Search Results (1,094)

Glioblastoma (GBM) is a highly aggressive brain tumor marked by invasive growth and therapy resistance. Tumor cells adapt to hostile conditions, such as hypoxia and nutrient deprivation, by activating survival mechanisms including autophagy and metabolic reprogramming. Among GBM-associated changes, hypersialylation, particularly, the aberrant expression of polysialic acid (PSA), has been linked to increased plasticity, motility, and immune evasion. PSA, a long α2,8-linked sialic acid polymer typically attached to the NCAM, is abundant in the embryonic brain and re-expressed in cancers, correlating with poor prognosis. Here, we investigated how PSA expression was regulated in GBM cells under nutrient-limiting conditions. Serum starvation induced a marked increase in PSA-NCAM, driven by upregulation of the polysialyltransferase ST8SiaIV and an autophagy-dependent recycling of sialic acids from degraded glycoproteins. Inhibition of autophagy or sialidases impaired PSA induction, and PSA regulation appeared dependent on p53 function. Immunohistochemical analysis of GBM tissues revealed co-localization of PSA and LC3, particularly around necrotic regions. In conclusion, we identified a novel mechanism by which GBM cells sustain PSA-NCAM expression via autophagy-mediated sialic acid recycling under nutrient stress. This pathway may enhance cell migration, immune escape, and stem-like properties, offering a potential therapeutic target in GBM. Full article

In this study, a Z-scheme Ho₂InSbO₇/Ag₃PO₄ (HAO) heterojunction photocatalyst was successfully fabricated for the first time by ultrasound-assisted solvothermal method. The structural features, compositional components and morphological characteristics of the synthesized materials were thoroughly characterized by a series of techniques, including X-ray diffraction, Fourier transform infrared spectroscopy, Raman spectrum, X-ray photoelectron spectroscopy, transmission electron microscopy, scanning electron microscopy and energy-dispersive X-ray spectroscopy. A comprehensive array of analytical techniques, including ultraviolet-visible diffuse reflectance absorption spectra, photoluminescence spectroscopy, time-resolved photoluminescence spectroscopy, photocurrent testing, electrochemical impedance spectroscopy, electron paramagnetic resonance, and ultraviolet photoelectron spectroscopy, was employed to systematically investigate the optical, chemical, and photoelectronic properties of the materials. Using oxytetracycline (OTC), a representative tetracycline antibiotic, as the target substrate, the photocatalytic activity of the HAO composite was assessed under visible light irradiation. Comparative analyses demonstrated that the photocatalytic degradation capability of the HAO composite surpassed those of its individual components. Notably, during the degradation process, the application of the HAO composite resulted in an impressive removal efficiency of 99.89% for OTC within a span of 95 min, along with a total organic carbon mineralization rate of 98.35%. This outstanding photocatalytic performance could be ascribed to the efficient Z-scheme electron-hole separation system occurring between Ho₂InSbO₇ and Ag₃PO₄. Moreover, the adaptability and stability of the HAO heterojunction were thoroughly validated. Through experiments involving the capture of reactive species and electron paramagnetic resonance analysis, the active species generated by HAO were identified as hydroxyl radicals (•OH), superoxide anions (•O₂⁻), and holes (h⁺). This identification provides valuable insights into the mechanisms and pathways associated with the photodegradation of OTC. In conclusion, this research not only elucidates the potential of HAO as an efficient Z-scheme heterojunction photocatalyst but also marks a significant contribution to the advancement of sustainable remediation strategies for OTC contamination. Full article

In recent years, growing concerns over environmental degradation and deepening awareness of the necessity of sustainable development have propelled green and low-carbon energy transition into a focal issue for both academia and policymakers. By decomposing energy transition into the transformation of energy structure and the upgrading of energy efficiency, this study investigates the impact and mechanisms of green finance on energy transition across 30 provinces (municipalities and autonomous regions) in China, with the exception of Tibet. In addition, the impact of climate change is incorporated into the analytical framework. Empirical results demonstrate that green finance development significantly accelerates energy transition, a conclusion robust to rigorous validation. Analysis of the mechanism shows that green finance promotes energy transition through the facilitation of technological innovation and the upgrade of industrial structures. Moreover, empirical evidence reveals that climate change undermines the promotional influence of sustainable finance on energy system transformation. The magnitude of this suppression varies nonlinearly across provincial jurisdictions with differing energy transition progress. Regional heterogeneity analyses further uncover marked discrepancies in climate–finance interactions, demonstrating amplified effects in coastal economic hubs, underdeveloped western provinces, and regions with mature eco-financial markets. According to these findings, actionable policy suggestions are put forward to strengthen green finance and accelerate energy transition. Full article

This convergent mixed-methods study explores the lived experiences of Black women DEI leaders at predominantly white institutions within the context of an increasingly contentious national discourse surrounding diversity, equity, and inclusion (DEI) in higher education. Conducted prior to the 2024 election, a period marked by escalating resistance to DEI efforts, this research explores how America’s racial reckoning influenced institutional DEI initiatives and shaped the realities of those leading this work. Data were collected through a climate survey of 20 DEI administrators and semi-structured interviews with three senior-level Black women DEI leaders. The survey findings suggest that institutional commitments to DEI were largely reactive, emerging as crisis responses to national calls for racial justice. These efforts resulted in the short-term elevation of Black women into leadership roles, often without sustained structural support. The interview data revealed that Black women senior DEI leaders routinely encounter discrimination, marginalization, and the paradox of hypervisibility and invisibility within their roles. This study concludes with implications and suggestions for institutional policy and structural reform aimed at fostering more equitable and sustainable DEI leadership environments. Full article

Background: The progression of Alzheimer’s Disease (AD) deeply affects not only the diagnosed person but also their close relatives, who are often called to take on the role of informal caregivers. This transition is frequently unplanned and emotionally complex, yet poorly understood in its deeper processual dimensions. This study aims to explore and theorize the transition experienced by a family member becoming the primary informal caregiver for a person with advanced AD. Methods: A qualitative study based on the Constructivist Grounded Theory according to Charmaz’s approach (2006) was conducted. In-depth interviews were carried out with 10 participants who had become informal caregivers for a loved one with advanced AD. Data were analyzed using initial coding, focused coding, the constant comparative method, and theoretical coding. Results: Ten caregivers (mean age 39 years, range 35–54; nine females) of patients with advanced AD participated in the study. The analysis revealed a complex, emotionally intense caregiving experience marked by sacrifice, feelings of powerlessness, identity loss, and the necessity of sharing caregiving responsibilities. A core category emerged: A Silent and Certain Willingness to Care, representing the caregivers’ deep, often unconscious commitment to prioritize the care of their loved ones above their own needs. Four interconnected phases characterized the caregiving process: (1) The Changing Daily Life—involving significant sacrifices in personal and social life; (2) Feeling Powerless—confronting the inevitable decline without means to alter the course; (3) Losing Oneself—experiencing physical and psychological exhaustion and a sense of identity loss; and (4) Sharing with Others—seeking external support to sustain caregiving. These findings highlight the evolving nature of becoming a caregiver and the enduring dedication that sustains this role despite the challenges. Conclusions: The progression of AD deeply transforms the lives of caregivers, who become co-sufferers and active participants in the disease’s management. The results underscore the urgency of designing integrative care strategies—including psychological, social, and potentially technological support—that can enhance both patient outcomes and caregiver resilience. Grounded in real-world experiences, this study contributes to the broader neurodegeneration discourse by emphasizing caregiving as a critical factor in long-term disease management and therapeutic success. Full article

Accurate forecasting of river siltation is essential for ensuring inland waterway navigability and guiding sustainable sediment management. This study investigates the downstream reach of the Shihutang navigation power hub along the Ganjiang River in Jiangxi Province, China, an area characterized by pronounced seasonal sedimentation and hydrological variability. To enable fine-scale prediction, we developed a data-driven framework using a random forest regression model that integrates high-resolution bathymetric surveys with hydrological and meteorological observations. Based on the field data from April to July 2024, the model was trained to forecast monthly siltation volumes at a 30 m grid scale over a six-month horizon (July–December 2024). The results revealed a marked increase in siltation from July to September, followed by a decline during the winter months. The accumulation of sediment, combined with falling water levels, was found to significantly reduce the channel depth and width, particularly in the upstream sections, posing a potential risk to navigation safety. This study presents an initial, yet promising attempt to apply machine learning for spatially explicit siltation prediction in data-constrained river systems. The proposed framework provides a practical tool for early warning, targeted dredging, and adaptive channel management. Full article

Background/Objectives: Wilson’s disease (WD) is a rare autosomal recessive disorder of copper metabolism that results in hepatic, neurological, and psychiatric manifestations. Despite being described globally, data from the Middle East remains limited. This study presents the first comprehensive national cohort analysis of WD in Oman, examining clinical features, diagnostic challenges, treatment patterns, and long-term outcomes. Methods: A retrospective cohort study was conducted on 36 Omani patients diagnosed with WD between 2013 and 2020 at Sultan Qaboos University Hospital using AASLD diagnostic criteria. Clinical presentation, biochemical parameters, treatment regimens, and progression-free survival were analyzed. Results: The median age at diagnosis was 14.5 years, with a slight female predominance (55.6%). Clinical presentation varied: 25% had hepatic symptoms, 22.2% had mixed hepatic-neurological features, and 16.7% presented with neurological symptoms alone. Asymptomatic cases identified via family screening accounted for 33.3%. Diagnostic delays were most pronounced among patients presenting with neurological symptoms. A positive family history was reported in 88.9% of cases, suggesting strong familial clustering despite a low rate of consanguinity (5.6%). Regional distribution was concentrated in Ash Sharqiyah North and Muscat. Chelation therapy with trientine or penicillamine, often combined with zinc, was the mainstay of treatment. Treatment adherence was significantly associated with improved progression-free survival (p = 0.012). Conclusions: WD in Oman is marked by heterogeneous presentations, frequent diagnostic delays, and strong familial clustering. Early detection through cascade screening and sustained treatment adherence are critical for favorable outcomes. These findings support the need for national screening policies and structured long-term care models for WD in the region. Full article

The process of urbanization has intensified the urban heat environment, with the degradation of thermal conditions closely linked to the morphological characteristics of different functional zones. This study delineated urban functional areas using a multivariate dataset and investigated the seasonal and threshold effects of landscape and architectural features on land surface temperature (LST) through boosted regression tree (BRT) modeling and Spearman correlation analysis. The key findings are as follows: (1) LST exhibits significant seasonal variation, with the strongest urban heat island effect occurring in summer, particularly within industry, business, and public service zones; residence zones experience the greatest temperature fluctuations, with a seasonal difference of 24.71 °C between spring and summer and a peak temperature of 50.18 °C in summer. (2) Fractional vegetation cover (FVC) consistently demonstrates the most pronounced cooling effect across all zones and seasons. Landscape indicators generally dominate the regulation of LST, with their relative contribution exceeding 45% in green land zones. (3) Population density (PD) exerts a significant, seasonally dependent dual effect on LST, where strategic population distribution can effectively mitigate extreme heat events. (4) Mean building height (MBH) plays a vital role in temperature regulation, showing a marked cooling influence particularly in residence and business zones. Both the perimeter-to-area ratio (LSI) and frontal area index (FAI) exhibit distinct seasonal variations in their impacts on LST. (5) This study establishes specific indicator thresholds to optimize thermal comfort across five functional zones; for instance, FVC should exceed 13% in spring and 31.6% in summer in residence zones to enhance comfort, while maintaining MBH above 24 m further aids temperature regulation. These findings offer a scientific foundation for mitigating urban heat waves and advancing sustainable urban development. Full article

In recent years, biofuels and bioenergy derived from algae have gained increasing attention, fueled by the growing demand for renewable energy sources and the urgent need to lower CO₂ emissions. This research examines the generation of bioethanol and biomethane using freshly harvested and sedimented algal biomass. Employing a factorial experimental design, various trials were conducted, with ethanol yield as the primary optimization target. The findings indicated that the sodium hydroxide concentration during pretreatment and the amylase dosage in enzymatic hydrolysis were key parameters influencing the ethanol production efficiency. Under optimized conditions—using 0.3 M NaOH, 25 μL/g starch, and 250 μL/g cellulose—fermentation yielded ethanol concentrations as high as 2.75 ± 0.18 g/L (45.13 ± 2.90%), underscoring the significance of both enzyme loading and alkali treatment. Biomethane potential tests on the residues of fermentation revealed reduced methane yields in comparison with the raw algal feedstock, with a peak value of 198.50 ± 25.57 mL/g volatile solids. The integrated process resulted in a total energy recovery of up to 809.58 kWh per tonne of algal biomass, with biomethane accounting for 87.16% of the total energy output. However, the energy recovered from unprocessed biomass alone was nearly double, indicating a trade-off between sequential valorization steps. A comparison between fresh and dried feedstocks also demonstrated marked differences, largely due to variations in moisture content and biomass composition. Overall, this study highlights the promise of integrated algal biomass utilization as a viable and energy-efficient route for sustainable biofuel production. Full article

The ongoing advancement of urbanization has significantly amplified its impacts on the water environment. Understanding the coupling relationships between urbanization and the water environment (UAWE) is crucial for Chinese policymakers aiming to promote sustainable urban development. In this study, a comprehensive UAWE evaluation model was developed to examine the development trajectories in Neijiang City from 2012 to 2022. Methodologically, a comprehensive evaluation approach was applied to assess urbanization and water resource trends over this period, followed by the development of a Coupling Coordination Degree Model (CCDM) to quantify their synergistic relationship. The results showed that the coupling between the comprehensive urbanization index and the water environment system evolved over time, as reflected in the following key findings: (1) Neijiang underwent three distinct stages from 2012 to 2022 in terms of coupling and coordination between urbanization and the water environment: Basic Coordination (2012–2015), Good Coordination (2016–2020), and Excellent Coordination (2020–2022). (2) Urbanization exerted varying impacts on subsystems of the water environment, with the pressure-response subsystems exhibiting marked volatility from 2012 to 2022. The impact intensity followed the order spatial urbanization > economic urbanization > social urbanization > population urbanization. These findings offer valuable theoretical and practical insights for aligning urban sustainability goals with effective water environment protection measures. This study provides essential guidance for policymakers in Neijiang and similar regions, enabling the development of tailored strategies for sustainable urbanization and enhanced water management. Full article

Actuators and power electronics are fundamental components of modern control systems, enabling high-precision functionality, enhanced energy efficiency, and sophisticated automation. This study investigates evolving research trends and thematic developments in these areas spanning the last two decades (2005–2024). This study analyzed 1840 peer-reviewed abstracts obtained from the Web of Science database using BERTopic modeling, which integrates transformer-based sentence embeddings with UMAP for dimensionality reduction and HDBSCAN for clustering. The approach also employed class-based TF-IDF calculations, intertopic distance visualization, and hierarchical clustering to clarify topic structures. The analysis revealed a steady increase in research publications, with a marked surge post-2015. From 2005 to 2014, investigations were mainly focused on established areas including piezoelectric actuators, adaptive control, and hydraulic systems. In contrast, the 2015–2024 period saw broader diversification into new topics such as advanced materials, robotic mechanisms, resilient systems, and networked actuator control through communication protocols. The structural topic analysis indicated a shift from a unified to a more differentiated and specialized spectrum of research themes. This study offers a rigorous, data-driven outlook on the increasing complexity and diversity of actuator and power electronics research. The findings are pertinent for researchers, engineers, and policymakers aiming to advance state-of-the-art, sustainable industrial technologies. Full article

Recent archaeological discoveries across the Aegean, Cyprus, and western Anatolia have renewed interest in pre-Neolithic seafaring and early island colonization. However, the environmental contexts that support such early coastal occupations remain poorly understood, largely due to the submergence of Pleistocene shorelines following post-glacial sea-level rise. This study addresses this gap through an integrated geoarchaeological investigation of the pre-Neolithic site of Ouriakos on Lemnos Island, northeastern Aegean (Greece), dated to the mid-11th millennium BCE. By reconstructing both the terrestrial and submerged paleolandscapes of the site, we examine ecological conditions, resource availability, and sedimentary processes that shaped human activity and site preservation. Employing a multiscale methodological approach—combining bathymetric survey, geomorphological mapping, soil micromorphology, geochemical analysis, and Optically Stimulated Luminescence (OSL) dating—we present a comprehensive framework for identifying and interpreting early coastal settlements. Stratigraphic evidence reveals phases of fluvial, aeolian, and colluvial deposition associated with an alternating coastline. The core findings reveal that Ouriakos was established during a phase of environmental stability marked by paleosol development, indicating sustained human presence. By bridging terrestrial and marine data, this research contributes significantly to the understanding of human coastal mobility during the Pleistocene–Holocene transition. Full article

A literature review about polymer composites reveals that natural fibers have been widely used as a reinforcement phase in recent years. In this framework, the lignocellulosic fibers have received marked attention because of their environmental, thermomechanical, and economic advantages for many industrial sectors. This research aims to identify the impact behavior of ramie reinforced epoxy composites with medium- and high-volume fractions of fibers in intact (nonaged) and aged conditions as well as to analyze if the influence of interface quality on the impact fracture energy can be described by a novel mathematical model. To reach these objectives, the study is designed with three groups (40%, 50%, and 60% of fiber theoretical volume fractions) of intact specimens and three groups of aged samples by condensation and ultraviolet radiation (C-UV) simulation containing the same fiber percentages. Consecutively, impact strength and fracture surface analyses are done to expand the comprehension of the damage mechanisms suffered by the biocomposites and to support the development of the mathematical relation. Certainly, this novel model can contribute to more sustainable and greener industries in the near future. Full article

Acute hepatopancreatic necrosis disease (AHPND), caused by the bacterium Vibrio parahaemolyticus, is a major threat to global shrimp aquaculture. In this study, we evaluated the therapeutic effects of phage therapy in Litopenaeus vannamei challenged with AHPND-causing Vibrio parahaemolyticus. Phage application at various concentrations significantly improved shrimp survival, with the 1 ppm group demonstrating the highest survival rate. Enzymatic assays revealed that phage-treated shrimp exhibited enhanced immune enzyme activities, including acid phosphatase (ACP), alkaline phosphatase (AKP), and lysozyme (LZM). In addition, antioxidant defenses such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-PX), and total antioxidant capacity (T-AOC) significantly improved, accompanied by reduced malondialdehyde (MDA) levels. Serum biochemical analyses demonstrated marked improvements in lipid metabolism, particularly reductions in triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL), alongside higher levels of beneficial high-density lipoprotein (HDL). Transcriptomic analysis identified 2274 differentially expressed genes (DEGs), notably enriched in pathways involving fatty acid metabolism, peroxisome functions, lysosomes, and Toll-like receptor (TLR) signaling. Specifically, phage treatment upregulated immune and metabolic regulatory genes, including Toll-like receptor 4 (TLR4), myeloid differentiation primary response protein 88 (MYD88), interleukin-1β (IL-1β), nuclear factor erythroid 2-related factor 2 (Nrf2), and peroxisome proliferator-activated receptor (PPAR), indicating activation of innate immunity and antioxidant defense pathways. These findings suggest that phage therapy induces protective immunometabolic adaptations beyond its direct antibacterial effects, thereby providing an ecologically sustainable alternative to antibiotics for managing bacterial diseases in shrimp aquaculture. Full article

The intersection of sports and natural forests and green spaces represents an emerging interdisciplinary field with implications for public health, environmental science, and sustainable land management and refers to the variety of cultural ecosystem services demanded by people from ecosystems. This manuscript presents a systematic bibliometric and thematic analysis of 148 publications for the period 1993–2024 identified through Web of Science and Scopus, aiming to evaluate the current state of research on sports activities conducted in natural forest environments. Findings indicated a marked increase in scientific interest of this topic over the past two decades, with key contributions from countries such as England, Germany, China, and the United States. Researchers most frequently examined sports such as hiking, trail running, mountain biking, and orienteering for their capacity to provide physiological and psychological benefits, reduce stress, and enhance mental well-being. The literature analysis highlights ecological concerns, particularly those associated with habitat disturbance, biodiversity loss, and conflicts between recreation and conservation. Six principal research themes were identified: sports in urban forests, sports tourism, hunting and fishing, recreational sports, health benefits, and environmental impacts. Keyword and co-authorship analyses revealed a multidisciplinary knowledge base with evolving thematic focuses. In conclusion, the need for integrated approaches that incorporate ecological impact assessment, stakeholder perspectives, and adaptive forest governance to ensure sustainable recreational use of natural forest ecosystems is underlined. Full article