Search Results (12,459)

In order to explore the outstanding problems, such as poor mechanical performance, of recycled aggregate from construction waste in the application of backfills, this study innovatively used accelerated carbonation treatment technology to pretreat the recycled aggregates, and systematically investigated the evolution of mechanical properties in carbonated recycled aggregate-based cemented paste backfill (CPB). By carbonizing the waste recycled concrete aggregate (RCA), carbonation recycled concrete aggregates (CRCA) were obtained, and coal gangue was replaced as the filling aggregate at 50% and 100% for mine paste filling. The mechanical properties of the CPB were measured, and the mechanism was analyzed in combination with the changes in the microstructure. The results showed that the physical properties of RCA were significantly improved by carbonation treatment compared with untreated raw RCA: the apparent density of C₆₀d-RCA increased by 2.88% relative to non-carbonated RCA, while its crushing value decreased by 51.45%, resulting in a more stable aggregate structure. In terms of mechanical properties, the compressive strengths of the 28day carbonated backfills with 50% and 100% CRCA contents (denoted as C₂₈d-RCA-50 and C₂₈d-RCA-100) reached 6.38 MPa and 5.32 MPa, representing increases of 61.52% and 46.33%, respectively, compared to the control group. Microstructure and phase composition analysis showed that the carbonation reaction not only produced calcium carbonate (CaCO₃) crystals to effectively fill the internal pores and reduce the total porosity of the matrix, but also promoted the generation of monocarboaluminate and provided abundant nucleation sites for calcium silicate hydrate (C-S-H) gel hydration, which significantly optimized the structure of the interfacial transition zone (ITZ) and improved its microhardness. Among all test groups, the CRCA-50 group showed the most optimized microstructure and the best mechanical properties. This study provides a theoretical reference for the resource utilization of this type of 30-year service life RCA in mine filling. Full article

Head and neck mucosal melanoma (HNMM) arises in the nasal and oral cavities and has the propensity to metastasize to local and distant body sites. HNMM is also notable for its resistance to available therapeutics. The rarity of this disease makes it difficult to conduct large-scale clinical studies to develop standard treatment protocols. In contrast to cutaneous melanoma, c-Kit-dependent pathways are well studied in HNNMM and provide a potential therapeutic target. We identified and isolated genetically distinct subpopulations with stem cell characteristics in HNMM samples bearing Kit wild-type and mutations. Functional analysis of these subpopulations reveals that, in addition to expressing the stem cell marker proteins CD20, CD117, CD133, and CD166, these subpopulations are characterized by self-renewal potential, migratory capacity, and resistance to Kit inhibitors such as Imatinib. Immunofluorescence staining and inhibition experiments demonstrate that the maintenance and resistance of HHMM subpopulations to Kit inhibitors is mediated by the Kit signal to the PI3K signaling pathway. The KIT signal to the PI3K signaling pathway does not result exclusively from a KIT mutation localized to Exon 17, but can also be triggered by mutations localized to Exons 11 and 13. In the present study, we identify and characterize an HNMM subpopulation with stemness properties in patients with c-Kit wild-type and mutation, and demonstrate for the first time the mechanisms by which the CD117⁺/CD133⁺ HNMM subpopulations survive and confer resistance to the specific inhibitor of c-Kit mutation. Full article

Na⁺,K⁺-ATPase possesses a highly conserved glycine (G358 in the α3 isoform) that—together with a nearby isoleucine (I363 in α3)—is targeted by mutations causing some of the most severe neurological phenotypes of the clinical spectrum of α3-Na⁺,K⁺-ATPase mutations. The disease mutations α3-G358V and α3-I363N affect Na⁺ and K⁺ transport to an extent incompatible with cell growth. However, alanine replacement of the corresponding glycine G363 in the α1 isoform is compatible with cell growth, allowing the effects on Na⁺,K⁺-ATPase function to be addressed using enzymatic assays on plasma membranes isolated from transfected cells. Occlusion of Na⁺ appears to be defective in mutant G363A, resulting in a reduced rate of phosphorylation from ATP. Furthermore, the mutation displaces the major conformational equilibrium of Na⁺,K⁺-ATPase such that the K⁺-occluded state is destabilized and occluded K⁺ is released faster, thereby leading to accumulation of a non-productive state without bound Na⁺ or K⁺. The critical function of the glycine can be ascribed to a strategic location at the bending point between an α helix and a β strand, where it connects the catalytic ATP hydrolysis site in the cytoplasmic P domain with the ion-binding region in the membrane and coordinates important intramolecular domain movements during the Na⁺,K⁺-ATPase transport cycle. Full article

Forests worldwide are increasingly affected by climate-driven stressors and large-scale disturbances that impair tree physiology, disrupt water and carbon balance, and increase mortality risk. In this context, successful natural and artificial regeneration is essential for maintaining forest continuity, carbon storage, and biodiversity. However, regeneration outcomes depend not only on site conditions but also on biotic pressures, especially browsing by cervids in temperate and boreal forests. The aim of this review was to identify and synthesize evidence on how silvicultural methods can reduce browsing damage in forest regeneration and to assess how these methods influence the underlying drivers of cervid pressure through stand structure and forage availability. We examine mechanisms operating at two spatial scales: at the microscale, regeneration type, planting density, structural heterogeneity, planting stock, and how species mixture influences browsing probability and intensity; at the macroscale, how cutting systems and the spatial and temporal arrangement of harvests shape foraging landscapes by concentrating or dispersing browse resources and edge habitats. The reviewed evidence shows that dense, structurally diverse natural regeneration can dilute browsing pressure, whereas uniform artificial regeneration may increase repeated damage, and that species composition and mixture patterns can either protect or expose palatable species. We conclude that integrating microscale regeneration design with landscape-level harvest planning can strengthen stand resilience, reduce dependence on fencing, and support climate-adaptive forest development. To the best of our knowledge, no previous review has synthesized this evidence across both micro- and macroscale silvicultural contexts. Although most of the studies included in this review originate from Europe, we believe that the knowledge presented here is relevant to the majority of boreal and temperate forests worldwide. Full article

Body temperature regulation in ectotherms is influenced by numerous environmental, morphological, and physiological factors, some of which operate in population-specific ways. Understanding how these factors shape thermal biology is important for species conservation. The nose-horned viper, an ecologically significant yet understudied mesopredator of southeastern Europe and Asia Minor, occupies diverse ecosystems facing ongoing degradation. Over five years, we investigated how 12 environmental, behavioral, morphological, and physiological variables influenced field body temperature across three climatically distinct populations of nose-horned vipers. Using an information-theoretic approach with model averaging, we identified important predictors and assessed population-specific effects. Air temperature at 5 cm above the snake’s position, humidity, and wind were highly important predictors across all populations, whereas physiological states (shedding and digestion) exerted weaker effects. Microhabitat type and time of day emerged as highly important population-specific predictors, while body size showed weaker, population-dependent effects. Neither sex, cloud cover, nor behavioral state contributed meaningfully to model fit. Mean body temperatures were similar across populations and sexes. By integrating environmental, behavioral, physiological, and morphological variables, this study comprehensively identifies predictors of body temperature in nose-horned vipers. Site-tailored maintenance of structurally diverse habitats is essential for preserving thermoregulatory opportunities and ensuring long-term persistence of nose-horned vipers. Full article

The rational design of supported Lewis acid catalysts is frequently impeded by an incomplete understanding of how the support’s synthetic history governs its intrinsic acidity and catalytic efficacy. Herein, we elucidate the structure–property–performance relationship linking the aging dynamics of a boehmite precursor to the activity of the resultant chlorinated alumina (Al₂O₃–Cl) catalyst in n-butane isomerization. Using n-butane as the probe feedstock, we investigated how alumina supports with distinct physicochemical properties regulate the performance of Al₂O₃–Cl catalysts for n-butane isomerization. By systematically adjusting the aging parameters (stirring rate, temperature, and time), we reveal that the structural evolution of the alumina support transitions from initial particle aggregation to Ostwald ripening and surface reconstruction. A decisive structure–performance correlation is identified: precursor synthesis conditions govern both the population and accessibility of specific surface hydroxyls (notably Type II terminal OH groups), which act as anchoring sites for the generation of active Lewis acid centers upon chlorination. Optimal aging parameters (300 rpm, 90 °C, 6 h) promote the formation of a hierarchical pore architecture with a maximized density of accessible hydroxyls, thereby affording enhanced Lewis acidity and superior isomerization activity. This work provides a fundamental framework for tailoring solid acid catalysts by precisely engineering the precursor architecture. Full article

Despite its potential to enhance construction quality, efficiency, and sustainability, modular construction continues to experience defects that hinder its broader adoption. Understanding and mitigating defects is essential for maximising the sustainability benefits of modular construction by reducing material waste, minimising rework and improving lifecycle performance. Existing research remains fragmented, with limited synthesis integrating defects with their root causes across the project lifecycle. To address this gap, this study investigates defect types, lifecycle-based causes, and mitigation strategies in modular building projects through a PRISMA-guided systematic literature review of 61 peer-reviewed journal articles published between 2015 and 2025 and retrieved from Scopus and Web of Science. Six major defect categories were identified: geometric and dimensional; material and component; joint and connection integrity; envelope performance and durability; structural; and mechanical, electrical, and plumbing (MEP) defects, with geometric and dimensional defects emerging as the most prevalent, accounting for 26.7% of reported cases. Lifecycle root-cause mapping indicates that poor workmanship during on-site assembly is the dominant contributor, accounting for 44.1% of identified root causes, with manufacturing errors (26.8%) and design limitations (13.4%) acting as critical upstream sources. Mitigation strategies cluster into three groups: general recommendations (39% of reported strategies), mainly focusing on low-cost organisational measures such as logistics coordination and workforce training; structured risk-management frameworks (9.1%), including assembly sequencing and tolerance planning; and digital and data-driven technologies (51.9%), such as laser scanning, AI-based inspection, and digital twins, enabling proactive quality assurance across the lifecycle. The study proposes an integrated lifecycle–defect–mitigation framework to strengthen quality governance and advance sustainable modular delivery. Full article

Highland barley (Hordeum vulgare var. nudum), a member of the genus Hordeum in the family Poaceae, represents a unique cultivated crop adapted to the Qinghai–Tibet Plateau. Weed infestation has long posed a serious threat to the yield and quality of highland barley, and the lack of effective weed management strategies has become a major constraint in its production. Pyroxsulam is an acetolactate synthase (ALS)-inhibiting herbicide widely used for weed control in highland barley fields. This study investigated the molecular mechanisms underlying the response of highland barley to pyroxsulam by integrating physiological, biochemical, and transcriptomic analyses. ALS activity assays showed that the resistant variety ‘Qing0306’ exhibited a significant increase in relative ALS activity within 1–4 days after pyroxsulam treatment. qRT-PCR analysis revealed a rapid induction of HvnALS expression, which was significantly higher in ‘Qing0306’ than in ‘Qing0160’ on the first day after treatment (p < 0.01), indicating that resistance is primarily associated with target-enzyme overexpression rather than target-site mutations. Moreover, transgenic Arabidopsis lines overexpressing HvnP450 and HvnGSTs displayed enhanced tolerance to pyroxsulam, as evidenced by an increased root length and fresh weight compared with wild-type plants. This study provides mechanistic insights that support the genetic improvement of pyroxsulam-resistant highland barley. Full article

In the context of digital tourism development, artificial intelligence has become one of the major techniques for tourists’ information acquisition and interaction in the field of intangible cultural heritage (ICH) tourism. However, whether AI with anthropomorphism elements attracts tourists to visit cultural heritage sites and how AI anthropomorphism design affects visitors’ visit intentions remains unclear. Therefore, based on the stimulus–organism–response (S–O–R) theory, this study proposes an “AI anthropomorphism–AI trust–visit intention” model and investigates the role of AI anthropomorphism in visit intention. In particular, this study tests the effects of perceived intelligence and perceived risk on AI anthropomorphism, as well as the role of AI trust and perceived cultural sustainability on the relationship between AI anthropomorphism and visit intention. With a sample of 478 Chinese respondents who are intangible cultural heritage (ICH) tourists, the hypothesized relationships are tested by employing structural equation modeling. The results show that perceived intelligence exerts a positive effect on AI anthropomorphism, while perceived risk exerts a negative effect on AI anthropomorphism. Moreover, AI anthropomorphism exerts an effect on AI trust, which in turn yields a great influence on visit intention. In addition, further analysis shows that AI type intensifies the effect of anthropomorphism on AI trust, and the relationship between AI trust and visit intention is regulated by perceived cultural sustainability. This study reveals how AI anthropomorphism functions in ICH tourism, and the findings provide practical guidance for advancing intelligent services and giving cultural sustainability top priority in order to support the sustainable growth of ICH tourism. Full article

The conservation of traditional villages has shifted from isolated site-by-site protection to regional collaboration, and exploring pathways for their sustainable development has become a key focus of research. Existing research still falls short in areas such as the integration of heritage value into decision-making mechanisms and the establishment of systematic conservation frameworks, leading to prominent issues of isolated conservation and homogeneous development. Taking traditional villages in Yanchuan County, China, as a case study, this research aims to establish a clustered conservation system and achieve a transition towards networked collaborative governance. The study utilised field surveys and literature review to establish a database and systematically catalogue heritage resources; it combined the Analytic Hierarchy Process (AHP) and the Delphi method to construct a value evaluation system and identify distinctive features; and it integrated cluster theory with GIS spatial analysis to construct a clustered conservation framework across three dimensions: classification and grading, symbiotic models, and the overall spatial pattern. The results indicate that: (1) the spatial distribution of villages in Yanchuan County is uneven, and the villages themselves exhibit significant homogeneity in their characteristics; (2) core characteristics include Loess culture, cave dwellings and revolutionary heritage sites, with comprehensive scores ranging from 0.4437 to 0.9116; these are classified into three protection levels, identifying five categories of villages of value. (3) Five major cluster zones were delineated based on resource and spatial characteristics. By integrating river basins and transport corridors, a comprehensive protection framework of ‘one belt, two wings, two centers and five zones’ was established, alongside three types of cluster symbiosis models, thereby achieving regional resource integration and enhancing collaborative efficiency. The cluster-based protection system proposed in this study can effectively address the challenges facing the conservation and development of traditional villages, providing a feasible solution for regional collaborative protection, and holds practical significance for cultural heritage management and sustainable development. Full article

Bowen disease (BD), or squamous cell carcinoma (SCC) in situ, represents a histologically defined but biologically heterogeneous group of intraepithelial neoplasms arising across different epithelial compartments. Human papillomavirus (HPV) plays a well-established causal role in anogenital squamous intraepithelial neoplasia, whereas its contribution to extragenital BD, including nail apparatus and general cutaneous lesions, has remained controversial. We performed a narrative review of the literature to synthesize current evidence on HPV prevalence, genotype distribution, and pathogenetic relevance in BD across three anatomical sites: nail apparatus, general cutaneous skin, and anogenital region. Available data reveal a clear site-dependent gradient of HPV involvement. Anogenital BD is overwhelmingly driven by high-risk α-HPV genotypes and shares molecular hallmarks of HPV-mediated carcinogenesis. Nail apparatus BD shows a consistently high prevalence of transforming α-HPV types, suggesting a biologically distinct subset of extragenital disease. In contrast, general cutaneous BD demonstrates highly variable HPV detection, predominantly involving β- and occasionally γ-HPV types, with evidence supporting a permissive or incidental rather than causal role. These findings indicate that BD should not be regarded as a unified viral neoplasm but as a convergent histologic phenotype arising from distinct pathogenetic pathways. Anatomical context is therefore essential for interpreting HPV detection and its diagnostic and clinical implications. Full article

The college access policy landscape across Alabama, U.S., has gained traction in K-12 schools and higher education institutions over the last few years. In Spring 2021, the Alabama State Board of Education approved a resolution to require all seniors to complete the Free Application for Federal Student Aid (FAFSA). In Fall 2025, the state began implementing its Alabama Direct Admission Initiative, a partnership between dozens of 2-year and 4-year in-state institutions to streamline college application processes for all seniors. Advocates of both anticipate an increase in college enrollment, particularly for students who have previously faced issues with financing postsecondary education. Despite such policies and initiatives, Black, rural students in Alabama still face unique challenges to college access. This paper addresses the following questions: How do Black, rural students access postsecondary education in Alabama? How do Black, rural students perceive and experience college access policies? What role does policy enactment play in Black, rural students’ college access experiences? Using a multi-site case study approach, we present insights gleaned from 16 virtual focus groups with students across five higher education institutions in Alabama. Findings from this study highlight how Black, rural students engage in three types of labor associated with college-going: assessment labor, simulation labor, and capacity-building labor. Full article

Under the combined pressures of urbanization and tourism development, terraced agricultural heritage sites are increasingly threatened by the degradation of traditional landscapes, the weakening of living cultural practices, and mismatches between the supply and demand of cultural ecosystem services (CESs). As a representative type of Globally Important Agricultural Heritage Systems (GIAHSs), the rice terrace landscapes of southern China have formed an integrated system of forests, villages, terraces, and water networks, embodying multiple values related to production, ecology, landscape, and culture. To support the coordination of heritage conservation, tourism development, and the transformation of cultural value, this study takes the core area of the Longji Terraced Fields as a case study and develops an improved SolVES–IPA collaborative assessment framework from the perspective of tourist perception. Four CES categories are examined: recreational value, aesthetic value, historical and cultural value, and educational value. The results show that (1) the four CES categories exhibit significant spatial differentiation. Recreational and aesthetic values are mainly concentrated in high-altitude viewing spaces, whereas historical, cultural, and educational values depend more heavily on traditional architectural spaces and interpretive nodes. (2) Clear supply–demand mismatches exist across CES categories. Recreational value is constrained by limited activity diversity; aesthetic value is limited by inadequate architectural harmony; historical and cultural value is primarily restricted by insufficient continuity of living traditions; and educational value is constrained by incomplete interpretive content and single presentation formats. (3) CES optimization in the Longji Terraced Fields should adopt both type-specific and hierarchical intervention strategies, including priority optimization for high-value units with critical shortcomings, near-term improvement for high-value units with general shortcomings, functional enhancement for medium-value units with critical shortcomings, progressive optimization for medium-value units with general shortcomings, and potential cultivation of low-value units. Based on these findings, this study proposes several optimization directions, including strengthening participatory experiences, promoting the coordinated renewal of the architectural landscape, creating multisensory cultural display spaces, and establishing a multidimensional interpretation network. The improved SolVES–IPA collaborative assessment framework developed in this study integrates CES spatial identification, supply–demand diagnosis, and optimization priority setting, providing a methodological reference and practical support for enhancing cultural services and promoting the coordinated development of heritage conservation and cultural tourism in the Longji Terraced Fields and similar agricultural heritage sites. Full article

High-voltage bushings, the fault-prone key electrical components of transformers, are critical for real-time and high-accuracy fault monitoring and management. Intelligent fault detection via infrared images is plagued by low classification accuracy due to massive interference from similar tubular objects and small target characteristics. This study proposes a lightweight deep learning model, MTrip–YOLO, an improved YOLO11n integrated with Mamba-2 (Structured State Space Duality, SSD) and Triplet Attention, to achieve efficient fault monitoring in complex backgrounds. The training and validation dataset comprises open-source images, on-site data from a substation, and field-collected infrared images, categorized into four types: normal bushings, poor contact, oil shortage, and high dielectric loss faults. Mamba-2 captures the long-range global context of infrared features with its linear-complexity long-range modeling capability to enhance feature extraction, while Triplet Attention suppresses complex background radiation noise through cross-dimensional interaction without dimensionality reduction, enabling the model to focus on small targets and accurately classify bushings from morphologically similar strip-shaped objects. Experimental results show that MTrip–YOLO achieves a top mAP50 of 91.6% and a minimal parameter count of 1.9 M, outperforming Faster R-CNN, RT-DETR, and YOLO26n across all evaluated metrics and being potentially suitable for edge deployment on UAV-mounted or handheld infrared platforms, pending hardware validation on embedded computing devices. Ablation experiments verify the independent contributions of Mamba-2 (0.8027% mAP50 improvement) and Triplet Attention (0.89327% mAP50 improvement), with a synergistic effect from their combination. MTrip–YOLO provides a potential edge-deployable solution for high-voltage bushing fault monitoring, offering important application value for the intelligent operation and maintenance of substations. Full article

The eco-health effects of urban green spaces are playing a vital role in mitigating urban environmental stress and promoting residents’ well-being. However, the specific differences and dominant factors influencing these effects across different green space types and plant community structures have not been fully elucidated. This study selected three typical green spaces in Tianfu New District of Chengdu—regional green space, comprehensive park, and specialized park—and focused on four community structures: tree–shrub–herb, tree–herb, tree-only, and herb-only. Multi-scale in situ monitoring was conducted during summer, and a comprehensive index method was employed for evaluation. The results demonstrated that (1) the tree–shrub–herb multi-layered structure exhibited the optimal eco-health function at the community scale, with a PM_2.5 reduction rate of 73.86%, a noise reduction rate of 25.13%, and a negative air ion supply rate of up to 396%, significantly outperforming other structures. (2) The overall effect of regional green space (composite index 10.41) at the site scale was significantly higher than that of comprehensive parks (6.42) and specialized parks (5.87), respectively. (3) The eco-health effect increased with the complexity of the community structure, ranking as: tree–shrub–herb > tree-only > tree–herb > herb-only, highlighting the prominent contribution of the tree layer. Plant diversity showed a positive but non-significant trend. In conclusion, this multi-scale comparative study clarifies the differential impacts of green space types and community structures on the eco-health effect. It is recommended that urban planning prioritizes the layout of regional green spaces and adopts the tree–shrub–herb multi-layered structure as the dominant configuration in design in order to enhance the eco-health effect. Full article