Search Results (29)

The number of people living with HIV in Kazakhstan increased from 11,000 to 35,000 between 2010 and 2021, with emerging antiretroviral therapy (ART) resistance posing a challenge to effective treatment. Unsafe injection practices among people who inject drugs (PWID), the stigma against men who have sex with men, sex work, drug possession, HIV transmission, HIV exposure, and the non-disclosure of HIV status create obstacles to effective prevention and care. Our recent studies with people living with HIV (PLWH) in Kazakhstan have revealed the prevalence of mutations in HIV that may confer resistance to certain ART components currently being administered in the country. Additionally, subtype A6- and CRF02_AG-infected PLWH displayed the occurrence of certain distinct subtype-specific DRMs. Subtype A6 exhibited a tendency for the DRMs A62V, G190S, K101E, D67N, and V77I, whereas CRF02_AG was more associated with S162A, K103N, and V179E. Both subtypes had a comparable frequency of the M184V mutation and displayed similar patterns in the distribution of Q174K. Based on our findings, we recommend that DRM screening and subtype diagnosis before the initiation of ART will improve treatment efficiency while preventing the emergence of further DRMs in Kazakhstan. Full article

This study analyzes and compares sports supplement (SS) consumption among federated road cyclists, considering sex and competition category. The aim is to identify key factors influencing SS use and provide insights for developing nutritional strategies in cycling. A cross-sectional, descriptive study was conducted, involving 1503 cyclists (1231 men and 272 women). Data were collected through a validated questionnaire assessing anthropometric data, training habits, SS consumption patterns, and sources of information. Results indicate that 64.3% of cyclists currently use SS. Women reported a significantly higher consumption rate (88.2%) compared to men (59.1%), although men had a higher average SS intake than women (8.28 ± 9.36 vs. 6.76 ± 5.96). Additionally, SS use decreased with age and competition level, with elite cyclists showing the highest prevalence (76.3%) and master 50 the lowest (58.4%). Group A supplements (scientifically supported) were the most frequently used, while Group C supplements (limited evidence) and Group D substances (prohibited) were more commonly consumed by men. Findings highlight significant differences in SS consumption based on sex and competition level, with elite cyclists and women reporting higher prevalence. However, men reported a higher average number of SS consumed. The study underscores the need for targeted nutritional education, particularly among master cyclists, to promote evidence-based SS use and minimize the risks of ineffective or unsafe supplementation. Future research should explore the long-term effects of SS consumption in cycling and the effectiveness of educational interventions for safe and optimized supplementation practices. Full article

Background/Objectives: CrossFit^® is one of the most popular yet controversial training regimens. Some groups extol the positive effects of its practice, while others argue that it is unsafe and that there is limited information. The aim of this study was to investigate, through a self-reported questionnaire, the epidemiology of Portuguese CrossFit^® training practitioners. Methods: Statistical analyses, including Mann–Whitney U, chi-square, Spearman’s rho correlations, and logistic regressions, were conducted. Results: A total of 288 practitioners completed the questionnaire, with 39.9% reporting injuries. These injuries occurred mainly during training, particularly when performing gymnastics exercises. Tendon (40.9%) and shoulder (46.1%) were the most common injuries. Key risk factors for injury included male gender (OR = 2.7), years of practice (4–6 years: OR = 7.22), heavier body weight (OR = 4.76), and higher weekly training volume (4–6 times per week). Conclusions: Approximately 40% of CrossFit^® practitioners are expected to experience injuries, particularly in the shoulder and tendons. Injury risk is influenced by factors such as practice years, weekly training, sex, and body weight. These findings may help guide practitioners, coaches, and health professionals in better understanding the risk factors, mitigating injuries, and developing effective injury prevention strategies. Full article

Background: In recent years, in Europe, there has been a growing concern about the use of sexualized drugs among men who have sex with men (MSM), due to its possible link to an increase in sexually transmitted infections. The aim of this review is to study the prevalence of chemsex, and the sexualized drug used in Europe, describing both different consumption patterns and other sexual behaviors considered risky and their possible relationship with positivity in diagnoses of sexually transmitted infections, including human immunodeficiency virus. Methods: We conducted a literature review in the main scientific databases (PubMed, Embase, Scopus, Cochrane Library, Web of Science), filtering for articles published between January 2018 and April 2023 that collect information on sexualized drug use and sexual practices conducted in European countries among men who have sex with men, including whether these behaviors can lead to diagnoses of sexually transmitted infections. Results: The definition of drugs included in chemsex is not clearly defined and shows heterogeneity between study publications; the three drugs presented in all manuscripts are mephedrone, GHB/GBL, and crystal methamphetamine. The prevalence of chemsex in Europe is 16% [11–21%] among MSM. The most frequent risky sexual behavior associated with chemsex practice was unprotected sex with a high number of partners. The log risk ratio of STIs was 0.86 (95% CI: 0.49 to 1.23). Conclusions: Adherence to definitions, stringent research methodologies, and focused interventions are needed to tackle the intricate relationship between substance use, sexual behavior, and the risk of HIV/STI transmission in MSM. Full article

In Italy, the vaccination campaign against hepatitis B virus has been characterized by two phases. In the first phase (1984–1991), vaccination with plasma-derived vaccines was first recommended for the high-risk group. In the second phase (1991–nowadays), recombinant vaccine targeted, by law, infants 2 months old and teenagers 12 years old (limited to the first 12 years of campaign); screening for HBsAg became compulsory for all pregnant women during the third trimester of pregnancy. Successful achievements have been attained: No acute HBV case has been observed in the age group targeted by vaccination, the pool of chronic HBsAg carriers is strongly reduced, perinatal HBV transmission is under control, and acute delta virus hepatitis cases are nearly eliminated. The key point of this success has been the peculiar vaccination policy adopted. The combined vaccination of teenagers has generated an early immune cohort of youths, who are no longer at risk of acquiring HBV infection by sources of exposure (i.e., drug use and unsafe sex practices) typical of the young adults. Vaccination of household contacts with HBsAg-positive subjects represents an area of improvement; providing migrants and refugees access to healthcare services is also a focal point. In 2020, Italy became the first country in Europe to achieve the WHO’s regional hepatitis targets. Full article

In many situations, domestic dogs display greater uneasiness with unfamiliar men than unfamiliar women. However, little is known about whether the sex of an unfamiliar person is a risk factor for stranger-directed aggression, especially with respect to behaviors less intense than biting. We analyzed data collected by behavioral staff over a 27-month period (n = 283 dogs) at a New York shelter to determine whether the sex of an unfamiliar person influenced behaviors assessed during the Stranger test of the canine behavioral evaluation. Scores ranged from 1 (calm and friendly) to 5 (will not approach stranger or unsafe to allow an approach). No concerning behaviors (scores 1–3) were assessed for 19.2% of 26 undersocialized dogs from one home and 89.9% of the remaining 257 dogs. Within the group of 257, those tested with a male stranger had significantly higher scores than those tested with a female stranger; the effect size was small to moderate. Thus, we found that dogs responded differently to male and female strangers during this testing situation, but from a practical standpoint, our findings do not warrant adjustments in how shelters conduct or interpret tests for stranger-directed aggression. Our findings also highlight the importance of early exposure to different people and situations for dogs. Full article

Background: Risky sexual behaviors remain common among adolescents regardless of those with comprehensive knowledge of safer sex practices. Self-efficacy has been shown to have a positive relationship with safer sex practices. Thus, investigating self-efficacy, and enhancing it to agency is important. The current study explores the predictors of self-efficacy for avoiding risky sexual behaviors and what limits agency among sexually active adolescents (15–19 years) in Northern Uganda. Methods: The study consisted of a sub-sample of 396 sexually active adolescents (145 in school, 251 out of school) interviewed as part of a household survey for the program on Advancing Sexual Reproductive Health and Rights in Northern Uganda. Poisson and Poisson regression models with survey weights were implemented in Stata. Results: A total of 94% of male and 64% of female adolescents reported self-efficacy to avoid unsafe sex, including using condoms and avoiding multiple sexual partnerships or transactional sex. At multivariable analysis, a higher proportion of adolescents who listened to a radio or television program about sexual and reproductive health within the past 12 months had self-efficacy as compared to others (PR = 1.13, p-value = 0.002). Similarly, higher proportions of adolescents who knew all the sexual and reproductive health (SRH) rights (PR = 1.33, p-value = 0.007) and who had comprehensive knowledge about pregnancy, prevention of sexual transmission infections, and sources of SRH services (PR = 1.24, p-value = 0.013) had self-efficacy as compared to others. However, among those who reported self-efficacy, 42% of the girls and 53% of the boys could not uphold their self-efficacy in actual sexual encounters in the past 12 months. Partner’s refusal or girls’ fear to ask their sexual partner to use a condom were commonly cited reasons. Alcohol consumption was associated with failure to act on one’s self-efficacy (RR = 0.74, p-value = 0.048). Conclusions: Programs should target self-efficacy beliefs and attempt to enhance them into agency by increasing positive and decreasing negative expectations associated with risky sexual behavior. Full article

Adolescents and young women in Mozambique experience high levels of unintended pregnancies, with induced abortion being a common outcome. Stigma and gender norms are likely to negatively impact experiences of pregnancy and abortion, and hamper access to information and services. We assessed knowledge, attitudes, practices, and experiences around pregnancy and abortion in six communities in Nampula and Zambézia provinces. We conducted 19 triad interviews with young women and girls, 19 focus group discussions with male and female adult community members, and 15 in-depth interviews with young women with abortion experience. Participants described how gender values, norms, and practices affect girls’ risk of unintended pregnancy and their experiences of pregnancy and abortion. The drivers of adolescent pregnancy included transactional sex and gender-based violence, including early marriage, and gender roles and expectations that lead parents and others to oppose contraception. Stigma around abortion, early or unintended pregnancy, and adolescent sexuality is fueled by gender norms and contributes to girls seeking unsafe abortions. Pregnancy and abortion decision making often involves male partners and family members. In conclusion, gender norms strongly influence the occurrence and outcome of unintended pregnancies and abortion in Mozambique. While abortion legislation was recently liberalized, gender values, norms, and practices inhibit young women’s and girls’ access to services and need to be addressed in policy and programming. Full article

Background: Many children who contracted Human Immunodeficiency Virus (HIV) through vertical transmission are now in their adolescent and early adult years. The aim was to explore the experiences of adolescents living with HIV (ALWHIV) during the transition from childhood to adulthood. Methods and Material: The study was conducted at selected primary healthcare facilities in the Mopani and Vhembe districts in July 2021. A qualitative research approach that included contextual, descriptive, and exploratory designs was used. The population comprised 27 ALWHIV who were purposively sampled and enrolled for ART care. Data were collected using in-depth interviews, and the question was “How is it for you as you live with a virus and transit from adolescent to adulthood”. The open coding approach was used to analyse the data. Measures to ensure trustworthiness articulated in Lincoln and Guba’s criteria and ethical considerations were adhered to. Findings: The findings revealed four themes: poor understanding of the disease condition, improved physical health when adhering to ARV treatments, challenges related to sexual maturity and intimate relationships, and parents not disclosing their children’s HIV status. Conclusion: Parents’ delayed and non-disclosure of adolescents’ positive HIV status led to a lack of awareness about the course of the disease, non-adherence to ART, and unsafe sex practices that could increase the risk of HIV transmission and re-infection. To address these multiple obstacles associated with ALWHIV, a comprehensive, multi-sectoral approach that is teenager-friendly should be undertaken. Full article

This scoping review synthesizes literature to examine the extent of research focusing on knowledge, awareness, perceptions, attitudes, and risky behaviors related to sexually transmitted infections (STIs) in Southeast Asia (SEA). The PRISMA-Scoping approach was adopted targeting articles published from 2018 to 2022, sought from CINALH, PubMed, Web of Science and Scopus. A process of screening and elimination resulted in a total of 70 articles reviewed. Most of the studies were conducted in Indonesia, Thailand, Vietnam, and Malaysia, with the majority focusing on HIV/AIDS. In general, studies examining knowledge, awareness, and risky behaviors related to STIs in SEA reported low levels across various cohorts. However, evidence suggests that these issues are more prominent among individuals with low levels of education or low socioeconomic status, those living in rural areas or those working in the sex/industrial sectors. Engaging in unsafe sex and having multiple partners are the key examples for risky sexual behavior, while fear of being rejected/discriminated/stigmatized and lacking STI awareness were identified as social risky behaviors in SEA. Overall, cultural, societal, economic and gender inequality (male dominance) greatly impact people’s knowledge, awareness, perceptions, attitudes, and risky behaviors in SEA. Education is an important factor influencing healthy behavior; therefore, this scoping review calls for increased investment in educating vulnerable populations to prevent STIs, particularly in less-developed countries/regions of SEA. Full article

We measured the arterial occlusion pressure (AOP) in the dominant (DOM) and non-dominant (NDOM) legs of males (n = 20) and females (n = 20), 19–26 years of age, using a continuous (CONT) and incremental (INCR) cuff inflation protocol. ANOVA revealed no significant differences in AOP within (<1 mmHg; p > 0.493) or between (<6 mmHg; p > 0.418) the DOM and NDOM legs in males or females with either CONT or INCR. There were no significant sex differences in AOP in the DOM or NDOM legs when using CONT (<3 mmHg; p > 0.838) or INCR (<3 mmHg; p > 0.856). Measures of AOP are highly reliable, as evidenced by correlation coefficients >0.96 and small mean differences (<1.5 mmHg) between repeated measures. The choice of which cuff inflation protocol to use is one of personal preference. The AOP is not always greater in the dominant or larger leg. Although mean differences in AOP between the two legs was small, actual differences of over 100 mmHg could lead to unsafe and ineffective cuff inflation pressures during BFR if AOP is measured in only one leg. Further investigation of factors that explain difference in AOP between legs and between males and females is warranted. To ensure safe and effective use of BFR during exercise, AOP of both limbs should be measured regularly. Full article

In people living with HIV (PLWH), a positive association is often found between depressive symptoms and unsafe sex, which means sex without a condom. However, the results of such studies are inconclusive. The present study compared the numbers of safe and unsafe sexual contacts from men who have sex with men (MSM) (N = 159), living with HIV and attending a mental health clinic, with those of HIV-negative MSM in the general population (N = 198). We determined whether the presence of depressive symptoms was associated with unsafe sex in either of the two study populations. The depressive symptoms were measured with the Inventory of Depressive Symptoms (IDS), (MSM living with HIV) and with the 2012 Sexual Health Monitor (HIV-negative MSM). Finally, we determined whether MSM living with HIV with depressive symptoms, who received psychiatric treatment as usual, engaged in fewer unsafe sexual contacts one year after baseline. The mental-health-treatment-seeking MSM living with HIV engaged in more unsafe sexual contact than the MSM comparison group without HIV. Neither the treatment-seeking MSM living with HIV nor the MSM without HIV in the general population exhibited a relationship between depressive symptoms and unsafe sex. Moreover, the successful treatment of depressive symptoms in the treatment group did not lead to any reduction in the number of unsafe sexual contacts. Further research is needed to develop interventions that might be effective for MSM living with HIV with mental health symptoms to reduce the number of unsafe sexual contacts. Full article

Background: The perception of COVID-19 vaccines as being unsafe is a major barrier to receiving the vaccine. Providing the public with accurate data regarding the vaccines would reduce vaccine hesitancy. Methods: A cross-sectional study was conducted to collect data on the side effects experienced by the vaccinated population to assess the safety of the inactivated COVID-19 vaccine. Results: The majority of the study participants (n = 386) were female (71.9%), and 38.6% of them were under 30 years old. Around half of the participants (52.8%) reported side effects after receiving the inactivated COVID-19 vaccine. Fatigue (85.1%), a sore arm at the site of the injection (82.1%), and discomfort (67.2%) were the most commonly reported side effects after the first dose. Reporting side effects was significantly associated with the female sex (p-value = 0.027). Significant associations between being female and experiencing chills, muscle or joint pain, anorexia, drowsiness, and hair loss were also found, as well as being above the age of 30 and experiencing a cough. Being a smoker was significantly associated with experiencing a cough, and a headache. Furthermore, chills, and a sore throat were significantly associated with individuals who had not been infected before. Conclusion: Mild side effects were reported after receiving the inactivated COVID-19 vaccine. Fatigue was the most commonly reported side effect. Females, older adults, smokers, and those who had never been infected with COVID-19 had a greater susceptibility to certain side effects. Full article

Adulterated, poor-quality, and unsafe foods, including meat, are still major issues for both the food industry and consumers, which have driven efforts to find alternative technologies to detect these challenges. This study evaluated the use of a portable near-infrared (NIR) instrument, combined with chemometrics, to identify and classify individual-intact fresh goat muscle samples. Fresh goat carcasses (n = 35; 19 to 21.7 Kg LW) from different animals (age, breeds, sex) were used and separated into different commercial cuts. Thus, the longissimus thoracis et lumborum, biceps femoris, semimembranosus, semitendinosus, supraspinatus, and infraspinatus muscles were removed and scanned (900–1600 nm) using a portable NIR instrument. Differences in the NIR spectra of the muscles were observed at wavelengths of around 976 nm, 1180 nm, and 1430 nm, associated with water and fat content (e.g., intramuscular fat). The classification of individual muscle samples was achieved by linear discriminant analysis (LDA) with acceptable accuracies (68–94%) using the second-derivative NIR spectra. The results indicated that NIR spectroscopy could be used to identify individual goat muscles. Full article

Non-prescription steroid use can negatively impact adolescent physical and mental health and wellbeing. Determining correlates of this risk behavior is needed to help mitigate its prevalence. Two potential correlates are physical activity and school safety. The purpose of this study was to examine the associations of physical activity, school safety, and non-prescription steroid use within a sample of adolescents from the 2015–2019 US National Youth Risk Behavior Survey (YRBS). A multi-stage cluster sampling procedure yielded a representative sample of US adolescents from the 2015–2019 YRBS (n = 44,066; 49.6% female). Two latent variables indicating physical activity and unsafe schools were the independent variables. The dependent variable was a self-report of non-prescription steroid use. A weighted structural equation model examined the associations between physical activity and unsafe schools with non-prescription steroid use, controlling for age, sex, BMI %tile, race/ethnicity, and sexual minority status. The latent physical activity variable did not associate with non-prescription steroid use (β = 0.007, 95%CI: −0.01–0.02, p = 0.436); however, the unsafe schools latent variable did associate with non-prescription steroid use (β = 0.64, 95%CI: 0.59–0.69, p < 0.001). An unsafe school environment may be a determinant of non-prescription steroid use in adolescents. Physical activity behaviors did not associate with steroid use. Full article