Search Results (379)

In recent years, advances in exoskeleton technology have increased the demand for human motion classification in terms of both movement diversity and recognition accuracy, making the effective classification of more complex asymmetric movements increasingly important. This study integrated surface electromyography (sEMG) and inertial measurement unit (IMU) signals and employed mutual information (MI) and muscle symmetry features (MSF) to analyze the characteristic differences between symmetrical muscles in both legs during asymmetric movements, with the aim of improving the accuracy of asymmetric motion classification. sEMG and IMU signals were collected from six movements, including three asymmetric postures: asymmetrical stance, single-knee kneeled position, and crouching advance. The acquired signals were processed through energy envelope analysis, active segment extraction, empirical mode decomposition (EMD), feature extraction, MI extraction, and MSF extraction. The relevance based on weight feature selection (RWFS) combined with conditional mutual information (CMI) method was then applied to reduce feature dimensionality, prioritize features with significant fluctuations, and preserve key characteristics. Finally, the CNN-LSTM-Attention algorithm was used for classification. Experimental results showed that fusing sEMG and IMU signals achieved 96.30% accuracy in lower limb motion recognition. The proposed method improves asymmetric movement classification and may provide a potential basis for exoskeleton motion classification in special environments. Full article

In operational terms, post-fire landscapes require monitoring priorities that reflect hydrogeomorphic susceptibility rather than burned extent alone. This study tests whether European Forest Fire Information System (EFFIS) burned area evidence, combined with open terrain, rainfall, drainage, soil, land cover, and settlement context data, can be translated into source-to-output traceable monitoring priority units across Mediterranean and Iberian–Atlantic regions. The backbone integrates Decision-Making Trial and Evaluation Laboratory (DEMATEL) driver structuring, cell criticality score (CCS) screening from the CCS-V0 conventional weighted linear GIS baseline to CCS-V5 staged refinement, upper-quartile (Q75) hotspot topology, multi-criteria decision analysis/cost penalty (MCDA/COST-PEN) ranking, and quadratic unconstrained binary optimization (QUBO)-ready selected/reserve organization. Across Vesuvius–Campania, Attica, Cyprus, Portugal, and Spain, the screening outputs show procedural portability without implying geomorphological equivalence, field-confirmed hydrogeomorphic damage, or cross-theater hazard comparability: hotspot geometry, dominance, fragmentation, and candidate composition remain theater-dependent. In Vesuvius–Campania, CCS-V1 rainfall conditioning reduced Q75 hotspot clusters from 58 to 18 and increased the dominant cluster ratio from 23.1% to 63.07%; in Portugal, CCS-V5 contracted hotspot support from 17,240 to 862 cells while increasing dominance to 66.13%. The final QUBO-ready layer retained 11 of 32 candidate units. The contribution links (i) EFFIS/Moderate-Resolution Imaging Spectroradiometer (MODIS) source sector traceability and valid support construction, (ii) DEMATEL-informed CCS refinement and hotspot topology interpretation, (iii) role-based transfer testing across non-equivalent theaters, and (iv) QUBO-ready prioritization for verification-oriented post-fire monitoring. Full article

Background: Retroperitoneoscopic laparoscopic adrenalectomy (RLA) is widely adopted for benign adrenal lesions due to its direct access and minimal bowel interference. However, expanding indications to larger tumors and complex anatomies increase technical difficulty because of the confined retroperitoneal space and obscured hilar landmarks. Current predictive models mainly focus on transperitoneal approaches and lack specificity for RLA. This study aimed to develop and internally validate a preoperative nomogram for predicting RLA-specific surgical difficulty. Methods: All patients undergoing RLA from April 2024 to February 2025 at a single center were included. Operative time and postoperative hemoglobin (Hb) reduction were used as surrogate markers of difficulty. Patients were classified into high- and standard-risk groups. Univariate and multivariate analyses were performed to identify predictors of difficult RLA and develop a composite difficulty score. Results: Tumor position (between the upper renal pole and renal pedicle: OR 8.819, 95% CI 3.981–21.462, p < 0.001) and pheochromocytoma (PHEO) pathology (OR 34.881, 95% CI 3.841–4719.428, p < 0.001) were the strongest independent predictors of high surgical difficulty, whereas tumor size (≥40 mm: OR 3.926, p = 0.071) showed limited predictive value. The composite score demonstrated excellent discrimination, with an optimism-corrected area under the curve (AUC) of 0.828 (95% CI 0.796–0.835). The nomogram showed robust calibration, and a cutoff score ≥ 2 yielded a negative predictive value of 0.940. Conclusions: This study developed an RLA-specific nomogram incorporating tumor size, position, and pathology. The tumor–renal pedicle relationship was more predictive of surgical difficulty than tumor size alone, providing risk stratification to guide surgical planning, optimize patient selection, and enhance safety as RLA indications expand. External validation is required to confirm its generalizability. Full article

Robust object detection for autonomous driving requires perception models that remain reliable when visible imagery is degraded by darkness, glare, rain, fog, motion blur, or long-range small targets. Visible and thermal infrared cameras provide complementary evidence, yet many RGB–thermal detectors fuse modalities, mainly as aligned tensors, and may underuse relational structure in channel responses, spatial layouts, semantic scales, and modality-specific uncertainty. This paper presents TopoGraph-Fusion, a hierarchical graph-guided dual-modal object detector that formulates fusion as topology-aware reasoning rather than direct feature concatenation. The proposed framework builds a dual-stream backbone for RGB and thermal images, constructs channel-wise topology through a channel-topology graph aggregation module, derives relation-aware spatial and channel global attention from affinity graphs, and replaces fixed feature-pyramid communication with a Graph-Guided Feature-Pyramid Network. A topology-regularized detection objective further encourages stable cross-modal correspondence while suppressing noisy all-to-all connections. Experiments on M3FD, FLIR, RGBTDronePerson, and VEDAI512 cover road scenes, adverse illumination, drone–person perception, and aerial vehicle detection. Within this validation scope, the results and visual analyses indicate that topology-guided fusion improves small-object recall, cross-modal consistency, and robustness under modality imbalance. Full article

This essay discusses feminist ideas in connection to the occulture—Christopher Partridge’s term for the re-enchantment of art, popular culture, and everyday life through esoteric and spiritual currents—present in opera, musical theater, and film, focusing on femmes fatales, tricksters and ‘wicked women’ in a transcultural approach to religion, (Western) esotericism, and the performing arts. The spiritual–scientific embodiment of Afro-Brazilian traditions is explored through the figure of Pombagira—a Brazilian occultural creation of a female enchantress with mystical powers connected to healing and sex, often placed in patriarchal opposition to her male counterpart, Exu. Drawing on Partridge’s notions of occulture and Walter Mignolo’s understanding of decoloniality, the Western gendering imposed on Pombagira as a purveyor of evil is discussed as both mythology and potential epistemicide. The thesis statement presented here is that the Pombagira episteme is an underlying emblem throughout art and scholarship invested in queering essential binary categories of womanhood, as seen in staged adaptations of Verdi’s La forza del destino (1862), Bizet’s Carmen (1875), and numerous cinematic Lola incarnations—Marlene Dietrich’s in Der blaue Engel (1930), Gwen Verdon’s in Damn Yankees (1958), and Almodóvar’s in Todo sobre mi madre (1999). This indisciplinary reading connects Gloria Anzaldúa’s queer feminist practice of spiritual mestizaje with the Pombagira as an occultural anti-patriarchal force. Full article

Objective: This study aimed to systematically evaluate risk prediction models for new vertebral fracture after vertebral augmentation in elderly patients with osteoporotic vertebral compression fractures (OVCFs) and to summarize their modeling methods, predictors, predictive performance, and methodological quality. Methods: This systematic review was prospectively registered in the Open Science Framework (OSF; DOI:10.17605/OSF.IO/S259R). PubMed, Embase, Web of Science, Cochrane Library, CNKI, Wanfang, and VIP were searched from inception to January 2026. Studies reporting model development, internal validation, external validation, or model updating for prediction models of new vertebral fracture after vertebral augmentation in elderly patients with OVCFs were included. Two reviewers independently screened the literature and extracted data. Methodological quality and risk of bias were assessed using the Prediction Model Risk of Bias Assessment Tool (PROBAST). Results: A total of 24 studies containing 29 prediction models were included, all of which were conducted in China. The incidence of new vertebral fracture after vertebral augmentation ranged from 10.60% to 38.08%. Logistic regression and nomograms were the most common modeling method and presentation format, respectively. The AUC values of the models ranged from 0.648 to 0.990. Only three studies conducted external validation. Bone mineral density, bone cement leakage, and anti-osteoporosis treatment were the leading predictive factors. PROBAST assessment confirmed that all included studies had a high overall risk of bias, with the statistical analysis domain being the most problematic area. Fourteen studies reported decision curve analysis (DCA), suggesting potential clinical utility within the development datasets. However, no study evaluated real-world clinical impact, and the overall high risk of bias and limited external validation substantially restrict confidence in clinical applicability. Conclusions: Although several models demonstrated moderate-to-good discrimination performance, methodological limitations, high overall risk of bias, and insufficient external validation substantially limit confidence in their clinical applicability. These models are not reliable for routine clinical use and should currently be regarded as research tools. Standardized study design, bias control, adequate external validation, and optimized statistical strategies are urgently required to establish credible prediction models for clinical practice. Full article

Background/Objectives: Total knee arthroplasty (TKA) relieves pain and restores function for most patients with end-stage knee disease; yet, a clinically important minority are left with persistent pain, stiffness or both despite well-fixed, well-aligned implants. These “hidden failures” are poorly captured by implant survivorship but drive disability, dissatisfaction and disproportionate cost—stiff knees incur roughly 1.5–7.5 times the two-year treatment costs of non-stiff knees. This review integrates three usually separate studies within one phenotype-based framework. Methods: A structured comprehensive narrative review and thematic synthesis was undertaken; PubMed/MEDLINE, Web of Science and Google Scholar were searched between 30 October 2025 and 1 May 2026, identifying 467 records, of which 239 met the eligibility criteria and informed the synthesis. Results: Clinically meaningful chronic pain affects roughly 10–30% of recipients and stiffness approximately 1–7%, with high-impact chronic pain persisting in about one-in-five and neuropathic features in a third to a half of those affected. Contemporary dissatisfaction estimates appear closer to 7–14% than the historical “one-in-five” paradigm, with persistent pain and stiffness the dominant drivers of residual dissatisfaction. Symptoms arise from interacting mechanical, fibrotic, infective, neuropathic, central and psychosocial mechanisms. Six practical phenotypes are proposed—pain-dominant with preserved motion, stiffness-dominant, combined stiff-and-painful, neuropathic-dominant, centrally sensitized, and arthrofibrosis with true mechanical block—and diagnosis, prevention and management are organized around them, spanning risk stratification, surgical technique, manipulation under anesthesia (mean gains ~30–47°, ~6% failure), arthrolysis, revision and multidisciplinary pain care. Conclusions: Chronic pain and stiffness are the quiet arithmetic of arthroplasty success—rare on the survivorship curve, common in the clinic. Matching treatment to phenotype and reserving the operating theater for a knee with a mechanical fault to fix rather than a nervous system to calm, offers the clearest path from a technically successful operation to a genuinely successful recovery. Full article

Mo Yan’s stage play Crocodile (Eyu) marks a shift away from novel-centered scholarship in Mo Yan studies. Centered on a continually fed, ever-growing crocodile, the play moves the animal from a textual symbol to a stage image. Existing studies emphasize theme, symbolism, or genre but say less about how stage procedures establish the crocodile’s presence as a publicly perceptible fact and generate meanings around power, desire, and judgment. This article addresses that gap through a script-based, stage-oriented semiotic analysis. Drawing on Barthes’s denotation and connotation together with Hjelmslev’s expression and content planes, it analyzes how stage images organize perception and meaning. It argues that presence in Crocodile is produced through linked sensory, spatial, and verbal cues: at moments of concealment and disclosure, expansion, threshold, and loss of control, the play turns the crocodile into a collectively witnessable event rather than a mere symbol, while repeated cues consolidate associations around power, desire, and judgment, reorienting spectatorship toward the conditions of witnessing. By treating the stage image as an operative mechanism rather than a symbol to be decoded, the article shows how the play, through stage procedures, establishes the crocodile as a perceptible and witnessable stage presence that generates meaning. Full article

Background: Neuropathic pain (NP), a debilitating condition resulting from nervous system lesions, is poorly managed by current therapies. The cingulate cortex is crucial for affective pain processing, yet a comprehensive spatiotemporal understanding of its molecular changes in NP is lacking. Methods: We performed RNA sequencing to profile transcriptomic alterations in the anterior cingulate (ACC) and midcingulate (MCC) cortices of mice at two and four weeks after spared nerve injury. Bioinformatics analyses, including differential expression, functional enrichment, weighted gene co-expression network analysis, and protein–protein interaction (PPI) network construction, were employed. Results: We identified widespread, time-dependent transcriptional dysregulation in both regions, with differentially expressed genes increasing over time. Functional analyses confirmed central roles for synaptic plasticity and neuroinflammatory pathways, and further identified pathways related with neurodegeneration and mitochondrial dysregulationin NP pathogenesis. Subregion analysis revealed that the ACC exhibited broader pathway alterations than the MCC, including neuroinflammation (early phase) and mitochondrial dysfunction/neurodegeneration (late phase), indicating a progressive stress response unique to the ACC. PPI analysis identified stage-specific hub genes (e.g., early interferon-stimulated genes and late ribosomal proteins in ACC; persistent extracellular matrix components in MCC). Conclusions: This study provides a detailed transcriptomic atlas of the cingulate cortex in NP, reinforcing known synaptic and neuroinflammatory mechanisms, and suggests a possible role of mitochondrial dysregulation in NP pathogenesis. The findings provide a basis for further mechanistic studies. Full article

This paper investigates folding as a practicable design methodology in response to the combined requirements of complex sites and public programs. A sloped waterfront community theater in Boston is used as a test case, where a parametric workflow in Rhino/Grasshopper is employed to translate continuous surfaces, via panelization, into buildable systems constrained by curvature and developability. In the Boston community theater case study, diamond panels are employed for the primary enclosure and seating; stepped panels organize circulation across the slope; and triangular closures resolve edge conditions and tolerances. Fold lines simultaneously function as legible paths, stitching exterior and interior into a continuous sequence. Parameters are used to align lines of sight, gradients, and drainage with structural supports, thereby demonstrating a traceable linkage from geometry to construction and operation. The findings reveal that folded geometries establish continuous linkages among topography, circulation, and program; that fold lines function as force paths, drainage organizers, and edge closures; and that interstitial layers between folded interfaces facilitate transitions between performance and everyday modes, thereby sustaining public use. The study proposes a reusable “folding–parametric–panelization–structural integration” framework, providing a transferable technical pathway for community-scale public architecture. Full article

The application of continuous carbon fiber (CCF) can reinforce the mechanical properties of 3D-printed parts, but the effect of reinforcement layer distribution on composite performance remains unclear. This study investigates the effect of concentrated and separated distributions of CCF layers with different numbers of reinforcement layers. Tensile and flexural tests are conducted in accordance with ASTM D5083 and ASTM D790, respectively. Under the conditions of a solid-filled matrix (Onyx) and 0° CCF deposition, both concentrated and separated CCF layers improve several mechanical properties. Compared with pure Onyx, one-layer CCF increases the tensile modulus by about six times and more than doubles the tensile strength. Increasing the CCF volume leads to further increases in these properties. With concentrated three-layer CCF, the tensile modulus and tensile strength reach 7.153 ± 0.090 GPa and 109.045 ± 5.124 MPa, respectively. For flexural properties, separated two- and three-layer CCFs significantly improve the tangent modulus of elasticity from 0.467 ± 0.106 GPa for pure Onyx to 2.246 ± 0.333 GPa and 3.394 ± 0.081 GPa, respectively. This study also compares the tensile and flexural strength-to-weight ratio of all specimen groups and analyzes the failure mechanisms based on macroscopic fracture appearance. The results can provide guidance for selecting appropriate CCF layer distribution strategies to reinforce composites in different applications. Full article

During deep anesthesia, the EEG becomes discontinuous. Burst-suppression is often an intended target during deep sedation or medically induced coma. Within this state, anesthetic depth is commonly monitored by the suppression ratio (SR), which expresses the fraction of time spent in suppression. However, accumulating evidence suggests that SR remains reactive to external stimulation. We tested whether ambient music commonly played in operating theaters alters the SR in male Wistar rats under sevoflurane, chloral hydrate, or isoflurane anesthesia. To this end, the first 60 s of the Stayin’ Alive audio track by the Bee Gees were played to examine auditory-induced burst-suppression reactivity in an experimental model previously established for intermittent photic stimulation. SR and the burst-suppression reactivity index (BSRi, derived as the decrease in SR during stimulation normalized to pre-stimulation SR) were measured in repeated trials. Auditory stimulation transiently decreased SR under all three anesthetics. This was associated with an increase in the rate of burst occurrence without increased burst duration. The BSRi changes depended on the anesthetic type, comparable to photic stimulation. Our experimental data suggest that the suppression ratio used to monitor targeted burst-suppression reflects both anesthetic depth and the level of ambient stimulation. Ambient sound in the operating theater or intensive care settings could influence EEG-based measures used for anesthesia monitoring. Full article

Aedes aegypti is a major invasive vector in China, where prolonged pyrethroid use has induced resistance, complicating dengue control. This study evaluated the resistance levels of Ae. aegypti to the pyrethroid beta-cypermethrin in Yunnan and explored the underlying mechanisms to inform control strategies. Mosquitoes were collected from five regions of Yunnan in 2015–2016. Larval bioassays, adult diagnostic dose determination, and adult bioassays were conducted to assess resistance to beta-cypermethrin. Mixed-function oxidase (MFO) amount was measured in larvae, and PCR amplification was used to detect mutations in the voltage-gated sodium channel (VGSC) gene. Correlations between enzyme activity, mutations, and phenotypic resistance were analyzed. Larval bioassays indicated that all five populations exhibited resistance to beta-cypermethrin, with resistance ratios ranging from 11.31 to 41.56. The adult diagnostic dose was determined as 0.74668 g/L, with mortality rates ranging from 8.89% to 58.89%, confirming resistance. A significant negative correlation was found between adult mortality and larval LC₅₀ values. MFO amount was closely correlated with resistance levels. The F1534C mutation was the only VGSC mutation detected, and its frequency showed a significant positive correlation with beta-cypermethrin resistance. Our data were collected in 2015–2016; resistance levels may have changed since then, and no confirmatory bioassays were performed by us after 2020. The findings demonstrate that the F1534C mutation and increased MFO amount contribute to enhanced beta-cypermethrin resistance of Ae. aegypti in Yunnan. By linking phenotype resistance to key molecular and biochemical mechanisms, these findings support the continued monitoring of resistance and provide a basis for the evidence-based optimization of dengue vector control strategies. Full article

Objective: Posterior lumbar interbody fusion (PLIF), posterolateral fusion (PLF), and Hybrid fusion are widely used fusion procedures for lumbar degenerative diseases (LDDs). Postoperative complications dominated by cage migration (CM) and adjacent segment degeneration (ASD) remain major challenges. This study aimed to identify and compare the independent risk factors for CM and ASD in PLIF, PLF, and Hybrid fusion, so as to provide evidence-based references for preoperative evaluation, surgical selection, and complication prevention in clinical practice. Methods: A retrospective cohort study was conducted in patients who underwent PLIF, PLF, or Hybrid fusion for LDDs at our institution. Demographic data (age, gender, and body mass index [BMI]), lifestyle factors (smoking and insobriety), comorbidities (hypertension, diabetes, hyperuricemia, osteoporosis, and hypoalbuminemia), surgical parameters (operative time, intraoperative blood loss, fusion segments, and lumbar lordosis angle), radiological indices (Pfirrmann grading of intervertebral disc degeneration and relative disc height), and biological markers (C-reactive protein/lymphocyte ratio [CLR], procalcitonin [PCT], and serum amyloid A [SAA]) were collected. Patients were stratified into complication and non-complication groups based on the occurrence of CM or ASD. Univariate and binary logistic regression analyses were performed to determine independent risk factors for postoperative complications. Results: A total of 203 patients were enrolled, including 80 cases with complications in the PLIF group, 64 in the Hybrid group, and 59 in the PLF group. No significant differences were noted in the distribution of complication types among the three groups (p = 0.179). Univariate analysis revealed that BMI, osteoporosis, the Pfirrmann grading of superior adjacent disc degeneration, lumbar lordosis angle, operative time, and intraoperative blood loss were significantly associated with postoperative complications across all three surgical groups (p < 0.05). Binary logistic regression analysis confirmed that elevated BMI (PLIF: OR = 1.18, 95%CI: 1.05–4.38; PLF: OR = 1.19, 95%CI: 0.76–2.18; Hybrid: OR = 1.14, 95%CI: 1.07–2.54), osteoporosis (PLIF: OR = 6.86; PLF: OR = 7.62; Hybrid: OR = 5.62), advanced superior adjacent disc degeneration (PLIF: OR = 8.04; PLF: OR = 4.49; Hybrid: OR = 2.87), prolonged operative time, and increased intraoperative blood loss were independent risk factors for postoperative complications. In contrast, age, gender, smoking, insobriety, hypertension, diabetes, CLR, PCT, and SAA were not identified as risk factors (p* > 0.05). Conclusions: Elevated BMI, osteoporosis, pre-existing superior adjacent disc degeneration, prolonged operative time, and increased intraoperative blood loss are shared independent risk factors for CM and ASD following PLIF, PLF, and Hybrid fusion for LDDs. Targeted interventions addressing these factors may reduce postoperative complication rates and improve patient outcomes. Full article

Objectives: Seawater-immersed burn wounds are highly susceptible to contamination, persistent inflammation, oxidative stress, and delayed healing, while current irrigation solutions remain suboptimal for such acute injuries. This study aimed to evaluate the therapeutic efficacy and underlying mechanisms of plasma-activated water (PAW) as a novel irrigation strategy for these complex wounds. Methods: The antibacterial efficacy of PAW against marine pathogens was first evaluated in vitro. Subsequently, a rat model of seawater-immersed burn injury was established in male Sprague-Dawley (SD) rats to assess the therapeutic effects of PAW irrigation on wound healing, infection control, and underlying biological mechanisms. Results: In vitro, PAW significantly eradicated two major marine pathogens, Vibrio vulnificus and Vibrio parahaemolyticus (p < 0.001). In vivo, PAW markedly accelerated wound closure, achieving complete healing in 23.60 ± 6.50 days vs. 38.67 ± 2.08 days (Normal saline group) and 58.33 ± 10.97 days (Model group) (p < 0.05). PAW significantly reduced bacterial burden, modulated inflammation by decreasing interleukin-6 and increasing interleukin-10, and alleviated oxidative stress, as evidenced by reduced malondialdehyde levels and enhanced superoxide dismutase activity. Histological evaluation demonstrated enhanced re-epithelialization, collagen deposition, and increased expression of vascular endothelial growth factor and platelet endothelial cell adhesion molecule-1. No adverse effects on serum biochemistry or major organ histopathology were observed. Conclusions: PAW may be a safe, promising, and multifunctional irrigation strategy that promotes seawater-immersed burn healing through coordinated antibacterial, anti-inflammatory, antioxidant, and pro-angiogenic effects, highlighting its strong potential for clinical translation. Full article