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27 pages, 13034 KiB  
Article
Losing One’s Place During Policy Suspension: Narratives of Indirect Displacement in Shanghai’s New-Build Gentrification
by Pan He, Jianwen Zheng and Weizhen Chen
Buildings 2025, 15(15), 2766; https://doi.org/10.3390/buildings15152766 - 6 Aug 2025
Abstract
While existing studies document physical and economic impacts of new-build gentrification, the temporally protracted trauma of indirect displacement in communities adjacent to redeveloped areas remains understudied. Employing constructivist grounded theory, this study asks the following question: how do residents experience place attachment erosion [...] Read more.
While existing studies document physical and economic impacts of new-build gentrification, the temporally protracted trauma of indirect displacement in communities adjacent to redeveloped areas remains understudied. Employing constructivist grounded theory, this study asks the following question: how do residents experience place attachment erosion during prolonged policy suspension in Shanghai’s new-build gentrification? Through iterative analysis of 25 interviews, we reveal a temporal vicious cycle of waiting triggered by uneven redevelopment and policy inertia. This cycle systematically dismantles belonging through several mechanisms: (1) chronic place-identity deterioration; (2) progressive social network fragmentation; (3) the collapse of imagined futures; and (4) the ambiguous loss of place attachment—where physical presence coexists with psychological disengagement. Crucially, we redefine indirect displacement as a temporal erosion of place identity and attachment, revealing a paradoxical state of physical presence coexisting with psychological disengagement. This paper provides a new perspective for better understanding the different dimensions of indirect displacement in new-build gentrification, which will help inform equitable development efforts that are more inclusive and just. Full article
(This article belongs to the Special Issue Emerging Trends in Architecture, Urbanization, and Design)
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18 pages, 756 KiB  
Article
How Visual and Mental Human-Likeness of Virtual Influencers Affects Customer–Brand Relationship on E-Commerce Platform
by Liangbo Zhang, Linlin Mo, Xiaohui Sun, Zhimin Zhou and Jifan Ren
J. Theor. Appl. Electron. Commer. Res. 2025, 20(3), 200; https://doi.org/10.3390/jtaer20030200 - 5 Aug 2025
Abstract
Virtual influencers (VIs) on e-commerce platforms are becoming increasingly popular, enhancing the consumer experience. This study examines the consumer–brand relationship (CBR) with VIs through the perspective of social presence. Data from 1041 e-commerce platform users (e.g., Douyin, RED, Weibo) were collected and analyzed [...] Read more.
Virtual influencers (VIs) on e-commerce platforms are becoming increasingly popular, enhancing the consumer experience. This study examines the consumer–brand relationship (CBR) with VIs through the perspective of social presence. Data from 1041 e-commerce platform users (e.g., Douyin, RED, Weibo) were collected and analyzed using Structural Equation Modeling (SEM). The findings reveal that both the visual and mental human-likeness of VIs significantly strengthen CBR, with social presence acting as a mediator. Additionally, the interaction between visual and mental human-likeness positively impacts social presence, which in turn enhances CBR. Moreover, consumers’ need for uniqueness moderates the relationship between social presence and CBR, providing valuable insights for virtual influencer strategies in e-commerce. This research suggests the feasibility of leveraging VI design both visually and mentally to capture new trends in developing effective virtual campaigns with digitization and metaverse technologies. This study extends the stream of research VIs use for interactive marketing, highlighting the role of parasocial relationships in interactive marketing. These findings can provide managers with a better understanding of VI design from both visual and mental aspects. Full article
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22 pages, 982 KiB  
Article
Cross-Cultural Adaptation and Validation of the Spanish HLS-COVID-Q22 Questionnaire for Measuring Health Literacy on COVID-19 in Peru
by Manuel Caipa-Ramos, Katarzyna Werner-Masters, Silvia Quispe-Prieto, Alberto Paucar-Cáceres and Regina Nina-Chipana
Healthcare 2025, 13(15), 1903; https://doi.org/10.3390/healthcare13151903 - 5 Aug 2025
Abstract
Background/Objectives: The social importance of health literacy (HL) is widely understood, and its measurement is the subject of various studies. Due to the recent pandemic, several instruments for measuring HL about COVID-19 have been proposed in different countries, including the HLS-COVID-Q22 questionnaire. The [...] Read more.
Background/Objectives: The social importance of health literacy (HL) is widely understood, and its measurement is the subject of various studies. Due to the recent pandemic, several instruments for measuring HL about COVID-19 have been proposed in different countries, including the HLS-COVID-Q22 questionnaire. The diversity of cultures and languages necessitates the cross-cultural adaptation of this instrument. Thus, the present study translates, adapts, and validates the psychometric properties of the HLS-COVID-Q22 questionnaire to provide its cross-cultural adaptation from English to Spanish (Peru). Methods: As part of ensuring that the final questionnaire accommodates the cultural nuances and idiosyncrasies of the target language, the following activities were carried out: (a) a survey of 40 respondents; and (b) a focus group with 10 participants, followed by expert approval. In addition, the validity and reliability of the health instrument have been ascertained through a further pilot test administered to 490 people in the city of Tacna in southern Peru. Results: The resulting questionnaire helps measure HL in Peru, aiding better-informed decision-making for individual health choices. Conclusions: The presence of such a tool is advantageous in case of similar global health emergencies, when the questionnaire can be made readily available to support a promotion of strategies towards better self-care. Moreover, it encourages other Latin American stakeholders to adjust the instrument to their own cultural, language, and socio-economic contexts, thus invigorating the regional and global expansion of the HL study network. Full article
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20 pages, 367 KiB  
Article
Power Dynamics and Discourse Technologies in Jordanian Colloquial Arabic Allophonic Consonant Variations
by Bassel Alzboun, Raed Al Ramahi and Nisreen Abu Hanak
Languages 2025, 10(8), 190; https://doi.org/10.3390/languages10080190 - 5 Aug 2025
Abstract
Most academic papers on Jordanian colloquial Arabic allophonic consonant variants have primarily examined their influence on the social status of speakers and their role in shaping linguistic prestige. However, there is a significant lack of research exploring the potential for manipulation and establishment [...] Read more.
Most academic papers on Jordanian colloquial Arabic allophonic consonant variants have primarily examined their influence on the social status of speakers and their role in shaping linguistic prestige. However, there is a significant lack of research exploring the potential for manipulation and establishment of power through the deliberate use of consonantal variants by Jordanian speakers in Arabic. Using a variety of allophonic consonantal variants, this study investigates how speakers of Jordanian colloquial Arabic attempt to construct their discourse of power. The targeted phonemes in the current study were /q/, /θ/, /ð/, and /k/. Focus groups were used to gather data, which were then examined within the framework of Fairclough’s technologized discourse and thematic approaches. Twenty persons, 10 women and 10 men, ranging in age from 18 to 45 years, comprised each of the two groups. The duration of each focus group session was 50 min. Analysis of the data indicates that the presence of [q], [θ], [ð], and [k] allophones in Standard Arabic is restricted to particular social circumstances, such as official and scientific environments. This usage is a common trait among those who have received formal education and privileged social standing. The findings also reveal that participants strategically utilize the allophonic variants [g], [ʔ], [k], [t̪], [d̪], and [tʃ] to exert influence over interlocutors by demonstrating authority related to social identity, gender, and emotional state. This study intends to advance discussions on allophonic consonant variants in Jordanian colloquial Arabic by providing insights into their manipulative functions. Full article
29 pages, 12422 KiB  
Article
Real-Time Foreshock–Aftershock–Swarm Discrimination During the 2025 Seismic Crisis near Santorini Volcano, Greece: Earthquake Statistics and Complex Networks
by Ioanna Triantafyllou, Gerassimos A. Papadopoulos, Constantinos Siettos and Konstantinos Spiliotis
Geosciences 2025, 15(8), 300; https://doi.org/10.3390/geosciences15080300 - 4 Aug 2025
Abstract
The advanced determination of the type (foreshock–aftershock–swarm) of an ongoing seismic cluster is quite challenging; only retrospective solutions have thus far been proposed. In the period of January–March 2025, a seismic cluster, recorded between Santorini volcano and Amorgos Island, South Aegean Sea, caused [...] Read more.
The advanced determination of the type (foreshock–aftershock–swarm) of an ongoing seismic cluster is quite challenging; only retrospective solutions have thus far been proposed. In the period of January–March 2025, a seismic cluster, recorded between Santorini volcano and Amorgos Island, South Aegean Sea, caused considerable social concern. A rapid increase in both the seismicity rate and the earthquake magnitudes was noted until the mainshock of ML = 5.3 on 10 February; afterwards, activity gradually diminished. Fault-plane solutions indicated SW-NE normal faulting. The epicenters moved with a mean velocity of ~0.72 km/day from SW to NE up to the mainshock area at a distance of ~25 km. Crucial questions publicly emerged during the cluster. Was it a foreshock–aftershock activity or a swarm of possibly volcanic origin? We performed real-time discrimination of the cluster type based on a daily re-evaluation of the space–time–magnitude changes and their significance relative to background seismicity using earthquake statistics and the topological metric betweenness centrality. Our findings were periodically documented during the ongoing cluster starting from the fourth cluster day (2 February 2025), at which point we determined that it was a foreshock and not a case of seismic swarm. The third day after the ML = 5.3 mainshock, a typical aftershock decay was detected. The observed foreshock properties favored a cascade mechanism, likely facilitated by non-volcanic material softening and the likely subdiffusion processes in a dense fault network. This mechanism was possibly combined with an aseismic nucleation process if transient geodetic deformation was present. No significant aftershock expansion towards the NE was noted, possibly due to the presence of a geometrical fault barrier east of the Anydros Ridge. The 2025 activity offered an excellent opportunity to investigate deciphering the type of ongoing seismicity cluster for real-time discrimination between foreshocks, aftershocks, and swarms. Full article
(This article belongs to the Special Issue Editorial Board Members' Collection Series: Natural Hazards)
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18 pages, 640 KiB  
Article
Suicidal Ideation, Lifestyle Factors, and Burnout Syndrome Among Spanish Professionals in Implant Dentistry: A Survey-Based Cross-Sectional Observational Study
by Ángel-Orión Salgado-Peralvo, Naresh Kewalramani, Eugenio Velasco-Ortega, José López-López, Álvaro Jiménez-Guerra, Loreto Monsalve-Guil, Jesús Moreno-Muñoz, José-Luis Rondón-Romero, Iván Ortiz-García and Enrique Núñez-Márquez
J. Clin. Med. 2025, 14(15), 5486; https://doi.org/10.3390/jcm14155486 - 4 Aug 2025
Abstract
Background: Burnout syndrome (BS) is an occupational phenomenon resulting from chronic workplace stress that has not been successfully managed. Although there are underlying causes associated with personal attributes, it is generally linked to external factors within the work environment. The aim of [...] Read more.
Background: Burnout syndrome (BS) is an occupational phenomenon resulting from chronic workplace stress that has not been successfully managed. Although there are underlying causes associated with personal attributes, it is generally linked to external factors within the work environment. The aim of the present study was to investigate the impact of lifestyle factors on BS and its dimensions, as well as on suicidal ideation among Spanish professionals dedicated to implant dentistry. Methods: A cross-sectional observational study was conducted in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines. An electronic survey based on the Maslach Burnout Inventory—Human Services Survey (MBI–HSS) was distributed to members of the Spanish Society of Implants. The data were analysed using descriptive statistical methods. Results: A total of 305 participants (20.9%) responded to the questionnaire. Notably, 10.8% of the professionals reported experiencing suicidal thoughts, a factor significantly associated with the presence of BS. The lifestyle factors associated with BS included the following: not engaging in aerobic exercise for at least 30 min per day (p < 0.05), not having hobbies that facilitate mental disconnection from work (p < 0.001), not following a balanced diet (p < 0.0001), having an insufficient social life (p < 0.0001), and experiencing suicidal ideation (p < 0.01). Conclusions: The surveyed dentists generally reported having healthy lifestyle habits. Nevertheless, one in ten professionals acknowledged having experienced suicidal ideation at some point, highlighting a concerning association with BS. Full article
(This article belongs to the Special Issue Mood Disorders: Diagnosis, Management and Future Opportunities)
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31 pages, 1741 KiB  
Review
Recycled Concrete Aggregate in Asphalt Mixtures: A Review
by Juan Gabriel Bastidas-Martínez, Hugo Alexander Rondón-Quintana and Luis Ángel Moreno-Anselmi
Recycling 2025, 10(4), 155; https://doi.org/10.3390/recycling10040155 - 2 Aug 2025
Viewed by 88
Abstract
Effective management and handling of construction and demolition waste (CDW) can yield significant technical and environmental benefits for road pavement construction. This article aims to provide a comprehensive and up-to-date chronological review of studies on the mechanical performance of asphalt mixtures—primarily hot mix [...] Read more.
Effective management and handling of construction and demolition waste (CDW) can yield significant technical and environmental benefits for road pavement construction. This article aims to provide a comprehensive and up-to-date chronological review of studies on the mechanical performance of asphalt mixtures—primarily hot mix asphalt (HMA)—incorporating recycled concrete aggregate (RCA). Since the main limitation of RCA is the presence of residual adhered mortar, the review also includes studies that applied various surface treatments (mechanical, chemical, and thermal, among others) to enhance mixture performance. The article summarizes the experimental procedures used and highlights the key findings and conclusions of the reviewed research. Although the results are varied and sometimes contradictory—mainly due to the source variability and heterogeneity of RCA—the use of these materials is technically viable. Moreover, their application can provide environmental, social, and economic advantages, particularly in the construction of low-traffic roadways. Finally, the article identifies research gaps and offers recommendations for future researches. Full article
(This article belongs to the Special Issue Recycled Materials in Sustainable Pavement Innovation)
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23 pages, 3427 KiB  
Article
Visual Narratives and Digital Engagement: Decoding Seoul and Tokyo’s Tourism Identity Through Instagram Analytics
by Seung Chul Yoo and Seung Mi Kang
Tour. Hosp. 2025, 6(3), 149; https://doi.org/10.3390/tourhosp6030149 - 1 Aug 2025
Viewed by 255
Abstract
Social media platforms like Instagram significantly shape destination images and influence tourist behavior. Understanding how different cities are represented and perceived on these platforms is crucial for effective tourism marketing. This study provides a comparative analysis of Instagram content and engagement patterns in [...] Read more.
Social media platforms like Instagram significantly shape destination images and influence tourist behavior. Understanding how different cities are represented and perceived on these platforms is crucial for effective tourism marketing. This study provides a comparative analysis of Instagram content and engagement patterns in Seoul and Tokyo, two major Asian metropolises, to derive actionable marketing insights. We collected and analyzed 59,944 public Instagram posts geotagged or location-tagged within Seoul (n = 29,985) and Tokyo (n = 29,959). We employed a mixed-methods approach involving content categorization using a fine-tuned convolutional neural network (CNN) model, engagement metric analysis (likes, comments), Valence Aware Dictionary and sEntiment Reasoner (VADER) sentiment analysis and thematic classification of comments, geospatial analysis (Kernel Density Estimation [KDE], Moran’s I), and predictive modeling (Gradient Boosting with SHapley Additive exPlanations [SHAP] value analysis). A validation analysis using balanced samples (n = 2000 each) was conducted to address Tokyo’s lower geotagged data proportion. While both cities showed ‘Person’ as the dominant content category, notable differences emerged. Tokyo exhibited higher like-based engagement across categories, particularly for ‘Animal’ and ‘Food’ content, while Seoul generated slightly more comments, often expressing stronger sentiment. Qualitative comment analysis revealed Seoul comments focused more on emotional reactions, whereas Tokyo comments were often shorter, appreciative remarks. Geospatial analysis identified distinct hotspots. The validation analysis confirmed these spatial patterns despite Tokyo’s data limitations. Predictive modeling highlighted hashtag counts as the key engagement driver in Seoul and the presence of people in Tokyo. Seoul and Tokyo project distinct visual narratives and elicit different engagement patterns on Instagram. These findings offer practical implications for destination marketers, suggesting tailored content strategies and location-based campaigns targeting identified hotspots and specific content themes. This study underscores the value of integrating quantitative and qualitative analyses of social media data for nuanced destination marketing insights. Full article
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24 pages, 6020 KiB  
Article
Seasonal Patterns of Preterm Birth During the COVID-19 Pandemic: A Retrospective Cohort Study in Romania
by Paula Trif, Cristian Sava, Diana Mudura, Boris W. Kramer, Radu Galiș, Maria Livia Ognean, Alin Iuhas and Claudia Maria Jurca
Medicina 2025, 61(8), 1398; https://doi.org/10.3390/medicina61081398 - 1 Aug 2025
Viewed by 199
Abstract
Background and Objectives: Preterm birth and stillbirth are primary adverse pregnancy outcomes. Research during the COVID-19 pandemic revealed reductions in preterm birth in some countries, while stillbirth rates increased or remained unchanged. These findings suggest the presence of preventable risk factors associated with [...] Read more.
Background and Objectives: Preterm birth and stillbirth are primary adverse pregnancy outcomes. Research during the COVID-19 pandemic revealed reductions in preterm birth in some countries, while stillbirth rates increased or remained unchanged. These findings suggest the presence of preventable risk factors associated with changes in physical activity and lower exposure to community-acquired infections due to lockdown measures, altered social interaction patterns or reduced access to antenatal care. Assessing seasonal variation may offer insights into whether lifestyle changes during the COVID-19 lockdown period influenced preterm birth rates. Materials and Methods: This retrospective cohort study used data from the electronic medical records of Bihor and Sibiu counties. Preterm deliveries (<37 weeks) and stillbirths during the COVID-19 pandemic (2020 and 2021) were compared with the corresponding pre-pandemic (2018 and 2019) and post-pandemic (2022 and 2023) period. Preterm birth rates during summer and winter in the pre-pandemic, pandemic, and post-pandemic years were analyzed. A comparison with rates during strict lockdown was made. Results: Out of 52,021 newborn infants, 4473 were born preterm. Preterm birth rates remained stable across all three periods (p = 0.13), and no significant seasonal pattern was identified (p = 0.65). In contrast, stillbirth rates increased notably during the strict lockdown period, with the median incidence almost doubling compared to other periods (0.87%, p = 0.05), while remaining unchanged during the rest of the pandemic (p = 0.52). Conclusions: Our study found that preterm birth rates remained unaffected by the pandemic and lockdown periods, while stillbirths increased significantly during the strict lockdown. These findings highlight the importance of maintaining access to timely antenatal care during public health emergencies to prevent adverse perinatal outcomes. Full article
(This article belongs to the Special Issue Advances in Obstetrics and Maternal-Fetal Medicine)
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10 pages, 459 KiB  
Article
Influence of Primary Care Physicians on End-of-Life Treatment Choices in Lung Cancer Diagnosed in the Emergency Department
by Tatsuyuki Kawahara, Nobuaki Ochi, Hirohito Kirishi, Yusuke Sunada, Ayaka Mimura, Naruhiko Ichiyama, Yoko Kosaka, Yasunari Nagasaki, Hidekazu Nakanishi, Hiromichi Yamane and Nagio Takigawa
J. Pers. Med. 2025, 15(8), 339; https://doi.org/10.3390/jpm15080339 - 1 Aug 2025
Viewed by 129
Abstract
Background: Lung cancer remains one of the leading causes of cancer-related mortality worldwide. While most diagnoses occur in outpatient settings, a subset of cases are incidentally identified during emergency department (ED) visits. The clinical characteristics and treatment decisions of these patients, particularly [...] Read more.
Background: Lung cancer remains one of the leading causes of cancer-related mortality worldwide. While most diagnoses occur in outpatient settings, a subset of cases are incidentally identified during emergency department (ED) visits. The clinical characteristics and treatment decisions of these patients, particularly in relation to social background factors such as living situation and access to primary care, remain poorly understood. Methods: We conducted a retrospective study of patients diagnosed with malignancies in the ED of a single institution between April 2018 and December 2021. Patients diagnosed with lung cancer within 60 days of an ED visit were included. Data on demographics, disease status, treatment decisions, and background factors—including whether patients lived alone or had a primary care physician (PCP)—were extracted and analyzed. Results: Among 32,108 patients who visited the ED, 148 were diagnosed with malignancy within 60 days; 23 had lung cancer. Of these, 69.6% had metastatic disease at diagnosis, and 60.9% received active treatment (surgery or chemotherapy). No significant associations were observed between the extent of disease and either living arrangement or PCP status. However, the presence of a PCP was significantly associated with the selection of best supportive care (p = 0.023). No significant difference in treatment decisions was observed based on age (cutoff: 75 years). Conclusions: Although social background factors such as living alone were not significantly associated with cancer stage or treatment choice, the presence of a primary care physician was associated with a higher likelihood of best supportive care being selected. This may indicate that patients with an established PCP have more clearly defined care goals at the end of life. These findings suggest that primary care access may play a role in shaping end-of-life care preferences, highlighting the importance of personalized approaches in acute oncology care. Full article
(This article belongs to the Special Issue New Insights into Personalized Care in Advance Care Planning)
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30 pages, 940 KiB  
Article
Language Contact and Population Contact as Sources of Dialect Similarity
by Jonathan Dunn and Sidney Wong
Languages 2025, 10(8), 188; https://doi.org/10.3390/languages10080188 - 31 Jul 2025
Viewed by 275
Abstract
This paper creates a global similarity network between city-level dialects of English in order to determine whether external factors like the amount of population contact or language contact influence dialect similarity. While previous computational work has focused on external influences that contribute to [...] Read more.
This paper creates a global similarity network between city-level dialects of English in order to determine whether external factors like the amount of population contact or language contact influence dialect similarity. While previous computational work has focused on external influences that contribute to phonological or lexical similarity, this paper focuses on grammatical variation as operationalized in computational construction grammar. Social media data was used to create comparable English corpora from 256 cities across 13 countries. Each sample is represented using the type frequency of various constructions. These frequency representations are then used to calculate pairwise similarities between city-level dialects; a prediction-based evaluation shows that these similarity values are highly accurate. Linguistic similarity is then compared with four external factors: (i) the amount of air travel between cities, a proxy for population contact, (ii) the difference in the linguistic landscapes of each city, a proxy for language contact, (iii) the geographic distance between cities, and (iv) the presence of political boundaries separating cities. The results show that, while all these factors are significant, the best model relies on language contact and geographic distance. Full article
(This article belongs to the Special Issue Dialectal Dynamics)
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12 pages, 1134 KiB  
Article
Household Water Insecurity in the Western Amazon, Amazonas, Brazil: A Preliminary Approach
by Mayline Menezes Da Mata, Adriana Sañudo, Hugo Melgar-Quiñonez, Mauro Eduardo Del Grossi and Maria Angélica Tavares De Medeiros
Water 2025, 17(15), 2253; https://doi.org/10.3390/w17152253 - 28 Jul 2025
Viewed by 281
Abstract
The objective was to evaluate the quality of an instrument to measure the experience of household water insecurity (WI) and the factors associated with the prevalence of WI in an urban area in a municipality in the Western Brazilian Amazon. A cross-sectional, population-based [...] Read more.
The objective was to evaluate the quality of an instrument to measure the experience of household water insecurity (WI) and the factors associated with the prevalence of WI in an urban area in a municipality in the Western Brazilian Amazon. A cross-sectional, population-based study was conducted to investigate 983 urban households. The Household Water Insecurity Experiences (HWISE) scale was used to measure the psychometric properties of reliability and validity. An exploratory factor analysis was conducted, and the prevalence ratio (PR, 95% CI) was calculated, considering WI as the dependent variable and the other household variables as independent variables. WI affected 46.2% (95% CI: 43.0–49.4%) of the households, independently associated with: head of the family as parent/other and presence of a child in the household. The instrument exhibited unidimensionality in the factor analyses and was considered to be both reliable and valid, as indicated by a Cronbach’s α coefficient of 0.958. Household WI is a serious public health problem in the Amazon in correlation with both social vulnerability and a lack of public services. As a preliminary approach, the scale proved to be valid and reliable. However, considering the Amazonian context, misunderstandings about some issues by respondents were identified, and further validation studies are needed to improve the intelligibility of these questions. Full article
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16 pages, 776 KiB  
Article
Safety and Toxicology Profile of TT-6-AmHap Heroin Conjugate Vaccine
by Essie Komla, Erwin G. Abucayon, C. Steven Godin, Agnieszka Sulima, Arthur E. Jacobson, Kenner C. Rice and Gary R. Matyas
Vaccines 2025, 13(8), 792; https://doi.org/10.3390/vaccines13080792 - 26 Jul 2025
Viewed by 414
Abstract
Background/Objectives: Opioid use disorder (OUD) remains a severe health problem globally, resulting in substantial social and economic challenges. While existing medications for managing OUD are proven to be effective, they also present certain challenges. A vaccine offers a promising therapeutic strategy to [...] Read more.
Background/Objectives: Opioid use disorder (OUD) remains a severe health problem globally, resulting in substantial social and economic challenges. While existing medications for managing OUD are proven to be effective, they also present certain challenges. A vaccine offers a promising therapeutic strategy to combat OUD and potentially reduce the risk of overdose death. The TT-6-AmHap heroin conjugate vaccine has effectively reduced heroin-induced pharmacological effects in behavioral assays as well as demonstrated the induction of high titer and high affinity antibody responses in mice and rats. In this GLP study conducted in rabbits, the potential local and systemic toxicity of the TT-6-AmHap heroin vaccine in combination with or without adjuvants ALF43 and Alhydrogel® (ALFA) was investigated. Methods: Male and female New Zealand White rabbits were administered with vaccines or a saline control intramuscularly at two-week intervals over a 57-day study period. The presence, persistence or reversibility of any toxic effects of the vaccine was determined over a four-week recovery period. Results: Administration of TT-6-AmHap with or without the adjuvants induced high antibody-specific IgG in treatment groups compared to the controls. The study found no TT-6-AmHap-related effects on mortality, physical examinations, dermal Draize observations, body weights, body weight changes, food consumption, ophthalmology, clinical pathology (hematology, coagulation, clinical chemistry, and urinalysis), macroscopic pathology, or organ weights. Conclusions: Under the conditions of this study, these results demonstrate that the TT-6-AmHap vaccine with or without adjuvants was well tolerated, immunogenic, and the effects were not considered adverse in both male and female rabbits. Full article
(This article belongs to the Section Vaccines and Public Health)
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15 pages, 642 KiB  
Article
MIH and Cavities as Markers of Oral Health Inequality in Children from Southwest Andalusia (Spain)
by Leidy Bech Barcaz, David Ribas-Pérez, Paloma Villalva Hernandez-Franch, Luis El Khoury-Moreno, Julio Torrejón-Martínez and Antonio Castaño-Séiquer
Dent. J. 2025, 13(8), 345; https://doi.org/10.3390/dj13080345 - 26 Jul 2025
Viewed by 268
Abstract
Introduction: Dental caries and molar–incisor hypomineralisation (MIH) are prevalent conditions affecting children’s oral health, with functional, aesthetic, and psychosocial implications. In Spain, previous studies have highlighted geographic and sociodemographic disparities in their distribution, particularly among rural and migrant populations. Objective: To characterise oral [...] Read more.
Introduction: Dental caries and molar–incisor hypomineralisation (MIH) are prevalent conditions affecting children’s oral health, with functional, aesthetic, and psychosocial implications. In Spain, previous studies have highlighted geographic and sociodemographic disparities in their distribution, particularly among rural and migrant populations. Objective: To characterise oral health status, in terms of caries and MIH, among 6–7-year-old children from the towns of Palos de la Frontera, Mazagón, and San Bartolomé. Methods: A cross-sectional study was conducted involving 229 children recruited from public primary schools. Sociodemographic, anthropometric, and behavioural data were collected through clinical examination and interview. Statistical analysis included univariate and multivariate logistic regression. The study protocol was approved by the Ethics Committee of Huelva. Results: The prevalence of caries (DMFT ≥ 1) was 53.3%, with mean DMFT and dft indices of 1.78 and 0.31, respectively. MIH affected 32.8% of the cohort, with a predominance in the first permanent molars (teeth 36 and 26). Multivariate analysis identified independent predictors of caries: African (OR = 7.47; 95% CI: 2.84–23.8) and European (OR = 4.56; 95% CI: 1.26–22.3) parental origin, poor oral hygiene (OR = 3.07; 95% CI: 1.60–6.03), and the presence of MIH (OR = 3.20; 95% CI: 1.64–6.42). The municipality of San Bartolomé was associated with a higher risk of MIH (OR = 2.90; 95% CI: 1.21–7.45). Conclusions: The high prevalence of caries and MIH in the Condado-Campiña district, exceeding national averages, reflects oral health inequities linked to social determinants (migrant origin, locality) and clinical factors (MIH, oral hygiene). Targeted preventive interventions are urgently needed in high-risk populations, including culturally tailored education and policies ensuring equitable access to dental care services. Full article
(This article belongs to the Topic Preventive Dentistry and Public Health)
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8 pages, 248 KiB  
Article
The Association Between Female Breast Size, Backache, and Quality of Life in Young Women: A Cross-Sectional Study
by Raphael Lotan, Natali Marmor, Sharon Weiss, Mojahed Sakhnini and Oded Hershkovich
Medicina 2025, 61(8), 1353; https://doi.org/10.3390/medicina61081353 - 26 Jul 2025
Viewed by 257
Abstract
Background and Objectives: The association between female breast size and spinal back pain is widely suggested in clinical practice but remains insufficiently quantified in general, non-surgical populations in the scientific literature. Larger breasts may increase biomechanical strain on the spine, contributing to [...] Read more.
Background and Objectives: The association between female breast size and spinal back pain is widely suggested in clinical practice but remains insufficiently quantified in general, non-surgical populations in the scientific literature. Larger breasts may increase biomechanical strain on the spine, contributing to musculoskeletal pain and reduced quality of life. This study aimed to evaluate the association between breast size and back pain in a general orthopedic population of young women. Materials and Methods: A cross-sectional study was conducted among 200 women aged 18–36 who attended orthopedic clinics for non-spinal complaints. Data were collected via structured telephone questionnaires, including demographics, self-reported breast size (cup and band), pain characteristics, and SF-12 quality of life scores. Binary logistic regression, ANOVA, and chi-square analyses assessed associations between breast size, pain presence, severity, and functional outcomes. Results: Back pain prevalence increased with breast size: only 4.9% of B cup participants reported backache, compared to 85% of DD/E cup participants. VAS scores rose from 0.3 ± 1.6 (B cup) to 6.0 ± 2.9 (DD/E cup). Each 1 cm increase in band length raised the odds of back pain by 19.8% (OR = 1.198, p < 0.001), while large cup size was associated with up to 12-fold increased odds of pain. Larger breast size was also significantly associated with work limitations and social impairment. Conclusions: Breast size was strongly associated with the presence and severity of back pain, particularly in the thoracic and cervical regions. Clinicians should consider breast size in the assessment of backache, and reduction mammaplasty may have therapeutic value beyond aesthetics. Full article
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