Search Results (3,297)

The dung beetle family Geotrupidae (Scarabaeoidea) plays a vital ecological role in nutrient cycling and soil health, yet the scarcity of complete mitochondrial genome (mitogenome) data has hindered phylogenetic and comparative studies within this family. Here, we sequenced, assembled, and annotated the first complete mitogenomes of Geotrupes stercorarius and Phelotrupes auratus, collected from the Qinghai–Tibetan Plateau. Comparative analysis of these two novel mitogenomes with eight existing mitogenomes revealed conserved architectural features across Geotrupidae, such as gene arrangement, tRNA secondary structures, and small intergenic spacers. Nucleotide composition was largely conserved, though marked divergence occurred at the third codon positions. Substantial structural variation was observed in non-coding regions, particularly in the control region and the nad2-trnW spacer. Evolutionary analyses indicated strong purifying selection across all protein-coding genes, with no evidence of widespread positive selection linked to high-altitude adaptation. Phylogenetic reconstruction consistently recovered the relationships (Bolboceratinae, (Lethrinae, Geotrupinae)), with Anoplotrupes and Geotrupes forming sister genera within Geotrupinae. This study provides additional mitogenomic resources and a well-supported phylogenetic framework for Geotrupidae, resolving key taxonomic uncertainties and establishing a basis for future evolutionary and ecological research. Full article

Background: The rapid ageing of the cardiovascular population has profoundly transformed clinical practice, with an increasing proportion of patients presenting advanced age, frailty, multimorbidity, and functional vulnerability. Conventional cardiology models, largely derived from younger and selected populations, often fail to adequately address the complexity of cardiovascular care in older adults. Despite the growing development of cardiogeriatrics, the core competencies required for contemporary geriatric cardiology practice remain insufficiently defined. Methods: This narrative review synthesises evidence from cardiology, geriatrics, heart failure, and the palliative care literature, complemented by clinical expertise in integrated cardiogeriatric care pathways, to identify key competencies relevant to the care of older adults with cardiovascular disease. Results: Four major domains of geriatric cardiology competencies were identified: (1) advanced cardiovascular expertise adapted to ageing physiology, frailty, and multimorbidity; (2) integration of comprehensive geriatric assessment into cardiovascular decision-making; (3) a dedicated cardiogeriatric communication mindset supporting shared decision-making under prognostic uncertainty; and (4) system-based competencies focused on multidisciplinary coordination, care transitions, and therapeutic proportionality. Conclusions: Defining the core competencies of the geriatric cardiologist is essential to addressing the clinical and organisational challenges of an ageing cardiovascular population. This framework provides a pragmatic foundation for clinical practice, education, and future research, supporting integrated cardiogeriatric care models aligned with patient-centred outcomes. Full article

High-resolution TIR missions require sustained and well-characterized radiometric accuracy to support applications such as land surface temperature retrieval, drought monitoring, and surface energy budget analysis. To address this need, we develop an operational and automated ground-based vicarious radiometric calibration framework for TIR sensors and demonstrate its performance using the Wide-swath Thermal Infrared Imager (WTI) onboard Gaofen-5 01A (GF-5A). Three arid Gobi calibration sites were selected by integrating Moderate Resolution Imaging Spectroradiometer (MODIS) cloud products, Shuttle Radar Topography Mission (SRTM)-derived topography, and WTI-based radiometric uniformity metrics to ensure low cloud cover, flat terrain, and high spatial homogeneity. Automated ground stations deployed at Golmud, Dachaidan, and Dunhuang have continuously recorded 1 min contact surface temperature since October 2023. Field-measured emissivity spectra, Integrated Global Radiosonde Archive (IGRA) radiosonde profiles, and MODTRAN (MODerate resolution atmospheric TRANsmission) v5.2 simulations were combined to compute top-of-atmosphere (TOA) radiances, which were subsequently collocated with WTI imagery. After data screening and gain-stratified regression, linear calibration coefficients were derived for each TIR band. Based on 189 scenes from February–July 2024, all four bands exhibit strong linearity (R-squared greater than 0.979). Validation using 45 independent scenes yields a mean brightness–temperature root-mean-square error (RMSE) of 0.67 K. A full radiometric-chain uncertainty budget—including contact temperature, emissivity, atmospheric profiles, and radiative transfer modeling—results in a combined standard uncertainty of 1.41 K. The proposed framework provides a low-maintenance, traceable, and high-frequency solution for the long-term on-orbit radiometric calibration of GF-5A WTI and establishes a reproducible pathway for future TIR missions requiring sustained calibration stability. Full article

Background/Objectives: Missing data in clinical observational studies, such as out-of-hospital cardiac arrest (OHCA) registries, can compromise statistical validity. Single imputation methods are simple alternatives to complete-case analysis (CCA) but do not account for imputation uncertainty. Multiple imputation (MI) is the standard for handling missing-at-random (MAR) data, yet its implementation remains challenging. This study evaluated the performance of MI in association analysis compared with CCA and single imputation methods. Methods: Using a simulation framework with real-world Singapore OHCA registry data (N = 13,274 complete cases), we artificially introduced 20%, 30%, and 40% missingness under MAR. MI was implemented using predictive mean matching (PMM), random forest (RF), and classification and regression trees (CART) algorithms, with 5–20 imputations. Performance was assessed based on bias and precision in a logistic regression model evaluating the association between alert issuance and bystander CPR. Results: CART outperformed PMM, providing more accurate β coefficients and stable CIs across missingness levels. Although K-Nearest Neighbours (KNN) produced similar point estimates, it underestimated imputation uncertainty. PMM showed larger bias, wider and less stable CIs, and in some settings performed similarly to CCA. MI methods produced wider CIs than single imputation, appropriately capturing imputation uncertainty. Increasing the number of imputations had minimal impact on point estimates but modestly narrowed CIs. Conclusions: MI performance depends strongly on the chosen algorithm. CART and RF methods offered the most robust and consistent results for OHCA data, whereas PMM may not be optimal and should be selected with caution. MI using tree-based methods (CART/RF) remains the preferred strategy for generating reliable conclusions in OHCA research. Full article

Effective drillhole placement is critical to the success of mineral exploration, particularly in brownfield settings where subsurface information remains sparse despite the availability of data from adjacent, previously explored areas. To address the challenges of uncertainty in resource estimation and the high cost of drilling, we present a drilling sequence optimization framework guided by geophysical and surface geochemical data. The framework integrates statistical learning and geostatistical simulation to construct a set of prior models of intrusion and nickel grade distribution. These models are used to quantify the expected reduction in uncertainty for each potential drillhole by evaluating their corresponding Efficacy of Information (EOI). This approach allows the sequential selection of drillhole locations that maximize information gain while managing exploration risk. We apply the methodology to a case study in the Curaçá Valley, Brazil, where prior data from a well-characterized nearby zone inform predictions in the adjacent target area. The results demonstrate that incorporating prior geological knowledge from nearby areas into the drilling strategy can significantly improve targeting efficiency and reduce uncertainty in early-stage brownfield exploration. Full article

Endometrial lesions are common in gynecology, exhibiting considerable clinical heterogeneity across different subtypes. Although ultrasound imaging is the preferred diagnostic modality due to its noninvasive, accessible, and cost-effective nature, its diagnostic performance remains highly operator-dependent, leading to subjectivity and inconsistent results. To address these limitations, this study proposes a hierarchical feature selection and optimization framework for endometrial lesions, aiming to enhance the objectivity and robustness of ultrasound-based diagnosis. Firstly, Kernel Principal Component Analysis (KPCA) is employed for nonlinear dimensionality reduction, retaining the top 1000 principal components. Secondly, an ensemble of three filter-based methods—information gain, chi-square test, and symmetrical uncertainty—is integrated to rank and fuse features, followed by thresholding with Maximum Scatter Difference Linear Discriminant Analysis (MSDLDA) for preliminary feature selection. Finally, the Whale Migration Algorithm (WMA) is applied to population-based feature optimization and classifier training under the constraints of a Support Vector Machine (SVM) and a macro-averaged F1 score. Experimental results demonstrate that the proposed closed-loop pipeline of “kernel reduction—filter fusion—threshold pruning—intelligent optimization—robust classification” effectively balances nonlinear structure preservation, feature redundancy control, and model generalization, providing an interpretable, reproducible, and efficient solution for intelligent diagnosis in small- to medium-scale medical imaging datasets. Full article

Agricultural robotics and artificial intelligence (AI) are becoming essential to building more sustainable, efficient, and resilient food systems. As climate change, food security pressures, and labour shortages intensify, the integration of intelligent technologies in agriculture has gained strategic importance. This systematic review provides a consolidated assessment of AI and robotics research in agriculture from 2000 to 2025, identifying major trends, methodological trajectories, and underexplored domains. A structured search was conducted in the Scopus database—which was selected for its broad coverage of engineering, computer science, and agricultural technology—and records were screened using predefined inclusion and exclusion criteria across title, abstract, keywords, and eligibility levels. The final dataset was analysed through descriptive statistics and science-mapping techniques (VOSviewer, SciMAT). Out of 4894 retrieved records, 3673 studies met the eligibility criteria and were included. As with all bibliometric reviews, the synthesis reflects the scope of indexed publications and available metadata, and potential selection bias was mitigated through a multi-stage screening workflow. The analysis revealed four dominant research themes: deep-learning-based perception, UAV-enabled remote sensing, data-driven decision systems, and precision agriculture. Several strategically relevant but underdeveloped areas also emerged, including soft manipulation, multimodal sensing, sim-to-real transfer, and adaptive autonomy. Geographical patterns highlight a strong concentration of research in China and India, reflecting agricultural scale and investment dynamics. Overall, the field appears technologically mature in perception and aerial sensing but remains limited in physical interaction, uncertainty-aware control, and long-term autonomous operation. These gaps indicate concrete opportunities for advancing next-generation AI-driven robotic systems in agriculture. Funding sources are reported in the full manuscript. Full article

Sustainability has become a central concern globally, and efforts to enhance it are being made across various fields. In line with this trend, corporate sustainability reports have become more widely published. These reports provide both financial and non-financial information on a company’s sustainability. In this context, this study aims to, first, analyze the key keywords contained in CEO messages. Second, it examines whether the keywords emphasized by CEOs change in response to shifts in corporate risk under economic uncertainty. Finally, it identifies how the categories of words included in these messages are classified. To address these research questions, text analysis was selected as the methodology. Specifically, a qualitative research approach using text mining and CONCOR analysis was conducted on the text from sustainability report. According to the Term Frequency and Term Frequency-Inverse Document Frequency analyses, the most frequently occurring keywords were ESG, Sustainable, Society, Stakeholders, Growth, Environment, Effort, and Future. Centrality analysis identified the following keywords as having high centrality: Sustainable, ESG, Society, Environment, Growth, Effort, and Stakeholders. Finally, CONCOR analysis revealed four clusters: Eco-friendly Energy, ESG Management, Global Crisis, and Technological Competitiveness. This study is significant in that it analyzes the major keywords and their changes within unstructured text data using text mining and CONCOR analysis, and it suggests the possibility of future quantitative analysis of non-financial information using these keywords. Full article

This study proposes a framework, the RA_WLTE_River model, for quantifying the reliability of flood-altering water-level thresholds, considering rainfall and runoff-related uncertainties. The Keelung River in northern Taiwan is selected as the study area, and associated hydrological data from 2008 to 2016 are applied in the development and application of the model. According to the results from the model development and demonstration, the average and maximum rainfall intensities, roughness coefficients, and maximum tide depths exhibit a significant contribution to the reliability quantification of the estimated water-level thresholds. In addition, empirically based water-level thresholds can achieve the goal of rainfall-induced flood early warning, with a high likelihood of nearly 0.95. Additionally, the probabilistically based water-level thresholds derived from the described reliability can efficiently ensure consistent flood early warning performance at all control points along the river. Full article

The discovery and development of new drugs is a lengthy, complex, and costly process, often requiring 10–20 years to progress from initial concept to market approval, with clinical trials representing the most resource-intensive stage. In recent years, Artificial Intelligence (AI) has emerged as a transformative technology capable of reshaping the entire pharmaceutical research and development (R&D) pipeline. The purpose of this narrative review is to examine the role of AI in drug discovery and development, highlighting its contributions, challenges, and future implications for pharmaceutical sciences and global public health. A comprehensive review of the scientific literature was conducted, focusing on published studies, reviews, and reports addressing the application of AI across the stages of drug discovery, preclinical development, clinical trials, and post-marketing surveillance. Key themes were identified, including AI-driven target identification, molecular screening, de novo drug design, predictive toxicity modelling, and clinical monitoring. The reviewed evidence indicates that AI has significantly accelerated drug discovery and development by reducing timeframes, costs, and failure rates. AI-based approaches have enhanced the efficiency of target identification, optimized lead compound selection, improved safety predictions, and supported adaptive clinical trial designs. Collectively, these advances position AI as a catalyst for innovation, particularly in promoting accessible, efficient, and sustainable healthcare solutions. However, substantial challenges remain, including reliance on high-quality and representative biomedical data, limited algorithmic transparency, high implementation costs, regulatory uncertainty, and ethical and legal concerns related to data privacy, bias, and equitable access. In conclusion, AI represents a paradigm shift in pharmaceutical research and drug development, offering unprecedented opportunities to improve efficiency and innovation. Addressing its technical, ethical, and regulatory limitations will be essential to fully realize its potential as a sustainable and globally impactful tool for therapeutic innovation. Full article

In struggling against invasive species ravaging riverscape ecosystems, gaps in dispersal pathway knowledge and fragmented approaches across scales have long stalled effective riparian management worldwide. To reduce these limitations and enhance invasion management strategies, selecting appropriate alien species as models for in-depth pathway analysis is essential. Alternanthera philoxeroides (Mart.) Griseb. (alligator weed) emerges as an exemplary model species, boasting an invasion record of around 120 years spanning five continents worldwide, supported by genetic evidence of repeated introductions. In addition, the clonal reproduction of A. philoxeroides supports swift establishment, while its amphibious versatility allows occupation of varied riparian environments, with spread driven by natural water-mediated dispersal (hydrochory) and human-related vectors at multiple scales. Thus, leveraging A. philoxeroides, this review proposes a comprehensive multi-scale framework, which integrates monitoring with remote sensing, environmental DNA, Internet of Things, and crowdsourcing for real-time detection. Also, the framework can further integrate, e.g., MaxEnt (Maximum Entropy Model) for climatic suitability and mechanistic simulations of hydrodynamics and human-mediated dispersal to forecast invasion risks. Furthermore, decision-support systems developed from the framework can optimize controls like herbicides and biocontrol, managing uncertainties adaptively. At the global scale, the dispersal paradigm can employ AI-driven knowledge graphs for genetic attribution, multilayer networks, and causal inference to trace pathways and identify disruptions. Based on the premise that our multi-scale framework can bridge invasion ecology with riverscape management using A. philoxeroides as a model, we contend that the implementation of the proposed framework tackles core challenges, such as sampling biases, shifting environmental dynamics, eco–evolutionary interactions using stratified sampling, and adaptive online algorithms. This methodology is purposed to offer scalable tools for other aquatic invasives, evolving management from reactive measures to proactive, network-based approaches that effectively interrupt dispersal routes. Full article

With the fast development of the 5G technology and IoV, a vehicle has become a smart device with communication, computing, and storage capabilities. However, the limited on-board storage and computing resources often cause large latency for task processing and result in degradation of system QoS as well as user QoE. In the meantime, to build the environmentally harmonious transportation system and green city, the energy consumption of data processing has become a new concern in vehicles. Moreover, due to the fast movement of IoV, traditional GSI-based methods face the dilemma of information uncertainty and are no longer applicable. To address these challenges, we propose a T2VC model. To deal with information uncertainty and dynamic offloading due to the mobility of vehicles, we propose a MAB-based QEVA-UCB solution to minimize the system cost expressed as the sum of weighted latency and power consumption. QEVA-UCB takes into account several related factors such as the task property, task arrival queue, offloading decision as well as the vehicle mobility, and selects the optimal location for offloading tasks to minimize the system cost with latency energy awareness and conflict awareness. Extensive simulations verify that, compared with other benchmark methods, our approach can learn and make the task offloading decision faster and more accurately for both latency-sensitive and energy-sensitive vehicle users. Moreover, it has superior performance in terms of system cost and learning regret. Full article

The medicinally and ornamentally valuable genus Thunbergia faces taxonomic uncertainty, while certain Acanthaceae species are threatened by habitat loss, underscoring the need for chloroplast genome studies to support conservation efforts. The chloroplast genome of Thunbergia grandiflora was sequenced and assembled. Additionally, 28 Acanthaceae species with significant medicinal value were selected for comparative genomic analysis. Based on the chloroplast genome data of Acanthaceae species, this study conducted phylogenetic and comparative evolutionary analyses. The results preliminarily support a systematic framework that divides Acanthaceae into eight tribes within five subfamilies. Concurrently, the study revealed significant inverted repeat (IR) region structural variations. A clear correspondence was observed between the contraction of IR length and the topological structure of the phylogenetic tree. In particular, species within the genus Strobilanthes exhibited significant contraction in their IR regions, which corresponded consistently with their tendency to cluster into an independent clade in the phylogenetic tree. This suggests that structural variation in the IR regions may be closely associated with the evolutionary divergence of this group. SSR analysis revealed a prevalent mononucleotide A/T repeat dominant pattern across Acanthaceae species. Furthermore, selection pressure analysis detected positive selection acting on multiple key genes, including rbcL, rps3, rps12, cemA, and ycf4, suggesting that these genes may play important roles in the adaptive evolution of Acanthaceae. This study reveals that the chloroplast genomes of Acanthaceae exhibit distinctive characteristics in phylogenetic architecture, dynamic variations in IR regions, and adaptive evolution of key genes, providing important molecular insights for understanding the mechanisms underlying species diversity and for the conservation of medicinal resources within this family. Full article

In complex decision-making scenarios, such as smart city renewable energy project selection, decision-makers must contend with multi-dimensional uncertainty, conflicting expert opinions, and evolving temporal dynamics. This study introduces a novel Fractional q-Rung Orthopair Fuzzy Tensor (Fq-ROFT)-based group decision-making methodology that integrates the flexibility of q-rung orthopair fuzzy sets with tensorial representation and fractional-order dynamics. The proposed framework allows for the modeling of positive and negative membership degrees in a multi-dimensional, time-dependent structure while capturing memory effects inherent in expert evaluations. A detailed case study involving six renewable energy alternatives and six criteria demonstrates the method’s ability to aggregate expert opinions, compute fractional dynamic scores, and provide robust, reliable rankings. Comparative analysis with existing approaches, including classical q-ROFSs, intuitionistic fuzzy sets, and weighted sum methods, highlights the superior discriminative power, consistency, and dynamic sensitivity of the Fq-ROFT approach. Sensitivity analysis confirms the robustness of the top-ranked alternatives under variations in expert weights and fractional orders and membership perturbations. The study concludes by discussing the advantages, limitations, and future research directions of the proposed methodology, establishing Fq-ROFT as a powerful tool for dynamic, high-dimensional, and uncertain group decision-making applications. Full article

Data uncertainty and limited model generalization remain critical bottlenecks in large-scale remote sensing of soil salinization. Although the integration of multi-source data has improved predictive potential, conventional deterministic feature selection methods often overlook stochastic noise inherent in environmental variables, leading to models that overfit spurious correlations rather than learning stable physical signals. To address this limitation, this study proposes a Bootstrap–Boruta feature stability assessment framework that shifts feature selection from deterministic “feature importance” ranking to probabilistic “feature stability” evaluation, explicitly accounting for uncertainty induced by data perturbations. The proposed framework is evaluated by integrating stability-driven feature sets with multiple machine learning models, including a Back-Propagation Neural Network (BPNN) optimized using the Red-billed Blue Magpie Optimization (RBMO) algorithm as a representative optimization strategy. Using the Minqin Lake region as a case study, the results demonstrate that the stability-based framework effectively filters unstable noise features, reduces systematic estimation bias, and improves predictive robustness across different modeling approaches. Among the tested models, the RBMO-optimized BPNN achieved the highest accuracy. Under a rigorous bootstrap validation framework, the quality-controlled ensemble model yielded a robust mean R² of 0.657 ± 0.05 and an RMSE of 1.957 ± 0.289 dS/m. The framework further identifies eleven physically robust predictors, confirming the dominant diagnostic role of shortwave infrared (SWIR) indices in arid saline environments. Spatial mapping based on these stable features reveals that 30.7% of the study area is affected by varying degrees of soil salinization. Overall, this study provides a mechanism-driven, promising, within-region framework that enhances the reliability of remote-sensing-based soil salinity inversion under heterogeneous environmental conditions. Full article