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Keywords = technology driven transition

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30 pages, 1655 KB  
Review
Harnessing Renewable Waste as a Pathway and Opportunities Toward Sustainability in Saudi Arabia and the Gulf Region
by Abdullah Alghafis, Haneen Bawayan, Sultan Alghamdi, Mohamed Nejlaoui and Abdullah Alrashidi
Sustainability 2025, 17(20), 8980; https://doi.org/10.3390/su17208980 - 10 Oct 2025
Abstract
This review examines the vast opportunities and key challenges in renewable waste management across the Gulf region, with a particular emphasis on Saudi Arabia. As global demand for sustainable energy intensifies, driven by technological advancements and environmental concerns, the Gulf Cooperation Council nations, [...] Read more.
This review examines the vast opportunities and key challenges in renewable waste management across the Gulf region, with a particular emphasis on Saudi Arabia. As global demand for sustainable energy intensifies, driven by technological advancements and environmental concerns, the Gulf Cooperation Council nations, notably Saudi Arabia, are beginning to acknowledge the urgency of transitioning from fossil fuel reliance to renewable waste management. This review identifies the abundant renewable resources in the region and highlights progress in policy development while emphasizing the need for comprehensive frameworks and financial incentives to drive further investment and innovation. Waste-to-energy (WTE) technologies offer a promising avenue for reducing environmental degradation and bolstering energy security. With Saudi Arabia targeting the development of 3 Gigawatts of WTE capacity by 2030 as part of national sustainability initiatives, barriers such as regulatory complexities, financial constraints, and public misconceptions persist. Ultimately, this review concludes that advancing renewable waste management in the Gulf, particularly through stronger policies, stakeholders’ collaboration, investment in WTE and an enhancement in public awareness and education, is critical for achieving sustainability goals. By harnessing these opportunities, the region can take decisive steps toward achieving sustainability, positioning Saudi Arabia as a leader in the global fight against climate change and resource depletion. Full article
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30 pages, 4876 KB  
Article
China’s Rural Industrial Integration Under the “Triple Synergy of Production, Livelihood and Ecology” Philosophy: Internal Mechanisms, Level Measurement, and Sustainable Development Paths
by Jinsong Zhang, Mengru Ma, Jinglin Qian and Linmao Ma
Sustainability 2025, 17(20), 8972; https://doi.org/10.3390/su17208972 - 10 Oct 2025
Abstract
Against the backdrop of global agricultural transformation, rural China faces the critical challenge of reconciling economic development with environmental conservation and social well-being. This study, grounded in the rural revitalization strategy, investigates the internal mechanisms, level measurement, and sustainable development paths of rural [...] Read more.
Against the backdrop of global agricultural transformation, rural China faces the critical challenge of reconciling economic development with environmental conservation and social well-being. This study, grounded in the rural revitalization strategy, investigates the internal mechanisms, level measurement, and sustainable development paths of rural industrial integration based on the “Triple Integration of Production, Livelihood and Ecology” (PLE) philosophy. Firstly, we discussed the suitability and the mechanisms of this philosophy on China’s rural industrial integration. Secondly, based on a textual corpus extracted from academic journals and policy documents, we employed an LDA topic model to cluster the themes and construct an evaluation indicator system comprising 29 indicators. Then, utilizing data from the China Statistical Yearbook and the China Rural Statistical Yearbook (2013–2022), we measured the level of China’s rural industrial integration using the entropy method. The composite integration index displays a continuous upward trend over 2013–2022, accelerating markedly after the 2015 stimulus policy, yet a temporary erosion of “production–livelihood–ecology” synergy occurred in 2020 owing to an exogenous shock. Lastly, combining the system dynamics model, we simulated over the period 2023–2030 the three sustainable development scenarios: green ecological development priority, livelihood standard development priority and production level development priority. Research has shown that (1) the “Triple Synergy of Production, Livelihood and Ecology” philosophy and China’s rural industrial integration are endogenously unified, and they form a two-way mutual mechanism with the common goal of sustainable development. (2) China’s rural industrial integration under this philosophy is characterized by production-dominated development and driven mainly by processing innovation and service investment, but can be constrained by ecological fragility and external shocks. (3) System dynamics simulations reveal that the production-development priority scenario (Scenario 3) is the most effective pathway, suggesting that the production system is a vital engine driving the sustainable development of China’s rural industrial integration, with digitalization and technological innovation significantly improving integration efficiency. In the future, efforts should focus on transitioning towards a people-centered model by restructuring cooperative equity for farmer ownership, building community-based digital commons to bridge capability gaps, and creating market mechanisms to monetize and reward conservation practices. Full article
(This article belongs to the Section Sustainable Urban and Rural Development)
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25 pages, 4379 KB  
Review
Bridging Global Perspectives: A Comparative Review of Agent-Based Modeling for Block-Level Walkability in Chinese and International Research
by Yidan Wang, Renzhang Wang, Xiaowen Xu, Bo Zhang, Marcus White and Xiaoran Huang
Buildings 2025, 15(19), 3613; https://doi.org/10.3390/buildings15193613 - 9 Oct 2025
Abstract
As cities strive for human-centered and fine-tuned development, Agent-Based Modeling (ABM) has emerged as a powerful tool for simulating pedestrian behavior and optimizing walkable neighborhood design. This study presents a comparative bibliometric analysis of ABM applications in block-scale walkability research from 2015 to [...] Read more.
As cities strive for human-centered and fine-tuned development, Agent-Based Modeling (ABM) has emerged as a powerful tool for simulating pedestrian behavior and optimizing walkable neighborhood design. This study presents a comparative bibliometric analysis of ABM applications in block-scale walkability research from 2015 to 2024, drawing on both Chinese- and English-language literature. Using visualization tools such as VOSviewer, the analysis reveals divergences in national trajectories, methodological approaches, and institutional logics. Chinese research demonstrates a policy-driven growth pattern, particularly following the introduction of the “15-Minute Community Life Circle” initiative, with an emphasis on neighborhood renewal, age-friendly design, and transit-oriented planning. In contrast, international studies show a steady output driven by technological innovation, integrating methods such as deep learning, semantic segmentation, and behavioral simulation to address climate resilience, equity, and mobility complexity. The study also classifies ABM applications into five key application domains, highlighting how Chinese and international studies differ in focus, data inputs, and implementation strategies. Despite these differences, both research streams recognize the value of ABM in transport planning, public health, and low-carbon urbanism. Key challenges identified include data scarcity, algorithmic limitations, and ethical concerns. The study concludes with future research directions, including multimodal data fusion, integration with extended reality, and the development of privacy-aware, cross-cultural modeling standards. These findings reinforce ABM’s potential as a smart urban simulation tool for advancing adaptive, human-centered, and sustainable neighborhood planning. Full article
(This article belongs to the Special Issue Sustainable Urban and Buildings: Lastest Advances and Prospects)
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22 pages, 1014 KB  
Review
Advances in IoT, AI, and Sensor-Based Technologies for Disease Treatment, Health Promotion, Successful Ageing, and Ageing Well
by Yuzhou Qian and Keng Leng Siau
Sensors 2025, 25(19), 6207; https://doi.org/10.3390/s25196207 - 7 Oct 2025
Viewed by 322
Abstract
Recent advancements in the Internet of Things (IoT) and artificial intelligence (AI) are unlocking transformative opportunities across society. One of the most critical challenges addressed by these technologies is the ageing population, which presents mounting concerns for healthcare systems and quality of life [...] Read more.
Recent advancements in the Internet of Things (IoT) and artificial intelligence (AI) are unlocking transformative opportunities across society. One of the most critical challenges addressed by these technologies is the ageing population, which presents mounting concerns for healthcare systems and quality of life worldwide. By supporting continuous monitoring, personal care, and data-driven decision-making, IoT and AI are shifting healthcare delivery from a reactive approach to a proactive one. This paper presents a comprehensive overview of IoT-based systems with a particular focus on the Internet of Healthcare Things (IoHT) and their integration with AI, referred to as the Artificial Intelligence of Things (AIoT). We illustrate the operating procedures of IoHT systems in detail. We highlight their applications in disease management, health promotion, and active ageing. Key enabling technologies, including cloud computing, edge computing architectures, machine learning, and smart sensors, are examined in relation to continuous health monitoring, personalized interventions, and predictive decision support. This paper also indicates potential challenges that IoHT systems face, including data privacy, ethical concerns, and technology transition and aversion, and it reviews corresponding defense mechanisms from perception, policy, and technology levels. Future research directions are discussed, including explainable AI, digital twins, metaverse applications, and multimodal sensor fusion. By integrating IoT and AI, these systems offer the potential to support more adaptive and human-centered healthcare delivery, ultimately improving treatment outcomes and supporting healthy ageing. Full article
(This article belongs to the Section Internet of Things)
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27 pages, 1588 KB  
Article
Toward the Theoretical Foundations of Industry 6.0: A Framework for AI-Driven Decentralized Manufacturing Control
by Andrés Fernández-Miguel, Susana Ortíz-Marcos, Mariano Jiménez-Calzado, Alfonso P. Fernández del Hoyo, Fernando E. García-Muiña and Davide Settembre-Blundo
Future Internet 2025, 17(10), 455; https://doi.org/10.3390/fi17100455 - 3 Oct 2025
Viewed by 359
Abstract
This study advances toward establishing the theoretical foundations of Industry 6.0 by developing a comprehensive framework that integrates artificial intelligence (AI), decentralized control systems, and cyber–physical production environments for intelligent, sustainable, and adaptive manufacturing. The research employs a tri-modal methodology (deductive, inductive, and [...] Read more.
This study advances toward establishing the theoretical foundations of Industry 6.0 by developing a comprehensive framework that integrates artificial intelligence (AI), decentralized control systems, and cyber–physical production environments for intelligent, sustainable, and adaptive manufacturing. The research employs a tri-modal methodology (deductive, inductive, and abductive reasoning) to construct a theoretical architecture grounded in five interdependent constructs: advanced technology integration, decentralized organizational structures, mass customization and sustainability strategies, cultural transformation, and innovation enhancement. Unlike prior conceptualizations of Industry 6.0, the proposed framework explicitly emphasizes the cyclical feedback between innovation and organizational design, as well as the role of cultural transformation as a binding element across technological, organizational, and strategic domains. The resulting framework demonstrates that AI-driven decentralized control systems constitute the cornerstone of Industry 6.0, enabling autonomous real-time decision-making, predictive zero-defect manufacturing, and strategic organizational agility through distributed intelligent control architectures. This work contributes foundational theory and actionable guidance for transitioning from centralized control paradigms to AI-driven distributed intelligent manufacturing control systems, establishing a conceptual foundation for the emerging Industry 6.0 paradigm. Full article
(This article belongs to the Special Issue Artificial Intelligence and Control Systems for Industry 4.0 and 5.0)
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39 pages, 1966 KB  
Article
Sustainable Urban Mobility Transitions—From Policy Uncertainty to the CalmMobility Paradigm
by Katarzyna Turoń
Smart Cities 2025, 8(5), 164; https://doi.org/10.3390/smartcities8050164 - 1 Oct 2025
Viewed by 485
Abstract
Continuous technological, ecological, and digital transformations reshape urban mobility systems. While sustainable mobility has become a dominant keyword, there are many different approaches and policies to help achieve lasting and properly functioning change. This study applies a comprehensive qualitative policy analysis to influential [...] Read more.
Continuous technological, ecological, and digital transformations reshape urban mobility systems. While sustainable mobility has become a dominant keyword, there are many different approaches and policies to help achieve lasting and properly functioning change. This study applies a comprehensive qualitative policy analysis to influential and leading sustainable mobility approaches (i.a. Mobility Justice, Avoid–Shift–Improve, spatial models like the 15-Minute City and Superblocks, governance frameworks such as SUMPs, and tools ranging from economic incentives to service architectures like MaaS and others). Each was assessed across structural barriers, psychological resistance, governance constraints, and affective dimensions. The results show that, although these approaches provide clear normative direction, measurable impacts, and scalable applicability, their implementation is often undermined by fragmentation, Policy Layering, limited intermodality, weak Future-Readiness, and insufficient participatory engagement. Particularly, the lack of sequencing and pacing mechanisms leads to policy silos and societal resistance. The analysis highlights that the main challenge is not the absence of solutions but the absence of a unifying paradigm. To address this gap, the paper introduces CalmMobility, a conceptual framework that integrates existing strengths while emphasizing comprehensiveness, pacing–sequencing–inclusion, and Future-Readiness. CalmMobility offers adaptive and co-created pathways for mobility transitions, grounded in education, open innovation, and a calm, deliberate approach. Rather than being driven by hasty or disruptive change, it seeks to align technological and spatial innovations with societal expectations, building trust, legitimacy, and long-term resilience of sustainable mobility. Full article
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22 pages, 1797 KB  
Article
A Novel Hybrid Deep Learning–Probabilistic Framework for Real-Time Crash Detection from Monocular Traffic Video
by Reşat Buğra Erkartal and Atınç Yılmaz
Appl. Sci. 2025, 15(19), 10523; https://doi.org/10.3390/app151910523 - 29 Sep 2025
Viewed by 318
Abstract
The rapid evolution of autonomous vehicle technologies has amplified the need for crash detection that operates robustly under complex traffic conditions with minimal latency. We propose a hybrid temporal hierarchy that augments a Region-based Convolutional Neural Network (R-CNN) with an adaptive time-variant Kalman [...] Read more.
The rapid evolution of autonomous vehicle technologies has amplified the need for crash detection that operates robustly under complex traffic conditions with minimal latency. We propose a hybrid temporal hierarchy that augments a Region-based Convolutional Neural Network (R-CNN) with an adaptive time-variant Kalman filter (with total-variation prior), a Hidden Markov Model (HMM) for state stabilization, and a lightweight Artificial Neural Network (ANN) for learned temporal refinement, enabling real-time crash detection from monocular video. Evaluated on simulated traffic in CARLA and real-world driving in Istanbul, the full temporal stack achieves the best precision–recall balance, yielding 83.47% F1 offline and 82.57% in real time (corresponding to 94.5% and 91.2% detection accuracy, respectively). Ablations are consistent and interpretable: removing the HMM reduces F1 by 1.85–2.16 percentage points (pp), whereas removing the ANN has a larger impact of 2.94–4.58 pp, indicating that the ANN provides the largest marginal gains—especially under real-time constraints. The transition from offline to real time incurs a modest overall loss (−0.90 pp F1), driven more by recall than precision. Compared to strong single-frame baselines, YOLOv10 attains 82.16% F1 and a real-time Transformer detector reaches 82.41% F1, while our full temporal stack remains slightly ahead in real time and offers a more favorable precision–recall trade-off. Notably, integrating the ANN into the HMM-based pipeline improves accuracy by 2.2%, while the time-variant Kalman configuration reduces detection lag by approximately 0.5 s—an improvement that directly addresses the human reaction time gap. Under identical conditions, the best RCNN-based configuration yields AP@0.50 ≈ 0.79 with an end-to-end latency of 119 ± 21 ms per frame (~8–9 FPS). Overall, coupling deep learning with probabilistic reasoning yields additive temporal benefits and advances deployable, camera-only crash detection that is cost-efficient and scalable for intelligent transportation systems. Full article
(This article belongs to the Section Computing and Artificial Intelligence)
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30 pages, 1430 KB  
Review
A Critical Review of Limited-Entry Liner (LEL) Technology for Unconventional Oil and Gas: A Case Study of Tight Carbonate Reservoirs
by Bohong Wu, Junbo Sheng, Dongyu Wu, Chao Yang, Xinxin Zhang and Yong He
Energies 2025, 18(19), 5159; https://doi.org/10.3390/en18195159 - 28 Sep 2025
Viewed by 267
Abstract
Limited-Entry Liner (LEL) technology has emerged as a transformative solution for enhancing hydrocarbon recovery in unconventional reservoirs while addressing challenges in carbon sequestration. This review examines the role of LEL in optimizing acid stimulation, hydraulic fracturing and production optimization, focusing on its ability [...] Read more.
Limited-Entry Liner (LEL) technology has emerged as a transformative solution for enhancing hydrocarbon recovery in unconventional reservoirs while addressing challenges in carbon sequestration. This review examines the role of LEL in optimizing acid stimulation, hydraulic fracturing and production optimization, focusing on its ability to improve fluid distribution uniformity in horizontal wells through precision-engineered orifices. By integrating theoretical models, experimental studies, and field applications, we highlight LEL’s potential to mitigate the heel–toe effect and reservoir heterogeneity, thereby maximizing stimulation efficiency. Based on a comprehensive review of existing literature, this study identifies critical limitations in current LEL models—such as oversimplified annular flow dynamics, semi-empirical treatment of wormhole propagation, and a lack of quantitative design guidance—and aims to bridge these gaps through integrated multiphysics modeling and machine learning-driven optimization. Furthermore, we explore its adaptability for controlled CO2 injection in geological storage, offering a sustainable approach to energy transition. This work provides a comprehensive yet accessible overview of LEL’s significance in both energy production and environmental sustainability. Full article
(This article belongs to the Special Issue Unconventional Energy Exploration Technology)
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37 pages, 964 KB  
Article
Linear Optimization Model with Nonlinear Constraints to Maximize Biogas Production from Organic Waste: A Practical Approach
by Juan Carlos Vesga Ferreira, Alexander Florez Martinez and Jhon Erickson Barbosa Jaimes
Appl. Sci. 2025, 15(19), 10453; https://doi.org/10.3390/app151910453 - 26 Sep 2025
Viewed by 282
Abstract
The excessive use of fossil fuels and the increasing generation of solid waste, driven by population growth, industrialization, and economic development, have led to serious environmental, energy, and public health issues. In light of this problem, it is crucial to adopt sustainable solutions [...] Read more.
The excessive use of fossil fuels and the increasing generation of solid waste, driven by population growth, industrialization, and economic development, have led to serious environmental, energy, and public health issues. In light of this problem, it is crucial to adopt sustainable solutions that promote the transition to renewable energy sources, such as biogas. Although progress has been made in optimizing biogas production, there is still no adaptable model for various environments that allows for the determination of optimal quantities of different organic wastes, simultaneously considering their composition, moisture content, and control of critical factors for biogas production, as well as the biodigester’s capacity and other relevant elements. In practice, the dosing of waste is conducted empirically, leading to inefficiencies that limit the potential for biogas production in real scenarios. The objective of this article is to propose a linear optimization model with nonlinear constraints that maximizes biogas production, considering fundamental parameters such as the moisture percentage, pH, carbon/nitrogen ratio (C/N), substrate volume, organic matter, volatile solids (VS), and biogas production potential from different wastes. The model estimates the optimal waste composition based on the biodigester capacity to ensure balanced substrates. The results for the proposed scenarios demonstrate its effectiveness: Scenario 1 achieved 3.42 m3 (3418.67 L) of biogas, while Scenario 2, with a greater diversity of waste, reached 8.06 m3 (8061.43 L). The model maintained pH (6.49–6.50), C/N ratio (20.00), and moisture (60.00%) within optimal ranges. Additionally, a Monte Carlo sensitivity analysis (1000 simulations) validated its robustness with a 95% confidence level. This model provides an efficient tool for optimizing biogas production and waste dosing in rural contexts, promoting clean and sustainable technologies for renewable energy generation. Full article
(This article belongs to the Section Energy Science and Technology)
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15 pages, 1460 KB  
Article
Areal Assessment in the Design of a Try-Out Grid-Tied Solar PV-Green Hydrogen-Battery Storage Microgrid System for Industrial Application in South Africa
by Blessed Sarema, Gibson P. Chirinda, Sören Scheffler, Stephen Matope and Ulrike Beyer
Sustainability 2025, 17(19), 8649; https://doi.org/10.3390/su17198649 - 26 Sep 2025
Viewed by 235
Abstract
The carbon emission reduction mission requires a multifaceted approach, in which green hydrogen is expected to play a key role. The accelerated adoption of green hydrogen technologies is vital to this journey towards carbon neutrality by 2050. However, the energy transition involving green [...] Read more.
The carbon emission reduction mission requires a multifaceted approach, in which green hydrogen is expected to play a key role. The accelerated adoption of green hydrogen technologies is vital to this journey towards carbon neutrality by 2050. However, the energy transition involving green hydrogen requires a data-driven approach to ensure that the benefits are realised. The introduction of testing sites for green hydrogen technologies will be crucial in enabling the performance testing of various components within the green hydrogen value chain. This study involves an areal assessment of a selected test site for the installation of a grid-tied solar PV-green hydrogen-battery storage microgrid system at a factory facility in South Africa. The evaluation includes a site energy audit to determine the consumption profile and an analysis of the location’s weather pattern to assess its impact on the envisaged microgrid. Lastly, a design of the microgrid is conceptualised. A 39 kW photovoltaic system powers the microgrid, which comprises a 22 kWh battery storage system, 10 kW of electrolyser capacity, an 8 kW fuel cell, and an 800 L hydrogen storage capacity between 30 and 40 bars. Full article
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27 pages, 1382 KB  
Article
Integrating AI and Geospatial Technologies for Sustainable Smart City Development: A Case Study of Yerevan
by Khoren Mkhitaryan, Anna Sanamyan, Mariam Mnatsakanyan, Erika Kirakosyan and Svetlana Ratner
Urban Sci. 2025, 9(10), 389; https://doi.org/10.3390/urbansci9100389 - 26 Sep 2025
Viewed by 549
Abstract
Urban growth and environmental pressures in rapidly transforming cities require innovative governance tools that integrate advanced technologies with institutional assessment. This study develops and applies a strategic integration framework that combines spatial analysis, Convolutional Neural Networks (CNNs)-based land-use classification, SHAP-based feature attribution, and [...] Read more.
Urban growth and environmental pressures in rapidly transforming cities require innovative governance tools that integrate advanced technologies with institutional assessment. This study develops and applies a strategic integration framework that combines spatial analysis, Convolutional Neural Networks (CNNs)-based land-use classification, SHAP-based feature attribution, and stakeholder interviews to evaluate Yerevan, Armenia, as a case of a mid-income city facing accelerated urbanization. The case selection is justified by Yerevan’s rapid built-up expansion, fragmented green areas, and institutional challenges in aligning urban development with sustainability goals. The CNN model achieved 92.4% accuracy in land-use classification, and projections under a business-as-usual scenario indicate a 12.8% increase in built-up areas and a 6.5% decline in green zones by 2030. SHAP analysis identified land surface temperature and NDVI as the most influential predictors, while governance interviews highlighted gaps in regulatory support and technical capacity. The proposed framework advances the literature by integrating AI-driven geospatial analysis with qualitative governance assessment, providing actionable insights for urban policymakers. Findings underscore the potential of combining machine learning, geospatial technologies, and institutional diagnostics to guide smart city planning in transition economies. Full article
(This article belongs to the Special Issue Sustainable Urbanization, Regional Planning and Development)
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12 pages, 1113 KB  
Review
Beyond PSA: The Future of Prostate Cancer Diagnosis Using Artificial Intelligence, Novel Biomarkers, and Advanced Imagery
by Moncef Al Barajraji, Mathieu Coscarella, Ilyas Svistakov, Helena Flôres Soares da Silva, Paula Mata Déniz, María Jesús Marugan, Claudia González-Santander, Lorena Fernández Montarroso, Isabel Galante, Juan Gómez Rivas and Jesús Moreno Sierra
Life 2025, 15(10), 1508; https://doi.org/10.3390/life15101508 - 25 Sep 2025
Viewed by 463
Abstract
Prostate cancer (PCa) diagnosis has historically relied on the prostate-specific antigen (PSA) testing. Although the screening significantly reduces mortality rates, PSA has low specificity with risks of overdiagnosis and overtreatment. These limitations highlight the need for a more accurate diagnostic approach. Emerging technologies, [...] Read more.
Prostate cancer (PCa) diagnosis has historically relied on the prostate-specific antigen (PSA) testing. Although the screening significantly reduces mortality rates, PSA has low specificity with risks of overdiagnosis and overtreatment. These limitations highlight the need for a more accurate diagnostic approach. Emerging technologies, such as artificial intelligence (AI), novel biomarkers, and advanced imaging techniques, offer promising avenues to enhance the accuracy and efficiency of PCa diagnosis and risk stratification. This narrative review comprehensively analyzed the current literature, focusing on new tools aiding PCa diagnosis (AI-driven image interpretation, radiomics, genomic classifiers, biomarkers, and multimodal data integration) with consideration for technical, regulatory, and ethical challenges related to clinical implementation of AI-based technologies. A literature search was performed using the PubMed and MEDLINE databases to identify relevant peer-reviewed articles published in English using the search terms “prostate cancer,” “artificial intelligence,” “machine learning,” “deep learning,” “MRI,” “histopathology,” and “diagnosis.” Articles were selected based on their relevance to AI-assisted diagnostic tools, clinical utility, and performance metrics. In addition, a separate section was developed initially to contextualize the limitations of current PSA-based screening approaches. The reviewed studies showed that AI had significant utility in prostate mpMRI interpretation (lesion detection; Gleason grading) with high accuracy and high reproducibility. For the pathologist, AI-driven algorithms improve the diagnostic accuracy of digital slide evaluation for histologic diagnosis of prostate cancer and automated Gleason score grading. Genomic tools such as the Oncotype DX test, combined with AI, could also allow for tailored and individualized risk prediction. Overall, multimodal models integrating clinical, imaging, and molecular data often outperform traditional PSA-based strategies and reduce unnecessary biopsies. Transition from PSA-centered toward AI-driven, biomarker-supported, and image-enhanced diagnosis marks a critical evolution in PCa diagnosis. Full article
(This article belongs to the Special Issue Diagnosis, Treatment and Prognosis of Prostate Cancer)
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45 pages, 10484 KB  
Systematic Review
Innovative Procedures and Tools for the Digitalisation of Management Construction Processes in PA: A Systematic Scoping Review
by Giulia D’Alberto, Kavita Raj, Virginia Adele Tiburcio and Ugo Maria Coraglia
Buildings 2025, 15(19), 3457; https://doi.org/10.3390/buildings15193457 - 24 Sep 2025
Viewed by 459
Abstract
In recent years, the construction sector has experienced a significant technological transition, driven by the introduction of innovative digital tools and the evolution of the legislative environment. This article presents a Systematic Scoping Review conducted in accordance with the PRISMA-ScR guidelines, aiming to [...] Read more.
In recent years, the construction sector has experienced a significant technological transition, driven by the introduction of innovative digital tools and the evolution of the legislative environment. This article presents a Systematic Scoping Review conducted in accordance with the PRISMA-ScR guidelines, aiming to examine the role of Public Administration (PA) regarding the adoption of innovative technologies, such as Building Information Modelling (BIM) and Digital Twin (DT), to improve the management of construction and public procurement processes. The review analyses the state of the art in the implementation of digitalised procedures for project management in the construction phase, according to PA organisational purposes and national and international standard requirements. The data obtained was used to structure the analysis in order to provide a useful framework for understanding the level of convergence between the academic world and public administration in the use of digital technologies and their combined applications. The review results are organised in a thematic matrix classifying contributions according to key topics, building process phases, and operational aims. This approach highlights adopted strategies and emerging best practices, aiming to support both PAs and professionals in overcoming digitalisation challenges. A specific focus has been dedicated to the need for continuous training and legislative adaptation, which are essential for integrating digital technologies into building processes. The analysis and verification of the results of the systematic scoping review on the digitalisation process in the construction sector, conducted between academia and the public administration, is supported by a comparison with an Italian case study from the Emilia-Romagna region, which illustrates the specific application of the strategies identified in the digital management of public construction processes. Full article
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25 pages, 562 KB  
Article
VeriFlow: A Framework for the Static Verification of Web Application Access Control via Policy-Graph Consistency
by Tao Zhang, Fuzhong Hao, Yunfan Wang, Bo Zhang and Guangwei Xie
Electronics 2025, 14(18), 3742; https://doi.org/10.3390/electronics14183742 - 22 Sep 2025
Viewed by 435
Abstract
The evolution of industrial automation toward Industry 3.0 and 4.0 has driven the emergence of Industrial Edge-Cloud Platforms, which increasingly depend on web interfaces for managing and monitoring critical operational technology. This convergence introduces significant security risks, particularly from Broken Access Control (BAC)—a [...] Read more.
The evolution of industrial automation toward Industry 3.0 and 4.0 has driven the emergence of Industrial Edge-Cloud Platforms, which increasingly depend on web interfaces for managing and monitoring critical operational technology. This convergence introduces significant security risks, particularly from Broken Access Control (BAC)—a vulnerability consistently ranked as the top web application risk by the Open Web Application Security Project (OWASP). BAC flaws in industrial contexts can lead not only to data breaches but also to disruptions of physical processes. To address this urgent need for robust web-layer defense, this paper presents VeriFlow, a static verification framework for access control in web applications. VeriFlow reformulates access control verification as a consistency problem between two core artifacts: (1) a Formal Access Control Policy (P), which declaratively defines intended permissions, and (2) a Navigational Graph, which models all user-driven UI state transitions. By annotating the graph with policy P, VeriFlow verifies a novel Path-Permission Safety property, ensuring that no sequence of legitimate UI interactions can lead a user from an authorized state to an unauthorized one. A key technical contribution is a static analysis method capable of extracting navigational graphs directly from the JavaScript bundles of Single-Page Applications (SPAs), circumventing the limitations of traditional dynamic crawlers. In empirical evaluations, VeriFlow outperformed baseline tools in vulnerability detection, demonstrating its potential to deliver strong security guarantees that are provable within its abstracted navigational model. By formally checking policy-graph consistency, it systematically addresses a class of vulnerabilities often missed by dynamic tools, though its effectiveness is subject to the model-reality gap inherent in static analysis. Full article
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20 pages, 890 KB  
Review
Innovative Approaches to EMT-Related Biomarker Identification in Breast Cancer: Multi-Omics and Machine Learning Methods
by Ghazaleh Khalili-Tanha and Alireza Shoari
BioTech 2025, 14(3), 75; https://doi.org/10.3390/biotech14030075 - 22 Sep 2025
Viewed by 403
Abstract
Breast cancer is the most prevalent cancer among women and is challenging to diagnose and treat due to its diverse subtypes and stages. Precision medicine aims to improve early detection, prognosis, and treatment planning by identifying new clinical biomarkers. The review emphasizes the [...] Read more.
Breast cancer is the most prevalent cancer among women and is challenging to diagnose and treat due to its diverse subtypes and stages. Precision medicine aims to improve early detection, prognosis, and treatment planning by identifying new clinical biomarkers. The review emphasizes the importance of using cutting-edge technology and artificial intelligence (AI) to identify new biomarkers associated with epithelial–mesenchymal transition (EMT). During EMT, epithelial cells transform into a mesenchymal state, a process driven by genetic and epigenetic alterations that facilitate cancer progression. The review discusses how statistical analysis and machine learning methods applied to multi-omics data facilitate the discovery of novel EMT-related biomarkers, thereby advancing therapeutic strategies. This conclusion is supported by numerous clinical and preclinical studies on breast cancer. Full article
(This article belongs to the Section Medical Biotechnology)
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