Search Results (905)

Organic–inorganic hybrid crystalline materials formed in multicomponent aqueous systems are of interest because their phase behavior and physicochemical properties can be controlled by composition and crystallization conditions. In this study, the phase equilibria and crystallization behavior of the ternary aqueous Ca(ClO₃)₂·2CO(NH₂)₂–CH₂ClCOOH·(C₂H₄OH)₃N–H₂O system were investigated over the temperature range of −24 to 60 °C using the visual-polythermal method. Experimental data obtained for the two boundary binary subsystems and eight internal sections were used to construct the polythermal phase diagram. The diagram revealed distinct crystallization fields corresponding to ice, Ca(ClO₃)₂·2CO(NH₂)₂·2H₂O, CH₂ClCOOH·(C₂H₄OH)₃N, and a separate crystallization region associated with a previously unreported crystalline phase with the proposed composition ClCH₂COOH·Ca(ClO₃)₂·(C₂H₄OH)₃N. The solid phase was isolated from its crystallization region, washed with cold distilled water, dried to constant mass, and characterized by complementary Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (SEM–EDS), thermogravimetric analysis, derivative thermogravimetry, and differential scanning calorimetry (TG–DTG–DSC), and powder X-ray diffraction (PXRD). The experimentally determined Ca²⁺ and ClO₃⁻ contents were reasonably consistent with the proposed composition, while FT-IR spectroscopy revealed characteristic chlorate vibrations and changes in the vibrational environment of the organic component. SEM showed predominantly prismatic and plate-like crystalline morphologies, and EDS confirmed the presence of Ca, Cl, O, C, and N. Thermal analysis demonstrated multistage decomposition, with comparatively good thermal stability below approximately 150 °C. PXRD revealed a diffraction fingerprint distinct from those of the starting components and the corresponding physical mixture. Preliminary indexing of 19 principal reflections was consistent with a tetragonal candidate lattice with a = b = 7.7411(5) Å, c = 24.7182(10) Å, V = 1481.2(5) ų, and M₂₀ ≈ 23.0. The crystallographic analysis is considered preliminary because the diffraction profile was reconstructed from the available pattern and was not subjected to complete structure refinement. Overall, the combined phase-equilibrium, compositional, spectroscopic, morphological, thermal, and diffraction data support the isolation of a distinct organic–inorganic crystalline phase with the proposed composition. Full article

The fate of heavy metals in agricultural soils is governed by organo-mineral–microbial interactions, which predictive models often fail to capture. The competitive sorption mechanisms of Cd(II) and Cu(II) on montmorillonite/kaolinite composites (Mont/Kao) functionalized with humic acid (HA) and Pseudomonas putida (P. p), a model system representative of contaminated agricultural soils, were investigated. Batch experiments, XRD, FTIR, and thermodynamic analysis reveal that metal retention is a non-additive function of competing interfacial processes. Bacterial biomass dominated sorption, accounting for >50% of total metal uptake, with capacity ranked as: P. p > Mont/Kao-P. p > Mont/Kao-HA-P. p > Mont/Kao-HA > Mont/Kao. Humic acid exerts a dual, concentration-dependent role: Low levels enhanced adsorption via mineral dispersion, while high levels induced surface masking, suppressing bacterial binding sites. Competition was highly asymmetric: Cd(II) reduced Cu(II) maximum adsorption capacity by 75.5% in the Mont/Kao-HA system by preferentially occupying montmorillonite interlayer sites, whereas Cu(II) inhibited Cd(II) below pH 6. Single-metal sorption was characterized by positive ΔS° (32.96–58.89 J·mol⁻¹·K⁻¹), indicative of inner-sphere complexation, while negative ΔS° under competitive conditions signals a transition to outer-sphere complexation. This work provides mechanistic insights into site masking, competitive displacement, and ternary cation bridging controlling metal immobilization in organo-mineral assemblages. Full article

“Altering the auxiliary atoms” is an effective approach for expanding the planar tetracoordinate carbon (ptC) family. The ternary CBe₄S₃²⁻ cluster has been designed by using the “isoelectronic replacement of auxiliary bridges” strategy, based on previously reported ptC CBe₄Cl₃⁺. It possesses a fan-shaped structure, containing one ptC center, an arc-shaped Be₄ ligand chain, and three auxiliary S bridges. The extensive search and high-level quantum chemistry calculations indicate that both ptC CBe₄S₃²⁻ and its derivative CBe₄S₃⁻ are global minima structures on their potential energy surfaces. Born–Oppenheimer molecular dynamics simulations suggest that they also possess good dynamical stability. Chemical bonding analyses indicate that the ptC center in CBe₄S₃²⁻ is stabilized by one delocalized π bond and three delocalized σ bonds within the CBe₄ core, while magnetically induced current density analysis reveals localized diatropic circulations without exhibiting a ring current. The current contribution introduces two new members to the ptC family, expanding the ptC bonding modes and design strategies. Full article

The synthetic industry has shortened human lifespans because of environmental contamination. Numerous physicochemical methods can be used to decompose the released organic contaminants, but heterogeneous photocatalysis stands out among them. The creation of a novel sunlight-active heterogeneous photocatalyst, ZVI@MnFe₂O₄/PTh, for possible degradation of RhB dye is discussed in this study. The nanocomposite was fabricated using the hydrothermal method and in situ polymerization of thiophene. The ternary composite photocatalyst (ZVI@MnFe₂O₄/PTh) and photocatalysts (ZVI@MnFe₂O₄ and MnFe₂O₄/PTh) were well characterized in terms of structure (Fourier transform infrared spectroscopy), morphology (scanning electron microscopy), composition (energy-dispersive X-ray), and crystallinity (X-ray diffraction). UV–visible spectroscopic analysis (Tauc plot) was used to determine the energy bandgaps of catalysts. The characterization study supports the successful assembly of ZVI@MnFe₂O₄ nanoparticles and polythiophene. To evaluate the photocatalytic performance, the photocatalytically helped degradation of Rhodamine B dye from wastewater was also investigated over the new catalysts. The designed heterojunction enhances photogenerated charge separation and stimulates the photocatalytic process. The proposed study’s findings demonstrated that the novel composite’s sunlight-active photocatalytic effectiveness (99% in 90 min at pH 4) was enhanced against the degradation of Rhodamine B dye. Different models were utilized to predict the reaction’s kinetics, and RSM was utilized as a statistical technique to examine the individual and then interaction effects of the influencing parameters. The RSM results were supported by the numerical values of the optimized parameters, which were pH = 4, H₂O₂ = 10 mM, and composite dose = 20 mg/50 mL, utilizing a 100 ppm RhB solution. Full article

Water hyacinth leaves (WHL) are an inexpensive renewable fuel resource that can be employed for energy creation through hydrolysis of simple fermentable reducing sugars. In this work, a hybrid microwave irradiation (MWI)–ternary deep eutectic solvent (TNDES) system involving choline chloride (ChCl) as a hydrogen bond acceptor (HBA), triethanolamine (TEOA) as an amine-based hydrogen bond donor (HBD), monoethylene glycol (MEG), diethylene glycol (DEG), or triethylene glycol (TEG) as polyol-based HBD components was employed as an efficient and green material for pretreatment of WHL for further transformation of the polysaccharide portion. The results showed that hybrid MWI/TNDES (ChCl-TEOA-MEG, ChCl-TEOA-DEG, and ChCl-TEOA-TEG) pretreatments were very efficient for lignin removal from WHL, with efficacy ranging from 80.4 ± 3.2 to 87.7 ± 3.8% compared with pretreatment using hybrid MWI/binary NDES (ChCl-TEOA) (75.6 ± 2.4%). The higher efficacy of the hybrid MWI/TNDES pretreatment was attributed to the impacts of MWI on extracting biological materials and the lower viscosity, higher pH, and lower density associated with the TNDESs. The results indicate that WHL pretreated using hybrid MWI and ChCl-TEOA-MEG, ChCl-TEOA-DEG, and ChCl-TEOA-TEG resulted in significantly boosting cellulose digestibility (4–5 times that of pristine WHL and 1.5 times that of hybrid MWI/ChCl-TEOA-treated WHL). The effect of MWI/TNDES pretreatment was confirmed by scanning electron microscope (SEM) pictures, and lignin and hemicellulose elimination were clearly observed in Fourier transform infrared (FTIR) spectra. The lignin-rich material separated by the hybrid MWI/TNDES pretreatment was analyzed using thermogravimetric analysis (TGA) to obtain the thermal behaviors of this hybrid, pretreated WHL material. In our experimentation with hybrid MWI/TNDES, under optimum circumstances of MWI time of 6 min, MWI power of 300 W, and a temperature of 90 °C, 43–49 g/L TRS yield was achieved by acid-catalyzed hydrolysis employing WHL substrate after being optimized by the single-factor experiments (SFE) approach, while the optimized TRS for untreated WHL and hybrid MWI/binary ChCl-TEOA were estimated to be 12 g/L and 32 g/L, respectively. The hybrid MWI/ChCl-TEOA-TEG pretreated WHL resulted in a high ethanol yield (ca. 22.3 g/L) by Saccharomyces cerevisiae after 72 h of fermentation. This work demonstrates the potential of WHL as a sustainable bioenergy feedstock for bioethanol production in industrial biorefineries. The research establishes effective and green solvent pre-treatment materials and methods (based on hybrid MWI/TNDES) for the efficient removal of lignin and hemicellulose from WHL and cellulose recovery. In general, the research contributes to the development of environmentally friendly and cost-effective hybrid MWI/TNDES processes for WHL biomass conversion and offers strong evidence that hybrid MWI/TNDES processes represent a high-potential method for managing WHL infestations while generating useful products. Future studies should further investigate ways to enhance the efficacy of acid-catalyzed hydrolysis processes and assess the scalability of the technology for industrial applications. Full article

Blockchain-based peer-to-peer (P2P) energy trading enables prosumers to sell surplus electricity directly to one another without a central intermediary, but its open ledger reveals each participant’s bid price to every blockchain node, including the distribution system operator (DSO) that settles the trades. Prior work has addressed this concern by using inner product encryption (IPE) to encode each bid as a vector and perform matching directly over ciphertexts, yet the resulting pairing-based comparison and heavy on-chain heap restructuring still incur substantial gas costs. To resolve this issue, this paper proposes two orthogonal optimization methods. First, we replace the pairing-based IPE of the prior baseline with a matrix-based IPE, which substitutes pairing operations with matrix multiplication and a trace evaluation. This allows compact ternary encoding of integers and enables ciphertext entries to be packed into narrower Solidity integer types. Second, we introduce two heap-management policies: (i) the index-based heap, which exchanges integer indices instead of full ciphertexts during swaps, and (ii) the root-retention heap, which eliminates redundant heap restructuring under residual rebidding. Our performance analysis shows that the proposed optimization strategies substantially reduce the total gas consumption of the energy trading system compared with the pairing-based baseline, and the heap-management policies deliver consistent savings regardless of the underlying cryptographic primitive. Full article

Designing multi-ingredient preservation systems is crucial for reducing the use of synthetic additives while maintaining food safety. This study evaluated the antimicrobial efficacy of ternary mixtures combining two natural antimicrobials (thymol, carvacrol, eugenol, citral, vanillin) and potassium sorbate (PS) against Listeria innocua and Salmonella Typhimurium at pH 4.5 and 5.5. The fractional inhibitory concentration index (FICI) and the total minimum inhibitory concentration (MIC) were determined to identify optimal synergistic combinations. Multivariate analysis, including Principal Component Analysis and Partial Least Squares (PLS) regression with standardized coefficients, was applied to decipher the relative impact and hierarchy of the predictor variables. At pH 4.5, concentrations of PS ≤ 64 ppm combined with any of the natural components resulted in higher synergistic mixtures (low FICI 0.318–0.378) for L. innocua. For Salmonella, only combinations of thymol, carvacrol, eugenol, and PS ≤ 32 ppm obtained the lowest FICI (0.252–0.344) at pH 4.5, while at pH 5.5, 128 ppm PS, thymol, and vanillin were required for a similar FICI (0.363). The PLS models revealed a distinct shift in variable importance between the synergistic index and the MIC. For the FICI model, mixture components exerted the primary influence; potassium sorbate displayed the highest predictive weight (standardized coefficient: +0.8736), followed by eugenol (+0.7757), carvacrol (+0.6206), and citral (+0.5119). This indicates that maximum synergism (lowest FICI) is constrained to lower fractional concentrations of natural compounds, thereby avoiding saturation of the cellular target site. Bacterial species (+0.2418) and pH (+0.3146) contributed less, indicating a homogeneous effect across the tested bacteria. For the total MIC model, potassium sorbate (+0.4701) and vanillin (+0.4492) regulated the antimicrobial quantity requirements. For the strains evaluated, the coefficients of the bacterial type in both models indicate that the ternary mixtures performed similarly. These findings demonstrate that integrating multivariate PLS modeling provides a robust framework for optimizing natural-synthetic antimicrobial blends, significantly reducing dependence on potassium sorbate through tailored synergism. Full article

Multifunctional polymer scaffolds with mechanical support, biocompatibility, and antimicrobial activity are key for next-generation biomedical materials. We report the fabrication of electrospun nanocomposite fibers made from polycaprolactone (PCL), starch, and mesoporous aluminum oxide nanoparticles (n-Al₂O₃). Nanoparticles (11 ± 4 nm) were synthesized via a sol-gel method, predominantly comprising γ- and α-Al₂O₃ phases. Four fiber systems were fabricated by side-by-side electrospinning: PCL, PCL/starch, PCL/n-Al₂O₃, and PCL/starch/n-Al₂O₃. SEM analysis confirmed uniform and bead-free fibers in all formulations. Tensile tests showed that the incorporation of starch and nanoparticles improved the mechanical performance compared with neat PCL. In particular, PCL/starch/n-Al₂O₃ fibers exhibited increases of 404% in Young’s modulus and 102% in elongation at break. In PBS, starch and n-Al₂O₃ enhanced hydrophilicity and accelerated weight loss, with PCL/starch/n-Al₂O₃ showing the highest mass loss. Antibacterial tests indicated that only fibers with nanoparticles could inhibit Staphylococcus aureus and Escherichia coli, with PCL/starch/n-Al₂O₃ showing a major effect. Although n-Al₂O₃ increased cytotoxicity toward NIH-3T3, starch mitigated this effect, and the ternary scaffold showed no detectable cytotoxicity. Moreover, PCL/starch/n-Al₂O₃ exhibited non-hemolytic behavior, enhanced fibroblast migration, and wound-healing-related protein expression. Overall, side-by-side electrospun PCL/starch/n-Al₂O₃ scaffold exhibited showed improved mechanical, biological, and antibacterial properties, supporting its potential as a wound-dressing material. Full article

A flexible skin patch based on thermochromic liquid crystals (TLCs) embedded within a polydimethylsiloxane (PDMS) elastomer is presented for passive visualization of skin–vein thermal contrasts. Five ternary TLC formulations composed of cholesteryl oleyl carbonate (COC), cholesteryl nonanoate (CN), and cholesteryl benzoate (CB) were systematically engineered to tune mesophase stability and helical pitch sensitivity within the physiological temperature range (32–37 °C). Small compositional adjustments (≤1 wt.%) produced pronounced and predictable shifts in color-play bandwidth and optical sensitivity, governed by thermally induced contraction of the cholesteric helix. Patterned TLC microdomains were integrated onto optically absorptive PDMS substrates and encapsulated within a transparent PDMS overlayer, yielding thin, mechanically compliant, and breathable films with uniform thermal transmission. Optical spectroscopy, optical microscopy, and RGB analysis revealed linear wavelength–temperature relationships (R² > 0.9) and red-to-green sensitivities of up to ~87 nm °C⁻¹, demonstrating high thermochromic sensitivity within the physiological skin temperature range. Mechanical characterization confirmed skin-matched elasticity, while preliminary sterilization studies indicated that the films retained their mechanical properties following ethanol immersion and UV exposure. As a feasibility study, the results demonstrate the potential of a compositionally tunable thermochromic elastomer platform for visualizing physiological skin temperature variations associated with superficial veins, providing a basis for further development toward wearable vein visualization for self-cannulation in home hemodialysis and related thermal sensing applications. Full article

Background: DNA methylation is a key epigenetic mechanism whose dynamics are closely linked to ageing. Modern epigenetic clocks predict biological age based on the average methylation level. The concept of “epigenetic rejuvenation” posits that at early stages of development, the biological age of the embryo may decrease, reaching a minimum (“ground zero”) at the gastrulation stage. However, standard averaging methods may not account for important rearrangements in the internal structure of methylation. Objective: To apply the apparatus of information theory and topological data science to the analysis of scNMT-seq data and to test whether DNA methylation entropy decreases from stage E4.5 to E6.5, which would correspond to an approach towards the biological zero state. Methods: Publicly available scNMT-seq data (GSE121690) were analyzed. Five entropy measures were calculated for each cell (Shannon, Renyi, Tsallis, LZ-complexity, local gradient entropy (entropy of variations in the smoothed histogram of the methylation distribution), and persistent entropy (PE)—a topological complexity measure). For the five-dimensional entropy feature space, a Rips complex was constructed, and persistence diagrams H_0 and H_1 were computed. Results: All five entropy measures decreased significantly, with LZ complexity showing the largest relative reduction (−28.4%) and the strongest independent signal (partial r = −0.181). Among all the complexity measures studied, LZ complexity exhibited the largest relative reduction, underscoring its heightened sensitivity to the progressive ordering of the epigenetic landscape. Notably, the ternary encoding of LZ complexity showed strong correlation with Shannon entropy (r = 0.71), indicating that algorithmic complexity, when accounting for partial methylation states, aligns closely with statistical entropy while retaining sensitivity to spatial order. The consistency of results across binary and ternary encodings confirms the robustness of LZ complexity as a structural biomarker. Persistent entropy confirmed the general dynamics (decrease from 15.91 to 14.89, p = 0.01). Topological analysis of the multidimensional space revealed a qualitative reorganization: at stage E6.5, stable cyclic structures (H₁) emerge, while at E4.5 the space is dominated by a single large-scale cycle. Null model validation confirmed that the observed H₁-cycles are genuine topological features rather than random fluctuations. Comprehensive topological characterization showed that normalized persistent entropy increases from 0.846 to 0.882 (p < 0.001), while maximum persistence decreases from 0.446 to 0.218 (p < 0.001), reflecting a transition from a homogeneous state to structured diversification—multiple, evenly distributed cycles corresponding to distinct cell lineages. Consistent with this, regional disorder (RE/RD) at the single-cell level decreases from E4.5 to E6.5 (RE: −25.5%, RD: −27.4%, p < 10⁻¹³), while global entropy also decreases, together painting a picture of epigenetic rejuvenation as ordered consolidation at the whole-genome scale. An SVM model trained on 15 entropy and structural features achieved stage classification with an accuracy of 93.4% and AUC of 0.981, confirming the diagnostic potential of the approach. Conclusions: The decrease in DNA methylation entropy from E4.5 to E6.5 corresponds to an approach to “ground zero”—the point of minimum biological age in embryogenesis—and supports the hypothesis of a link between decreasing entropy and epigenetic rejuvenation. The addition of topological analysis reveals the hidden organization of epigenetic diversity, showing that ordering does not lead to homogenization but is accompanied by the formation of distinguishable cell lineages. Full article

The microstructure of ternary precursors significantly influences the electrochemical performance of ternary cathode materials and, consequently, the overall performance of lithium-ion batteries. In industrial production utilizing traditional co-precipitation methods, Scanning Electron Microscopy (SEM) is typically employed for particle detection. However, this approach is limited by offline sampling lag, poor representativeness, cumbersome sample preparation, and low efficiency, failing to achieve real-time quality feedback on production lines. To enable high-throughput particle detection, this study proposes a multi-layer PDMS chip designed for three-dimensional (3D) hydrodynamic focusing. The sheath fluid compressed the sample flow in horizontal and vertical directions, respectively, to form a flat ribbon flow passing through the detection area. High-fidelity raw images are captured for automated particle microstructure analysis. Firstly, a chemical pretreatment protocol was optimized to ensure stable precursor solution transport. Secondly, a three-layer composite microchannel featuring a sequential horizontal and vertical sheath-flow compression mechanism was designed, with its geometry optimized via Computational Fluid Dynamics (CFD) simulations. Subsequently, experimental optimizations of flow rate ratios were performed using sodium fluorescein, followed by validation with ternary precursor solutions. The results indicate that the microchannel achieves flattened monolayer focusing of randomly distributed precursor particles, compressing the sample stream height to approximately 15.44 μm, thereby maintaining the particle stream within the microscope’s depth of field and analyzing particle microstructure efficiently based on a microscopic image. Moreover, it is confirmed that the focused stream dimensions are primarily governed by the flow rate ratio, allowing for a flexible increase in detection throughput by adjusting the total flow rate. Different from static offline particle analyzers, this platform captures dynamic particle morphology under continuous flow, providing real-time data to guide co-precipitation reaction adjustment. Full article

Spray pyrolysis is a popular method for the low-cost synthesis of oxides and other compounds in thin-film form. Here, we discuss several nuances of using this method for ternary and quaternary compounds. Specifically, we outline how precursor solubility and thermal decomposition, as well as desorption of intermediate species from the sample surface govern the spray pyrolysis growth process. We demonstrate how the stoichiometry transfer from solution to film can be affected in selected test cases. We present real-time optical growth measurements of the behaviour of individual Cu, Cr, Zn, and Sn precursors, as well as post-growth analysis of film composition by X-ray photoelectron spectroscopy for ternary transparent conducting oxides (TCOs; p-type: Cu_xCrO₂, SnTiO_x; and n-type: a-ZnSnO₃). We illustrate how several steps of spray pyrolysis affect the stoichiometry transfer from the solution to the ternary thin film. Using binary Cu₂O as a test case, we also show how the choice of instrument geometry and nozzle type can affect film homogeneity. All materials discussed have been chosen to highlight potential difficulties of the spray pyrolysis process of ternary, quaternary, or even more complex oxides, and the mechanisms should be considered for other materials as well. We therefore also provide an extensive overview of suitable precursor salts with similar expected properties as used in this experimental work to guide future ternary oxide studies. Full article

The corrosion inhibition performance of a ternary inhibitor based on alkyl phosphate esters was investigated in environments simulating geothermal CO₂ systems at 60 °C and 80 °C using AISI 1018 steel as the test material. The inhibition efficiency was evaluated using mass loss method and electrochemical techniques, including linear polarization resistance (LPR), potentiodynamic polarization, and electrochemical impedance spectroscopy (EIS). Structural and surface characterization of the samples were performed using Fourier transform infrared spectroscopy (FTIR) and intermittent contact–alternating current scanning electrochemical microscopy (IC-AC-SECM). The results demonstrated a significant reduction in the corrosion rate in the presence of the inhibitor at both investigated temperatures, accompanied by an increase in polarization resistance and a decrease in corrosion current density. Electrochemical measurements indicated that the investigated inhibitor acts as a mixed-type corrosion inhibitor. FTIR analysis supported the presence of inhibitor-related species at the steel interface, while IC-AC-SECM measurements indicated a relatively homogeneous and electrochemically protected surface under the investigated conditions. The concentration–surface-coverage relationship was close to the Langmuir-type form at 60 °C, whereas greater deviations were observed at 80 °C, together with a lower apparent adsorption parameter, suggesting temperature-dependent changes in the interfacial layer. The results demonstrate the strong corrosion-protection performance of the investigated commercial ternary inhibitor formulation under the tested conditions. Full article

The chronic overuse of antibiotics has accelerated the emergence of antibiotic-resistant bacteria, creating a global public health crisis as conventional therapies fail against multidrug-resistant pathogens spreading through water and food chains. Cadmium sulfide (CdS) has been established as an important visible-light-driven photocatalyst for antibacterial applications. This brief review systematically examines the structure–property relationships governing CdS-based antibacterial materials, including crystallographic polymorphs (cubic sphalerite and hexagonal wurtzite), morphological diversity from quantum dots to hierarchical architectures, and synthesis methodologies that critically influence particle size, crystallinity, and surface chemistry. The mechanisms of antibacterial action are elucidated, encompassing photocatalytic reactive oxygen species (ROS) generation, controlled Cd²⁺ ion release, and membrane disruption. A detailed tabulated analysis is presented across three material classes: pristine CdS, binary composites, and ternary Z-scheme heterostructures. Density functional theory (DFT) calculations and molecular docking simulations provide atomic-level insights into charge transfer dynamics and enzyme inhibition mechanisms. Finally, critical challenges, photocorrosion, toxicity, biocompatibility concerns, and scalability limitations are addressed. This review bridges fundamental materials science with antimicrobial applications to guide rational design of next-generation CdS-based antibacterial materials. Full article

Hydrogen-rich compounds under high pressure are promising for high-temperature superconductivity, but many high-$T_{\mathrm{c}}$ hydrides rely on rare-earth or alkaline-earth elements and remain difficult to tune chemically. Transition-metal hydrides offer an alternative platform because partially filled d states can modify the electronic density of states, metal–hydrogen hybridization, and electron–phonon coupling. Here, ${\mathrm{VH}}_3$ is used as a parent high-pressure transition-metal hydride framework, and Ti substitution is introduced as a chemically compatible way to tune the d-derived states near the Fermi level. Two ternary hydrides, ${\mathrm{Ti}}_3{\mathrm{VH}}_{12}$ and ${\mathrm{TiV}}_3{\mathrm{H}}_{12}$, are therefore constructed from the ${\mathrm{VH}}_3$ lattice and investigated by first-principles calculations at 200 GPa. Both compounds are thermodynamically and dynamically stable under this pressure condition, as indicated by formation energies, the Ti–V–H convex hull, and phonon spectra. Within the same ultrasoft-pseudopotential computational framework, ${\mathrm{Ti}}_3{\mathrm{VH}}_{12}$ and ${\mathrm{TiV}}_3{\mathrm{H}}_{12}$ yield Allen–Dynes $T_{\mathrm{c}}$ values of 42.1 K and 36.8 K, respectively, higher than the corresponding ${\mathrm{VH}}_3$ value. A norm-conserving cross-check for ${\mathrm{VH}}_3$ gives a different absolute value, indicating that the $T_{\mathrm{c}}$ estimates are method-dependent. Electronic structure analysis indicates that Ti incorporation shifts pronounced van Hove singularities close to the Fermi level, enhances the density of states, and changes the Fermi surface topology. These results suggest that Ti–V–H hydrides are a useful model system for examining how transition-metal substitution can couple structural stability with electronic tuning in compressed hydride superconductors. Full article