Search Results (634)

Background: Foster adolescents face elevated socioemotional risk, yet the joint and differential contributions of family adversity, attachment insecurity, and relational trauma to distinct adjustment domains remain poorly understood. The present study aimed to examine their joint, incremental, and differential contribution to emotional regulation difficulties and social competence. Methods: Forty-six adolescents (12–17 years; 63% female) in residential care in Uruguay completed self-report measures of family problems, attachment dimensions (anxiety, avoidance, socioemotional functioning), and relational trauma (SENA, CAA-R, CaMir-R). Hierarchical multiple regression examined their sequential prediction of emotional regulation difficulties and social competence. Results: Emotional regulation difficulties were explained by family problems, avoidant attachment, and relational trauma, whereas social competence was explained by anxious attachment and socioemotional attachment functioning. Final models explained 49% and 47% of variance, respectively. Discussion: This differential predictive pattern aligns with theoretical distinctions between deactivating and hyperactivating attachment strategies. Relational trauma’s specific contribution to regulatory, but not social, functioning supports neurobiologically grounded models of complex trauma. Conclusions: Findings suggest that emotional regulation difficulties were more closely associated with family problems, avoidant attachment, and relational trauma, whereas social competence was more strongly linked to anxious attachment and socioemotional attachment functioning. These results support differentiated, attachment-informed, and trauma-sensitive approaches in residential care settings. Full article

Ototoxicity represents a clinically significant complication of anticancer therapy in pediatric patients. Cytotoxic agents used in oncology, particularly platinum-based chemotherapy, may induce damage to the auditory and vestibular systems, resulting in hearing loss, tinnitus, and balance disturbances. Even mild hearing impairment during childhood may negatively affect speech perception, language development, communication abilities, and subsequent educational and psychosocial functioning. This narrative review aims to synthesize current evidence on treatment-related ototoxicity in children, with particular focus on commonly implicated therapies, clinical consequences, diagnostic approaches, and potential preventive strategies. A focused literature search was conducted in PubMed for publications from 2019 to 2025 addressing ototoxicity associated with pediatric anticancer treatment and audiological monitoring methods. The analysis indicates that platinum-based compounds, especially cisplatin and carboplatin, remain the primary agents associated with ototoxicity, with reported incidence ranging from approximately 20–70% for cisplatin and 10–30% for carboplatin. Additional risk factors include young age, baseline hearing status, renal function, and exposure to other ototoxic agents such as aminoglycoside antibiotics. Early detection relies on comprehensive audiological monitoring combining behavioral and objective methods, including pure-tone audiometry, extended high-frequency audiometry, otoacoustic emissions, and auditory brainstem response testing. Standardized grading systems such as ASHA, Brock, Chang, and SIOP Boston criteria play a key role in identifying and classifying ototoxic changes. Emerging research focuses on improved monitoring protocols, biomarker identification, and the development of otoprotective strategies, including sodium thiosulfate and experimental molecular therapies. Implementing systematic hearing monitoring and preventive strategies is essential to reduce long-term auditory complications and improve quality of life in pediatric cancer survivors. Full article

Gender-based violence constitutes a major public health and social concern, with particularly complex implications in structurally vulnerable contexts such as rural settings. However, empirical evidence regarding the specific profile and risk perception of women experiencing gender-based violence in small municipalities remains limited. The aim of this study was to analyze the sociodemographic characteristics of women victims of gender-based violence residing in small rural municipalities and to examine their associations with mental health indicators and perceived risk of future violence. The sample comprised 30 women receiving support at a Specialized Care Centre for Victims of Gender-Based Violence (CAVI) serving three small municipalities in the Vega Media region (Region of Murcia, Spain). Standardized measures of depression, anxiety, and stress were administered, together with an assessment of perceived risk. The findings suggest a specific sociodemographic profile characterized by moderate levels of depression, anxiety, and stress symptoms and generally low perceived risk. Women without children reported higher levels of psychological distress and perceived risk than those with children, although these differences should be interpreted with caution given the sample size. Overall, these findings provide preliminary insights into the characteristics and risk perception of women experiencing gender-based violence in rural settings and highlight the need for context-sensitive prevention and intervention strategies. Full article

Background and Objectives: Primary progressive aphasia (PPA) and its variants—logopenic (lvPPA), semantic (svPPA), and nonfluent/agrammatic (nfvPPA)—are progressive neurocognitive syndromes characterized by predominant language impairment and associated with heterogeneous underlying neuropathologies. Accurate diagnosis remains challenging due to overlapping clinical features and complex pathobiological mechanisms. Fluorodeoxyglucose positron emission tomography (FDG-PET), which reflects regional cerebral glucose metabolism, may provide valuable insights into both the diagnosis and pathophysiological characterization of PPA. Materials and Methods: We reviewed the current literature and identified 48 original research articles that utilized FDG-PET in the evaluation of at least one PPA variant. Eight studies focused exclusively on lvPPA, six on svPPA, and two on nfvPPA, either alone or in comparison with other neurodegenerative diseases. Eighteen studies evaluated at least two PPA variants, while thirteen compared multiple PPA variants with other neurodegenerative disorders. Results: Most studies identified characteristic hypometabolic patterns for each PPA variant: left temporoparietal regions in lvPPA, bilateral anterior temporal regions with left predominance in svPPA, and left posterior frontal regions in nfvPPA. These variant-specific metabolic signatures may support differential diagnosis. Additionally, FDG-PET provided important insights into disease progression, including associations with worsening language impairment, evolution toward broader neurodegenerative syndromes, and correlations with specific neurocognitive deficits. These findings are largely consistent with other neuroimaging modalities and disease-specific biomarkers. However, limitations such as small sample sizes and the lack of autopsy confirmation in most studies limit the robustness of the results. Conclusions: FDG-PET appears to be a valuable tool for the diagnosis, differential diagnosis, and pathophysiological understanding of PPA. Nevertheless, large-scale, multicenter investigations incorporating pathologically confirmed cases to further validate its clinical utility are needed. Full article

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity, compounded by difficulties in emotional regulation, which have sparked growing interest due to their relationship with emotional intelligence (EI). Background/Objectives: The objective of this study was to analyze the effectiveness and characteristics of interventions aimed at developing EI in people diagnosed with ADHD. Methods: A systematic review was conducted following PRISMA 2020 in the Web of Science, Scopus, PubMed, Dialnet, ERIC, and SpringerLink databases. After applying inclusion and exclusion criteria and evaluating methodological quality, 31 studies were selected. Results: The evidence shows that children and adolescents with ADHD have lower levels of EI than the typically developing population, especially in emotional regulation, stress management, adaptability, and interpersonal skills. Interventions focused on emotional training have demonstrated improvements in emotional competencies, self-control, ADHD symptoms, and social functioning. However, variations are observed according to age, clinical subtype, the presence of comorbidities, and the type of informant, as well as heterogeneity in the assessment instruments used. Conclusions: Strengthening EI emerges as a promising complementary strategy for improving the emotional and social adaptation of people with ADHD. It is recommended to move toward longitudinal studies and more personalized interventions tailored to the clinical and developmental characteristics of the disorder. Full article

Background: Dysphagia and malnutrition are common among head and neck squamous cell carcinoma (HNSCC) patients. Evidence and guidelines emphasize treatment and prevention of these conditions before surgery. In this context, multimodal prehabilitation (MP) is an essential part of a holistic treatment approach. However, the specific components and their relative importance remain debated. This study aimed to evaluate the impact of nutritional, logopedic and psychological MP. Methods: Adult HNSCC patients who completed the German version of the Functional Assessment of Cancer Therapy—Head and Neck (FACT-H&N) quality-of-life (QOL) questionnaire after undergoing curative resection and reconstructive surgery were included in this cross-sectional study. Clinical data on psychological, logopedic and nutritional MP and possible confounders was collected. To evaluate the nutritional status, bodyweight loss, the body mass index (BMI) and the Graz Malnutrition Screening (GMS) score were recorded. We determined the length of stay (LOS), the QOL, the Clavien–Dindo type III and IV complication rate (CR) as the outcome parameters for MP. Results: In total, 102 patients were included. Of those, 68 were male, while the other 34 were female. The mean age was 59.82 ± 12.27 years. The average GMS was 3.11 ± 1.45. Simultaneously, 62.75% of patients were at risk or malnourished. Malnutrition was significantly associated with adverse outcomes in the univariate, but only with decreased QOL in the multivariate model. On the other hand, MP was significantly associated with reduced LOS and improved QOL. These findings remained robust even after adjustment for possible confounders. Neither had a significant effect on the CR. Conclusions: Our findings suggest that malnutrition is a potential risk factor for adverse outcomes in curative HNSCC therapy. The GMS is a sensitive tool for identifying patients at risk of malnutrition in HNSCC surgery prehabilitation. Our multimodal protocol was associated with improved postoperative outcomes following curative surgical resection and free flap reconstruction. The observed associations may reflect potential synergistic interactions within the multimodal framework. Full article

Background: Orthodontic treatment is increasingly recognised as a complex, patient-centred intervention whose impact extends beyond occlusal correction to include physical comfort, psychosocial well-being, and self-perceived esthetics. Oral health-related quality of life (OHRQoL) has therefore become a key outcome for evaluating orthodontic care across all treatment stages. Aim: This narrative review of 140 studies synthesises current evidence on OHRQoL changes in orthodontic patients before treatment, during active therapy, and after treatment completion, with particular emphasis on temporal patterns and appliance-related differences. Methods: A comprehensive narrative review of 140 studies was conducted using PubMed, Scopus, Web of Science, Cochrane Library, and Google Scholar (search period: inception to December 2025). Studies assessing OHRQoL or patient-reported outcomes in orthodontic patients of any age were included. Only studies employing validated instruments, such as OHIP, CPQ, OIDP, and PIDAQ, were considered. Dual-reviewer agreement was assessed using Cohen’s kappa (κ = 0.82). Formal risk-of-bias assessment was conducted using ROBINS-I for non-randomised studies and the Cochrane Risk of Bias tool for RCTs. Sensitivity analyses were performed comparing high-quality studies (low risk of bias, n = 52) versus all included studies. Results: The reviewed evidence consistently demonstrates that malocclusion is associated with impaired baseline OHRQoL, particularly affecting psychosocial and esthetic domains. The early phase of orthodontic treatment is marked by a transient deterioration in OHRQoL due to pain, discomfort, speech disturbances, and functional limitations (87% of studies report pain peaks within 24–48 h; 79% report resolution by 4–7 days). These effects typically diminish as patients adapt to the appliance. Progressive improvement is observed during mid-treatment, while treatment completion is associated with substantial long-term gains in self-esteem, social functioning, and overall quality of life. Appliance type influences short-term outcomes, with clear aligners generally associated with better early OHRQoL than fixed and lingual systems (65–75% of studies favour aligners for early comfort; 78% favour lingual systems for esthetic satisfaction). Conclusions: Orthodontic treatment follows a dynamic, time-dependent OHRQoL trajectory characterised by short-term impairment and significant long-term psychosocial benefits. Systematic integration of validated OHRQoL measures into orthodontic care may enhance patient-centred decision-making and optimise clinical outcomes. Full article

Early identification of language and literacy disorders (LLDs) in multilingual children remains a challenge in linguistically diverse educational systems shaped by ongoing migration. In many contexts, including Greece and Cyprus, where LLDs have been poorly investigated, teachers lack screening tools that can reliably distinguish typical multilingual development from possible indicators of LLDs. This study presents the development and preliminary piloting of two teacher-report screening questionnaires for multilingual children aged 4–6 and 6–9 years, designed for use in everyday classroom settings to support early identification and referral. A structured multi-stage procedure guided development. First, items were derived from internationally established clinical markers of multilingual LLDs, covering oral language, phonological awareness, communication, literacy, and related cognitive domains. Second, a scoring framework was created to support consistent, referral-oriented interpretation across languages. Third, the questionnaires were reviewed by specialists in linguistics, education, and speech-language therapy. Fourth, pilot testing with teachers evaluated clarity, feasibility, and classroom relevance. Expert and teacher feedback indicated that the questionnaires are practical and support differentiation between multilinual language differences and potential underlying difficulties. Overall, this study introduces two promising cross-linguistic screening tools for educators in multilingual educational settings, currently undergoing psychometric validation. Full article

Speech sound disorder (SSD) is common in childhood and can persist, adversely affecting language, literacy, and social functioning. Yet consonant error patterns in school-age children, particularly in non-English-speaking populations, remain insufficiently characterized. Short-term memory (STM) supports phonological processing and speech learning, but its relationship with SSD severity in school-age children is not well established. This study profiles consonant errors and short-term memory in school-age Chinese children with SSD and examines short-term memory correlates and predictors of disorder severity to inform targeted interventions. A total of 142 Mandarin-speaking school-age children with SSD were recruited. For the short-term memory analyses, we randomly selected 70 children with SSD and recruited 70 typically developing controls. Speech was assessed using a word-level picture-naming task to derive consonant accuracy and characterize error types/patterns, and short-term memory was measured with the WISC-IV Digit Span (forward and backward). Substitutions predominated for most consonants, and individual phonemes often exhibited co-occurring error patterns. In addition, school-age children with SSD showed significantly poorer short-term memory than typically developing peers across multiple indices. Notably, backward digit span was positively associated with consonant accuracy and remained an independent predictor of consonant accuracy. These results advance our understanding of the mechanisms underlying SSD and provide an evidence-based rationale for future interventions that combine speech-focused therapy with cognitive training to enhance clinical outcomes. Full article

Background/Objectives: Alcohol Use Disorder (AUD) represents a significant global public health challenge that is associated with cognitive deficits, immune dysfunction, and increased susceptibility to different comorbidities. Recent evidence suggests that neuroimmune signalling, particularly microglial activation and cytokine-mediated pathways, plays a critical role in the development, persistence, and relapse vulnerability of AUD. This narrative review aims to synthesize current evidence on the role of cytokines and interleukins (ILs) in AUD, emphasizing their modulation during alcohol exposure, withdrawal, and abstinence. Methods: A comprehensive narrative review methodology was employed, including a search in PubMed, Scopus, and Web of Science using relevant keywords. Peer-reviewed studies published in English that examined cytokine and interleukin profiles in adults with AUD were included. The main findings were synthesized into thematic domains to identify recurring patterns, inconsistencies, and research gaps. Results: AUD is associated with significant alterations in cytokine profiles. Pro-inflammatory markers such as IL-1β, IL-6, tumour necrosis factor alpha (TNF-α), IL-8, and IL-18 are elevated during active alcohol use and early abstinence, while anti-inflammatory markers like IL-10 show fluctuations. These immune changes are linked to systemic inflammation, neurotoxicity, and AUD severity. Cytokine levels tend to normalize with sustained abstinence, although severe AUD may lead to prolonged immune dysregulation. Associations between inflammatory markers and psychiatric symptoms, including anxiety and depression, were also observed. Conclusions: Immune dysregulation plays a central role in AUD pathophysiology, with cytokines serving as potential biomarkers for disease progression and treatment response. Future research should focus on longitudinal studies, diverse patient populations, and mechanistic investigations to refine biomarker utility and develop targeted immunomodulatory therapies. Addressing inflammation and neuroplasticity may enhance clinical outcomes in AUD management. Full article

Background and Clinical Significance: Modern neuro-oncologists encounter a major challenge when dealing with glioblastomas located in the dominant hemisphere’s temporo-basal area, because their invasive nature disrupts the proximity to eloquent cortical areas (language and speech), as well as skull base venous structures, which can lead to a quick decline in function from the disruptions in these networks and the disconnection of corridor-level pathways. This manuscript illustrates the application of metric-based phenotyping, anatomically defined imaging, and venous-anchored microsurgical techniques that can aid in preserving the remaining functional reserve in patients with dominant hemisphere glioblastomas and demonstrate measurable outcomes through longitudinal follow-up data. Case Presentation: A 48-year-old right-handed male patient presented with a four-week history of progressively worsening symptoms consistent with a dominant hemisphere syndrome, resulting in a significant decrease in his independence (mRS 0 → 4; BI 55/100; IADL 2/8). His symptoms included non-fluent expressive aphasia with a marked inability to generate words and respond to verbal cues (BNT 8/30; SF 4 WPM). Additionally, he experienced prolonged lateralizing hemisensory decompensation and corticospinal tract dysfunction. Imaging studies revealed a large multiloculated cystic lesion located in the left temporo-basal region. The lesion displayed a thick irregular peripheral enhancement pattern with mural nodules and septa, and surrounding T2 hyperintensity extending into the temporal associative white matter, indicating disruption of the lexical–semantic networks and corridor-level tracts. Utilizing continuous SSEPS/MEPs during surgery, a skull base parallel ventral temporal corridor was developed to allow decompression of the cyst first, followed by cyst evacuation, inside-out cytoreduction, subpial dissection, and specific preservation of both superficial and deep temporal veins using selective capsular preservation at venous interface locations where necessary. Postoperative CT scans performed on POD #3 and POD #7 indicated stable decompression without hemorrhage or hydrocephalus complications, followed by rapid quantitative improvement in NIHSS (8 → 2), MoCA (18 → 26), BNT (8 → 26), SF (4 → 12), mRS (2 at discharge, 1 at follow-up), BI (85 at discharge, 95 at follow-up), and IADL (6/8 at discharge, 8/8 at follow-up). Histopathological examination confirmed a diagnosis of glioblastoma. Conclusions: This case study supports a model of a network- and vein-constrained glioblastoma of the dominant hemisphere in the temporo-basal region that can result in substantial restoration of language capabilities and preservation of functional reserves for additional therapies using venous-anchored subpial microsurgical approaches. The use of objective and quantifiable measures of phenotyping and longitudinal follow-up tracking could provide a reproducible method for measuring the degree of recovery of the affected network(s) and establishing safe boundaries for temporal glioma surgery. Full article

Introduction: University students are vulnerable to psychological distress due to the academic and social demands of this life stage. Mindfulness and self-compassion are effective and adaptable strategies in an academic environment that promote emotional regulation and psychological well-being. This study aims to conduct a systematic review and meta-analysis to evaluate the combined impact of mindfulness- and self-compassion-based interventions (MBSCIs) on psychological distress. It will also analyze their role as predictors of therapeutic change, as well as the moderating influence of sociodemographic and contextual factors. Method: We systematically searched PubMed, Scopus and Web of Science for randomized controlled trials (RCTs) and single-group pre-post trials investigating the effect of MBSCI on anxiety, depression and stress in college students. Studies were combined using the inverse variance method in a random effects model. Additional subgroup and meta-regression analyses were performed, and risk of bias was assessed. The review was pre-registered (PROSPERO registration number: CRD420251003822). Results: Our review included 49 studies with a total of 5043 participants (3721 in the intervention group, and 1322 in the control group). The results provide relevant evidence on the efficacy of MBSCI in the university population, especially in reducing symptoms of stress, anxiety, and depression. The effect sizes observed were moderate-to-large for stress and small-to-moderate for anxiety and depression, supporting their clinical usefulness in university educational settings. However, these findings should be interpreted with caution, as no included study achieved low risk of bias, and heterogeneity was moderate-to-high across most outcomes. Conclusions: The results suggest that MBSCI could alleviate psychological distress in university students. However, these results are limited by some methodological issues (risk of bias, heterogeneity, lack of follow-ups, poor standardization). It would be advisable to integrate these practices into the university curriculum as workshops or complementary activities. Further studies are needed to confirm their effectiveness and explore sustained effects and differences according to individual characteristics. Full article

Effective rehabilitation tools are essential for improving language outcomes in chronic aphasia. Speech entrainment is a behavioral treatment that has shown promise in enhancing speech output in nonfluent aphasia, potentially by acting as an external mechanism to synchronize anterior and posterior language regions in the left hemisphere. Transcranial alternating current stimulation has been hypothesized to enhance functional connectivity between brain regions by amplifying endogenous oscillations. This proof-of-concept study explored whether high-definition tACS (HD-tACS) could improve speech fluency in nonfluent aphasia when paired with speech entrainment. In a double-blind, pseudorandomized study, 1 mA of HD-tACS at 7 Hz was applied to anterior and posterior left-hemisphere regions of individuals with nonfluent aphasia (N = 13). Stimulation was applied under three conditions: in-phase, anti-phase, and sham, and paired speech entrainment. Three outcome measures were examined: (1) number of words produced; (2) number of errors, and (3) ‘entrainment’ to the speech entrainment model. Group-level analyses for two of the three outcome measures reveal statistically significant differences between the experimental conditions. In-phase alternating current stimulation yielded more words and better entrainment to the audiovisual model than the sham condition. This study provides promising evidence that HD-tACS could improve speech production in individuals with nonfluent aphasia. These results contribute to growing evidence supporting the therapeutic potential of non-invasive brain stimulation approaches as an adjuvant to traditional behavioral speech-language therapy in stroke survivors. Full article

Background: Societal stigma toward eating disorders and obesity remains pervasive and is associated with psychological distress, maladaptive eating behaviors, reduced help-seeking, and barriers to care. Despite its documented impact, comprehensive and psychometrically robust instruments to assess stigma—particularly in Spanish-speaking populations—are scarce. This study aimed to develop and validate a multidimensional measure of societal stigma toward eating disorders and obesity in Spain, grounded in contemporary stigma frameworks. Methods: A cross-sectional observational study was conducted in a large community sample recruited online (N = 2121). An initial pool of stigma-related items was developed based on theoretical and empirical literature and refined through expert content validation. Psychometric evaluation included item screening, exploratory factor analysis (EFA), confirmatory factor analysis (CFA), bifactor modeling, and reliability assessment. The sample was randomly split for EFA (n = 988) and CFA (n = 658). Associations between stigma scores and sociodemographic and experiential variables were examined. Results: The final 36-item instrument demonstrated excellent psychometric properties. Bifactor analyses supported an essentially unidimensional structure dominated by a strong general stigma factor, with secondary content-specific dimensions (e.g., legitimacy, personal responsibility, visibility, and treatment beliefs). The theory-driven bifactor model showed excellent fit (CFI = 0.991; TLI = 0.990; RMSEA = 0.024). The general factor exhibited high reliability (ω_h = 0.87). Higher stigma was observed among men, older participants, and individuals without personal or familial experience of eating disorders or obesity. Conclusions: This study provides a reliable and theoretically grounded instrument for assessing societal stigma toward eating disorders and obesity in Spain. The scale enables systematic research on stigma and offers a valuable tool for public health surveillance, intervention development, and evaluation of anti-stigma initiatives aimed at promoting compassionate and equitable care. Full article

Background/Objectives: Stroke is a leading cause of mortality and disability in Saudi Arabia; however, national estimates of stroke-related rehabilitation needs remain limited. This study quantified temporal trends in stroke incidence, prevalence, premature mortality, and disability from 1990 to 2021. It also examined disparities in stroke-related disability by subtype, sex, and age in 2021 and projected rehabilitation demand to 2030 to inform health system planning under Vision 2030. Methods: We conducted a secondary analysis of Global Burden of Disease (GBD) 2021 estimates for Saudi Arabia. Age-standardized rates for incidence, prevalence, years of life lost (YLLs), and years lived with disability (YLDs) were extracted for overall stroke and three subtypes: ischemic stroke, intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH). Temporal trends were evaluated using log-linear regression to estimate the average annual percentage change (AAPC). YLDs were mapped to severity levels and four rehabilitation modalities, physiotherapy (PT), occupational therapy (OT), speech–language therapy (SLT), and multidisciplinary comprehensive rehabilitation (MCR), using utilization probabilities informed by the literature. Projections to 2030 incorporated national population forecasts and included 95% prediction intervals and sensitivity analyses. Results: From 1990 to 2021, age-standardized stroke incidence declined from 166.3 to 130.7 per 100,000 (−21.4%; AAPC, −0.86%, p = 0.004), prevalence from 982.4 to 965.2 per 100,000 (−1.8%; AAPC, −0.10%, p = 0.056), and YLL rates from 3209.0 to 1893.4 per 100,000 (−41.0%; AAPC, −1.76%, p < 0.001). In contrast, YLD rates declined modestly from 133.5 to 129.9 per 100,000 (−2.7%; AAPC, −0.13%; p = 0.032). Despite these reductions in age-standardized rates, absolute stroke-related YLDs more than tripled, increasing from approximately 10,900 (95% UI: 8100–13,900) in 1990 to 36,245 (95% UI: 26,600–46,100) in 2021, largely driven by population growth and aging. In 2021, ischemic stroke accounted for 71.1% of total YLDs, followed by ICH (20.3%) and SAH (8.5%). Among adults aged 15–49 years, females had higher hemorrhagic YLD rates than males, with particularly pronounced differences for SAH (female-to-male ratio, 1.5–1.7). By 2030, the projected YLD-equivalent workload, a standardized proxy measure of relative service demand rather than a direct headcount of required therapists, is expected to increase to 29,758 for PT, 21,809 for OT, 14,879 for SLT, and 15,083 for MCR. Sensitivity analyses showed that rehabilitation demand estimates were sensitive to assumptions regarding severity distribution, with a hemorrhagic-weighted scenario increasing projected MCR demand by 6.8%. Conclusions: The increasing absolute burden of stroke-related disability in Saudi Arabia, despite declining age-standardized rates and substantial reductions in premature mortality, highlights the necessity to expand rehabilitation capacity. Scaling community-based, outpatient, and telerehabilitation services in alignment with the Health Sector Transformation Program and integrating disability-informed planning into Vision 2030 should be prioritized. Full article