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Search Results (3,553)

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Keywords = sustainable-related technology

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27 pages, 7899 KiB  
Article
Digital Enablers of Sustainability: Insights from Sustainable Development Goals (SDGs) Research Mapping
by Jeongmi Ga, Jaewoo Bong, Myeongjun Yu and Minjung Kwak
Sustainability 2025, 17(15), 7031; https://doi.org/10.3390/su17157031 (registering DOI) - 2 Aug 2025
Abstract
As the global emphasis on sustainable development intensifies, the integration of digital technologies (DTs) into efforts to address the Sustainable Development Goals (SDGs) has gained increasing attention. However, existing research on the link between the SDGs and DTs remains fragmented and lacks a [...] Read more.
As the global emphasis on sustainable development intensifies, the integration of digital technologies (DTs) into efforts to address the Sustainable Development Goals (SDGs) has gained increasing attention. However, existing research on the link between the SDGs and DTs remains fragmented and lacks a comprehensive perspective on their interconnections. We aimed to address this gap by conducting a large-scale bibliometric analysis based on Elsevier’s SDG research mapping technique. Drawing on approximately 1.17 million publications related to both the 17 SDGs and 11 representative DTs, we explored research trends in the SDG–DT association, identified DTs that are most frequently tied to specific SDGs, and uncovered emerging areas of research within this interdisciplinary domain. Our results highlight the rapid expansion in the volume and variety of SDG–DT studies. Our findings shed light on the widespread relevance of artificial intelligence and robotics, the goal-specific applications of technologies such as 3D printing, cloud computing, drones, and extended reality, as well as the growing visibility of emerging technologies such as digital twins and blockchain. These findings offer valuable insights for researchers, policymakers, and industry leaders aiming to strategically harness DTs to support sustainable development and accelerate progress toward achieving the SDGs. Full article
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20 pages, 9174 KiB  
Review
Marine-Derived Collagen and Chitosan: Perspectives on Applications Using the Lens of UN SDGs and Blue Bioeconomy Strategies
by Mariana Almeida and Helena Vieira
Mar. Drugs 2025, 23(8), 318; https://doi.org/10.3390/md23080318 (registering DOI) - 1 Aug 2025
Viewed by 34
Abstract
Marine biomass, particularly from waste streams, by-products, underutilized, invasive, or potential cultivable marine species, offers a sustainable source of high-value biopolymers such as collagen and chitin. These macromolecules have gained significant attention due to their biocompatibility, biodegradability, functional versatility, and broad applicability across [...] Read more.
Marine biomass, particularly from waste streams, by-products, underutilized, invasive, or potential cultivable marine species, offers a sustainable source of high-value biopolymers such as collagen and chitin. These macromolecules have gained significant attention due to their biocompatibility, biodegradability, functional versatility, and broad applicability across health, food, wellness, and environmental fields. This review highlights recent advances in the uses of marine-derived collagen and chitin/chitosan. In alignment with the United Nations Sustainable Development Goals (SDGs), we analyze how these applications contribute to sustainability, particularly in SDGs related to responsible consumption and production, good health and well-being, and life below water. Furthermore, we contextualize the advancement of product development using marine collagen and chitin/chitosan within the European Union’s Blue bioeconomy strategies, highlighting trends in scientific research and technological innovation through bibliometric and patent data. Finally, the review addresses challenges facing the development of robust value chains for these marine biopolymers, including collaboration, regulatory hurdles, supply-chain constraints, policy and financial support, education and training, and the need for integrated marine resource management. The paper concludes with recommendations for fostering innovation and sustainability in the valorization of these marine resources. Full article
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20 pages, 865 KiB  
Review
Barriers and Facilitators to Artificial Intelligence Implementation in Diabetes Management from Healthcare Workers’ Perspective: A Scoping Review
by Giovanni Cangelosi, Andrea Conti, Gabriele Caggianelli, Massimiliano Panella, Fabio Petrelli, Stefano Mancin, Matteo Ratti and Alice Masini
Medicina 2025, 61(8), 1403; https://doi.org/10.3390/medicina61081403 (registering DOI) - 1 Aug 2025
Viewed by 32
Abstract
Background and Objectives: Diabetes is a global public health challenge, with increasing prevalence worldwide. The implementation of artificial intelligence (AI) in the management of this condition offers potential benefits in improving healthcare outcomes. This study primarily investigates the barriers and facilitators perceived by [...] Read more.
Background and Objectives: Diabetes is a global public health challenge, with increasing prevalence worldwide. The implementation of artificial intelligence (AI) in the management of this condition offers potential benefits in improving healthcare outcomes. This study primarily investigates the barriers and facilitators perceived by healthcare professionals in the adoption of AI. Secondarily, by analyzing both quantitative and qualitative data collected, it aims to support the potential development of AI-based programs for diabetes management, with particular focus on a possible bottom-up approach. Materials and Methods: A scoping review was conducted following PRISMA-ScR guidelines for reporting and registered in the Open Science Framework (OSF) database. The study selection process was conducted in two phases—title/abstract screening and full-text review—independently by three researchers, with a fourth resolving conflicts. Data were extracted and assessed using Joanna Briggs Institute (JBI) tools. The included studies were synthesized narratively, combining both quantitative and qualitative analyses to ensure methodological rigor and contextual depth. Results: The adoption of AI tools in diabetes management is influenced by several barriers, including perceived unsatisfactory clinical performance, high costs, issues related to data security and decision-making transparency, as well as limited training among healthcare workers. Key facilitators include improved clinical efficiency, ease of use, time-saving, and organizational support, which contribute to broader acceptance of the technology. Conclusions: The active and continuous involvement of healthcare workers represents a valuable opportunity to develop more effective, reliable, and well-integrated AI solutions in clinical practice. Our findings emphasize the importance of a bottom-up approach and highlight how adequate training and organizational support can help overcome existing barriers, promoting sustainable and equitable innovation aligned with public health priorities. Full article
(This article belongs to the Special Issue Advances in Public Health and Healthcare Management for Chronic Care)
38 pages, 959 KiB  
Review
Emerging Trends in Active Packaging for Food: A Six-Year Review
by Mariana A. Andrade, Cássia H. Barbosa, Regiane Ribeiro-Santos, Sidney Tomé, Ana Luísa Fernando, Ana Sanches Silva and Fernanda Vilarinho
Foods 2025, 14(15), 2713; https://doi.org/10.3390/foods14152713 (registering DOI) - 1 Aug 2025
Viewed by 42
Abstract
The development of active food packaging has evolved rapidly in recent years, offering innovative solutions to enhance food preservation and safety while addressing sustainability challenges. This review compiles and analyzes recent advancements (2019–2024) in release-type active packaging, focusing on essential oils, natural extracts, [...] Read more.
The development of active food packaging has evolved rapidly in recent years, offering innovative solutions to enhance food preservation and safety while addressing sustainability challenges. This review compiles and analyzes recent advancements (2019–2024) in release-type active packaging, focusing on essential oils, natural extracts, and phenolic compounds as active agents. Primarily plant-derived, these compounds exhibit significant antioxidant and antimicrobial activities, extending shelf life and enhancing food quality. Technological strategies such as encapsulation and polymer blending have been increasingly adopted to overcome challenges related to volatility, solubility, and sensory impact. Integrating bio-based polymers, including chitosan, starch, and polylactic acid, further supports the development of environmentally friendly packaging systems. This review also highlights trends in compound-specific research, release mechanisms, and commercial applications, including a detailed analysis of patents and case studies across various food matrices. These developments have already been translated into practical applications, such as antimicrobial sachets for meat and essential oil-based pads for fresh produce. Moreover, by promoting the valorization of agro-industrial by-products and the use of biodegradable materials, emission-type active packaging contributes to the principles of the circular economy. This comprehensive overview underscores the potential of natural bioactive compounds in advancing sustainable and functional food packaging technologies. Full article
28 pages, 694 KiB  
Article
Artificial Intelligence-Enabled Digital Transformation in Circular Logistics: A Structural Equation Model of Organizational, Technological, and Environmental Drivers
by Ionica Oncioiu, Diana Andreea Mândricel and Mihaela Hortensia Hojda
Logistics 2025, 9(3), 102; https://doi.org/10.3390/logistics9030102 (registering DOI) - 1 Aug 2025
Viewed by 42
Abstract
Background: Digital transformation is increasingly present in modern logistics, especially in the context of sustainability and circularity pressures. The integration of technologies such as Internet of Things (IoT), Radio Frequency Identification (RFID), and automated platforms involves not only infrastructure but also a [...] Read more.
Background: Digital transformation is increasingly present in modern logistics, especially in the context of sustainability and circularity pressures. The integration of technologies such as Internet of Things (IoT), Radio Frequency Identification (RFID), and automated platforms involves not only infrastructure but also a strategic vision, a flexible organizational culture, and the ability to support decisions through artificial intelligence (AI)-based systems. Methods: This study proposes an extended conceptual model using structural equation modelling (SEM) to explore the relationships between five constructs: technological change, strategic and organizational readiness, transformation environment, AI-enabled decision configuration, and operational redesign. The model was validated based on a sample of 217 active logistics specialists, coming from sectors such as road transport, retail, 3PL logistics services, and manufacturing. The participants are involved in the digitization of processes, especially in activities related to operational decisions and sustainability. Results: The findings reveal that the analysis confirms statistically significant relationships between organizational readiness, transformation environment, AI-based decision processes, and operational redesign. Conclusions: The study highlights the importance of an integrated approach in which technology, organizational culture, and advanced decision support collectively contribute to the transition to digital and circular logistics chains. Full article
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20 pages, 621 KiB  
Article
Support Needs of Agrarian Women to Build Household Livelihood Resilience: A Case Study of the Mekong River Delta, Vietnam
by Tran T. N. Tran, Tanh T. N. Nguyen, Elizabeth C. Ashton and Sharon M. Aka
Climate 2025, 13(8), 163; https://doi.org/10.3390/cli13080163 (registering DOI) - 1 Aug 2025
Viewed by 40
Abstract
Agrarian women are at the forefront of rural livelihoods increasingly affected by the frequency and severity of climate change impacts. However, their household livelihood resilience (HLR) remains limited due to gender-blind policies, scarce sex-disaggregated data, and inadequate consideration of gender-specific needs in resilience-building [...] Read more.
Agrarian women are at the forefront of rural livelihoods increasingly affected by the frequency and severity of climate change impacts. However, their household livelihood resilience (HLR) remains limited due to gender-blind policies, scarce sex-disaggregated data, and inadequate consideration of gender-specific needs in resilience-building efforts. Grounded in participatory feminist research, this study employed a multi-method qualitative approach, including semi-structured interviews and oral history narratives, with 60 women in two climate-vulnerable provinces. Data were analyzed through thematic coding, CATWOE (Customers, Actors, Transformation, Worldview, Owners, Environmental Constraints) analysis, and descriptive statistics. The findings identify nine major climate-related events disrupting livelihoods and reveal a limited understanding of HLR as a long-term, transformative concept. Adaptation strategies remain short-term and focused on immediate survival. Barriers to HLR include financial constraints, limited access to agricultural resources and technology, and entrenched gender norms restricting women’s leadership and decision-making. While local governments, women’s associations, and community networks provide some support, gaps in accessibility and adequacy persist. Participants expressed the need for financial assistance, vocational training, agricultural technologies, and stronger peer networks. Strengthening HLR among agrarian women requires gender-sensitive policies, investment in local support systems, and community-led initiatives. Empowering agrarian women as agents of change is critical for fostering resilient rural livelihoods and achieving inclusive, sustainable development. Full article
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36 pages, 6545 KiB  
Review
MXene-Based Composites for Energy Harvesting and Energy Storage Devices
by Jorge Alexandre Alencar Fotius and Helinando Pequeno de Oliveira
Solids 2025, 6(3), 41; https://doi.org/10.3390/solids6030041 (registering DOI) - 1 Aug 2025
Viewed by 65
Abstract
MXenes, a class of two-dimensional transition metal carbides and nitrides, emerged as a promising material for next-generation energy storage and corresponding applications due to their unique combination of high electrical conductivity, tunable surface chemistry, and lamellar structure. This review highlights recent advances in [...] Read more.
MXenes, a class of two-dimensional transition metal carbides and nitrides, emerged as a promising material for next-generation energy storage and corresponding applications due to their unique combination of high electrical conductivity, tunable surface chemistry, and lamellar structure. This review highlights recent advances in MXene-based composites, focusing on their integration into electrode architectures for the development of supercapacitors, batteries, and multifunctional devices, including triboelectric nanogenerators. It serves as a comprehensive overview of the multifunctional capabilities of MXene-based composites and their role in advancing efficient, flexible, and sustainable energy and sensing technologies, outlining how MXene-based systems are poised to redefine multifunctional energy platforms. Electrochemical performance optimization strategies are discussed by considering surface functionalization, interlayer engineering, scalable synthesis techniques, and integration with advanced electrolytes, with particular attention paid to the development of hybrid supercapacitors, triboelectric nanogenerators (TENGs), and wearable sensors. These applications are favored due to improved charge storage capability, mechanical properties, and the multifunctionality of MXenes. Despite these aspects, challenges related to long-term stability, sustainable large-scale production, and environmental degradation must still be addressed. Emerging approaches such as three-dimensional self-assembly and artificial intelligence-assisted design are identified as key challenges for overcoming these issues. Full article
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23 pages, 849 KiB  
Article
Assessment of the Impact of Solar Power Integration and AI Technologies on Sustainable Local Development: A Case Study from Serbia
by Aco Benović, Miroslav Miškić, Vladan Pantović, Slađana Vujičić, Dejan Vidojević, Mladen Opačić and Filip Jovanović
Sustainability 2025, 17(15), 6977; https://doi.org/10.3390/su17156977 (registering DOI) - 31 Jul 2025
Viewed by 91
Abstract
As the global energy transition accelerates, the integration of solar power and artificial intelligence (AI) technologies offers new pathways for sustainable local development. This study examines four Serbian municipalities—Šabac, Sombor, Pirot, and Čačak—to assess how AI-enabled solar power systems can enhance energy resilience, [...] Read more.
As the global energy transition accelerates, the integration of solar power and artificial intelligence (AI) technologies offers new pathways for sustainable local development. This study examines four Serbian municipalities—Šabac, Sombor, Pirot, and Čačak—to assess how AI-enabled solar power systems can enhance energy resilience, reduce emissions, and support community-level sustainability goals. Using a mixed-method approach combining spatial analysis, predictive modeling, and stakeholder interviews, this research study evaluates the performance and institutional readiness of local governments in terms of implementing intelligent solar infrastructure. Key AI applications included solar potential mapping, demand-side management, and predictive maintenance of photovoltaic (PV) systems. Quantitative results show an improvement >60% in forecasting accuracy, a 64% reduction in system downtime, and a 9.7% increase in energy cost savings. These technical gains were accompanied by positive trends in SDG-aligned indicators, such as improved electricity access and local job creation in the green economy. Despite challenges related to data infrastructure, regulatory gaps, and limited AI literacy, this study finds that institutional coordination and leadership commitment are decisive for successful implementation. The proposed AI–Solar Integration for Local Sustainability (AISILS) framework offers a replicable model for emerging economies. Policy recommendations include investing in foundational digital infrastructure, promoting low-code AI platforms, and aligning AI–solar projects with SDG targets to attract EU and national funding. This study contributes new empirical evidence on the digital–renewable energy nexus in Southeast Europe and underscores the strategic role of AI in accelerating inclusive, data-driven energy transitions at the municipal level. Full article
27 pages, 565 KiB  
Review
Review of the Use of Waste Materials in Rigid Airport Pavements: Opportunities, Benefits and Implementation
by Loretta Newton-Hoare, Sean Jamieson and Greg White
Sustainability 2025, 17(15), 6959; https://doi.org/10.3390/su17156959 (registering DOI) - 31 Jul 2025
Viewed by 124
Abstract
The aviation industry is under increasing pressure to reduce its environmental impact while maintaining safety and performance standards. One promising area for improvement lies in the use of sustainable materials in airport infrastructure. One of the issues preventing uptake of emerging sustainable technologies [...] Read more.
The aviation industry is under increasing pressure to reduce its environmental impact while maintaining safety and performance standards. One promising area for improvement lies in the use of sustainable materials in airport infrastructure. One of the issues preventing uptake of emerging sustainable technologies is the lack of guidance relating to the opportunities, potential benefits, associated risks and an implementation plan specific to airport pavements. This research reviewed opportunities to incorporate waste materials into rigid airport pavements, focusing on concrete base slabs. Commonly used supplementary cementitious materials (SCMs), such as fly ash and ground granulated blast furnace slag (GGBFS) were considered, as well as recycled aggregates, including recycled concrete aggregate (RCA), recycled crushed glass (RCG), and blast furnace slag (BFS). Environmental Product Declarations (EPDs) were also used to quantify the potential for environmental benefit associated with various concrete mixtures, with findings showing 23% to 50% reductions in embodied carbon are possible for selected theoretical concrete mixtures that incorporate waste materials. With considered evaluation and structured implementation, the integration of waste materials into rigid airport pavements offers a practical and effective route to improve environmental outcomes in aviation infrastructure. It was concluded that a Triple Bottom Line (TBL) framework—assessing financial, environmental, and social factors—guides material selection and can support sustainable decision-making, as does performance-based specifications that enable sustainable technologies to be incorporated into airport pavement. The study also proposed a consequence-based implementation hierarchy to facilitate responsible adoption of waste materials in airside pavements. The outcomes of this review will assist airport managers and pavement designers to implement practical changes to achieve more sustainable rigid airport pavements in the future. Full article
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6 pages, 771 KiB  
Case Report
Sustained Complete Response to Trastuzumab Deruxtecan Beyond Treatment Discontinuation in a Heavily Pretreated HER2-Positive Breast Cancer Patient with Skin Metastases: A Case Report
by Maria Puleo, Sarah Pafumi, Martina Di Pietro, Giuseppina Rosaria Rita Ricciardi and Maria Vita Sanò
Reports 2025, 8(3), 126; https://doi.org/10.3390/reports8030126 - 31 Jul 2025
Viewed by 101
Abstract
Background and Clinical Significance: Breast cancer is a heterogeneous disease with different spread of metastases. In particular, skin metastases are common in HER2-positive metastatic breast cancer (mBC). However, anti-HER2 therapies have shown limited activity in this context. Recently, Trastuzumab Deruxtecan (T-DXd), a [...] Read more.
Background and Clinical Significance: Breast cancer is a heterogeneous disease with different spread of metastases. In particular, skin metastases are common in HER2-positive metastatic breast cancer (mBC). However, anti-HER2 therapies have shown limited activity in this context. Recently, Trastuzumab Deruxtecan (T-DXd), a novel potent anti-HER2 antibody–drug conjugate (ADC), has revolutionized the therapeutic armamentarium of HER2 mBC with unprecedented evidence of efficacy in pretreated patients. However, the activity of this drug in patients with skin involvement is largely unknown. Case Presentation: Here, we report a case of extensive cutaneous involvement in a heavily pretreated patient who achieved a long-lasting complete response to T-DXd, which, unexpectedly, remained sustained for more than three years following treatment discontinuation. Conclusions: Skin toxicity is not a common adverse event with this agent, and, as demonstrated in the present case, it might not be drug-related, and additional causes might be ruled out before treatment discontinuation. However, the possibility of discontinuing anti-Her2 treatment in a patient who has achieved a complete response could represent a field of research, potentially using liquid biopsy or other new technologies. Full article
(This article belongs to the Section Oncology)
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16 pages, 581 KiB  
Article
Financial Literacy and Sustainable Food Production in Rural Nigeria: Access and Adoption Perspectives
by Benedict Ogbemudia Imhanrenialena and Eveth Nkeiruka Nwobodo-Anyadiegwu
Sustainability 2025, 17(15), 6941; https://doi.org/10.3390/su17156941 - 30 Jul 2025
Viewed by 202
Abstract
Despite the importance of financial literacy, particularly in sustaining and improving rural agriculture, it is documented in the literature that little is known about financial literacy, particularly in rural communities in developing countries. Responding to the calls for research to address this gap, [...] Read more.
Despite the importance of financial literacy, particularly in sustaining and improving rural agriculture, it is documented in the literature that little is known about financial literacy, particularly in rural communities in developing countries. Responding to the calls for research to address this gap, the current study investigates how financial literacy relates to access to funding, innovative service adoption, and sustainable food production among agricultural food producers in Nigeria’s rural communities. A probability sampling technique was used to draw 460 samples from registered rural farmers in the Central Bank of Nigeria’s Anchored Borrower’s Programme for food production in Edo State, Nigeria. Quantitative data were collected using a structured questionnaire. The hypotheses were tested using regression analysis, while descriptive statistics were deployed to analyse the demographic data of the respondents. The outcomes suggest that financial literacy has significant links with access to funding, innovative service adoption and sustainable food production among agricultural food producers in Nigerian rural communities. Based on the outcomes, it is concluded that financial literacy significantly influences sustainable food production in Nigerian rural communities. As such, there is a need for the Nigerian government and financial authorities to embark on a financial literacy drive to increase financial literacy, particularly in light of ever-evolving disruptive financial technologies. Full article
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36 pages, 9312 KiB  
Review
Current Progress in the Biosynthesis of Metal Sulfide Nanomaterials for the Degradation of Dyes: A Review
by Carol D. Langa, Nonhlangabezo Mabuba and Nomso C. Hintsho-Mbita
Catalysts 2025, 15(8), 727; https://doi.org/10.3390/catal15080727 - 30 Jul 2025
Viewed by 174
Abstract
The contamination of water bodies by industrial dyes poses a significant environmental challenge on a global scale. Conventional wastewater treatment methods often suffer from limitations related to high cost, limited efficiency, and potential secondary environmental impacts. Recent advances in photocatalytic technologies have highlighted [...] Read more.
The contamination of water bodies by industrial dyes poses a significant environmental challenge on a global scale. Conventional wastewater treatment methods often suffer from limitations related to high cost, limited efficiency, and potential secondary environmental impacts. Recent advances in photocatalytic technologies have highlighted the potential of metal sulfide-based photocatalysts, particularly those synthesized through environmentally friendly, plant-mediated approaches, as promising alternatives for efficient and sustainable dye degradation. However, despite their promising potential, metal sulfide photocatalysts often suffer from limitations such as photocorrosion, low stability under irradiation, and rapid recombination of charge carriers, which restrict their long-term applicability. In light of these challenges, this review provides a comprehensive examination of the physicochemical characteristics, synthetic strategies, and photocatalytic applications of metal sulfides. Particular emphasis is placed on green synthesis routes employing plant-derived extracts, which offer environmentally benign and sustainable alternatives to conventional methods. Moreover, the review elucidates various modification approaches, most notably, the formation of heterostructures, as viable strategies to enhance photocatalytic efficiency and mitigate the aforementioned drawbacks. The green synthesis of metal sulfides, aligned with the principles of green chemistry, offers a promising route toward the development of sustainable and environmentally friendly water treatment technologies. Full article
(This article belongs to the Special Issue Recent Advances in Photocatalysis for Environmental Applications)
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24 pages, 1806 KiB  
Article
Optimization of Cleaning and Hygiene Processes in Healthcare Using Digital Technologies and Ensuring Quality Assurance with Blockchain
by Semra Tebrizcik, Süleyman Ersöz, Elvan Duman, Adnan Aktepe and Ahmet Kürşad Türker
Appl. Sci. 2025, 15(15), 8460; https://doi.org/10.3390/app15158460 - 30 Jul 2025
Viewed by 121
Abstract
Many hospitals still lack digital traceability in hygiene and cleaning management, leading to operational inefficiencies and inconsistent quality control. This study aims to establish cleaning and hygiene processes in healthcare services that are planned in accordance with standards, as well as to enhance [...] Read more.
Many hospitals still lack digital traceability in hygiene and cleaning management, leading to operational inefficiencies and inconsistent quality control. This study aims to establish cleaning and hygiene processes in healthcare services that are planned in accordance with standards, as well as to enhance the traceability and sustainability of these processes through digitalization. This study proposes a Hyperledger Fabric-based blockchain architecture to establish a reliable and transparent quality assurance system in process management. The proposed Quality Assurance Model utilizes digital technologies and IoT-based RFID devices to ensure the transparent and reliable monitoring of cleaning processes. Operational data related to cleaning processes are automatically recorded and secured using a decentralized blockchain infrastructure. The permissioned nature of Hyperledger Fabric provides a more secure solution compared to traditional data management systems in the healthcare sector while preserving data privacy. Additionally, the execute–order–validate mechanism supports effective data sharing among stakeholders, and consensus algorithms along with chaincode rules enhance the reliability of processes. A working prototype was implemented and validated using Hyperledger Caliper under resource-constrained cloud environments, confirming the system’s feasibility through over 100 TPS throughput and zero transaction failures. Through the proposed system, cleaning/hygiene processes in patient rooms are conducted securely, contributing to the improvement of quality standards in healthcare services. Full article
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50 pages, 937 KiB  
Review
Precision Neuro-Oncology in Glioblastoma: AI-Guided CRISPR Editing and Real-Time Multi-Omics for Genomic Brain Surgery
by Matei Șerban, Corneliu Toader and Răzvan-Adrian Covache-Busuioc
Int. J. Mol. Sci. 2025, 26(15), 7364; https://doi.org/10.3390/ijms26157364 - 30 Jul 2025
Viewed by 269
Abstract
Precision neurosurgery is rapidly evolving as a medical specialty by merging genomic medicine, multi-omics technologies, and artificial intelligence (AI) technology, while at the same time, society is shifting away from the traditional, anatomic model of care to consider a more precise, molecular model [...] Read more.
Precision neurosurgery is rapidly evolving as a medical specialty by merging genomic medicine, multi-omics technologies, and artificial intelligence (AI) technology, while at the same time, society is shifting away from the traditional, anatomic model of care to consider a more precise, molecular model of care. The general purpose of this review is to contemporaneously reflect on how these advances will impact neurosurgical care by providing us with more precise diagnostic and treatment pathways. We hope to provide a relevant review of the recent advances in genomics and multi-omics in the context of clinical practice and highlight their transformational opportunities in the existing models of care, where improved molecular insights can support improvements in clinical care. More specifically, we will highlight how genomic profiling, CRISPR-Cas9, and multi-omics platforms (genomics, transcriptomics, proteomics, and metabolomics) are increasing our understanding of central nervous system (CNS) disorders. Achievements obtained with transformational technologies such as single-cell RNA sequencing and intraoperative mass spectrometry are exemplary of the molecular diagnostic possibilities in real-time molecular diagnostics to enable a more directed approach in surgical options. We will also explore how identifying specific biomarkers (e.g., IDH mutations and MGMT promoter methylation) became a tipping point in the care of glioblastoma and allowed for the establishment of a new taxonomy of tumors that became applicable for surgeons, where a change in practice enjoined a different surgical resection approach and subsequently stratified the adjuvant therapies undertaken after surgery. Furthermore, we reflect on how the novel genomic characterization of mutations like DEPDC5 and SCN1A transformed the pre-surgery selection of surgical candidates for refractory epilepsy when conventional imaging did not define an epileptogenic zone, thus reducing resective surgery occurring in clinical practice. While we are atop the crest of an exciting wave of advances, we recognize that we also must be diligent about the challenges we must navigate to implement genomic medicine in neurosurgery—including ethical and technical challenges that could arise when genomic mutation-based therapies require the concurrent application of multi-omics data collection to be realized in practice for the benefit of patients, as well as the constraints from the blood–brain barrier. The primary challenges also relate to the possible gene privacy implications around genomic medicine and equitable access to technology-based alternative practice disrupting interventions. We hope the contribution from this review will not just be situational consolidation and integration of knowledge but also a stimulus for new lines of research and clinical practice. We also hope to stimulate mindful discussions about future possibilities for conscientious and sustainable progress in our evolution toward a genomic model of precision neurosurgery. In the spirit of providing a critical perspective, we hope that we are also adding to the larger opportunity to embed molecular precision into neuroscience care, striving to promote better practice and better outcomes for patients in a global sense. Full article
(This article belongs to the Special Issue Molecular Insights into Glioblastoma Pathogenesis and Therapeutics)
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17 pages, 1207 KiB  
Article
Assessing Critical Risk Factors to Sustainable Housing in Urban Areas: Based on the NK-SNA Model
by Guangyu Sun and Hui Zeng
Sustainability 2025, 17(15), 6918; https://doi.org/10.3390/su17156918 - 30 Jul 2025
Viewed by 178
Abstract
Housing sustainability is a cornerstone element of sustainable economic and social development. This is particularly true for China, where high-rise residential buildings are the primary form of housing. In recent years, China has experienced frequent housing-related accidents, resulting in a significant loss of [...] Read more.
Housing sustainability is a cornerstone element of sustainable economic and social development. This is particularly true for China, where high-rise residential buildings are the primary form of housing. In recent years, China has experienced frequent housing-related accidents, resulting in a significant loss of life and property damage. This study aims to identify the key factors influencing housing sustainability and provide a basis for the prevention and control of housing-related safety risks. This study has developed a housing sustainability evaluation indicator system comprising three primary indicators and 16 secondary indicators. This system is based on an analysis of the causes of over 500 typical housing accidents that occurred in China over the past 10 years, employing research methods such as literature reviews and expert consultations, and drawing on the analytical frameworks of risk management theory and system safety theory. Subsequently, the NK-SNA model, which significantly outperforms traditional models in terms of adaptive learning and optimization, as well as the explicit modeling of complex nonlinear relationships, was used to identify the key risk factors affecting housing sustainability. The empirical results indicate that the risk coupling value is correlated with the number of risk coupling factors; the greater the number of risk coupling factors, the larger the coupling value. Human misconduct is prone to forming two-factor risk coupling with housing, and the physical risk factors are prone to coupling with other factors. The environmental factors easily trigger ‘physical–environmental’ two-factor risk coupling. The key factors influencing housing sustainability are poor supervision, building facilities, the main structure, the housing height, foundation settlement, and natural disasters. On this basis, recommendations are made to make full use of modern information technologies such as the Internet of Things, big data, and artificial intelligence to strengthen the supervision of housing safety and avoid multi-factor coupling, and to improve upon early warnings of natural disasters and the design of emergency response programs to control the coupling between physical and environmental factors. Full article
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