Search Results (145)

Background: The goal of this study was to evaluate whether medical recommendation of Angocin^® Anti-Infekt N (hereafter referred to as Angocin^®) on the day of diagnosis of an acute upper respiratory tract infection (aURTI) or acute sinusitis (AS) is negatively associated with a recurrence of these diagnoses, incidence of antibiotic prescriptions, incidence of chronic sinusitis, nasal polyps, or sick leave duration. Methods: This retrospective cohort study utilized the IQVIA^TM Disease Analyzer database and included patients by general practitioners with at least one diagnosis of aURTI or AS from 2005 to 2024 and a prescription of Angocin^®, nasal medications (xylometazoline, oxymetazoline) and mucolytics (ambroxol or acetylcysteine), other phytopharmaceutical drugs, or antibiotics on the day of diagnosis. Patients who received Angocin^® were matched separately to each of the three comparison cohorts in a 1:5 ratio using a nearest-neighbor propensity score approach. The relationship between Angocin^® prescription and the risks of a recurrence, subsequent antibiotic use or progression to chronic disease was then estimated with Cox proportional hazard models. To examine whether Angocin^® exposure was associated with the length of sick leave, univariable conditional logistic regression was applied. Results: A total of 3501 Angocin^® patients and 17,505 patients in each further cohort were investigated. Angocin^® prescription was associated with a significantly lower incidence of a newly diagnosed aURTI/AS as compared to other phytopharmaceuticals (Hazard ratio (HR): 0.78; 95% confidence interval (CI): 0.68–0.86), nasal medications and mucolytics (HR: 0.79; 95% CI: 0.71–0.88), or antibiotics (HR: 0.85; 95% CI: 0.77–0.95). In addition, there was a significantly lower incidence of subsequent further prescriptions of antibiotics when compared to other phytopharmaceuticals (HR: 0.92; 95% CI: 0.82–0.99), nasal medications and mucolytics (HR: 0.87 (95%; CI: 0.80–0.95), or antibiotics (HR: 0.62; 95% CI: 0.57–0.67). Furthermore, Angocin^® was associated with the most advantageous pattern of work absence across all time periods examined. Conclusions: Considering the limitations of the study, the results cast a positive light on Angocin^® prescription in the management of aURTI/AS, particularly with regard to recurrence rates, subsequent antibiotic prescriptions, and sick leave duration. Full article

Sick leave in physically demanding warehouse logistics poses persistent challenges for employee well-being, operational performance, and sustainable work participation. This study investigates how warehouse employees and supervisors understand drivers of absence and presence, and which workplace resources are perceived as most important for sustaining work happiness and attendance. Using an explanatory sequential mixed-methods design, phase 1 comprised in-depth interviews with warehouse leaders and focus groups with employees (N = 20). Qualitative findings highlight physical strain and sustained pace demands, but also emphasized psychosocial drivers such as emotional exhaustion, limited recognition, insufficient relational support, and a “push-through” culture that normalized strain and hindered recovery. At the same time, collegial support, humor, and everyday recognition were described as critical resources for coping and maintaining presence. Building on these insights, we used a cross-sectional survey (N = 99) to assess work happiness and perceived negative workplace conditions. Exploratory factor analysis identified four work happiness dimensions—supervisor support and recognition; self-development, meaning and autonomy; interpersonal relationships; and collaboration to achieve goals and four dimensions of negative workplace conditions: structural alienation, work-related exhaustion, adverse social climate, and work intensity. Multiple regression analyses showed that interpersonal relationships were the most consistent protective resource, negatively associated with exhaustion, adverse social climate, and work intensity, while supervisor support and recognition primarily reduced structural alienation. Overall, the findings suggest that social relationships constitute a central resource for sustainable well-being and attendance in physically demanding work, offering actionable implications for HRM. Full article

Sick leave is a key indicator of labour market performance and public health, reflecting employee well-being and working conditions while creating a socioeconomic burden. Rates have increased in Europe due to ageing and shrinking workforces, yet research has focused mainly on medical risks, with limited attention to psychosocial factors and subjective well-being. This study analysed the relationship between sick leave, employees’ subjective well-being, self-rated health, and psychosocial work factors. A cross-sectional survey was conducted in Latvia (July–September 2024) among employees in four sectors, public administration, healthcare, pharmaceuticals, and energy, yielding 1628 valid responses (81.6%). Data from online questionnaires (WHO-5, OECD frameworks) were linked to organisational sick leave records. Analyses used descriptive statistics, generalised linear models, bootstrapping, and structural equation modelling. Employees reported an average of 12 sick leave days in 2023, with higher levels among women and healthcare workers. Health problems and work environment risks were positively associated with the likelihood of sick leave, whereas greater job autonomy showed a negative association. Subjective well-being was indirectly related to sick leave through its association with health problems. These findings highlight the multifactorial nature of sick leave and underscore the importance of fostering healthy and supportive psychosocial work environments to promote employee well-being. Full article

Background/Objectives: Nursing professionals were among the most affected groups during the COVID-19 pandemic, exposed to simultaneous physical demands and emotional strain. This study examined the interplay between work engagement, compassion fatigue, and musculoskeletal symptoms among frontline nurses in a Brazilian public hospital. Methods: A cross-sectional study (n = 77) was conducted between February and April 2022 using validated instruments (Work Stress Scale, ProQoL-BR, Nordic Musculoskeletal Questionnaire, and UWES-9). Descriptive and inferential analyses were performed (p ≤ 0.05). Results: Most participants did not report occupational stress (84.4%). No profiles of compassion fatigue were identified, although notable rates of burnout (26.0%) and secondary traumatic stress (23.4%) were observed. Engagement scores were very high in vigor and dedication. Musculoskeletal symptoms were prevalent, especially in the lumbar region (chronic: 60.0%). Female sex, statutory employment, and lack of physical activity were associated with a higher prevalence of symptoms and sick leave. Work engagement (vigor and overall score) showed negative correlations with absenteeism. Conclusions: The coexistence of high engagement and emotional vulnerability, in the absence of compassion fatigue, suggests that higher levels of engagement may be associated with lower occupational stress. These findings highlight the importance of integrated strategies, including ergonomic interventions, health promotion, and organizational support, to preserve the physical and mental health of frontline nursing professionals. This study provides new evidence of engagement as a potential protective factor that may mitigate physical and emotional burden among nurses in resource-limited settings. Full article

Background: In Europe, Vipera ammodytes ammodytes (Vaa, nose-horned viper) is considered the most venomous of the European vipers. The antivenom Viperfav^®, composed of polyvalent equine F(ab′)₂ fragments, is effective against Vipera aspis, Vipera berus and Vaa. Objectives: This study aimed to evaluate the clinical efficacy and pharmacokinetics of Viperfav in Vaa envenomations. Methods: Patients presenting with Vaa snakebite and treated with intravenous Viperfav were included. Clinical manifestations and laboratory findings were assessed on admission to the Emergency Department, prior to antivenom therapy, and monitored throughout hospitalization. Blood samples were collected on arrival and at defined intervals after Viperfav administration. Venom and antivenom concentrations in serum were determined by ELISA and subjected to pharmacokinetic analysis. Results: Twenty-one patients bitten by Vaa and classified with a severity score of 2b on the modified Audebert clinical severity scale received a single intravenous dose of Viperfav within 4 h of the bite. Viperfav attenuated the progression of local symptoms and prevented the development of new systemic manifestations. The serum concentrations of F(ab′)₂ fragments reached 196 µg/mL, far exceeding the venom concentration at admission (35 ng/mL). The prolonged elimination half-life of Viperfav (49 h) corresponded with the absence of recurrent symptoms after a single dose. Bradycardia or hypotension occurred in 10% of patients; no cases of anaphylaxis or serum sickness were observed. Conclusions: A single intravenous dose of Viperfav demonstrated clinical efficacy and a favourable pharmacokinetic profile in Vaa envenomed patients when administered within hours of the bite. Full article

Background/Objectives: Given the high prevalence of mental health problems in the workplace, fostering disclosure and reducing sickness absence are critical for ensuring timely support and sustaining employees’ work ability. Drawing on the health-oriented riented leadership (HoL) model, this paper examines the associations between staff care, disclosure, and sickness absence, and addresses the underexplored question of whether staff care continues to show beneficial relationships when employees experience acute health deterioration. To account for differing perspectives, we included samples with employees and with leaders. Methods: We conducted three distinct cross-sectional studies with (1) predominantly healthy employees (N₁ = 148), (2) employees with severe mental health issues or a diagnosis (N₂ = 338), and (3) leaders (N₃ = 91). Results: Staff care is positively related to disclosure across all studies. In study 1, this relationship was unexpectedly stronger for low than for high health deterioration, though still significant for high deterioration. In studies 2 and 3, the interaction was non-significant. However, a perceptual gap emerged: simple slopes showed that leaders with low staff care still expected disclosure from employees with high health deterioration (study 3), whereas employees reported higher concealment intentions (study 1). Staff care was negatively related to sickness absence only in study 2, with this relationship strengthened under high health deterioration. Conclusions: Staff care seems particularly relevant for supporting disclosure during early health declines and for mitigating sickness absence during acute deterioration among those already affected. Divergent leader–employee perceptions may hinder timely support. We provide practical recommendations for organizations. Full article

Despite an abundance of available research, calf mortality persists as a multifaceted phenomenon that presents ongoing challenges in practical management. This historical single-cohort study was conducted to provide a more comprehensive layer of knowledge to the existing information pool on calf mortality risk factors by using multiblock partial least squares analysis. The method reveals the contribution of several variables aggregated into thematic blocks and allows to include multiple outcome variables describing the same phenomenon. Such an analysis of the data provides valuable information to farmers, veterinarians, and advisors alike, not only about single risk factors, but also about management areas to prioritize when tackling calf mortality. Data was gathered from 118 Estonian dairy herds, each comprising ≥100 cows, via questionnaire, sample collection, and on-farm scoring and measurements. The final dataset included 147 questions divided into 13 meaningful blocks. The outcome variables were annual herd-level calf mortality risk during the first 21 days (MR21) and 22–90 days (MR90) using farm records and the national cattle database, respectively. The average MR21 was 5.9% (median 4.4%, range 0.0–26.8%) and the average MR90 was 2.7% (median 2.3%, range 0.0–12.7%). Of the 13 thematic variable blocks, the most important blocks explaining calf mortality were ‘Routine stress-inducing activities’, ‘Herd characteristics’, ‘Calving management’, ‘Calf housing during 5–21 days’, and ’External biosecurity’. The most influential single variables associated with higher overall calf on-farm mortality during the preweaning period were poorer cleanliness scores of calving animals and calves having access to an outdoor area during the first 21 days of life. Detected risk factors for MR21 were calf barn age > 20 years, allowing the calves to suckle the first colostrum, bucket feeding calves during the first three weeks, disbudding all calves (compared to only heifer calves), and disbudding at 21–29 days of age. Risk factors for MR90 included the use of automatic milk feeders and feeding waste milk during the first three weeks, early introduction of calves to large group pens and higher in-pen age differences, absence of forced ventilation during the first three weeks, opportunity for feces to spread between calf pens, and use of calving pens for sick animals. Washing and disinfection of newborn calves’ pens and testing colostrum quality were protective factors against both MR21 and MR90. Other protective practices for MR21 were related to proper colostrum feeding routines, whereas lower MR90 was mostly associated with efficient external biosecurity practices and vaccination programs. The multiblock model proved to be beneficial in providing a broader understanding of the importance of different management areas on calf mortality. Full article

Background: Infectious diseases pose a serious epidemiological and economic challenge for all healthcare systems. However, there is a lack of comprehensive analyses assessing the cost of absenteeism attributable to all infectious diseases. Our objective was to evaluate the burden of absenteeism-related costs due to infectious diseases in comparison with other major public health challenges. Methods: We applied the human capital approach to estimate the indirect costs of absenteeism caused by infectious diseases in Poland between 2018 and 2023. In particular, we assessed the relative contribution of different groups of infectious diseases to the overall economic burden. Data were obtained from the Social Insurance Institution (ZUS). Results: The total cost of absenteeism due to infectious diseases in Poland during the six-year period was EUR 5.3 billion. Over 78% of these costs were attributed to pneumonia and other acute lower respiratory tract infections (ICD-10: J12–J22): EUR 1.89 billion, COVID-19 (ICD-10: U07–U09): EUR 1.82 billion, and influenza (ICD-10: J09–J11): EUR 444.5 million. Infectious diseases imposed a greater economic burden in terms of absenteeism than each of the three conditions used as comparators: malignant neoplasms, depression, and ischemic heart disease. Conclusions: Our six-year analysis of sickness absence in Poland indicates that infectious diseases—particularly during the COVID-19 pandemic—are major drivers of productivity loss. When compared with other leading public health challenges, their economic burden is substantial. These findings underscore the importance of investing in preventive measures, particularly vaccination programs. Full article

Biosecurity is essential in livestock farming to prevent the spread of diseases, ensure animal welfare, and maintain farm sustainability. In Portugal, small ruminant farms are predominantly extensive and small-scale, and most of them are familiar, especially in the northern and inland regions. Thus, biosecurity implementation on these farms is low due to factors such as an aging livestock farmer population, poor training, limited veterinary support, and economic constraints. This study, the first to assess biosecurity on Portuguese small ruminant farms, evaluated compliance levels and the influence of sociodemographic factors. A cross-sectional study was conducted between July 2023 and April 2024, through structured interviews with 276 farmers. A 32-question checklist covering nine biosecurity categories was used to assess compliance. The results revealed poor implementation of key biosecurity measures, particularly cleaning and disinfection, quarantine protocols, and visitor control. Inadequate premises infrastructure, including the absence of quarantine areas, isolation facilities for sick animals, and farrowing rooms, further hampered disease prevention. Compliance was influenced by farmers’ age, education level, herd size, and production. Larger farms, particularly dairy farms, demonstrated better biosecurity practices, likely due to better management and infrastructure. This study highlights the challenges of implementing biosecurity measures on small-scale, extensive farms and argues that standardized plans are ineffective. Instead, region- and farm-specific strategies are needed, considering the socioeconomic realities of farmers. Improving farmers’ education and access to veterinary services is crucial. Furthermore, public policies should provide financial incentives and educational programs to improve biosecurity without compromising farm viability. Strengthening biosecurity on small ruminant farms is vital to protecting animal and public health and ensuring the long-term sustainability of rural communities in Portugal. Full article

Acquired brain injury (ABI) is one of the leading causes of disability worldwide. Immersive virtual reality (IVR) is an emerging tool in the field of neurological rehabilitation that has shown promising results, although it has been little studied in patients with ABI. The main objective of this study was to explore the feasibility of a TEVI-DCA program as a rehabilitation tool for people with ABI. In this study, 14 people with ABI were recruited (mean age of 52.43 years (range from 35 to 65 years), 57.1% men) and took part in a twice-weekly IVR therapy program. The intervention was feasible and safe. The participants completed the program with no adverse effects (no symptoms on the Simulator Sickness Questionnaire), and experienced high usability (System Usability Scale > 80%) and outstandingly positive post-game experiences (Game Experience Questionnaire 2.56/4). In addition, the participants significantly improved several of their physical and cognitive capacities, showing increased strength (handgrip p = 0.042), reduced fall risk (Tinetti test p < 0.001), an increase in the physical component of the quality of life (PCS-SF-8 p = 0.006), and improved executive functions (Wisconsin Card Sorting Test p = 0.005). These findings demonstrate that the TEVI-DCA program appears to be a feasible therapeutic tool for people with ABI, as it has shown maximum adherence, with an absence of adverse events, and was shown to lead to improvements in physical–cognitive aspects, although further studies are needed to corroborate the findings of this study. Full article

This study aimed to predict employee sickness absence, vital for sustainable workforce management and organizational productivity. Despite its importance, gaps exist in using advanced machine learning for this purpose. This research developed and validated models—Gradient Boosting, CatBoost, and Random Forest—focused on predictors like health conditions, mental well-being, and work stress. Using a factory worker dataset, this study conducted feature engineering, causal inference, and model performance evaluation. Random Forest proved especially effective in predicting absence, with key factors including recent performance and health. The findings support targeted interventions and efficient resource allocation, promoting sustainable business practices. Full article

Background/Objectives: A person-under-train (PUT) incident is a traumatic event for train drivers that can result in serious health consequences. This systematic review aimed to identify and synthesize evidence on these health effects, including post-traumatic stress disorder (PTSD), sickness absence (SA), and other related mental health outcomes. Methods: Following the PECO scheme, we searched the PubMed, Web of Science, and Embase databases for studies published between 1980 and 2021. We included cross-sectional, case–control, prospective, and interventional studies focusing on train drivers exposed to PUT incidents. Data synthesis followed PRISMA guidelines, with quality appraisal using the Downs and Black checklist. Results: The search was conducted on 22 September 2022, resulting in 3673 records. Nine studies were included, involving a total of 3425 participants. PTSD prevalence ranged from 0% to 55.3%, depending on study design and timing of data collection. Risk factors included repeated exposure, lack of social support, and proximity to the victim. SA varied widely, with durations ranging from 1 day to over 6 months. Drivers frequently reported depression, somatoform disorders, and other long-term psychological impacts. Conclusions: PUT incidents significantly affect the mental health of train drivers and their ability to return to work, frequently leading to extended sickness absence. The timely identification of at-risk individuals and the implementation of best-practice interventions could mitigate long-term effects. Future research should explore standardized follow-up periods to improve comparability. Full article

Background: Absenteeism among healthcare workers (HCWs) disrupts workflows and hampers the delivery of adequate patient care. The aim of the study was to examine predictors of sick leaves among HCWs in a tertiary medical center in Lebanon. Methods: A retrospective analysis of sick leaves linked to health records of 2850 HCWs between 2015 and 2018 was performed. Sick leave episodes were stratified by diagnosis. Bivariate and negative binomial regression analyses were performed to investigate predictors. Results: The mean number of sick leave episodes was 10.6 per person over 4 years. The strongest predictor of higher sickness absenteeism was low job grade (IR = 1.52; 95% CI = 1.39, 1.67). Female sex (IR = 1.24; 95% CI = 1.14, 1.36), older age (IR = 1.19; 95% CI = 1.08, 1.30), being married (IR = 1.21; 95% CI = 1.11, 1.33), being a current smoker (IR = 1.21; 95% CI = 1.11, 1.32), and having a history of selected medical conditions were all significant sick leave predictors. Conclusion: Demographic, work-related, and health-related predictors are associated with the number of sick leave episodes. To address the health inequity, additional research should evaluate how some socio-economic factors determine poorer health outcomes and should guide approaches to address this crucial issue to protect the health and well-being of this key workforce. Full article

Background and Objectives: Depression is a common geriatric problem globally. It is particularly burdensome in low- and middle-income countries, where care for older people mainly relies on the family in the absence of long-term care facilities. This study aimed to assess the level of caregivers’ burden among family caregivers who are taking care of older persons with depression in the home care setting within the communities of Chiang Mai, Northern Thailand. Materials and Methods: This cross-sectional study investigated 867 pairs of community-dwelling older adults and their family caregivers in Chiang Mai, Thailand. The depression of older people was screened using the 15-item Geriatric Depression Scale. The family caregivers’ burden and quality of life were measured using the Caregiver Burden Inventory (CBI) and the European Quality of Life (EQ) Five Dimension Five Level scales. The analysis applied was multivariable regression. Results: Two-thirds of the family caregivers were female. The mean age was 55.3 ± 13.8 years. The family caregivers caring for older persons with depression experienced significantly higher levels of burden in terms of the CBI total score (Coefficient: 10.60, 95% CI: 8.60, 12.60) and lower quality of life in terms of the EQ visual analogue scale (Coefficient: −5.52, 95% CI: −8.41, −2.62). They were more likely to take sick leave from their jobs (adj. OR 4.00, 95% CI: 1.73, 9.24) and more often to get sick (adjusted OR 7.26, 95% CI: 2.68, 19.64) than the caregivers of older adults without depression. Conclusions: Urgent interventions to prevent depression among older adults and systematic support to relieve family caregiver burden are necessary. The measures to relieve family caregiver burden include care capacity building, psychological support, respite care service, financial support, and other health promotion activities. Full article

Background/Objectives: Absenteeism refers to the frequent, often unplanned, absence from the workplace. This study examines the interrelations among job satisfaction, quality of life (QoL), and absenteeism among formal caregivers for elderly individuals. With the significant demographic shift toward an aging population, understanding these dynamics is increasingly important. Methods: A sample of 82 caregivers from Portuguese Private Social Solidarity Institutions was used, with QoL assessed through the WHOQOL-Bref and job satisfaction measured via the Minnesota Satisfaction Questionnaire (MSQ). Results: The results reveal that higher levels of job satisfaction are associated with improved QoL and lower rates of absenteeism. Specifically, caregivers with higher satisfaction reported fewer sick leaves and a more favorable perception of their QoL. Conclusions: These findings underscore the need for supportive workplace policies that enhance caregiver satisfaction, ultimately contributing to both caregiver well-being and the quality of care provided. Full article