Search Results (52)

This study analyzes technological system stability during side milling by evaluating the influence of two critical parameters: the radial depth of cut (A_e) and feed per tooth (f_z). The experiment was conducted on prismatic samples with stepped geometries to measure deformation at various levels of Ae and f. Regression analysis showed a significant influence of both factors on deformation, with Ae having a stronger effect. The model explains a high level of the variance, confirming the reliability of the experimental data. The results provide guidance for optimizing parameters to improve stability and reduce dimensional deviations. Full article

Plasma jet cutting is a non-conventional process commonly used in modern industry for processing metal sheets and preparing them for subsequent technological steps. In this context it is very important to achieve the best possible final-quality workpiece to minimize additional post-processing costs, and time. This is especially challenging by the plasma jet processing of aluminum and its alloys. In this paper, a comprehensive analysis regarding the machinability and optimal circular quality of aluminum alloy 5083 was performed. Process parameters whose effects were analyzed are the cutting speed, arc current and cutting height. The circular quality was considered through responses: the circular kerf width, circular bevel angle, and circularity error on the top and bottom sheet of the metal side. To design functional relations between the process inputs and quality performances, an artificial intelligence fuzzy logic technique supported by ANOVA was applied. In order to define the process conditions that result in optimal cut quality responses, the multi-objective optimization of hybrid grey relational analysis (GRA) and the fuzzy logic approach was presented. Corresponding surface plots were created to determine the Pareto front of optimal solutions that simultaneously optimize all circular quality objective functions. The optimization procedure was confirmed through a test in which the mean absolute percentage error represented as the validation metric. Full article

Medical images demand robust privacy protection, driving research into advanced image encryption (IE) schemes. However, current IE schemes still encounter certain challenges in both security and efficiency. Fractional-order Hopfield neural networks (HNNs) demonstrate unique advantages in IE. The introduction of fractional-order calculus operators enables them to possess more complex dynamical behaviors, creating more random and unpredictable keystreams. To enhance privacy protection, this paper introduces a high-performance medical IE scheme that integrates a novel 4D fractional-order HNN with a differentiated encryption strategy (MIES-FHNN-DE). Specifically, MIES-FHNN-DE leverages this 4D fractional-order HNN alongside a 2D hyperchaotic map to generate keystreams collaboratively. This design not only capitalizes on the 4D fractional-order HNN’s intricate dynamics but also sidesteps the efficiency constraints of recent IE schemes. Moreover, MIES-FHNN-DE boosts encryption efficiency through pixel bit splitting and weighted accumulation, ensuring robust security. Rigorous evaluations confirm that MIES-FHNN-DE delivers cutting-edge security performance. It features a large key space ($2^{383}$), exceptional key sensitivity, extremely low ciphertext pixel correlations (<0.002), excellent ciphertext entropy values (>7.999 bits), uniform ciphertext pixel distributions, outstanding resistance to differential attacks (with average NPCR and UACI values of $99.6096\%$ and $33.4638\%$, respectively), and remarkable robustness against data loss. Most importantly, MIES-FHNN-DE achieves an average encryption rate as high as 102.5623 Mbps. Compared with recent leading counterparts, MIES-FHNN-DE better meets the privacy protection demands for medical images in emerging fields like medical intelligent analysis and medical cloud services. Full article

3D-printing enables the fabrication of membranes with desired shapes and geometrical parameters. In this study, a membrane for pressure-driven processes was manufactured in a single step using the fused deposition modeling (FDM) technique. The membrane was produced from a mixture of polylactic acid (PLA) with sucrose as a pore-forming agent. Sucrose was removed from the final membrane by washing it with water. The membrane consists of three layers, and this sandwich-like structure ensures its mechanical stability. The material obtained was characterized using SEM and AFM imaging, as well as nitrogen adsorption-desorption and contact angle measurements. The porosity of each layer of the membrane is due to a loose region, which is coated on both sides with a dense film formed during printing. The pores responsible for rejection capability can be found in grooves between the polymer stripes in the dense layer. The membrane exhibits a water permeability of 64 L m⁻²h⁻¹bar⁻¹, with a molecular weight cut-off of 69 kDa. The PLA membrane can be used for polyphenol concentration, demonstrating a permeability of 2–3.4 L m⁻²h⁻¹bar⁻¹ and a selectivity towards these compounds of 78–98% at 0.5 bar, with a flux decline ratio of up to 50%. Full article

The current study aimed to assess the effect of including the lateral-step or sidestep exercise with elastic bands on multidirectional speed abilities (linear, change of direction, and curve sprinting) and navicular drop and to know the impact of navicular drop changes on multidirectional sprinting changes in young male football players. Thirty-two young male football players (age: 14.7 ± 0.82) were randomly divided into group A (n = 16) or group B (n = 16). Using a crossover design trial (ABBA), a group performed three sets of six repetitions per side in the lateral-step exercise with elastic bands attached in a low vector, three days per week, plus their regular training sessions, while the other continued with their regular football training sessions during the first 3 weeks, changing the role during the next 3 weeks of the intervention. Pre-intervention and three and six weeks after the beginning of the intervention, a navicular drop test, a 10 m linear sprint test, a multiple change of direction test (V-cut), and a curvilinear sprinting test were assessed. The sidestep exercise with elastic bands significantly improved the ability to sprint multidirectionally in only three weeks of training (p < 0.05, n² = 0.56 to 0.74), and there was a trend in the impact of multidirectional sprinting performance through those changes reported in the navicular drop test (r = −0.23 to 0.45). Full article

Backside alignment is a key microfabrication process step, especially in micro-electromechanical systems (MEMS). The double-side mask aligners used for this purpose are unaffordable for many research centres. We propose a new method that aligns the backside mask to the features on the topside using a direct laser writer, which is available in many cleanrooms. In this method, the corner co-ordinates of the sample are used as alignment features, and a transformation matrix is developed to map the design co-ordinates to the stage co-ordinates. This method has been validated on copper features as small as 100 $\mathsf{\mu }$m on silicon substrates. Test samples are cut from a 2 inch Si wafer, and copper features are sputtered and developed onto the topside. Backside patterns that are aligned to these copper features are created using photolithography through the application of this alignment method. This method exhibited challenges for samples without sharp right-angled corners, where the estimation of the corner co-ordinates resulted in misalignment. Sixteen areas over nine samples were analysed. An average alignment resolution of 23 ± 1 $\mathsf{\mu }$m was established in the x and 8 ± 4 $\mathsf{\mu }$m in the y direction, and a rotation misalignment of less than 1° was achieved. Differences in alignment were due to the individual quality of each sample’s corners and to the clarity of the corner co-ordinates. This new approach provides a route towards low-cost microfabrication process development. Full article

The demand for clean-cut seafood fillets has led to an increase in fish processing side streams, which are often considered to be low-value waste despite their potential as a source of high-quality proteins. Valorizing these side streams through innovative methods could significantly enhance global food security, reduce environmental impacts, and support circular economy principles. This study evaluates the environmental sustainability of protein recovery from herring, salmon, and cod side streams using pH-shift technology, a method that uses acid or alkaline solubilization followed by isoelectric precipitation to determine its viability as a sustainable alternative to conventional enzymatic hydrolysis. Through a Life Cycle Assessment (LCA), five key environmental impact categories were analyzed: carbon footprint, acidification, freshwater eutrophication, water use, and cumulative energy demand, based on a functional unit of 1 kg of the protein ingredient (80% moisture). The results indicate that sodium hydroxide (NaOH) use is the dominant environmental impact driver across the categories, while energy sourcing also significantly affects outcomes. Compared to conventional fish protein hydrolysate (FPH) production, pH-shift technology achieves substantial reductions in carbon footprint, acidification, and water use, exceeding 95%, highlighting its potential for lower environmental impacts. The sensitivity analyses revealed that renewable energy integration could further enhance sustainability. Conducted at a pilot scale, this study provides crucial insights into optimizing fish side stream processing through pH-shift technology, marking a step toward more sustainable seafood production and reinforcing the value of renewable energy and chemical efficiency in reducing environmental impacts. Future work should address scaling up, valorizing residual fractions, and expanding comparisons with alternative technologies to enhance sustainability and circularity. Full article

Background: The ankle joint is among the most vulnerable areas for injuries during daily activities and sports. This study focuses on individuals with chronic ankle instability (CAI), comparing the biomechanical characteristics of the lower limb during side-step cutting under various conditions. The aim is to analyze the impact of kinesiology tape (KT) length on the biomechanical properties of the lower limb during side-step cutting, thereby providing theoretical support and practical guidance for protective measures against lower-limb sports injuries. Methods: Twelve subjects with CAI who met the experimental criteria were recruited. Each subject underwent testing without taping (NT), with short kinesiology tape (ST), and with long kinesiology tape (LT), while performing a 45° side-step cutting task. This study employed the VICON three-dimensional motion capture system alongside the Kistler force plate to synchronously gather kinematic and kinetic data during the side-step cutting. Visual 3D software (V6.0, C-Motion, Germantown, MD, USA) was utilized to compute the kinematic and kinetic data, while OpenSim 4.4 software (Stanford University, Stanford, CA, USA) calculated joint forces. A one-way Analysis of Variance (ANOVA) was conducted using SnPM, with the significance threshold established at p < 0.05. The Origin software 2021 was used for data graphic processing. Results: KT was found to significantly affect joint angles, angular velocities, and moments in the sagittal, frontal, and transverse planes. LT increased hip and knee flexion angles as well as angular velocity, while ST resulted in reduced ankle inversion and increased knee internal rotation. Both types of KT enhanced hip abduction moment and knee adduction/abduction moment. Additionally, LT reduced the ankle joint reaction force. Conclusions: These findings suggest that the application of KT over a short duration leads to improvements in the lower-limb performance during side-step cutting motions in individuals with CAI, thus potentially decreasing the risk of injury. Full article

Opioid-induced constipation (OIC) is a very common and troublesome gastrointestinal side effect following the use of opioids. Despite existing international guidelines, OIC is largely underdiagnosed and undertreated. ECHO OIC is a European project designed to improve the diagnosis and management of OIC at the primary care level. The next phase of the ECHO OIC project is to review and adapt the proposed European pathway at national level, considering the local patient journey and clinical practice. A multidisciplinary group of 12 Italian experts reviewed and discussed the European path and formulated a seven-step guide for the practical management of OIC that is also easily applicable in primary care: 1. When prescribing long-term opioids, the physician should inform the patient of the possibility of the onset of OIC; 2. At opioid prescription, doctors should also prescribe a treatment for constipation, preferably macrogol or stimulant laxatives; 3. The patient should be evaluated for OIC within the second week of initiating opioid treatment, by clinical history and Rome IV criteria; 4. In the presence of constipation despite laxatives, prescription of a PAMORA (Peripherally Acting Mu Opioid Receptor Antagonist) should be considered; 5. When prescribing a PAMORA, prescribing information should be carefully reviewed, and patients should be accurately instructed for appropriate use; 6. Efficacy and tolerability of the PAMORA should be monitored regularly by Bowel Function Index, considering a cut-off of 30 for the possible step-up of OIC treatment; 7. After 4 weeks of treatment, if the efficacy of PAMORA is deemed inadequate, discontinuation of the PAMORA, addition of an anti-constipation drugs, change of opioid type, or referral to a specialist should be considered. Spreading knowledge about the OIC problem as much as possible to the health community is crucial to obtain not only an early treatment of the condition but also to promote its prevention. Full article

In the new construction of a seventeen-storey building, a provisional prop of fourteen-meter height, horizontally braced on two intermediate levels, has been used. Despite the fact that structural logic suggests that it can be cut without having any added safety precautions, the structure of the building, made up of cores and reinforced concrete slabs working spatially, indicates that certain mechanisms be introduced so that, in the event that different and worse behaviors than expected are detected, the process can be stopped and the consequences of the new situation observed can be analyzed. For this purpose, two pairs of four metallic cantilevers were introduced at mid-height with four hydraulic pistons. In addition, the best position of a series of strain gauges as well as transducers were analyzed. At first, a load test was carried out to check that the brackets worked correctly. Once this step was verified, the abutment was cut, and the results were read. The results of stresses and deformations were compared with those expected, always being satisfactory. Finally, four provisional profiles were placed in case after a few days the structure suddenly gave way. The research focuses on obtaining an efficient control system and achieving total security throughout the process, with the comparison of the results strictly necessary for this case. Few resources were used so as not to make the work excessively expensive. We have found important divergences, on the side of security, between calculation and reality. We have also considered that the construction process has an impact on the final results. In the same way, the rigidity of the temporal abutment must be considered before the calculation. All these factors have generated a lower-than-expected deformation in an 8 m cantilever. Full article

(1) This study examined the impact of fatigue and unanticipated factors on knee biomechanics during sidestep cutting and lateral shuffling in female basketball players, assessing the potential for non-contact anterior cruciate ligament (ACL) injuries. (2) Twenty-four female basketball players underwent fatigue induction and unanticipated change of direction tests, and kinematic and kinetic parameters were collected before and after fatigue with a Vicon motion capture system and Kistler ground reaction force (GRF) sensor. (3) Analysis using two-way repeated-measures ANOVA showed no significant interaction between fatigue and unanticipated factors on joint kinematics and kinetics. Unanticipated conditions significantly increased the knee joint flexion and extension angle (p < 0.01), decreased the knee flexion moment under anticipated conditions, and increased the knee valgus moment after fatigue (p ≤ 0.05). One-dimensional statistical parametric mapping (SPM1d) results indicated significant differences in GRF during sidestep cutting and knee inversion and rotation moments during lateral shuffling post-fatigue. (4) Unanticipated factors had a greater impact on knee load patterns, raising ACL injury risk. Fatigue and unanticipated factors were independent risk factors and should be considered separately in training programs to prevent lower limb injuries. Full article

This review delves into the most recent therapeutic approaches for pediatric chronic heart failure (HF) as proposed by the International Society for Heart and Lung Transplantation (ISHLT), which are not yet publicly available. The guideline proposes an exhaustive overview of the evolving pharmacological strategies that are transforming the management of HF in the pediatric population. The ISHLT guidelines recognize the scarcity of randomized clinical trials in children, leading to a predominance of consensus-based recommendations, designated as Level C evidence. This review article aims to shed light on the significant paradigm shifts in the proposed 2024 ISHLT guidelines for pediatric HF and their clinical ramifications for pediatric cardiology practitioners. Noteworthy advancements in the updated proposed guidelines include the endorsement of angiotensin receptor-neprilysin inhibitors (ARNIs), sodium-glucose cotransporter 2 inhibitors (SGLT2is), and soluble guanylate cyclase (sGC) stimulators for treating chronic HF with reduced ejection fraction (HFrEF) in children. These cutting-edge treatments show potential for enhancing outcomes in pediatric HFrEF. Nonetheless, the challenge persists in validating the efficacy of therapies proven in adult HFrEF for the pediatric cohort. Furthermore, the proposed ISHLT guidelines address the pharmacological management of chronic HF with preserved ejection fraction (HFpEF) in children, marking a significant step forward in pediatric HF care. This review also discusses the future HF drugs in the pipeline, their mechanism of actions, potential uses, and side effects. Full article

Laboratory studies have limitations in screening for anterior cruciate ligament (ACL) injury risk due to their lack of ecological validity. Machine learning (ML) methods coupled with wearable sensors are state-of-art approaches for joint load estimation outside the laboratory in athletic tasks. The aim of this study was to investigate ML approaches in predicting knee joint loading during sport-specific agility tasks. We explored the possibility of predicting high and low knee abduction moments (KAMs) from kinematic data collected in a laboratory setting through wearable sensors and of predicting the actual KAM from kinematics. Xsens MVN Analyze and Vicon motion analysis, together with Bertec force plates, were used. Talented female football (soccer) players (n = 32, age 14.8 ± 1.0 y, height 167.9 ± 5.1 cm, mass 57.5 ± 8.0 kg) performed unanticipated sidestep cutting movements (number of trials analyzed = 1105). According to the findings of this technical note, classification models that aim to identify the players exhibiting high or low KAM are preferable to the ones that aim to predict the actual peak KAM magnitude. The possibility of classifying high versus low KAMs during agility with good approximation (AUC 0.81–0.85) represents a step towards testing in an ecologically valid environment. Full article

Soccer athletic performance varies across a soccer season due to training and fatigue. In addition, it is known that core stability is linked with anterior cruciate ligament (ACL) injury risk but their variations over a season are unknown. The aim of the study was to determine the evolution of core stability, athletic performance, and ACL injury risk among young high-level soccer players at four key moments of a season: pre-season (PRE), start of season (START), mid-season (MID), and the end of the season (END). Core stability scores increased until mid-season, while ACL injury risk scores (measured during sidestep cuttings and single-leg landing) decreased thanks to an injury prevention program between START and MID. These results are in line with the literature, which demonstrates that a high level of core stability is linked to a low injury risk. Evolution of athletic performance was not consistent throughout the season, being dependent on the specific phases of training performed by the athletes. Therefore, assessing core stability, athletic performance, and ACL injury risk multiple times across a soccer season could help coaches to adapt their training programs properly. Full article

Research on the evolution of performance throughout a season in team sports is scarce and mainly focused on men’s teams. Our aim in this study was to examine the seasonal variations in relevant indices of physical performance in female football players. Twenty-seven female football players were assessed at week 2 of the season (preseason, PS), week 7 (end of preseason, EP), week 24 (half-season, HS), and week 38 (end of season, ES). Similar to the most common used conditioning tests in football, testing sessions consisted of (1) vertical countermovement jump (CMJ); (2) 20 m running sprint (T20); (3) 25 m side-step cutting maneuver test (V-CUT); and (4) progressive loading test in the full-squat exercise (V1-LOAD). Participants followed their normal football training procedure, which consisted of three weekly training sessions and an official match, without any type of intervention. No significant time effects were observed for CMJ height (p = 0.29) and T20 (p = 0.11) throughout the season. However, significant time effects were found for V-CUT (p = 0.004) and V1-LOAD (p = 0.001). V-CUT performance significantly improved from HS to ES (p = 0.001). Significant increases were observed for V1-LOAD throughout the season: PS-HS (p = 0.009); PS-ES (p < 0.001); EP-ES (p < 0.001); and HS-ES (p = 0.009). These findings suggest that, over the course of the season, female football players experience an enhancement in muscle strength and change of direction ability. However, no discernible improvements were noted in sprinting and jumping capabilities during the same period. Full article