutrality. The findings reveal the following: (1) Research attention has grown steadily from 2000 to 2023, with climate change, carbon emission dynamics, and biodiversity emerging as core themes, reflecting increasing global focus on the carbon neutrality functions of urban ecological corridors. (2) CiteSpace analysis identified key research hotspots through keywords including climate change, carbon cycle, ecosystem services, model simulation, and ecological network analysis, revealing the functional mechanisms and pathways of urban ecological corridors in carbon neutrality contexts. (3) Current scientific challenges focus on understanding three core aspects of urban ecological corridors, the compositional elements, spatial structural design, and functional capacity assessment, requiring systematic theoretical breakthroughs. (4) Future research should prioritize exploring mechanisms to enhance urban ecological corridor functions and constructing low-carbon urban ecological networks, providing theoretical guidance and practical pathways for achieving urban emission reduction and climate goals. This study contributes to integrating research on the effectiveness of urban ecological corridors and carbon sinks, offering theoretical insights and practical guidance for reducing urban emissions and achieving climate goals. Full article

Background/Objectives: High-frequency ultrasonography (HFUS) has gained increasing attention in dermatology as a non-invasive imaging technique capable of visualizing cutaneous structures with high resolution. In cutaneous T-cell lymphomas (CTCL), including mycosis fungoides (MF)/Sézary syndrome (SS), HFUS may provide an objective method for assessing disease activity and monitoring treatment response. This study aimed to evaluate the clinical utility of HFUS in detecting therapy-induced changes in subepidermal low-echogenic band (SLEB) thickness. Methods: We conducted a prospective, single-center study between May 2021 and May 2025. Thirty-three patients with histologically confirmed MF (n = 31) or SS (n = 2) underwent HFUS at baseline and after 4–8 weeks of treatment. SLEB thickness was measured before (E1) and after early treatment (E2). Patients received systemic agents, phototherapy, or topical regimens. Statistical analysis included mixed-model ANOVA with repeated measures to assess SLEB changes, and post hoc tests were applied to explore the influence of therapy type, age, and gender. Results: Among 31 evaluable patients with MF, HFUS revealed a significant reduction in SLEB thickness after treatment (0.90 ± 1.10 mm vs. 0.69 ± 0.89 mm; F(1,29) = 8.88, p = 0.006, η² = 0.23). The type of early therapy (systemic vs. topical) did not significantly affect outcomes (p = 0.452). Age emerged as a relevant factor: patients ≥ 66 years exhibited higher baseline SLEB values and a significant reduction post-treatment (p < 0.001), whereas no comparable effect was observed in younger patients. Gender did not significantly influence SLEB changes. Conclusions: HFUS is a sensitive and clinically applicable imaging tool for monitoring treatment response in MF/SS. Reductions in SLEB thickness were observed across therapeutic modalities and aligned with early clinical improvement. HFUS may serve as a valuable adjunct to standard clinical and histopathological evaluation in the routine management of MF/SS. Full article

Background: Amlodipine besylate (AML) is recognized as a calcium channel blocker curative for hypertension. However, the drug emerged recently as an antibacterial cure that competently prevails over resistant strains. Methods: Incorporating amlodipine into zein nanoparticles was employed to innovate a suitable carrier for loading and targeting deep corneal infection. The Box–Behnken design was adopted to produce various formulations of amlodipine-loaded zein nanoparticles (AML-ZNs) with diversity in composition concentration (% w/v), comprising zein, Labrafac, and poloxamer 407. Results: Relying on the optimization criterion, the chosen preference formulation concentration (% w/v) consists of 2.068 for zein, 0.75 for Labrafac, and 1.0 for Poloxamer. Morphological micrography of AML-ZNs showed regular spherical particles in the nanometric scale, and physicochemical characterization procedures confirmed system suitability. While tracking eyedrop optimum features, sodium alginate was selected for coating nanoparticles to improve stability and system viscosity. Both pH and sterility were also considered and maintained. Comparative studies were conducted pre- and post-coating, and the assessed features for the final selected formulation were 349.9 ± 5.8 nm, 0.2186 ± 0.0271, −55.45 ± 1.84 mV, 81.293 ± 0.9%, and 19.3 ± 0.19 cp for size, PDI, surface charge, entrapment, and viscosity, respectively. The AML-ZNs-Alg formulation demonstrates a more controlled pattern of release of roughly 40% of the drug released after 48 h, while the permeation profile shows 37 ± 3.52% permeated after 24 h, confirmed visually. In vitro microbial assay alongside the corneal in vivo microbial and histological pathology evaluation proved the efficacy of amlodipine as an antibacterial agent. Conclusions: These findings highlighted that the prepared AML-ZNs-Alg eyedrop can be a promising system as an antibacterial therapy. Full article

This paper introduces Contextual Object Grouping (COG), a specific computer vision framework that enables automatic interpretation of technical security diagrams through dynamic legend learning for intelligent sensing applications. Unlike traditional object detection approaches that rely on post-processing heuristics to establish relationships between the detected elements, COG embeds contextual understanding directly into the detection process by treating spatially and functionally related objects as unified semantic entities. We demonstrate this approach in the context of Cyber-Physical Security Systems (CPPS) assessment, where the same symbol may represent different security devices across different designers and projects. Our proof-of-concept implementation using YOLOv8 achieves robust detection of legend components (mAP50 ≈ 0.99, mAP50–95 ≈ 0.81) and successfully establishes symbol–label relationships for automated security asset identification. The framework introduces a new ontological class—the contextual COG class that bridges atomic object detection and semantic interpretation, enabling intelligent sensing systems to perceive context rather than infer it through post-processing reasoning. This proof-of-concept appears to validate the COG hypothesis and suggests new research directions for structured visual understanding in smart sensing environments, with applications potentially extending to building automation and cyber-physical security assessment. Full article

This paper presents the design, development, and preliminary validation of a haptic virtual reality simulator for Shielded Metal Arc Welding (SMAW) at the Pontificia Universidad Católica de Valparaíso, Chile, aimed at enhancing psychomotor training for mechanical engineering students in line with Industry 4.0 demands. The system integrates Unity 3D, a commercial haptic device, and a custom 3D-printed electrode holder replicating the welding booth, enabling interaction through visual, auditory, and tactile feedback. Thirty students with minimal welding experience and seven experts participated in usability and realism assessments. The results showed that 80% of students perceived motor skill improvement, 60% rated realism as adequate, and 90% preferred hybrid training (simulator + workshop). The prototype was practically implemented at the mechanical engineering school, requiring only a mid-range workstation, the Touch haptic device, and the developed software, demonstrating feasibility in real academic settings. The findings indicate potential to build confidence, support motor coordination, and provide a safe, resource-efficient training environment, while experts emphasized the need for automated feedback and improved haptic fidelity. The modular architecture allows scalability, extension to other welding processes, and adaptation for inclusive education. This prototype demonstrates how locally developed immersive technologies can modernize technical education while promoting sustainability, accessibility, and skill readiness. Full article

Hyaluronic acid (HA) fillers and botulinum toxin remain among the most frequently requested non-surgical esthetic procedures, due to their favorable safety profile and ability to restore volume and improve skin quality. However, variability in product performance and the lack of objective measurement tools remain challenges in clinical practice. This prospective, single-arm, non-randomized pilot study aimed to assess the esthetic efficacy, tolerability, and duration of effect of Sofiderm^® HA fillers in Caucasian patients with signs of facial aging, and to explore the correlation between subjective visual grading and instrumental imaging outcomes. Five patients with Griffiths photoaging scores ranging from 4 to 8 were treated with different Sofiderm^® formulations. Standardized evaluations were performed at baseline, 2 months, and 9 months using VISIA-CR and PRIMOS 3D optical profilometry. All subjects experienced measurable improvements, with an average 2-point reduction in Griffiths scores at 2 months, maintained at 9 months in most cases. Objective imaging data confirmed enhancements in volume, texture, and surface regularity. No serious adverse events occurred. These findings suggest that Sofiderm^® fillers may offer sustained esthetic benefits with a favorable safety profile and demonstrate how integrated digital imaging can enhance treatment evaluation in esthetic dermatology. Full article

Background/Objectives: In oral and maxillofacial surgery, apicoectomy is a standard procedure for treating persistent periapical infections after insufficient conservative treatment. Traditional techniques rely on direct visualization, while navigated methods offer advantages in precision and safety. This in vitro study compared conventional apicoectomy with dynamically guided navigation. The aim was to assess the feasibility, accuracy, and safety of dynamic navigation and to determine whether it reduces complication risks, improves surgical predictability, and minimizes bone loss. Methods: Ten experienced surgeons performed both techniques on custom-designed models. Operation time was assessed, as well as cavity volume, resected root length, incision width and height, and preservation of adjacent structures. Results: The navigated approach demonstrated significantly improved accuracy in root-end resection, with a reduction in access cavity volume (p < 0.001). No significant differences were found in operation time (p = 0.499), resection length (p = 0.054), or incision dimensions (p > 0.05). The risk of damaging adjacent structures was not significantly different between the two methods. Conclusions: Dynamic navigation for apicoectomy can offer an alternative in cases requiring high precision to conventional techniques. However, the routine clinical implementation of dynamic navigation remains limited due to the extensive preoperative planning required. The necessity for additional planning increases complexity, time, and cost. Full article

Nannorrhops ritchieana (Mazri) forests are found in Pakistan, Afghanistan, Iran, and Oman. These forests are ecologically and economically important to local communities and exhibit complex spatial distributions. This research examines the distribution of Mazri forests and their responses to varying phosphorus levels across different climatic zones. We collected data from 508 plots in the Khyber Pakhtunkhwa region of Pakistan, gathering 500 g of soil from each plot for phosphorus analysis, along with measurements of abundance and various traits. A distribution map was constructed to assess the impact of phosphorus levels on Mazri forest distribution and traits across climatic zones. Using a PCA biplot, we visualized the abundance and density and studied the effects of different climatic and environmental factors. Our findings suggest that phosphorus levels do not significantly influence the distribution of Mazri forests, which vary across different climatic regions. Forests are stable in the eastern wet mountain zone (EWMZ) and northern dry mountain zone (NDMZ), although without a significant pattern. A weak positive correlation was observed in the western dry mountain zone (WDMZ). In contrast, the Sulaiman piedmont zone (SPMZ) presented minor variations in abundance, indicating that phosphorus, in conjunction with other edaphic and climatic factors, affects Mazri forest distribution and abundance. Further research is needed to investigate the combined effects of various soil nutrients and climatic factors on the distribution, abundance, and functional traits of Mazri forests across different regions. Full article

Background/Objectives: Transurethral incision (TUI) is a common procedure for posterior urethral valves (PUV). However, no standardized method has been established to assess its efficacy intraoperatively. In this study, we aimed to develop and evaluate a real-time ultrasound-guided TUI (RUG-TUI) technique. Methods: A single-center, retrospective feasibility study with a cohort design was conducted using historical controls to compare RUG-TUI with standard TUI in children with PUV. Data from patients who underwent RUG-TUI for PUV between April 2021 and July 2022 or TUI without real-time ultrasound guidance between August 2020 and March 2021 (control group) were retrospectively reviewed. A transperineal linear probe provided longitudinal imaging. The diameters of the constricted (C) and expanded (E) portions of the urethra before and after the procedure were measured, and the E/C ratio was calculated. The primary outcome was the duration of postoperative gross hematuria, and the secondary outcomes included changes in the urethral diameter ratio (E/C ratio), intraoperative complications, and residual obstruction on VCUG. Results: The mean duration of post-procedure macroscopic hematuria was significantly shorter in the RUG-TUI group than in the control group (p = 0.049). No massive intraoperative bleeding or sphincter damage occurred. In the RUG-TUI group, the mean diameters of the constricted segment before and after the procedure were 3.0 (±1.0) and 5.7 (±1.2) mm, respectively, while the pre- and postoperative E/C ratios were 1.8 (±0.5) and 0.9 (±0.1), respectively (p < 0.0001). Conclusions: RUG-TUI for PUV enabled visualization of the longitudinal axis of the urethra, allowing assessment of the anatomical relationship between the stenosis and external urethral sphincter. In this retrospective feasibility cohort, RUG-TUI was associated with a shorter duration of postoperative gross hematuria. These exploratory findings suggest that RUG-TUI may support intraoperative evaluation of procedural adequacy. Full article

Cell spheroids are widely studied for their potential applications in tissue engineering and regenerative medicine. The present work investigated the effects of cryopreservation on spheroids derived from ovine fibroblasts, depending on spheroid size (140 or 220 µm). Specifically, it explored how cryopreservation impacted several biological and physical parameters including cell damage, viability, metabolism, adhesion, proliferation, and spheroid mass density, weight, and diameter at three time points after thawing. A Live/Dead assay provided a visual assessment of cell damage, cell viability and metabolic activity were assessed by an Alamar Blue assay, and a replating assay evaluated cell adhesion and proliferation capabilities. Spheroid mass density, weight, and diameter were quantified by the W8 Biophysical Analyzer, creating accurate biophysical profiles. Real-time PCR (RT-PCR) analysis was employed to uncover gene expression changes following cryopreservation. Our findings indicate that spheroids measuring 140 µm in diameter largely maintained their biophysical features and cell viability post-cryopreservation, whereas those at 220 µm exhibited a decline in both vitality and mass density. The reduced vitality of 220 µm spheroids likely reflects size-related limitations in cryoprotectant diffusion and stress within the core. Overall, this study provides a comprehensive understanding of how cryopreservation affects ovine fibroblast spheroid biophysics and cellular integrity, laying the groundwork for improved preservation techniques for cell spheroids. Full article