Search Results (284)

The Beijing–Tianjin–Hebei (BTH) region is a critical political and economic hub in China, which has long faced challenges related to atmospheric conditions. Traditional aerosol optical depth (AOD) monitoring methods suffer from issues of data discontinuity and gaps, limiting the ability for continuous long-term observation of aerosols. Aerosols have significant impacts on climate change and air quality, with AOD serving as a key indicator for characterizing atmospheric particulate concentration. Therefore, this study applied a machine learning model to improve all-day AOD estimation based on ground-level air quality and meteorological data, generating a long-term dataset spanning from 2018 to 2023. The results of the all-day AOD estimation method were evaluated through comparisons with Himawari-8, the Aerosol Robotic Network (AERONET), and the Copernicus Atmosphere Monitoring Service (CAMS). The estimated AOD demonstrated good agreement with AHI data, achieving an annual R² greater than 0.96 and RMSE less than 0.1. Spatially, the estimated AOD also showed strong consistency with AHI, AERONET, and CAMS. Additionally, the annual, seasonal, and hourly distribution characteristics of AOD from 2018 to 2023 were analyzed. Two typical cases of aerosol variation in the BTH region were selected and examined: a dust storm event in 2023 and changes during the Spring Festival in 2021. This method provides continuous data support for air pollution monitoring and control in the BTH region and offers valuable references for pollution prevention efforts. Full article

The convergence of the Internet of Everything (IoE) and healthcare requires ultra-reliable, low-latency, and intelligent communication systems. Sixth-generation (6G) wireless networks, coupled with digital twin (DT) models and large AI models (LAMs), are envisioned to promise substantial and practically meaningful improvements in smart healthcare by enabling real-time monitoring, diagnosis, and personalized treatment. In this article, we propose an LAM-enhanced DT-driven network slicing framework for healthcare applications. The framework leverages large models to provide predictive insights and adaptive orchestration by creating virtual replicas of patients and medical devices that guide dynamic slice allocation. Reinforcement learning (RL) techniques are employed to optimize slice orchestration under uncertain traffic conditions, with LAMs augmenting decision-making through cognitive-level reasoning. Numerical results show that the proposed LAM–DT–RL framework reduces service-level agreement (SLA) violations by approximately 42–43% compared to a reinforcement-learning-only slicing strategy, while improving spectral efficiency and fairness among heterogeneous healthcare services. Finally, we outline open challenges and future research opportunities in integrating LAMs, DTs, and 6G for resilient healthcare IoE systems. Full article

Accurate estimation of Leaf Area Index (LAI) is essential for monitoring vegetation structure and ecosystem services in urban and peri-urban environments, particularly in small, heterogeneous patches typical of semi-arid cities. This study presents a comparative assessment of four empirical LAI estimation methods—NDVI-based, NDVI-advanced, SAVI-based, and EVI-based methods—applied to atmospherically corrected Sentinel-2 Level-2A imagery (10 m spatial resolution) over a 0.045 km² urban–agricultural polygon in the Tashkent region, Uzbekistan. Multi-temporal observations acquired during the 2023 growing season (June–August) were used to examine intra-seasonal vegetation dynamics. In the absence of field-measured LAI, a Random Forest regression model was implemented as an inter-method consistency analysis to assess agreement among index-derived LAI estimates rather than to perform external validation. Statistical comparisons revealed highly systematic and practically significant differences between methods, with the EVI-based approach producing the highest and most dynamically responsive LAI values (mean LAI = 1.453) and demonstrating greater robustness to soil background and atmospheric effects. Mean LAI increased by 66.7% from June to August, reflecting irrigation-driven crop phenology in the semi-arid study area. While the results indicate that EVI provides the most reliable relative LAI estimates for small urban–agricultural patches, the absence of ground-truth data and the influence of mixed pixels at 10 m resolution remain key limitations. This study offers a transferable methodological framework for comparative LAI assessment in data-scarce urban environments and provides a basis for future integration with field measurements, higher-resolution imagery, and LiDAR-based 3D vegetation models. Full article

This report describes the development and deployment of the Public Health Quality Tool (PHQTool), an online resource designed to help mobile health clinics (MHCs) assess and improve the quality of their public health services. MHCs provide essential clinical and public health services to underserved populations but have historically lacked tools to assess and improve the quality of their work. To address this gap, the PHQTool was developed as an online, evidence-based, self-assessment resource for MHCs, hosted on the Mobile Health Map (MHMap) platform. This report documents the collaborative development process of the PHQTool and presents preliminary evaluation findings related to usability and relevance among mobile health clinics. Drawing from national public health frameworks and Honore et al.’s established public health quality aims, the PHQTool focuses on six aims most relevant to mobile care: Equitable, Health Promoting, Proactive, Transparent, Effective, and Efficient. Selection of the six quality aims was guided by explicit criteria developed through pilot testing and stakeholder feedback. The six aims were those that could be directly implemented through mobile clinic practices and were feasible to assess within diverse mobile clinic contexts. The remaining three aims (“population-centered,” “risk-reducing,” and “vigilant”) were determined to be less directly actionable at the program level or required system-wide or data infrastructure beyond the scope of individual mobile clinics. Development included expert consultation, pilot testing, and iterative refinement informed by user feedback. The tool allows clinics to evaluate practices, identify improvement goals, and track progress over time. Since implementation, 82 MHCs representing diverse organizational types have used the PHQTool, reporting high usability and identifying common improvement areas such as outreach, efficiency, and equity-driven service delivery. Across pilot and post-pilot implementation phases, a majority of respondents agreed or strongly agreed that the tool was user-friendly, relevant to their work, and appropriately scoped for mobile clinic practice. Usability and acceptance were assessed using descriptive statistics, including percentage agreement across Likert-scale items as well as qualitative feedback collected during structured debriefs. Reported findings reflect self-reported perceptions of feasibility, clarity, and relevance rather than inferential statistical comparisons. The PHQTool facilitates systematic quality assessment within the mobile clinic sector and supports consistent documentation of public health efforts. By providing a standardized, accessible framework for evaluation, it contributes to broader efforts to strengthen evidence-based quality improvement and promote accountability in MHCs. Full article

Container-based cloud platforms enable flexible and lightweight application deployment, yet container scheduling remains challenged by resource fragmentation, load imbalance, excessive energy consumption, and service-level agreement (SLA) violations. To address these issues, this paper proposes a hybrid multi-objective optimization approach, termed HHO-GWO, which combines Harris Hawks Optimization (HHO) with the Grey Wolf Optimizer (GWO) for container initial placement in cloud environments. A unified fitness function is designed to jointly consider resource utilization, load balancing, resource fragmentation, energy consumption, and SLA violation rate. In addition, a dynamic weight adjustment mechanism and Lévy flight perturbation are incorporated to improve search adaptability and prevent premature convergence. The proposed method is evaluated through extensive simulations under different workload scales and compared with several representative metaheuristic algorithms. The results show that HHO-GWO achieves improved convergence behavior, solution quality, and stability, particularly in large-scale container deployment scenarios. These findings suggest that the proposed approach provides a practical and energy-aware solution for multi-objective container scheduling in cloud data centers. Full article

Source plasma centers sustain hematology therapeutics by safeguarding testing, traceability, and cold-chain integrity before fractionation. Despite regulatory requirements (21 CFR 606/640; EU Directive 2005/62/EC), published pre-operational validation frameworks demonstrating deviation-readiness before first collections remain sparse. We conducted a simulation-based pre-operational validation of an electronic quality management system (eQMS) with an Incident → Deviation → Corrective Action and Preventive Action (CAPA) pathway at a new source plasma center, performing 20 chairside mock runs, 3 freezer-alarm drills, and a document-control stress test. Primary endpoints were anomaly rate, alarm-response time relative to a 15 min service-level agreement (SLA), and deviation-closure SLA compliance. Analyses were descriptive and designed to demonstrate system functionality, not long-term process stability. Minor anomalies occurred in 6/20 mock runs (30.0%; 95% CI 11.9–54.3); no major/critical events were observed (0/20; 95% CI 0–16.8). Deviation-closure SLAs were met in 6/6 tests (100%; 95% CI 54.1–100). Alarm-response times averaged 7.0 min (SD 1.0; range 6–8 min; 95% CI 4.5–9.5), and all drills met the 15 min vendor SLA, illustrating a preliminary readiness margin (Cpu ≈ 2.7) rather than a statistically stable capability estimate. Simulation-based pre-operational validation produced inspection-ready documentation and quantitative acceptance criteria aligned to U.S./EU expectations, supporting reproducible multi-site deployment. By protecting cold-chain integrity and traceability before first collections, the validated QMS helps preserve supply reliability for plasma-derived therapeutics central to hematology care and establishes the measurement infrastructure for post-operational performance validation. Full article

Integrating emerging Industry 4.0 technologies into smart factories has been widely discussed, particularly challenges regarding the practical use of a blockchain; one remaining challenge is the role of a blockchain beyond logistics and traceability, as well as its ability to support explicit trust measurement in real industrial environments. Existing studies often treat trust as a conceptual or cloud-oriented construction, without linking it to measurable production events. This study proposes a blockchain service-level agreement (SLA) to measure trust at an open-source frugal smart factory (SF). Trust is defined as a dynamic quantitative score derived from measurable process events, including estimated and response times, assembly correctness, and transaction outcomes; all of this is calculated through a smart contract implemented on a blockchain network. The approach is implemented in a tangram puzzle assembly process that integrates cyber-physical systems, edge computing, artificial intelligence, cloud computing, data analytics, cybersecurity, and the blockchain within a unified SF architecture. The framework was experimentally validated across four representative assembly scenarios: (i) the SF delivered the puzzle in time and was correctly assembled (${\lambda }_s$ = 0.1734), (ii) the puzzle was completed within tolerance time (${\lambda }_s$ = 0.0649), (iii) the puzzle was delivered on time and was incorrectly assembled (${\lambda }_s$ = 0.0005), and (iv) the puzzle was completed outside the tolerance time and was correctly assembled (${\lambda }_s$ = 4.91 × ${10}^{-5}$); demonstrating that the model accurately estimates expected assembly times and updates trust without manual intervention during a physical manufacturing task, addressing the limitations of prior conceptual and cloud-based approaches. The main research contributions include an operational SLA-based trust model, the demonstration of the feasibility of applying blockchain-based SLAs in a physical SF environment, and evidence that a blockchain can be justified as a mechanism for managing and measuring trust in SF, rather than solely for traceability or logistics. Full article

The explosive growth of artificial intelligence (AI) services has led to massive scaling of GPU computing clusters, causing sharp rises in power consumption and carbon emissions. Although hardware-level accelerator enhancements and deep neural network (DNN) model compression techniques can improve power efficiency, they often encounter deployment barriers and risks of accuracy loss in practice. To address these issues without altering hardware or model architectures, we propose a novel Carbon-Aware Resource Management (CA-RM) framework for GPU clusters. In order to minimize the carbon emission, the CA-RM framework dynamically adjusts energy usage by combining real-time GPU core frequency scaling with intelligent workload placement, aligning computation with the temporal availability of renewable generation. We introduce a new metric, performance-per-carbon (PPC), and develop three optimization formulations: carbon-constrained, performance-constrained, and PPC-driven objectives that simultaneously respect DNN model training deadlines, inference latency requirements, and carbon emission budgets. Through extensive simulations using real-world renewable energy traces and profiling data collected from NVIDIA RTX4090 GPU running representative DNN workloads, we show that the CA-RM framework substantially reduces carbon emission while satisfying service-level agreement (SLA) targets across a wide range of workload characteristics. Through experimental evaluation, we verify that the proposed CA-RM framework achieves approximately 35% carbon reduction on average, compared to competing approaches, while still ensuring acceptable processing performance across diverse workload behaviors. Full article

Zero-Touch Network (ZTN) represents a cornerstone approach of Next Generation Networks (NGNs), enabling fully automated and AI-driven network and service management. However, their distributed and multi-domain nature introduces critical security challenges, particularly regarding service identity and data integrity. This paper proposes a novel blockchain-based framework to enhance the security of ZTN through two complementary mechanisms: decentralized digital identity management and oracle-assisted network monitoring. First, a Decentralized Identity Management framework aligned with Zero-Trust Architecture principles is introduced to ensure tamper-proof authentication and authorization in a trustless environment among network components. By leveraging decentralized identifiers, verifiable credentials, and zero-knowledge proofs, the proposed Decentralized Authentication and Authorization component eliminates reliance on centralized authorities, while preserving privacy and interoperability across domains. Second, the paper investigates blockchain oracle mechanisms as a means to extend data integrity guarantees beyond the blockchain, enabling secure monitoring of Network Services and validation of Service-Level Agreements. We propose a four-dimensional framework for oracle design, based on qualitative comparison of oracle types—decentralized, compute-enabled, and consensus-based—to identify their suitability for NGN scenarios. This work proposes an architectural and design framework for Zero-Touch Networks, focusing on system integration and security-aware orchestration rather than large-scale experimental evaluation. The outcome of our study highlights the potential of integrating blockchain-based identity and oracle solutions to achieve resilient, transparent, and self-managed network ecosystems. This research bridges the gap between theory and implementation by offering a holistic approach that unifies identity security and data integrity in ZTNs, paving the way towards trustworthy and autonomous 6G infrastructures. Full article

Background: Periprosthetic joint infections (PJI) represent a serious complication following joint arthroplasty and require, in addition to surgical intervention, a targeted antibiotic therapy. The aim of this study was to compare microbiological recommendations for the antibiotic treatment of fictitious PJI patients generated by an artificial intelligence (AI) system with those of an interdisciplinary team (IT) consisting of microbiologists and orthopedic surgeons. The differences between the recommendations suggested by AI and the IT were analyzed with regard to the suggested agents and duration of antibiotic therapy. Methods: Based on meta-analyses, a cohort of 100 fictitious patients with acute early- and acute late-onset PJI was created, reflecting the typical demographic data, comorbidities and pathogen profiles of such a population. This information was input into the AI system ChatGPT (OpenAI, GPT-5 “Thinking mode” accessed via ChatGPT Plus, San Francisco, CA, USA) to generate corresponding recommendations. The objective was to use these profiles to obtain recommendations for definitive antibiotic therapy, including daily dosage, intravenous and oral treatment durations. Simultaneously, the same fictitious patient data were reviewed by the IT to produce their own recommendations. Results: The results revealed both concordances and discrepancies in the selection of antibiotics. Notably, in cases involving multidrug-resistant organisms and more complex clinical scenarios, the AI-generated recommendations were incongruent with those of the IT, with estimated percentage agreement ranging from 0–33%. In straightforward clinical scenarios with monomicrobial infections, AI reached an estimated percentage agreement of up to 57% (95%-CI [0.47–0.67]). Furthermore, AI consistently recommended 12 weeks of therapy duration vs. six weeks usually recommended by the IT. Conclusions: The study provides important insights into the potential and limitations of AI-assisted decision-making models in orthopedic infection treatments. Consultation of AI is universally accessible at all times of day, which may offer a significant advantage in the future for the treatment of PJI. This kind of application will be of particular interest for institutions without in-house microbiology services. However, from our perspective, the current level of incongruence between the AI-generated recommendations and those of an experienced interdisciplinary team remains too high for this approach to be clinically implemented at this time. Furthermore, AI lacks transparency regarding the sources it uses to inform about its decision-making and therapeutic recommendations, currently carries no legal weight and clinical implementation is severely hindered by restrictive privacy laws regarding health care data. Full article

Efficient resource allocation is a central challenge in multi-tenant cloud, fog, and edge environments, where heterogeneous tenants compete for shared resources under dynamic and uncertain workloads. Static or purely heuristic methods often fail to capture strategic tenant behavior, whereas many existing game-theoretic approaches overlook stochastic demand variability, fairness, or scalability. This paper proposes a Dynamic and Stochastic Game-Theoretic Allocation (DSGTA) model that jointly models non-cooperative tenant interactions, repeated strategy adaptation, and random workload fluctuations. The framework combines a Nash-like dynamic equilibrium, achieved via a lightweight best-response update rule, with an approximate Shapley-value-based fairness mechanism that remains tractable for large tenant populations. The model is evaluated on synthetic scenarios, with a trace-driven setup built from the Google 2019 Cluster dataset, and a scalability study is conducted with up to $K=500$ heterogeneous tenants. Using a consistent set of core metrics (tenant utility, resource cost, fairness index, and SLA satisfaction rate), DSGTA is compared against a static game-theoretic allocation (SGTA) and a dynamic pricing-based allocation (DPBA). The results, supported by statistical significance tests, show that DSGTA achieves higher utility, lower average cost, improved fairness and competitive utilization across diverse strategy profiles and stochastic conditions, thereby demonstrating its practical relevance for scalable, fair, and economically efficient resource allocation in realistic multi-tenant cloud environments. Full article

Ecosystems provide essential services to local communities, which in turn offer incentives for the preservation of natural resources, as these resources are crucial to the sustainability and evolution of human societies. So, this study examined the demand for ecosystem services among communities surrounding the Luki Biosphere Reserve in the Democratic Republic of Congo. Data were collected through semi-structured interviews with 361 randomly selected individuals and focus group discussions in 18 villages, complemented by field observations on local resource use (agriculture, charcoal production, wood harvesting, and tree felling). The services provided by the reserve were identified according to citation frequency, perceived usefulness, and level of agreement among respondents. Results indicate that agricultural products (28.5%), charcoal (19.1%), non-timber forest products (17.5%), and firewood (10%) are the most requested. The Chi-square test showed significant associations between dependence on ecosystem services and socio-economic variables such as gender (p = 0.014 < 0.05), education level (p = 0.033 < 0.05), and annual income (p = 0.000 < 0.05), while age was not significant (p = 0.504 > 0.05). Poverty and rapid demographic growth were identified as key drivers of demand and factors contributing to growing pressure on natural resources. The study emphasizes feedback loops between changes in ecosystem service supply and community responses, as well as trade-offs between services and actors. It recommends integrating ecosystem values into agricultural and forestry policies, while raising awareness and educating local communities to promote sustainable resource management. Full article

Reliable forecasting of network QoS indicators such as latency, jitter, and packet loss is essential for managing real-time and risk-sensitive applications. This study addresses the challenge of uncertainty quantification in QoS prediction by proposing a Bayesian Regression-enhanced Long Short-Term Memory (BR-LSTM) framework. The method integrates Bayesian mean variance estimates into sequential LSTM learning to enable accurate point forecasts and well-calibrated confidence intervals. Experiments are conducted using a Mininet-based emulation platform that simulates dynamic esports network environments. The proposed model is benchmarked against ten probabilistic and deterministic baselines, including ARIMA, Gaussian Process Regression, Bayesian Neural Networks, and Monte Carlo Dropout LSTM. Results demonstrate that BR-LSTM achieves competitive accuracy while providing uncertainty intervals that improve decision confidence for Service-Level Agreement (SLA) management. The calibrated upper bound $(\mu +k\sigma )$  can be compared directly against SLA thresholds to issue early warnings and prioritize rerouting, pacing, or bitrate adjustments when the bound approaches or exceeds policy limits, while calibration controls false alarms and prevents unnecessary interventions. The findings highlight the potential of uncertainty-aware forecasting for intelligent information systems in latency-critical networks. Full article

This Perspective presents a framework for US hospitals treating foreign patients to reconceptualize international healthcare trade by leveraging all four modes of trade in health services under the General Agreement on Trade in Services (GATS), which include information exchange (Mode 1), patient travel/medical tourism (Mode 2), commercial presence (Mode 3), and temporary movement of healthcare personnel (Mode 4). This framework illustrates how hospitals could adopt multi-modal approaches and describes the strategic implications for hospitals and their international patient programs. Historically, US hospitals have focused primarily on international patient travel (Mode 2), but this narrow approach creates vulnerability to disruption. Mode 2 exports by US hospitals have not recovered to pre-pandemic levels, making expansion into other modes essential for maintaining competitive advantages while mitigating systemic risks. Diversification into other modes, such as digital health and telemedicine (Mode 1), co-branding and managing facilities (Mode 3) and visiting professorships (Mode 4) are single-mode approaches for diversification. Multi-country clinical trials are an example of cross-border trade that addresses all four modes of GATS. Overall, this perspective provides a new framework for US providers engaged in or considering entry into international markets that does not solely rely on Mode 2 medical tourism but instead adopts a multi-modal, cross-border health service paradigm. Full article

This paper presents an after-sales service optimization problem (ASOP) that integrates technician scheduling with spare parts inventory management, multi-day planning horizons, team coordination requirements, and customer satisfaction modeling. We developed a comprehensive mixed-integer programming model that simultaneously optimizes technician assignments, inventory allocation, team collaborations, and emergency response capabilities while maintaining service-level agreement (SLA) compliance. The model includes novel constraints for equipment availability, certification requirements, spare parts consumption, and dynamic customer priority adjustments. Computational experiments on test instances demonstrated 50.0% SLA compliance with 25.8% average technician utilization across 12 service requests, 6 technicians, and a 3-day planning horizon. The integrated approach achieved an 18% cost reduction compared to sequential optimization while improving the customer satisfaction scores by 13.9%. A sensitivity analysis revealed critical trade-offs between inventory holding costs, team coordination benefits, and service quality metrics. The proposed framework provides comprehensive decision support for modern after-sales service operations requiring integrated resource management. Full article